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173results about "Sonopheresis" patented technology
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Integrated poration, harvesting and analysis device, and method therefor
An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum comeum. In one embodiment, the photosensitizing assembly comprises photosensitizing material combined with a carrier, such as, for example, an adhesive or an ink, and the resulting combination is applied to a substrate, such as, for example, an inert polymeric substrate to form a photosensitizing assembly. In another embodiment, the photosensitizing assembly comprises photosensitizing material incorporated into a film-forming polymeric material.
Owner:NITTO DENKO CORP +1
Microporation of tissue for delivery of bioactive agents
InactiveUS20050165393A1Improve throughputImprove breathabilitySonopheresisUltrasound therapyBiological bodyThermal energy
A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
Owner:ALTEA THERAPEUTIC CORP +1
Enhanced transport using membrane disruptive agents
Owner:UNIV OF WASHINGTON +1
Composition for therapy of diseases with ultrasonic and pharmaceutical liquid composition containing the same
InactiveUSRE36939E1Good effectWeaken energySonopheresisUltrasonic/sonic/infrasonic diagnosticsDiseaseTreatment effect
A booster comprising a plenty of microbubbles of a gas in a liquid, e.g. about 4x107 cells / ml of microbubbles of a gas having a diameter of 0.1 to 100 mu m in a 3 to 5% human serum albumin solution, and a pharmaceutical liquid composition comprising the booster as set forth above and a medicament, which are useful for the therapy of various diseases together with exposure of ultrasonic, where the therapeutic effects of the medicament is enhanced by the application of ultrasound in the presence of the booster.
Owner:EKOS CORP
Biological Cell Acoustic Enhancement and Stimulation
InactiveUS20080045882A1Improve efficiencyAccelerate patient recoverySonopheresisUltrasound therapyBiological cellAcoustic energy
A method for enhancing the uptake of a therapeutic biological agent by treated cells. A low-power, unfocused field of acoustic energy is directed at the treated cells after the delivery of the therapeutic agent to the treated cells. A related method for stimulating either neural cells or cells in a cell culture. A portable sized device provides the field, and may include either an array of emitters or a scanable emitter.
Owner:FINSTERWALD P MICHAEL
Enhanced drug delivery
InactiveUS20050175541A1Reduce deliveryPrecise positioningSonopheresisUltrasonic/sonic/infrasonic diagnosticsLipid formationEmulsion
The invention is directed to methods for the delivery of a therapeutic agent using lipid-encapsulated particles containing the therapeutic agent and ultrasound energy. For example, it particularly relates to the use of ultrasound with a lipid-encapsulated emulsion comprising an oil where the emulsion is coupled a targeting ligand and comprises a therapeutic agent.
Owner:BARNES JEWISH HOSPITAL
Methods and compositions for targeting agents into and across the blood-brain barrier
This invention relates to modified nucleic acid compositions encoding therapeutic polypeptides and methods of producing the therapeutic polypeptides in cells.
Owner:MODERNATX INC
Methods and Devices for Thermal Treatment
ActiveUS20080045879A1Improve breathabilityMinimizing barrier propertySonopheresisElectrotherapyActive agentThermal treatment
The present invention comprises methods and devices for thermal treatment of a barrier to increase the permeability of the barrier. One form of increasing the permeability of the barrier comprises forming micropores which may be used for administration of active agents across the barrier, or may be used for sampling or collecting fluids, or may be used for detecting, measuring or determining analytes, or may be used for monitoring of physiological or other conditions. Devices of the present invention may comprise microheaters that are activated by inductive or ohmic heating power supply components.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV +1
Method and device for non-invasive acoustic stimulation of stem cells and progenitor cells in a patient
The present invention provides a method for non-invasive acoustic stimulation of stem cells and / or progenitor cells in a patient. The invention also provides a device for non-invasive stimulation of stem cells and / or progenitor cells in the patient by generating and delivering acoustic waves of a suitable frequency and intensity to the stem cells and / or progenitor cells. The method and device of the present invention is useful in enhancing regeneration of bones and other tissues, such as cartilages, muscles, and nerve tissues, in a patient, for treatment of conditions such as bone loss or fracture.
Owner:THE RES FOUND OF STATE UNIV OF NEW YORK
Ultrasound delivery of nanoparticles
ActiveUS20140316387A1Substantial patient painSubstantial discomfortSonopheresisCosmetic preparationsPlasmonic nanoparticlesSkin tissue
Enhanced delivery of compositions for treatment of skin tissue with photoactive plasmonic nanoparticles and light, with embodiments relating to delivery devices using, for example, ultrasound. Treatments are useful for cosmetic, diagnostic and therapeutic applications.
Owner:CORONADO AESTHETICS LLC
Booster for therapy of disease with ultrasound and pharmaceutical liquid composition containing the same
A booster comprising a plurality of microbubbles of a gas in a liquid, e.g. about 4x107 cells / ml of microbubbles of a gas having a diameter of 0.1. to 100 mum in a 3 to 5% human serum albumin solution, and a pharmaceutical liquid composition comprising the booster as set forth above and a medicament, which are useful for the therapy of various diseases together with exposure of ultrasonic, where the therapeutic effects of the medicament is enhanced by the application of ultrasound in the presence of the booster.
Owner:EKOS CORP
Method of applying acoustic energy effective to alter transport or cell viability
InactiveUS7273458B2Altering permeability of cellImprove breathabilitySonopheresisUltrasound therapyAcoustic energyTissue viability
A method for reversibly, or irreversibly, altering the permeability of cells, tissues or other biological barriers, to molecules to be transported into or through these materials, through the application of acoustic energy, is enhanced by applying the ultrasound in combination with devices for monitoring and / or implementing feedback controls. The acoustic energy is applied directly or indirectly to the cells or tissue whose permeability is to be altered, at a frequency and intensity appropriate to alter the permeability to achieve the desired effect, such as the transport of endogenous or exogenous molecules and / or fluid, for drug delivery, measurement of analyte, removal of fluid, alteration of cell or tissue viability or alteration of structure of materials such as kidney or gall bladder stones. In the preferred embodiment, the method includes measuring the strength of the acoustic field applied to the cell or tissue at the applied frequency or other frequencies, and using the acoustic measurement to modify continued or subsequent application of acoustic energy to the cell or tissue. In another preferred embodiment, the method further includes simultaneously, previously, or subsequently exposing the cell or tissue to the chemical or biological agent to be transported into or across the cell or tissue. In another preferred application, the method includes removing biological fluid or molecules from the cells or tissue simultaneously, previously or subsequently to the application of acoustic energy and, optionally, assaying the biological fluid or molecules.
Owner:GEORGIA TECH RES CORP
Microporation of tissue for delivery of bioactive agents
InactiveUS7758561B2Improve throughputImprove breathabilitySonopheresisUltrasound therapyThermal energyBiological body
A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
Owner:ALTEA THERAPEUTIC CORP +1
Compositions and methods comprising energy absorbing compoundfs for follicular delivery
InactiveUS20130315999A1Reduce deliveryAchieve therapeutic effectSonopheresisHeavy metal active ingredientsNanoparticleMedicine
The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.
Owner:THE GENERAL HOSPITAL CORP
Applications of HIFU and chemotherapy
InactiveUS20070088345A1Promote absorptionUltrasonic/sonic/infrasonic diagnosticsSonopheresisAbnormal tissue growthMilia
A method, using high intensity ultrasound, which may also be combined with a chemotherapy agent, that can result the direct destruction of tumor cells and in the reduction or elimination of local reoccurrence of cancer after removal of cancerous tissue, such as a surgical breast lumpectomy or surgical excision of a brain tumor. The method comprises either (1) the treatment of the tumor directly with High Intensity Focused Ultrasound, or (2) the treatment of the margins of the tissue surrounding the surgical cavity or void with ablative continuous wave high intensity ultrasound and a combination of a locally delivered chemotherapy agent and high intensity ultrasound, termed sonoporation. The present invention permits both the direct destruction (ablation) of tumor tissue as well as the destruction of tissue around the surgical margin and may include the enhanced local cellular uptake of locally injected chemotherapeutic drugs, all of which can be accomplished by a therapeutic ultrasound device used during surgery.
Owner:UST INC
Using Alternating Electric Fields to Increase Cell Membrane Permeability
ActiveUS20200009377A1Good cell membrane permeabilityReduced viabilityElectrotherapyEnergy modified materialsCancer cellCell membrane
Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).
Owner:NOVOCURE GMBH +1
Enhanced transport using membrane disruptive agents
Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and / or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and / or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and / or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and / or electrophereis can also be used with the disrupting agents.
Owner:UNIV OF WASHINGTON +1
Assessment and control of acoustic tissue effects
InactiveUS20070073197A1Altering permeability of cellChange in permeabilityUltrasonic/sonic/infrasonic diagnosticsSonopheresisTissue viabilityBiologic Agents
A method for reversibly, or irreveribly, altering the permeability of cells, tissues or other biological barriers, to molecules to be transported into or through these materials, through the application of acoustic energy, is enhanced by applying the ultrasound in combination with means for monitoring and / or implementing feedback controls. The acoustic energy is applied directly or indirectly to the cells or tissue whose permeability is to be altered, at a frequency and intensity appropriate to alter the permeability to achieve the desired effect, such as the transport of endogenous or exogenous molecules and / or fluid, for drug delivery, measurement of analyte, removal of fluid, alteration of cell or tissue viability or alteration of structure of materials such as kidney or gall bladder stones. In the preferred embodiment, the method includes measuring the strength of the acoustic field applied to the cell or tissue at the applied frequency or other frequencies, and using the acoustic measurement to modify continued or subsequent application of acoustic energy to the cell or tissue. In another preferred embodiment, the method further includes simultaneously, previously, or subsequently exposing the cell or tissue to the chemical or biological agent to be transported into or across the cell or tissue. In another preferred application, the method includes removing biological fluid or molecules from the cell or tissue simultaneously, previously or subsequently to the application of acoustic energy and, optionally, assaying the biological fluid or molecules.
Owner:GEORGIA TECH RES CORP
Using Alternating Electric Fields to Increase Cell Membrane Permeability
PendingUS20200009376A1Good cell membrane permeabilityReduced viabilityElectrotherapyEnergy modified materialsCancer cellGlioblastoma
Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV +1
Compositions and methods comprising energy absorbing materials for follicular delivery
InactiveUS20130323305A1Reduce deliveryMaterial is facilitatedSonopheresisPowder deliveryMedicineEnergy absorption
The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20 kHz, ultrasound, alternating suction and pressure, and microjets.
Owner:THE GENERAL HOSPITAL CORP
Ultrasound catheter with utility lumen
InactiveUS7186246B2Encourage flexibilityGuaranteed normal transmissionSonopheresisUltrasonic/sonic/infrasonic diagnosticsMedicineTransducer
The invention relates to a catheter system. The system comprises a catheter body having a chamber containing a low acoustic impedance medium. The catheter body includes an elongated body with an external surface and an ultrasound transducer having an external side between a first end and a second end. The ultrasound transducer is positioned over the external surface of the elongated body such that the first end is adjacent to the chamber.
Owner:EKOS CORP
Methods for delivering nucleic acid molecules into cells and assessment thereof
InactiveUS6936469B2Accurate and fast measurementMonitor delivery and expression of nucleic acidsSonopheresisMicroencapsulation basedIn vivoCell biology
Owner:GLAXO GRP LTD
Pharmaceutical composition and system for permeabilizing fetal membranes
Provided is a pharmaceutical composition for permeabilizing fetal membranes including an active ingredient having a log K in the range of 2 to 4, where K is the octanol / water partition coefficient. The active ingredient may be, for example, bupivacaine, sodium lauryl sulfate or oleic acid. Further provided is a system for transfetal membrane transport. The system includes a probe unit adapted for insertion into a female reproductive tract and releasing a substance onto fetal membranes that permeabilizes the membranes. The system is also configured to apply ultrasound radiation to the fetal membranes to further increase the membrane permeability.
Owner:B G NEGEV TECH & APPL LTD
Therapeutic applications of calcium electroporation to effectively induce tumor necrosis
ActiveUS9943599B2Limited amountImprove efficiencySonopheresisOrganic active ingredientsAbnormal tissue growthMedicine
The present inventors have shown that electroporation with calcium ions are efficient on cutaneous and subcutaneous nodules. In particular the present inventors here disclose that a solution comprising calcium ions (Ca2+) with a concentration of at least 0.1 M is extremely useful in a method of treating a neoplasm, such as cancer with means for causing transient permeabilization of the cell membranes of at least part of the neoplasm before, during and / or after administration of said solution, wherein said solution is administered with a ratio of 0.2 to 0.8 of the volume of said part of the neoplasm.
Owner:HERLEV HOSPITAL
Therapeutic applications of calcium electroporation to effectively induce tumor necrosis
ActiveUS20150065946A1Limited amountImprove efficiencySonopheresisOrganic active ingredientsIonNeoplasm
The present inventors have shown that electroporation with calcium ions are efficient on cutaneous and subcutaneous nodules. In particular the present inventors here disclose that a solution comprising calcium ions (Ca2+) with a concentration of at least 0.1 M is extremely useful in a method of treating a neoplasm, such as cancer with means for causing transient permeabilisation of the cell membranes of at least part of the neoplasm before, during and / or after administration of said solution, wherein said solution is administered with a ratio of 0.2 to 0.8 of the volume of said part of the neoplasm.
Owner:HERLEV HOSPITAL
Methods for delivering nucleic acid molecules into cells and assessment thereof
InactiveUS20050112661A1Accurate and fast measurementMonitor delivery and expression of nucleic acidsSonopheresisMicroencapsulation basedIn vivoCell biology
Methods for delivering nucleic acid molecules into cells and methods for measuring nucleic acid delivery into cells and the expression of the nucleic acids are provided. The methods are designed for introduction of large nucleic acid molecules, including artificial chromosomes, into cells, and are practiced in vitro and in vivo.
Owner:GLAXO GROUP LTD
Methods for iontophoretically treating nausea and migraine
Owner:TEVA PHARMACEUTICALS INTERNATIONAL GMBH
Ultrasound catheter
InactiveUS20070149917A1Encourage flexibilityGuaranteed normal transmissionSonopheresisChiropractic devicesMedicineTransducer
The invention relates to a catheter system. The system comprises a catheter body having a chamber containing a low acoustic impedance medium. The catheter body includes an elongated body with an external surface and an ultrasound transducer having an external side between a first end and a second end. The ultrasound transducer is positioned over the external surface of the elongated body such that the first end is adjacent to the chamber.
Owner:EKOS CORP
Methods and devices for thermal treatment
ActiveUS8690865B2Improve breathabilityMinimizing barrier propertySonopheresisElectrotherapyAnalyteMedicine
The present invention comprises methods and devices for thermal treatment of a barrier to increase the permeability of the barrier. One form of increasing the permeability of the barrier comprises forming micropores which may be used for administration of active agents across the barrier, or may be used for sampling or collecting fluids, or may be used for detecting, measuring or determining analytes, or may be used for monitoring of physiological or other conditions. Devices of the present invention may comprise microheaters that are activated by inductive or ohmic heating power supply components.
Owner:KONINK PHILIPS ELECTRONICS NV +1
MULTIFUNCTIONAL Fe3O4 CORED MAGNETIC-QUANTUM DOT FLUORESCENT NANOCOMPOSITES FOR RF NANO-HYPERTHERMIA OF CANCER CELLS
A magnetic oxide-quantum dot nanocomposite and methods of synthesizing it. In one embodiment, the magnetic oxide-quantum dot nanocomposite has at least one magnetic oxide nanoparticle coated with a silica (SiO2) shell and terminated with at least one thiol group (—SH), and at least one CdSe / ZnS quantum dot linked with the at least one SiO2-coated magnetic oxide nanoparticle via the at least one thiol group. In one embodiment, the at least one magnetic oxide nanoparticle comprises at least one iron oxide (Fe3O4) nanoparticle.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ARKANSAS
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