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5252 results about "Covalent bond" patented technology
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A covalent bond, also called a molecular bond, is a chemical bond that involves the sharing of electron pairs between atoms. These electron pairs are known as shared pairs or bonding pairs, and the stable balance of attractive and repulsive forces between atoms, when they share electrons, is known as covalent bonding. For many molecules, the sharing of electrons allows each atom to attain the equivalent of a full outer shell, corresponding to a stable electronic configuration. In organic chemistry covalent bonds are much more common than ionic bonds.
Controlled drug delivery system using the conjugation of drug to biodegradable polyester
The present invention relates to a molecular sustained controlled release system constructed by the conjugation of molecules to be released with biodegradable polyester polymer via covalent bond and method for preparation thereof. In accordance with the present invention, the system may be formulated into microspheres, nanoparticles, or films. The molecular release rate from the above system can be regulated to be proportional to the chemical degradation rate of the biodegradable polyester polymers, resulting in near zero order kinetics profile of release without showing a burst effect, Moreover, a high loading efficiency of hydrophilic drugs can be achieved.
Owner:MOGAM BIOTECH RES INST +1
Platinum complex and light emitting device
ActiveUS20070103060A1Enhanced glowSolve low luminous efficiencyDischarge tube luminescnet screensElectroluminescent light sourcesOxygenLight emission
Provision of a novel platinum complex which is useful as a material for a light-emitting device of good light emission characteristic and light emission efficiency, and a novel light-emitting material that may be utilized in various fields. A platinum complex represented by the following general formula (1): (in which two rings of ring A, ring B, ring C, and ring D represent nitrogen-containing heterocyclic rings which may have a substituent and the remaining two rings of them represent aryl rings or hetero aryl rings which may have a substituent, the ring A and the ring B, the ring A and the ring C or / and the ring B and the rind D may form condensed rings. Two of X1, X2, X3, and X4 represent nitrogen atoms coordination bonded to a platinum atom and the remaining two of them represent carbon atoms or nitrogen atoms. Q1, Q2, and Q3 each represents a bond, oxygen atom, sulfur atom or bivalent group, two of Z1, Z2, Z3, and Z4 represent coordination bonds, and the remaining two of them represent covalent bonds, oxygen atoms or sulfur atoms), and a light-emitting device containing the platinum complex.
Owner:TAKASAGO INTERNATIONAL CORPORATION
Coupled electrochromic compounds with photostable dication oxidation states
InactiveUS6249369B1High photochemical stabilityTenebresent compositionsNon-linear opticsAction spectrumElectronic communication
Coupling of anodic electrochromic compounds by a covalent bond or a bridge link which provides for electronic communication between the coupled electrochromic compounds results in coupled electrochromic compounds which exhibit greater stability as well as electrochromic activity that differs from the monomeric electrochromic compounds. Extension of the absorption spectrum into the near-infrared region of the spectrum is frequently observed. The coupled electrochromic compounds are highly suitable for use in electrochromic media used to produce electrochromic devices.
Owner:GENTEX CORP
Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
InactiveUS6309633B1Reduce deliveryExtended durationAntibacterial agentsOrganic active ingredientsTherapeutic proteinCholesterol
The invention provides a drug-oligomer conjugate having the following general formula:wherein D is a therapeutic drug moiety; H and H' are each a hydrophilic moiety, independently selected from the group consisting of straight or branched PEG polymers having from 2 to 130 PEG subunits, and sugars; L is a lipophilic moiety selected from the group consisting of alkyl groups having 2-26 carbon atoms, cholesterol, adamantane and fatty acids; o is a number from 1 to the maximum number of covalent bonding sites on H; m+n+p together have a value of at least one and not exceeding the total number of covalent bonding sites on D for the -H', -L and -H-L substituents; the H-L bond(s) are hydrolyzable and the D-L' bond(s), when present, are hydrolyzable; the conjugate being further characterized by one of the following: (i) m is 0 and p is at least 1; (ii) n is 0 and p is at least 1; (iii) m and n are each 0 and p is at least 1; (iv) p is 0 and m and n are each at least 1. The therapeutic drug moiety is preferably a therapeutic protein or peptide, preferably insulin or a functional equivalent thereof.
Owner:BIOCON LTD
Organic electroluminescent materials and device made from such materials
Electroluminescent devices and materials including an electroluminescent organo-siloxane polymer. The main chain of the organo-siloxane polymer comprises an organic component that can be alkenyl, alkynyl, aralkyl, aryl, heteroaralkyl, and heteroaryl which can be substituted optionally with hydrogen, alkyl, aryl, heteroalkyl, heteroaralkyl, nitro, cyano, hydroxy, alkoxy, aryloxy, thio, alkylthio, arylthio, amino, halogen, dialkylamino, diarylamino, diaralkylamino, arylamino, alkylamino, arylalkylamino, carbonyloxy, carbonylalkoxy, carbonylalkyloxy, alkylcarbonyloxy, arylcarbonyloxy, alkoxylcarbonyloxy, sulfonyl, or sulfonyloxy. The organic component includes at least two covalent bonds coupling the organic component to the main chain of the organo-siloxane polymer. Such devices provide superior performance and mechanical stability compared with conventional organic electroluminescent materials and devices made from such materials.
Owner:ORGANIC DISPLAY TECH
Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
InactiveUS6887470B1Easy to testPeptide/protein ingredientsImmunoglobulins against cell receptors/antigens/surface-determinantsBlood componentCombinatorial chemistry
A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a reactive group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity.
Owner:CONJUCHEM
Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use
InactiveUS6906182B2Abnormal proliferationInhibition of replicationOrganic active ingredientsBiocideNucleotideEthylene Homopolymers
A conjugate of formula A-L-P, in which:A represents a glycosylated / galactosylated peptide that binds to a cell-surface receptor,L represents a bifunctional linker, which does not comprise a naturally occurring amino acid and is covalently bonded to A and P in a regiospecific manner, andP represents a monomer, homopolymer or heteropolymer comprising at least one nucleotide or an analogue thereof, which inhibits the intracellular biosynthesis of nucleotides or nucleic acids in a sequence-independent manner,wherein either or both of the covalent bond between A and L and the covalent bond between L and P can be cleaved intracellularly; a composition comprising such a conjugate; and a method of inhibiting abnormal cellular proliferation in a mammal; and a method of inhibiting replication of a virus in a mammal.
Owner:CELLECTIVE DX CORP
Photoacid generators for use in photoresist compositions
A photoacid compound having the following general structure:<paragraph lvl="0"><in-line-formula>R-O(CF2)nSO3X< / in-line-formula>wherein n is an integer between about 1 to 4; R is selected from the group consisting of: substituted or unsubstituted C1-C12 linear or branched alkyl or alkenyl, substituted or unsubstituted araalkyl, substituted or unsubstituted aryl, substituted or unsubstituted bicycloalkyl, substituted or unsubstituted tricycloalkyl, hydrogen, alkyl sulfonic acid, substituted or unsubstituted perfluoroalkyl, the general structure F((CF2)pO)m(CF2)q- wherein p is between about 1 to 4, m is between about 0 to 3 and q is between about 1 to 4, and substituted or unsubstituted partially fluorinated alkyl, halofluoroalkyl, perfluoroalkylsulfonic, or glycidyl; and X is selected from the group consisting of: organic cations and covalently bonded organic radicals.
Owner:FUJIFILM ELECTRONICS MATERIALS US
Long lasting synthetic glucagon-like peptide {GLP-1}
Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are capable of forming covalent bonds with one or more blood components to form a conjugate. The conjugates may be formed in vivo or ex vivo. The modified peptides are administered to treat humans with diabetes and other related diseases.
Owner:CONJUCHEM
Enhanced transport using membrane disruptive agents
Owner:UNIV OF WASHINGTON +1
Silicone hydrogel lens with a covalently attached coating
ActiveUS20110134387A1Good coating durabilityIncreased durabilityOptical articlesEye diagnosticsHydrophilic coatingPolymer chemistry
The invention provides a cost-effective method for making a silicone hydrogel contact lens having a hydrophilic coating thereon that is covalently attached to the lens and has a good hydrophilicity, intactness and durability. The invention also provides a silicone hydrogel contact lenses having a hydrophilic coating consisting of a prime coating covalently attached to the contact lens and a top coating covalently attached to the prime coating.
Owner:ALCON INC
Targeted dendrimer-drug conjugates
InactiveUS20130004427A1Improve solubilityStrong therapeutic activityBiocideSugar derivativesDendrimerEnzyme
Owner:RGT UNIV OF MICHIGAN
Platinum complex and light-emitting device
InactiveUS20080036373A1Superior in short wavelengthEasy to useDischarge tube luminescnet screensLamp detailsPlatinum complexAtomic group
A platinum complex represented by the general formula (1) below, useful as a phosphorescence emission material, a tetradentate ligand useful for synthesizing the platinum complex, and a light-emitting device containing at least one of the platinum complex.wherein ring B represents a nitrogen-containing aromatic heterocyclic ring; rings A, C and D each independently represent an aromatic or aromatic heterocyclic ring, while either of the rings C and D represents five-membered ring, the other represents a five- or six-membered ring; RA, RB, RC, and RD respectively represent substituents on the rings A, B, C, and D; two of XA, XB, XC, and XD represent a nitrogen atom that may be bound with the platinum atom by a coordinate bond, the others each independently represent a carbon atom or nitrogen atom that may be bound with the platinum atom by a covalent bond; Q represents a bivalent atom or atomic group bridging the rings B and C; and YC and YD each independently represent a carbon atom or nitrogen atom.
Owner:TAKASAGO INTERNATIONAL CORPORATION
Thermoset materials with improved impact resistance
The present invention relates to a thermoset material with improved impact resistance comprising:99 to 20% of a thermoset resin, and1 to 80% of an impact modifier comprising at least one copolymer comprising S-B-M, B-M and M-B-M blocks,wherein:each block is connected to the other by means of a covalent bond or of an intermediate molecule connected to one of the blocks via a covalent bond and to the other block via another covalent bond,M is a PMMA homopolymer or a copolymer comprising at least 50% by weight of methyl methacrylate,B is incompatible with the thermoset resin and with the M block and its glass transition temperature Tg is less than the operating temperature of the thermoset material, andS is incompatible with the thermoset resin, the B block and the M block and its Tg or its melting temperature is greater than the Tg of B.S is advantageously polystyrene and B polybutadiene. The thermoset resin advantageously originates from the reaction of a thermosetting epoxy resin and of a hardener.
Owner:ATOFINA
Nano carbon materials for enhancing thermal transfer in fluids
InactiveUS6695974B2Improve thermal conductivityImprove heat transfer performanceMaterial nanotechnologyNanostructure manufactureOrganic groupElectrical polarity
A novel fluid heat transfer agent suitable for use in a closed heat transfer system, for example, wherein energy is transferred between an evaporator and a condenser in heat exchange relationship with the heat transfer agent that is caused to flow from one to the other. The novel heat transfer agent is a complex comprising a body of heat transfer fluid, for example, ethylene glycol or water, having suspended therein carbon nanoparticles in a quantity sufficient to enhance the thermal conductivity of the body of heat transfers fluid, per se. The carbon nanoparticles are selected from carbon in the form of sp<2 >type and sp<3 >type bonding and preferably comprise nanotubes or fullerenes and may have a coupling agent bonded thereto or enclosed therein when the nanotube or fullerene forms a hollow capsule. The coupling agent may be a polar organic group covalently bonded to the carbon nanoparticles and miscible in the fluid medium.
Owner:MATERIALS & ELECTROCHEM RES
Compositions comprising porous articles and uses in implantable medical devices
A composition comprising a first polymer having pores, nanoparticles dispersed within the pores of the first polymer, the nanoparticles comprising a second polymer and at least one pharmaceutically active agent dispersed in the second polymer, and heparin covalently bonded to at least one of the first and second polymer.
Owner:SAHAJANAND TECHNOLOGIES PRIVATE LTD
Semiconductor device and manufacturing method of the same
InactiveUS6930360B2High activation rateSuppress DiffuseTransistorSolid-state devicesNear neighborSite location
A semiconductor device having a semiconductor layer, includes: a first impurity atom having a covalent bond radius larger than a minimum radius of a covalent bond of a semiconductor constituent atom of a semiconductor layer; and a second impurity atom having a covalent bond radius smaller than a maximum radius of the covalent bond of the semiconductor constituent atom; wherein the first and second impurity atoms are arranged in a nearest neighbor lattice site location and at least one of the first and second impurity atoms is electrically active.
Owner:KK TOSHIBA
Security paper
InactiveUS6159585AAvoid the needLow compositionNon-fibrous pulp additionNatural cellulose pulp/paperOrganic solventChemical separation
A security paper indicates exposure to a solvent by a solvent resistant color signal. A metal mordant dye first co-reactant and a mordant dye second co-reactant form an organic solvent-insoluble colored reaction product when the paper is washed with an organic solvent. The metal mordant dye first co-reactant and a mordant dye second co-reactant are chemically isolated from each other so as to prevent the coordinate covalent bond from forming until the paper is washed with an organic solvent. The chemical isolation can be effected by encapsulation or other physical separation of the co-reactants. The organic solvent-insoluble colored reaction product, once formed, remains entrapped in the web when the paper is washed with an organic solvent. The chemical isolation prevents the organic solvent-insoluble colored reaction product from forming upon the application of pressure alone to the paper.
Owner:DOMTAR +1
Carbon nanotubes functionalized with fullerenes
InactiveUS20090226704A1Enhancement in cold electron field emissionImprove mechanical propertiesSpecific nanostructure formationMaterial nanotechnologyC60 fullereneNanotube
The present invention relates to covalently bonded fullerene-functionalized carbon nanotubes (CBFFCNTs), a method and an apparatus for their production and to their end products. CBFFCNTs are carbon nanotubes with one or more fullerenes or fullerene based molecules covalently bonded to the nanotube surface. They are obtained by bringing one or more catalyst particles, carbon sources and reagents together in a reactor.
Owner:CANATU OY
Compositions comprising carbon nanotubes and articles formed therefrom
InactiveUS20050186378A1Easy injectionImprove the immunityMaterial nanotechnologyCell electrodesFiberPolymer science
Improved compositions comprise a polymer and carbon fibers, such as nanotubes. In some embodiments, the carbon fibers, e.g., nanotubes, can be mechanically blended or incorporated into the polymer, while in some embodiments carbon nanotubes also may be covalently bonded to the polymer to form corresponding covalent materials. In particular, the polymer can be covalently bonded to the side walls of the carbon nanotubes to form a composite with particularly desirable mechanical properties. Specifically, the bonding of the polymer to the nanotube sidewall can provide desirable mechanical properties of the composite due to the orientation relative to other types of association between the nanotubes and the polymer. The processing of the nanotubes can be facilitated by the dispersion of the nanotubes in an aqueous solution comprising a hydrophylic polymer, such as ethyl vinyl acetate. A dispersion of nanotubes can be combined with a polymer in an extrusion process to blend the materials under high shear, such as in an extruder. In general, various articles can be formed that take advantage of the properties of the composite materials incorporating a polymer and carbon fibers, such as carbon nanotubes.
Owner:ENTEGRIS INC
Method for reducing odor using metal-modified silica particles
ActiveUS20050084438A1Stability can be compromisedAmeliorate pH-lowering affectMaterial nanotechnologyNon-fibrous pulp additionSilica particleCompound (substance)
A method for reducing odor is provided. In one embodiment, the method comprises modifying the surface of silica particles with a transition metal so that the silica particles are bonded to the transition metal through a covalent or coordinate bond. The method further comprises contacting the modified silica particles with an odorous compound, the transition metal facilitating the capture of the odorous compound.
Owner:KIMBERLY-CLARK WORLDWIDE INC
Platinum complex and light emitting device
ActiveUS7442797B2Enhanced glowHigh luminous efficiencySilicon organic compoundsDischarge tube luminescnet screensOxygenLight emission
Provision of a novel platinum complex which is useful as a material for a light-emitting device of good light emission characteristic and light emission efficiency, and a novel light-emitting material that may be utilized in various fields.A platinum complex represented by the following general formula (1):(in which two rings of ring A, ring B, ring C, and ring D represent nitrogen-containing heterocyclic rings which may have a substituent and the remaining two rings of them represent aryl rings or hetero aryl rings which may have a substituent, the ring A and the ring B, the ring A and the ring C or / and the ring B and the rind D may form condensed rings. Two of X1, X2, X3, and X4 represent nitrogen atoms coordination bonded to a platinum atom and the remaining two of them represent carbon atoms or nitrogen atoms. Q1, Q2, and Q3 each represents a bond, oxygen atom, sulfur atom or bivalent group, two of Z1, Z2, Z3, and Z4 represent coordination bonds, and the remaining two of them represent covalent bonds, oxygen atoms or sulfur atoms), and a light-emitting device containing the platinum complex.
Owner:TAKASAGO INTERNATIONAL CORPORATION
Process for preparing major histocompatibility antigen class II protein and materials in which the same is bound
InactiveUS6630315B1Produce significantIon-exchanger regenerationMicroorganism based processesFiberMajor histocompatibility
This invention provides a process for producing major histocompatibility antigen class II protein (hereinafter referred to as "MHC class II" for short) which occurs on the surfaces of antigen-presenting cells and the like, and MHC class II-bound materials in which MHC class II, alpha and / or beta subunit of MHC class II, or a part thereof is bound to a carrier such as beads, fibers and hollow fibers via covalent bond, as well as a module for removing superantigen using the same. This invention also provides a method for detecting or quantifying superantigens using MHC class II or a part thereof having an affinity to the superantigens, as well as an assay kit therefor.
Owner:TORAY IND INC
Silicone hydrogel lens with a crosslinked hydrophilic coating
ActiveUS20130118127A1Increased durabilitySpectales/gogglesPackage sterilisationHydrophilic coatingPolymer science
The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves autoclaving, in a sealed lens package, a silicone hydrogel contact lens having a base coating of polyacrylic acid thereon in an aqueous solution in the presence of a water-soluble, crosslinkable hydrophilic polymeric material having epoxide groups, for a period of time sufficient to covalently attach the crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one epoxide group and one of the carboxyl groups on and / or near the surface of the silicone hydrogel contact lens.
Owner:ALCON INC
Permanent fixation of dyes to surface-modified inorganic particulate-coated media
Systems and methods for producing permanent ink-jet images are provided. In one embodiment, a system comprises a media substrate coated with a porous media coating, wherein the porous media coating comprises inorganic porous particulates, and wherein at least a portion of the inorganic porous particulates have a first reactive group covalently attached thereto. The system further includes an ink-jet ink containing a dye, wherein the dye comprises a second reactive group, and wherein the first reactive group and the second reactive group are configured to react with one another upon contact to form a covalent bond. In an alternative embodiment, a method of producing permanent ink-jet images can comprise the steps of covalently bonding a first reactive group to an inorganic porous particulate; coating the inorganic porous particulate onto a media substrate to form a coated media substrate; ink-jetting a dye-containing ink-jet ink composition onto the coated media substrate, wherein the dye includes a second reactive group. The first reactive group and the second reactive group, upon contact, can interact to form a covalent bond.
Owner:HEWLETT PACKARD DEV CO LP
Modified therapeutic peptides with extended half-lives in vivo
A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a reactive group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity.
Owner:CONJUCHEM
Curable high refractive index compositions
The invention provides an organic / inorganic hybrid material with a high refractive index at telecommunications wavelengths. Energy curable compositions of the present invention include condensed metal oxide nanoparticles, a high refractive index organometallic coupling agent, an energy curable organometallic coupling agent, and a high refractive index monomer or oligomer. Polymeric materials of the present invention include condensed metal oxide nanoparticles having a mixture of organometallic coupling agents covalently bound to the exterior surface of the nanoparticles and a high refractive index solid polymer matrix, wherein the mixture of organometallic coupling agents includes a high refractive index coupling agent, and a coupling agent covalently bound to the polymer matrix. The materials of the present invention are useful in making optical devices for telecommunications applications.
Owner:CORNING INC
Mixed matrix membranes
InactiveUS20030220188A1High selectivityIncrease productivitySemi-permeable membranesMembranesFiberHollow fibre
Mixed matrix membranes are prepared from zeolites and polymers, such as polyimides, in a void free fashion where either no voids or voids of less than several Angstroms are present at the interface of the polymer and the zeolite by bonding (hydrogen, ionic, or covalent) functional groups on the zeolite with functional groups on the polymer. The mixed matrix membranes may be cast or formed by ISAM processes, and may be present on a variety of supports including hollow fibers.
Owner:VIRGINIA TECH INTPROP INC +1
Process for sulfiding a hydrotreating catalyst comprising an organic compound comprising n and carbonyl
InactiveUS6540908B1Inorganic chemistryOrganic-compounds/hydrides/coordination-complexes catalystsNitrogenSulfidation
The invention pertains to a process for preparing a sulfided hydrotreating catalyst in which a hydrotreating catalyst is subjected to a sulfidation step, wherein the hydrotreating catalyst comprises a carrier comprising at least 50 wt % of alumina, the catalyst comprising at least one hydrogenation metal component and an organic compound comprising at least one covalently bonded nitrogen atom and at least one carbonyl moiety, the molar ratio between the organic compound and the total hydrogenation metal content being at least 0.01:1. The invention further pertains to the use of said hydrotreating catalyst in hydrotreating a hydrocarbon feed, in particular to achieve hydrodenitrogenation, (deep) hydrodesulfurization, or hydrodearomatization.
Owner:ALBEMARLE NETHERLANDS BV
Prodrug composition
A prodrug composition is provided which includes a pharmaceutical species and an amino acid having a covalent bond to the pharmaceutical species. The pharmaceutical species is characterized by bioavailability of 30% or less and a molecular weight in the range of 100-1000 Daltons. The composition is characterized further in that the pharmaceutical species is not acyclovir, ganciclovir, BRL44385, or penciclovir. Also described is an inventive method of delivering a pharmaceutical species to an individual including the step of orally administering an inventive prodrug to an individual. In one embodiment the prodrug includes a pharmaceutical species characterized by bioavailability of 30% or less, wherein the pharmaceutical species has a molecular weight in the range of 100-1000 Daltons. The inventive prodrug is transported from the gastrointestinal lumen by a specific transporter and is enzymatically cleaved to yield the pharmaceutical species, such that the pharmaceutical species is delivered to the individual.
Owner:HILFINGER JOHN
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