6070 results about "Hydroxymethyl" patented technology

The present invention relates to a new method for the synthesis of purine LNA (Locked Nucleic Acid) analogues which provides a higher overall yield. The method comprising a regioselective 9-N purine glycosylation reaction followed by a one-pot nucleophilic aromatic substitution reaction of the 6-substituent in the purine ring and simultaneous nucleophile-induced intramolecular ring closure of the C-branched carbohydrate to form novel purine LNA analogues. The novel strategy is illustrated by the synthesis of the novel compound (1S,3R,4R,7S)-7-benzyloxy-1-methanesulfonylmethyl-3-(guanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane which is easily converted into (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-((2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane after isobutyryl protection of the 2-amino purine group and subsequent substitution of 1-methanesulfonyl with benzoate, debenzoylation and debenzylation.

This disclosure provides double-stranded RNA complexes having one or more hydroxymethyl substituted nucleomonomer(s) in the passenger strand (or sense strand) of an RNA complex. RNA complexes of the disclosure may be useful for therapeutic applications, diagnostic applications or research applications. RNA complexes include short interfering RNA complexes (siRNA) capable of modulating gene expression comprising an antisense strand and a continuous or a discontinuous passenger strand (“sense strand”). Further, one or more hydroxymethyl substituted nucleomonomer(s) of this disclosure may be positioned at the 3′-end, at the 5′-end, at both the 3′-end and 5′end.

The present invention relates to a composition for and a method of treating hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, hepatitis D virus (HDV) infection or a proliferative disorder in a patient using an effective amount of a compound selected from the group consisting of formulas [I]- [IV] below and mixtures of two or more thereof: wherein the substituents are as defined herein. Pharmaceutical compositions comprising these compounds in combination with other HBV, HCV, or HDV agents is also disclosed.

There are disclosed a method for removing CO2 from a combustion exhaust gas which comprises the step of bringing the combustion exhaust gas under atmospheric pressure into contact with an aqueous solution of a hindered amine selected from the group consisting of 2-amino-2-methyl-1-propanol, 2-methylaminoethanol, 2-ethylaminoethanol and 2-piperidineethanol; and another method for removing carbon dioxide from a combustion exhaust gas which comprises the step of bringing the combustion exhaust gas under atmospheric pressure into contact with a mixed aqueous solution of 100 parts by weight of an amine compound (X) selected from the group consisting of 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, 2-amino-2-ethyl-1,3-propanediol, t-butyldiethanolamine and 2-amino-2-hydroxymethyl-1,3-propanediol; and 1-25 parts by weight of an amine compound (Y) selected from the group consisting of piperazine, piperidine, morpholine, glycine, 2-methylaminoethanol, 2-piperidineethanol and 2-ethylaminoethanol.

A method of oxidizing hydroxymethylfurfural (HMF) includes providing a starting material which includes HMF in a solvent comprising water into a reactor. At least one of air and O2 is provided into the reactor. The starting material is contacted with the catalyst comprising Pt on a support material where the contacting is conducted at a reactor temperature of from about 50° C. to about 200° C. A method of producing an oxidation catalyst where ZrO2 is provided and is calcined. The ZrO2 is mixed with platinum (II) acetylacetonate to form a mixture. The mixture is subjected to rotary evaporation to form a product. The product is calcined and reduced under hydrogen to form an activated product. The activated product is passivated under a flow of 2% O2.

A biosensor that is highly responsive and capable of rapid and highly sensitive quantification of a specific component contained in a sample is provided. The biosensor of this invention comprises: an electrically insulating base plate; an electrode system comprising a working electrode and a counter electrode disposed on the base plate; and a reagent system comprising an oxidoreductase which catalyzes the oxidation reaction of glucose, gluconolactonase and a buffer. The buffer is selected from the group consisting of phthalic acid and its salts, maleic acid and its salts, succinic acid and its salts, phospholic acid and its salts, acetic acid and its salts, boric acid and its salts, citric acid and its salts, glycine, tris(hydroxymethyl)aminomethane, piperazine-N,N'-bis(2-ethane sulfonic acid) and the like.

Polyols useful in the manufacture of polyurethanes are disclosed. The polyols are prepared by reacting a vegetable oil based (hydroxymethyl containing) monomer with a polyol, polyamine or aminoalcohol under vacuum.

A 5-(3-cyanophenyl)-3-formylbenzoic acid compound of the formula (IV) is prepared by reacting a 5-bromo-3-(hydroxymethyl)benzoic acid compound of the formula (I) with manganese dioxide to provide a 5-bromo-3-formylbenzoic acid compound of the formula (II), and then reacting the resultant compound of the formula (II) with 3-cyanophenylboronic acid of the formula (III) in the presence of a palladium complex. R is a H atom or a C1-C10 alkyl group.

Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.

The present invention provides an amorphous form of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid. This invention also provides processes for preparing the amorphous form and pharmaceutical compositions including the amorphous form.

Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.

This invention provides a method of treating a dry or processed fluid pipe line susceptible to the build-up of iron sulfide deposits by complexing the iron sulfide in the pipe lines. The method of the present invention introduces the composition on a continuous or a batch basis to a gas pipe line. The composition is made of a solution of 1) water, 2) [tetrakis(hydroxymethyl)phosphonium]sulfate or chloride, and 3) a soluble ammonium salt, such as ammonium chloride or the like.

A method for producing furan-2,5-dicarboxylic acid (FDCA) is provided which can efficiently and quantitatively producing FDCA under mild conditions, without employing an expensive catalyst and with a reduced energy consumption. A furan ring compound having two functional groups selected from a hydroxymethyl group, a formyl group and a carboxyl group in the 2- and 5-positions of the furan ring, is oxidized with a metal permanganate in an alkaline environment to produce furan-2,5-dicarboxylic acid. Advantageously, the alkaline environment contains at least one of alkali metal hydroxides and alkali earth metal hydroxides, and the oxidation is performed at a temperature of from 1 to 50° C. by adding the permanganate metal salt to the alkaline aqueous solution containing the furan ring compound.

An aldehyde composition derived by hydroformylation of a transesterified seed oil and containing a mixture of formyl-substituted fatty acids or fatty acid esters having the following composition by weight: greater than about 10 to less than about 95 percent monoformyl, greater than about 1 to less than about 65 percent diformyl, and greater than about 0.1 to less than about 10 percent triformyl-substituted fatty acids or fatty acid esters, and having a diformyl to triformyl weight ratio of greater than about 5 / 1; preferably, greater than about 3 to less than about 20 percent saturates; and preferably, greater than about 1 to less than about 20 percent unsaturates. An alcohol composition derived by hydrogenation of the aforementioned aldehyde composition, containing a mixture of hydroxymethyl-substituted fatty acids or fatty acid esters having the following composition by weight: greater than about 10 to less than about 95 percent monoalcohol {mono(hydroxymethyl)}, greater than about 1 to less than about 65 percent diol {di(hydroxymethyl)}, greater than about 0.1 to less than about 10 percent triol, tri(hydroxmethyl)-substituted fatty acids or fatty acid esters; preferably greater than about 3 to less than about 35 percent saturates; and preferably, less than about 10 percent unsaturates. The alcohol composition can be converted into an oligomeric polyol for use in the manufacture of polyurethane slab stock flexible foams.

The invention relates to coating material compositions for, for example, metallic, mineral substrates or for substrates of wood, paper and plastics, which comprise yellowing-resistant, low-viscosity, unsaturated, amorphous polyesters which are very largely free of benzene and formaldehyde, as a result of which the adhesion of these coating material compositions is improved even under critical ambient conditions, and to a preparation process and use of said compositions. More specifically, the invention relates to coating material compositions, substantially including 1, yellowing-resistant, low-viscosity, unsaturated, amorphous polyesters which are very largely free of benzene and formaldehyde; 2, at least one other adhesive; 3, at least one accessory ingredient and / or additive; 4, at least one colorant and / or stuffing. The yellowing-resistant, low-viscosity, unsaturated, amorphous polyesters are composed by the following components: I. acid components, made up of A) at least one alpha, beta-unsaturated dicarboxilic acid, and B) at least one linear and / or branch fatty group and / or alicyclic and / or aromatic bifunctional and / or polyfunctional carboxyl acid, which is not provided with alpha, beta-unsaturated part; II. alcohol components, made up of C) bis(hydroxymethyl)tricyclo compounds and D) at least one bifunctional and / or polyfunctional alcohol, wherein, based on the polyesters, the content of benzene is lower than 10mg / kg and the content of formaldehyde is lower than 10mg / kg, the molecular weight distribution polydispersity of the polyesters is 1.3-4.5, the content of tricyclodecane(mono- / di-)aldehyde in the bis(hydroxymethyl)tricyclo compound C) is lower than 2 weight percent; mono(hydroxymethyl)tricyclo [5.2.1.0<2,6>] decane in the compound C) is lower than 10 weight percent, and the content of chromium, nickel, copper, cadmium and plumbum in the compound C) is lower than 2mg / kg.

A method preparing controlled release nitrogen in particulate fertilizers which exhibit single growing season availabilities to plants of about 80 percent or higher. The method utilizes relatively low urea and ammonia to formaldehyde mol ratios of about 1.7 urea to 0.1 ammonia to 1 formaldehyde to assure high conversions to controlled release nitrogen with low free ureas, and carefully controlled elevated temperatures, acid dehydration condensation catalyst concentrations and short dehydration reaction times of about 2-4 minutes to provide effective conversion of hydroxymethyl nitrogen compounds by dehydration condensation reaction to controlled release methylene nitrogen compounds. Quick neutralization of the dehydration catalyst in a turbulent mixing reactor minimizes the formation of undesirable methylene nitrogen polymers which are hot water insoluble and unavailable to plants in a single growing season.

The invention discloses a grafted modified aromatic polyamide composite reverse osmosis membrane and a preparation method thereof, belonging to preparation technology of composite reverse osmosis membranes. The structural formula of the membrane is shown as follow. The preparation process comprises the following steps: taking a polysulphone membrane as a support membrane, preparing an aromatic polyamide composite reverse osmosis membrane to be grafted by an interfacial polymerization; enabling a graft modified solution containing 3-hydroxymethyl-5,5-dimethylhydantoin to contact the surface of the membrane to be grafted quickly for reacting, and conducting heat treatment to obtain the modified aromatic polyamide composite reverse osmosis membrane grafted with hydantoin derivatives. The invention has simple process, and the prepared membrane has the characteristics of good chlorine resistance and good microbial contamination resistance.

The compound 4-{4-[({3-tert-Butyl-1-[3-(hydroxymethyl)phenyl]-1H-pyrazol-5-yl}carbamoyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide and alternative forms thereof (e.g., salts, solvates, hydrates, prodrugs, polymorphs and metabolites); pharmaceutical compositions which contain them; and methods for treating cancer using them.

The invention discloses a method for coproduction of 5-hydroxymethyl furfural, an acetylpropionic acid and a formic acid through high-temperature catalysis and dehydration of the formic acid of glucose. The method specifically comprises the following steps: firstly, establishment of a formic acid reaction system, namely the glucose is added into the formic acid solution, and the weight ratio of the glucose to the formic acid in the reaction system is 0.05-0.2 to 1; and the mixture is reacted for 2 to 6 hours in the presence of the catalyst at a temperature of between 120 and 220 DEG C which is higher than the boiling temperature of the formic acid, and the reaction system is single-phase reaction or biphase reaction; and secondly, separation of products after reaction by a fractionating tower device, namely graded separation of 5-HMF, LA and the formic acid. The method can convert the glucose into the products, namely the 5-HMF, the LA and the formic acid with high added values through effective acid catalysis and dehydration, and has high conversion of reactant during the reaction process and obvious economic benefit; and the 5-HMF, the LA and the formic acid can be directly taken as chemical products to be further converted, and are good raw materials for synthesizing other chemical products.

A method for preparing alkali lignin modified phenol-formaldehyde resin comprises the following steps: phenol, a first batch of formaldehyde solution, alkali lignin, metal oxide and dilution water are added into a reactor; a second batch of formaldehyde solution is added into the reactor; and a third batch of formaldehyde solution and a first batch of alkaline solution are added, formaldehyde trapping agent and a second batch of alkaline solution are added, and then material is discharged after cooling. The invention adopts the copolymerization technique to prepare an alkali lignin phenol formaldehyde adhesive, lignin and the phenol are added simultaneously, obtained hydroxymethylated lignin is reacted with hydroxymethyl phenol, a small part of the obtained hydroxymethylated lignin participates in the polycondensation of the hydroxymethyl phenol to form a main chain, and a large part of the obtained hydroxymethylated lignin forms branch chains through graft copolymerization, therefore, the lignin is introduced into a molecular chain and the aim of modifying phenol-formaldehyde resin is achieved. The invention can replace the use of 30-50 percent of the phenol, realizes stable and easy reaction control and easy industrial production; the bonding strength satisfies the requirements of national I-level plates; formaldehyde release reaches E0 level; therefore, the invention provides a new approach to the development of environment-friendly biomass-based wood adhesive and resource utilization of waste materials.

A process to produce a dry purified furan-2,5-dicarboxylic acid (FDCA) is described. After oxidation of 5-(hydroxymethyl)furfural (5-HMF), a crude FDCA stream is produced that is fed to a crystallization zone followed by a solid-liquid displacement zone to form a low impurity slurry stream. The solids in the low impurity slurry stream are dissolved in a dissolution zone to produce a hydrogenation feed that is hydrogenated in a hydrogenation reactor to generate a hydrogenated FDCA composition. The hydrogenated FDCA composition is routed to a crystallization zone to form a crystallized produce stream that is separated from liquid in a solid-liquid separation zone to generate a purified wet cake stream containing FDCA that can be dried in a drying zone to generate a dry purified FDCA product stream.

Water-resistant, protein-based adhesive compositions and methods for preparing them are provided. The adhesives are prepared by copolymerizing a denatured vegetable protein, such as soy flour, that has been functionalized with methylol groups with one or more reactive comonomers. The adhesives exhibit superior water resistance, and can be used to bond wood substrates, such as panels or laminate, or in the preparation of composite materials.

Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1-methyl-2-[1H-indole-4,7-dione]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9 and a formulation vehicle. The formulation vehicle improves the solubility and stability of EO9. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.

The invention relates to a water-soluble chitosan quaternary ammonium salt antibiotic finishing agent. The invention is characterized in that the antibiotic finishing agent is names as O-methacrylamide-N-hydroxypropyl alkyl dimethyl ammonium chloride chitosan and the concrete structural formula is as follows. The preparation thereof includes that: alkyl dimethyl tertiary amide and epichlorohydrin are taken as raw materials to synthesize 2, 3-epoxy alkyl dimethyl ammonium chloride, then the 2, 3-epoxy alkyl dimethyl ammonium chloride is introduce onto the ammonium group of chitosan, so as to obtain N-hydroxypropyl alkyl dimethyl ammonium chloride chitosan HDCC, and then crosslinking is carried out on the HDCC and hydroxymethyl acrylamide is carried out, thus obtaining NMA-HDCC. The quaternary ammonium salt antibiotic finishing agent contains water-soluble group and fibrous reactivity group and has good water solubility, the bacterial inhibition rate of finished cotton fabrics is close to 100%, and the finishing agent can be combined with cellulose fiber by covalent bond and is wash-resistant; and cost is low, raw material is environmental friendly, environmental pollution is less, thus having industrialization application prospect.

The invention relates to compositions and methods for cleaning integrated circuit substrates. The compositions are in the form of an aqueous solution and include a quaternary ammonium hydroxide compound and a chelating compound. The chelating compound includes either boric acid or at least one N-substituted aminocarboxylate selected from the group consisting of N-bis(2-hydroxyethyl)glycine(bicine), N-tris(hydroxymethyl)methyl glycine (tricine) and mixtures thereof, and can optionally include glycine, Iminodiacetic acid (IDA), Nitrilo trizacetic acid (NTA), Ethylenediammine Tetraacetic acid (EDTA), or mixtures thereof.