83 results about "Surgical excision" patented technology

The invention belongs to the technical field of biological materials and particularly relates to a near-infrared second window emitted micro-molecular rear earth complex fluorescence probe and a preparation method thereof. The near-infrared second window emitted micro-molecular rear earth complex fluorescence probe comprises a complex coordinated by DOTA (1, 4, 7, 10-tetraazacyclododecan-1, 4, 7,10-tetraacetic acid) and rear earth Ln(III) metal, a complex coordinated by DOTA-NHS (DOTA-n-hydroxysuccinimide) ester and rear earth Ln(III) metal, and a reaction product of Ln-DOTA-NHS and amino-PEG(polyethylene glycol)-folic acid. By changing the functional groups in macrocyclic polyamine structures without affecting the coordinating ability of macrocyclic polyamines and rear earth ions, the near-infrared second window emitted micro-molecular rear earth complex fluorescence probe achieves tumor targeting effects after being specifically combined with tumor surface receptors and meanwhile achieves surgical excision of under the guidance of a near-infrared window. According to the variety of receptors to be modified by the micro-molecular rear earth complex fluorescence probe, the micro-molecular rear earth complex fluorescence probe can specifically target various tumors to achieve antibody-antigen immunoreaction, and through pairing of base pairs of DNA (deoxyribonucleic acid) sequences, to achieve gene expression.