8082 results about "Ethyl group" patented technology

The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

The invention relates to polymers with antimicrobial properties, consisting of: a) 99-40 wt % non functional vinylically polymerizable monomers and b) 1-60 wt % functional vinylically polymerizable monomers of general formula (I) wherein V=vinyl, (meth)acroyl, allyl or styryl, A=a possibly available linking unit, which can be alkyl, aryl, arylalkyl or hydroxy alkyl, which can also be interrupted by hetero atoms, e.g. by hetero atoms in urethane, carbonate, ester, amide or ether groups, wherein y=0 or is 1, Hsp=a hydrophilic spacer of general formula (i) -(O-CH2-CH2)r- and/or (ii) -(O-CH2-CH(CH3))s with r=0-40, s=0-40 and r+s=2-40, also m=1.2 or 3 and R1=CH3, ethyl or benzyl, R2=an alkyl radical with 8-20 C-atoms, wherein t=1, 2 or 3 and X-=Cl-, Br-, I- or alkyl sulphate.

An environmentally clean dual fuel for an internal combustion engine, comprising acetylene as a primary fuel and a combustible fuel, such as one or more fluids selected from an alcohol such as ethanol, methanol or any other alcohol or alcohols from the group comprising C1-C20 carbon chains, ethers such as from the group comprising dimethyl ether, diethyl ether, methyl t-butyl ether, ethyl t-butyl ether, t-amyl methyl ether, di-isopropyl ether and the like, low-molecular-weight esters such as from the group comprising methyl formate, methyl acetate, ethyl acetate, methyl propionate, ethyl propionate and the like, or other suitable combustible fluid such as mineral spirits and the like, as a secondary fuel for operatively preventing early ignition and knock arising from the primary fuel. The dual fuel, internal combustion system, which generally utilizes a two-stage process for start-up and operation and can be operated with air- or liquid-cooling, is environmentally clean with hydrocarbon, CO, NOx, and SOx emissions substantially eliminated.

An environmentally-friendly cleaning composition for industrial and consumer applications comprising (a) a blend of dibasic esters, (b) one or more surfactants (c) and, optionally, (d) water or a solvent. The dibasic esters are be derived from a blend of adipic, glutaric, and succinic diacids, and, in one particular embodiment, the blend comprises dialkyl adipate, dialkyl methylglutarate and dialkyl ethylsuccinate, wherein the alkyl groups individually comprise a C₁-C₁₂ hydrocarbon group. The one or more surfactants are typically chosen from alcohol alkoxylate, an alkyl phenol ethoxylate, a terpene, a terpene alkoxylate or any derivates thereof. Optionally, additional components or additives including delaminates such as pinene and d-limonene, fragrances, whiteners, stabilizers, thickeners and the like can be added to the composition. The industrial or consumer application selected from the group consisting of a graffiti cleaner, a painted-substrate cleaner, an ink cleaner, a metal substrate cleaner, a plastic substrate cleaner, an environmentally friendly cleaner, a stain-spot cleaner, an industrial hand cleaner, a resin cleaner, a tar resin cleaner, a textile cleaner, a paint stripper and any combination thereof.

Stereomerically pure (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, substantially free of its (-) isomer, and prodrugs, metabolites, polymorphs, salts, solvates, hydrates, and clathrates thereof are discussed. Also discussed are methods of using and pharmaceutical compositions comprising the (+) enantiomer of 2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-alpha or the inhibition of PDE4.

The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.

The provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and non-toxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring occurring 5-hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl-2-furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.

The invention relates to a 4-benzoyl pyrazole compound with herbicidal activity. The structural formula of the 4-benzoyl pyrazole compound with the herbicidal activity is as shown in specifications, wherein R1 in the structural formula is selected from hydrogen, methyl or ethyl, R2 in the structural formula is selected from methylsulfonyl, methoxyl, methylthio, fluorine, chlorine or cyan, R3 in the structural formula is selected from hydrogen, methyl, methyl fluoride, difluoromethyl or trifluoromethyl, R in the structural formula is selected from a five-membered heteroaromatic ring, a six-membered heteroaromatic ring, C1-C6 alkoxyl, aromatic hetero-oxy, six-membered aryloxy or six-membered aromatic amino, and hydrogen in the C1-C6 alkoxyl can be replaced by fluorine or chlorine; m and n are selected from 0 or 1 and cannot be 1 at the same time. A series of relatively efficient weed killers and plant growth regulators with relative good selectivity and safety are synthesized by introducing a fluorine-containing functional group to a pyrazole 3-site and chemically modifying a pyrazole 5-site.

A water-base resin has both excellent storage stability and excellent curability at room temperature, the water base resin being obtained by mixing a composite resin (C) and a polysiloxane (D), bringing about a condensation reaction partially between them if necessary, and thereafter dispersing or dissolving the resulting mixture or partially condensed product into a water-base medium, wherein the composite resin (C) comprises a polysiloxane segment (A) and a polymer segment (B), the polysiloxane segment (A) having at least one silicon atom selected from the group consisting of a silicon atom bearing at least one organic group having a total carbon number of at least 3 together with at least one hydrolyzable group and/or at least one hydroxyl group, a silicon atom bearing one hydrolyzable group or one hydroxyl group together with two groups selected from the group consisting of methyl groups and ethyl groups, and a silicon atom bearing at least one triorganosiloxy group together with at least one hydrolyzable group and/or at least one hydroxyl group, and the polymer segment (B) having at least one type of hydrophilic group selected from the group consisting of an anionic group, a cationic group, and a non-ionic group, and wherein the polysiloxane (D) has a hydrolyzable group bonded to a silicon atom and/or a hydroxyl group bonded to a silicon atom, the polysiloxane (D) having a structure represented by the following structural formula (S-I) as an essential structural unit:(wherein R1 in the formula denotes a methyl group or an ethyl group). A water-base curable resin composition comprising the water-base resin as an essential component produces a cured material which possesses excellent resistance stain during outdoor exposure as well as excellent durability such as acid rain resistance and gloss retention during outdoor exposure.

Cosmetic compositions containing a micronized metal oxide along with a 4-substituted resorcinol derivatives of the general formula I exhibit improved storage stability:

• • where each R₁ and R₂, independently, represents a hydrogen atom, —CO—R (acyl group), —COO—R, CONHR; where R represents saturated or unsaturated, linear, branched or cyclic C₁-C₁₈ hydrocarbon groups; and
  • R₃ represents (1) an alkyl group, having from 1 to 18 carbon atoms, preferably having from 2 to 12 carbon atoms, with or without substitution of one or more hydrogen atoms of a linear alkyl group with a methyl or ethyl group; e.g., R₃ constitutes linear or branched chain alkyls, or (2) a group of the general formula formula (II)
  • Where X is preferably H, n is 0 to 3 and the dashed lines represents an optional double bond.

This invention provides a compound of the following formula:and the pharmaceutically acceptable salts thereof, wherein L is oxygen or sulfur; Y is a direct bond or C1-4 alkylidene; Q is C1-6 alkyl, C3-7 cycloalkyl, phenyl, naphthyl, heteroaryl or the like; R1 is hydrogen, C1-6 alkyl or the like; R2 is hydrogen, C1-4 alkyl, C(O)R5 wherein R5 is C1-22 alkyl or C2-22 alkenyl, halosubstituted C1-8 alkyl, halosubstituted C2-8alkenyl, -Y-C3-7 cycloalkyl, -Y-C3-7 cycloalkenyl, phenyl, naphthyl, heteroaryl or the like; X is halo, C1-4 alkyl, hydroxy, C1-4 alkoxy or the like; and n is 0, 1, 2 or 3, with the proviso that a group of formula -Y-Q is not methyl or ethyl when X is hydrogen; L is oxygen; R1 is hydrogen; and R2 is acetyl.This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.

The present invention provides a salicylic acid ester derivative having an impurity content lower than a specific level and expressed by the following formula (1)(in the formula, R1 is methyl group or ethyl group, R2, which may be substituted optionally, is an alkyl group having a carbon number of from 1 to 30, alkoxy group having a carbon number of from 1 to 30, aryl group having a carbon number of from 6 to 30, aryloxy group having a carbon number of from 6 to 30, aralkyl group having a carbon number of from 6 to 30 or aralkyloxy group having a carbon number of from 6 to 30). The salicylic acid ester derivative is effective as a terminal blocking agent or a polymerization. promoting agent for a polycarbonate, and gives a polycarbonate having good color tone and suitable for optical material use.

Saturated and unsaturated compounds having sweet, salt or umami taste enhancement qualities. The compounds have the structure:

where R¹═H or methyl;

• R² is selected from the group consisting of H, C1-C4 alkyl, alkenyl and methylene;
• R³ is selected from the group consisting of H, C1-C8 straight or branched chain alkyl, alkenyl, dienalkyl or phenyl;
• or if R¹═H, R² and R³ taken together can represent

cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, or cyclohexenyl;

R⁴ is selected from the group consisting of H, methyl and ethyl;

R⁵ is selected from the group consisting of H, methyl and ethyl;

R⁶ is selected from the group consisting of H, C1-C9 straight or branched chain alkyl, alkenyl, alkyldienyl, acyclic or containing no more than one ring;

with the proviso that in structure 1 when R⁴ is H or Me; and

R⁵═H or methyl, R⁶ may be selected from the group described above or phenyl.

It is an object of the present invention to provide a powder coating composition, which can exhibit a sufficient hiding power, a corrosion resistance and an excellent appearance and can reduce a coating process and is particularly suitable for coating of an aluminum wheel because of its high low temperature curability and has excellent storage stability, and a coating method of an aluminum wheel using the same. A powder coating composition consisting of a powder coating composition particle, wherein said powder coating composition particle comprises at least a thermosetting resin powder formed by binding a metallic pigment with a binder and

said thermosetting resin powder comprises a β-hydroxyalkylamide curing agent expressed by the following general formula (1):

wherein R¹ represents a hydrogen atom, a methyl group or an ethyl group, R² represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms or HOCH(R¹)CH₂—, and A represents a bivalent hydrocarbon group.

Methods and compositions related to treating, controlling or inhibiting acne vulgaris by reducing or inhibiting growth of Proprionibacterium acnes employing a compound having the following structure:

or a pharmaceutically acceptable salt thereof,

• • wherein R₁, R₂, R₃ and R₄ are selected from a group consisting of a carboxyl group, methyl group, ethyl group, propyl group, isopropyl group, butyl group, isobutyl group, secondary butyl group, tertiary butyl group, pentyl group, isopentyl group, neopentyl group, fluorine, chlorine, bromine, iodine and hydrogen.