33 results about "HATU" patented technology

The invention belongs to the technical field of nano materials, and particularly relates to AlP quantum dots and a preparing method thereof. The preparing method includes the steps that aluminum chloride hexahydrate and a phosphorus source are subjected to solvothermal reaction in organic solvent to obtain the AlP quantum dots which are small in size distribution and high in crystallinity degree and are distributed uniformly, wherein the phosphorus source is selected from one or two of tri-o-methylphenylphosphine, triphenylphosphine, phosphorus pentachloride and HATU and [BMIM]PF6. The synthesis method is easy to operate, mild in reaction and high in repeatability; the obtained quantum dots have strong fluorescence-emission in the blue light region after being irradiated with ultraviolet light, can serve as a blue light emitter applied to a light-emitting diode and can also be applied to biomarking and imaging. In addition, the fluorescence Stock displacement of the quantum is large, interference to transmission signals by exciting light can be effectively avoided, and the quantum dots have extraordinary potential advantages in developing novel optoelectronic devices in the future.

The invention provides a method for preparing a novel natural active polypeptide Tubulysin U. In the preparation method, compound 2 is dissolved in trifluoroacetic acid, heated to reflux to prepare an intermediate, and reacted with compound 3 and diisopropylethylamine to obtain The product is reacted with 2,6-lutidine and tert-butyldimethylsilyl trifluoromethanesulfonate. After the reaction, sodium hydroxide is added to treat the intermediate acid. The intermediate acid is mixed with compound 6, HATU and diiso Propylethylamine reaction, the obtained product is added with triphenylphosphine to make intermediate amine, and compound 8 and HATU are added to react, ammonium fluoride is added to make the first intermediate, and the first intermediate is added with sodium hydroxide to make the second intermediate , the second intermediate adds acetic anhydride to prepare the third intermediate, the third intermediate adds trifluoroacetic acid to obtain the fourth intermediate, and the fourth intermediate adds formaldehyde and sodium cyanoborohydride to react to produce the target product; compound 2, The structures of compound 3, compound 6 and compound 8 are:

The invention discloses a preparation method of a bulk drug olbitasvir, which comprises bis Nitro reduction reaction S1, diamino proline peptide coupling reaction S2, pyrrolidine amino deprotection reaction S3, and pyrrolidine amino valine peptide coupling reaction S4. 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride is used as the valine peptide coupling reagent in the preparation method of the raw material drug obitavir, which is disclosed in the prior art Compared with peptide coupling reagents such as EDAC / HOBT, PyBOP, HATU, and T3P, the final product synthesis step has a higher yield, and the separation and purification of the product is easier.

The invention relates to a method for synthesizing drug polypeptide nafarelin with a microwave solid-phase synthesis method. According to the solid-phase synthesis method, a raw material is sequentially connected with Fmoc (fluorenylmethoxy carbony) protected amino acids through a microwave reaction instrument, protective decapeptide resin is obtained, meanwhile, Fmos protecting groups are removed sequentially, one of DIC / HOBt, DIC / HOAt, BOP / HOBt, BOP / HOAt, HBTU / HOBt, HBTU / HOAt, HATU / HOBt, HATU / HOAt and HCTU / HOBt is taken as a condensing agent for a peptide synthesis reaction, side chain protecting group removing and peptide cutting are performed synchronously after the protective decapeptide resin is obtained, a crude product of nafarelin is obtained, the crude product is separated and purified by a C18 chromatographic column, the nafarelin is obtained and then subjected to freeze drying, and accordingly, a nafarelin acetate or trifluoroacetate product is obtained.

The present invention relates to a metal-organic framework composite material grafted with ionic liquid and a preparation method and application thereof. The technical scheme adopted is: adding ionic liquid 1-vinyl-3-carboxymethylimidazolium bromide, HATU and triethylamine into N,N-dimethylformamide, stirring evenly at room temperature, adding metal Organic Frameworks MIL‑101‑NH 2 , stirred at room temperature for 22h, the resultant was washed with N,N-dimethylformamide, filtered and dried to obtain metal organic framework composite material MIL-101-NH 2 ‑IL. The metal-organic framework composite material prepared by the invention can efficiently catalyze the cycloaddition reaction of carbon dioxide and epoxide.

The invention discloses a preparation method for solid-phase synthesis of salmon calcitonin, which comprises (1) preparing calcitonin deprotected docosopeptide resin, (2) preparing reduced salmon calcitonin crude product, (3) compounding (4) Separation and purification step, characterized in that: said step (1) prepares calcitonin-deprotected docosopeptide resin specifically as follows: amino resin is used as starting material, and amino acid protected by Fmoc is used as monomer , using HOBT / HATU as condensation reagent, take off the Fmoc protecting group sequentially in the polypeptide synthesis column, couple corresponding amino acids one by one, obtain deprotected thirty-docosopeptide resin; wherein, in the amino acid coupling step, according to each amino acid According to the degree of difficulty of synthesis, different coupling times are designed. In the present invention, by analyzing the difficulty of amino acid synthesis and changing the coupling time, the synthesis efficiency can be improved, the product purity can be increased, and the production cost can be reduced.