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392 results about "Squamous Carcinomas" patented technology
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Squamous cell carcinomas, also known as epidermoid carcinoma are a number of different types of cancer that result from squamous cells. These cells form the surface of the skin lining of hollow organs in the body and line the respiratory and digestive tracts.
Detecting tumor biomarker in oral cancer
InactiveUS20080038738A1Rapid and non-invasive analysisHigh sensitivityDiagnostics using lightMicrobiological testing/measurementSquamous cancerTumor Biomarkers
Methods and device for detecting the presence of tumor biomarkers in oral squamous cell carcinoma. A membrane based cell capture device allows deliver of cell samples and reagents to the membrane
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Prognostic signature for oral squamous cell carcinoma
InactiveUS20130303826A1Raise the possibilityImprove expression levelMicrobiological testing/measurementLibrary screeningPrognostic signatureSquamous Carcinomas
The present disclosure describes methods and compositions for diagnosing or predicting likelihood of a OSCC recurrence in a subject having undergone OSCC resection comprising: a) determining an expression level of one or more biomarkers selected from Table 4, 5 and / or 7, optionally MMP1, COL4A1, THBS2 and / or P4HA2 in a test sample from the subject, the one or more biomarkers comprising at least one of THBS2 and P4HA2, and b) comparing the expression level of the one or more biomarkers with a control, wherein a difference or a similarity in the expression level of the one or more biomarkers between the test sample and the control is used to diagnose or predict the likelihood of OSCC recurrence in the subject In particular, the present disclosure describes methods and compositions using a four-gene biomarker signature that can predict recurrence of oral squamous cell carcinoma in subjects that have histologically normal surgical resection margins.
Owner:UNIV HEALTH NETWORK
Mutant Viruses
Owner:SLOAN KETTERING INST FOR CANCER RES +1
Metastasis-associated gene profiling for identification of tumor tissue, subtyping, and prediction of prognosis of patients
InactiveUS20060211036A1Bioreactor/fermenter combinationsBiological substance pretreatmentsAbnormal tissue growthReal-Time PCRs
The present invention provides methods using a gene expression profiling analysis (1) to determine whether a human sample is a tumor using a gene set containing nucleic acid sequences of SEQ ID NOS: 1-7, 8-17 or 1-17; (2) to identify whether a tumor tissue is an adenocarcinoma (using a gene set containing nucleic acid sequences of SEQ ID NOS: 15, and 18-21) or a squamous cell carcinoma (using a gene set containing nucleic acid sequences of SEQ ID NOS: 22-27); and (3) to predict the prognosis of survival and metastasis in humans with tumor (using a gene set containing nucleic acid sequences of SEQ ID NOS:19, and 28-42 or SEQ ID NOS: 19, 29, 31, 40, and 42), particularly for those humans who are at the early stage of lung cancer. The gene expression profiling is preferably performed by cDNA microarray-based techniques and / or Real-Time Reverse Transcription-Polymerase Chain Reaction (Real-Time RT-PCR), and analyzed by statistical means.
Owner:ADVPHARMA
Intelligentize lung cancer early cell pathological picture recognition processing method
InactiveCN101226155AHigh simulationAvoid situations with low classification accuracyImage analysisMaterial analysis by optical meansSmall-cell carcinomaSquamous Carcinomas
The invention relates to an intelligent lung cancer early cell pathological image recognition processing method, which comprises image pretreatment, image segmentation, laminate cell separation and reconstruction, cell character extraction and cell classification. The invention has the advantages that the image segmentation based on reinforcement learning uses incremental learning and continuous interaction with environment to search for optimized segmentation threshold value to obtain the segmentation effect which average value is 91%, the laminate cell separation and reconstruction uses B spline and modified deBoor-Cox method to simulate true cell edge better, the classifier uses general vote method to avoid low classifying accuracy of single classifier and improve total classifying accuracy, the application of two-stage classifier can reduce the possibility of false positive and false negative. Tests prove that the classifying accuracy of cancer or no cancer can average reach 93.8%, the classifying accuracy of squamous cell carcinoma, adenocarcinoma and small cell carcinoma average reaches 75%, and the false positive and negative average reach 4-6%.
Owner:中国人民解放军第八一医院 +1
PYRAZOLE DERIVATIVES AS TNIK, IKKe AND TBK1 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Provided is pyrazole derivatives as a TNIK (Traf2- and NCK-interacting kinase), IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor; the pyrazole derivative according to the present invention effectively inhibits TNIK, IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.
Owner:THE GREEN CROSS CORP
Topical Use of Valproic Acid for the Prevention or Treatment of Skin Disorders
The present invention relates to a topically applicable formulation containing Valproic Acid or a derivative thereof which can be used alone or in combination with topically applicable formulations of retinoids or of nuclear receptor ligands, or of chemotherapeutic agents (e.g. 5-Fluorouracil). The formulation is useful for the topical treatment of cancerous skin disorders, such as Basal Cell Carcinoma, Squamous Cell Carcinoma, Keratoakantoma, Bowen Disease, cutaneous T-Cell Lymphoma and also for the topical treatment of pre-malignant lesions, and of inflammations of the skin and / or mucosa. The invention also relates to the use of this topically applicable formulation for the protection from UV light and for the treatment of sun burn. The invention includes the use of VPA for the manufacture of a clinically used medicament for the topical treatment of the human diseases listed above.
Owner:TOPOTARGET GERMANY AG
Method for screening cervical cancer
InactiveUS20050221399A1Effective diagnosisEfficient screeningBiological testingSquamous CarcinomasScreening method
The invention provides a reagent for diagnosing cervical cancer, which can not only detect the presence or absence of cervical cancer but can also distinguish squamous cell carcinoma and adenocarcinoma from each other, a method for screening cervical cancer by using the reagent, particularly a screening method capable high speed processing by utilizing flow cytometry. The reagent comprises a first labeled antibody reacting with gland cells, a second labeled antibody reacting with adenocarcinoma cells and a third labeled antibody reacting with atypical cervical squamous cells, the antibodies being labeled with mutually distinguishable labels respectively. Preferably, at least one selected from the group consisting of MUC1 antibody, cytokeratin 7 antibody, and cytokeratin 18 antibody is used as the first labeled antibody, at least one selected from the group consisting of cytokeratin 8 antibody and HIK1083 antibody is used as the second labeled antibody, and at least one member selected from the group consisting of NMP179 antibody, p16INK4A antibody, Ki-67 antibody, p53 antibody, p21 antibody, EMA antibody, CEA antibody and MIB-1 antibody is used as the third labeled antibody.
Owner:SYSMEX CORP
Hybrid model for the classification of carcinoma subtypes
ActiveUS20130172203A1Effective treatmentMicrobiological testing/measurementLibrary screeningSquamous CarcinomasPrimary sites
A two-tiered classification system that can be integrated with the current algorithm used by pathologists for identification of the site of origin for ‘malignancy with unknown primary ’ is presented. In use, morphology, immunohistochemical (IHC) studies, and microarry-based top tier gene expression classifiers first subclassify cytokeratin positive carcinomas into adenocarcinoma, squamous cell carcinoma, neuroendocrine carcinoma and urothelial carcinoma. Subsequently, organ-specific IHC-markers, if available, are used in conjunction with microarray-based second tier gene expression classifiers to assign the primary site of origin to the sample. This new hybrid approach combines IHC with a hierarchy of quantitative gene expression based classifiers into an algorithmic method that can assist pathologists to further refine and support their decision making process.
Owner:H LEE MOFFITT CANCER CENT & RES INST INC
Antibodies, pharmaceutical compositions and methods
ActiveUS20170283488A1Polypeptide with localisation/targeting motifAntibody mimetics/scaffoldsURINARY BLADDER CARCINOMASquamous Carcinomas
Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as breast cancer, lung cancer, esophageal cancer, rectal cancer, biliary cancer, liver cancer, buccal cancer, gastric cancer, colon cancer, nasopharyngeal cancer, kidney cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, pancreatic cancer, testicular cancer, bladder cancer, head and neck cancer, oral cancer, neuroendocrine cancer, adrenal cancer, thyroid cancer, bone cancer, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, and / or brain tumor.
Owner:OBI PHARMA INC
Treatment of hyperproliferative, inflammatory and related mucocutaneous disorders using inhibitors of mevalonate synthesis and metabolism
InactiveUS20020010128A1Inhibit cell proliferationInhibit expressionCosmetic preparationsBiocideSquamous CarcinomasAntiinflammatory drug
The present invention provides methods for treating a variety of hyperproliferative and inflammatory mucocutaneous disorders, including, basal cell carcinoma, squamous cell carcinoma, psoriasis and atopic dermatitis, as well as skin irritation and disorders associated with skin aging and skin photodamage using inhibitors of cholesterol metabolism. The present invention further relates to the discovery that the combined use of several inhibitors of cholesterol metabolism produces synergistic effects. Furthermore, the present invention is directed to the use of inhibitors of cholesterol metabolism as excipients to enhance the effects of antiinflammatory drugs.
Owner:CELLEGY PHARMACEUTICALS INC
Method for screening cervical cancer
InactiveCN1677109AEfficient screeningChemiluminescene/bioluminescenceSurgerySquamous CarcinomasKeratin Antibody
Owner:SYSMEX CORP
Application of differential expression of gene in oral cancer diagnosis
ActiveCN105483246AHigh selectivitySimplify the process of quantitative detectionMicrobiological testing/measurementGenetic material ingredientsSquamous CarcinomasNormal tissue
The invention relates to application of differential expression of a gene in oral cancer diagnosis, and particularly relates to application of differential expression of LRRC26 gene in oral squamous cell carcinoma diagnosis. Transcriptome deep sequencing analysis is performed by virtue of a high-throughput sequencing platform to preliminarily screen the gene LRRC26 with remarkable differential depression in oral squamous cell carcinoma tissues, para-carcinoma tissues and normal tissues; and the RT-PCR experiment further proves that the LRRC26 gene has low expression with oral squamous cell carcinoma tissues, can be used for preparing oral squamous cell carcinoma auxiliary diagnosis or prognosis preparations, and has an important clinical practical application value.
Owner:BEIJING MEDINTELL BIOMED CO LTD
Methods and compositions for the diagnosis and treatment of cancer
Methods for the treatment of squamous cell carcinoma using a p53-expressing viral vector are disclosed. In particular embodiments, the vector is a replication-deficient adenovirus. In addition, there are provided methods for examining the development and treatment of microscopic residual disease in the context of post-surgical environments and in body cavities.
Owner:CLAYMAN GARY
OSCC (oral squamous cell carcinoma) biomarker and application thereof
ActiveCN106435002AAchieve early diagnosisMicrobiological testing/measurementBiological material analysisSquamous CarcinomasFhit gene
The invention discloses an OSCC (oral squamous cell carcinoma) biomarker and an application thereof. The biomarker is XIRP2, an experiment proves that an XIRP2 gene expresses up regulation in OSCC tissue, and the silent XIRP2 gene can reduce transcription and translation of the gene to inhibit excessive proliferation of OSCC cells. The invention provides the application of the gene or an expression product of the gene in diagnosis and treatment of OSCC.
Owner:BEIJING MEDINTELL BIOMED CO LTD
Protein chip reagent kit and method for comprehensively detecting lung cancer marker
InactiveCN103033619AReduce detection errorImprove accuracyFluorescence/phosphorescenceSquamous CarcinomasAntibody antigen reactions
The invention belongs to the technical field of biology and relates to a protein chip reagent kit and a method for comprehensively detecting a lung cancer marker. The protein chip reagent kit for comprehensively detecting the lung cancer marker comprises: (1) a chip (1) and (2) a reaction agent and a detection agent, wherein a plurality of specific antibodies are simultaneously fixed on the chip, can generate antibody-antigen reaction with the lung cancer marker and are fixed on a bottom film of the chip to form a plurality of independent recognition sites; and the reaction agent and the detection agent are used for detecting whether a matter capable of generating antibody-antigen reaction with the specific antibodies exists in a sample to be detected or not through a TRFIA (Time Resolved Fluorescence Immunoassay) method. The reagent kit and the method have the beneficial effects that the six indexes of NSE (Neuron Specific Enolase), SCC (Squamous Cell Carcinoma), CEA (Carcino Embryonie Antigen), CA (Carbonic Anhydrase) 19-9, CYFR (Cytokeratin Fragment) A21-1 and pro-GRP (Glass Reinforced Plastic) can be simultaneously detected, the detection accuracy is improved, the repetitive experimental steps are reduced, and the time and the cost are saved.
Owner:河南生生医疗器械有限公司
Polymeric formulations for drug delivery
Poly(ester-anhydrides) or polyesters formed from ricinoleic acid and natural fatty diacids and their method of preparation and its use for delivering bioactive agents including small drug molecules, peptides and proteins, DNA and DNA complexes with cationic lipids or polymers or nano and microparticles loaded with bioactive agents are disclosed herein. The drug delivery compositions are administered to a patient in a liquid form, increase in viscosity in vivo to form a drug depot or implant, and are able to release the incorporated bioactive agent for weeks. In the preferred embodiment, the drug delivery formulations are administered by injection. In one embodiment, the compositions are suitable for local or regional delivery of drugs to diseased sites, such as treating solid tumors and bone infections. In a preferred embodiment, the drug delivery compositions are suitable for site-specific chemotherapy for the treatment of solid tumors including: squamous cell carcinoma (SCC) of the head and neck, prostate cancer, and sarcomas for intratumoral injection or insertion.
Owner:EFRAT BIOPOLYMERS LTD
Methods of cytodiagnostic staging of neoplasia and squamous cell carcinoma
InactiveUS7258987B2Microbiological testing/measurementPeptide preparation methodsEpitheliumSquamous Carcinomas
Methods of diagnosing whether an epithelial tissue is an abnormal tissue by determining an expression pattern for PML in the epithelial tissue; determining an expression pattern for nuclear bodies in the epithelial tissue; determining SUMO-1 colocalization and comparing the expression pattern for PML and the expression pattern for nuclear bodies with a control are disclosed. Also disclosed are methods for diagnosing whether a subject has mild dysplasia, moderate dysplasia, Type A severe dysplasia, Type B severe dysplasia, cervical squamous cell carcinoma, or poorly-differentiated cervical squamous cell carcinoma, by determining an expression pattern for PML, an expression pattern for nuclear bodies, and SUMO-1 colocalization and determining whether the sample is consistent with expression patterns expected for mild dysplasia, moderate dysplasia, Type A severe dysplasia, Type B severe dysplasia, cervical squamous cell carcinoma, or poorly-differentiated cervical squamous cell carcinoma.
Owner:RGT UNIV OF CALIFORNIA
Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas
InactiveCN101861401ASugar derivativesMicrobiological testing/measurementSquamous CarcinomasSquamous Cell Cancers
Owner:THE OHIO STATE UNIV RES FOUND +1
RNA from cytology samples to diagnose disease
InactiveUS20120231468A1Monitor progressMicrobiological testing/measurementSquamous CarcinomasWhite blood cell
The invention relates to methods and kits for detecting the likelihood that a subject has cancer, e.g., squamous cell carcinoma, by assaying the expression levels of tumor associated genes. More specifically, the expression levels of nucleic acids or proteins can be assayed in the tumor associated genes, e.g., over-expression of beta-2 microgobulin (B2M), keratin 17 (KRT17), interleukin 8 (IL8), or annexin A2 (ANXA2), and under-expression of cytochrome p450 1B1 (CYP1B1) or laminin gamma-2 (LAMC2) can be indicative of the likelihood a subject has squamous cell carcinoma or a precancerous squamous cell disorder. The expression levels compared to standards can be indicative of the likelihood a subject has squamous cell carcinoma. The expression levels of B2M, CYP1B1, KRT17, IL8, ANXA2, or LAMC2 can also be repeatedly assayed to monitor the progression of a squamous cell neoplasia.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
Application of LCE3E to diagnosis and treatment of oral cancer
ActiveCN105385781AHigh selectivitySimplify the process of quantitative detectionMicrobiological testing/measurementBiological material analysisSquamous CarcinomasNormal tissue
The invention relates to application of LCE3E to diagnosis and treatment of an oral cancer. According to the application, transcriptome deep sequencing analysis is performed through a high-throughput sequencing platform to preliminarily screen out LCE3E genes obvious in differential expression in oral squamous cell carcinoma tissue and normal tissue, a further RT-PCR experiment proves high expression of the LCE3E genes in the oral squamous cell carcinoma tissue, and an siRNA interference experiment shows that interference to expression of the LCE3E genes can effectively suppress proliferation of oral cancer cells. Oral cancer molecular markers in the application have significant clinical practical application value.
Owner:BEIJING MEDINTELL BIOMED CO LTD
Method of inhibiting osteoclast activity
InactiveUS20090004196A1Peptide/protein ingredientsAntibody mimetics/scaffoldsMelanomaSquamous Carcinomas
Owner:IMMUNEX CORP
MAGE-A3/HPV 16 peptide vaccines for head and neck cancer
InactiveUS20060222656A1Tumor rejection antigen precursorsPeptide/protein ingredientsSquamous CarcinomasHead and neck
The present invention relates to Trojan antigens, and immunogenic compositions comprising the Trojan antigens. The present invention also relates to methods of generating an immune response in a subject using the Trojan antigens or immunogenic compositions. The present invention further relates to methods of treating squamous cell carcinoma of the head and neck (SCCHN) using the Trojan antigens and immunogenic compositions of the present invention.
Owner:MAYO FOUND FOR MEDICAL EDUCATION & RES +1
Antibodies, pharmaceutical compositions and methods
ActiveUS20180339061A1Effective preventionEffective treatmentOrganic active ingredientsImmunoglobulins against cell receptors/antigens/surface-determinantsSquamous CarcinomasProstate cancer
Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as breast cancer, lung cancer, esophageal cancer, rectal cancer, biliary cancer, liver cancer, buccal cancer, gastric cancer, colon cancer, nasopharyngeal cancer, kidney cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, pancreatic cancer, testicular cancer, bladder cancer, head and neck cancer, oral cancer, neuroendocrine cancer, adrenal cancer, thyroid cancer, bone cancer, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, and / or brain tumor.
Owner:OBI PHARMA
Molecular subtyping of oral squamous cell carcinoma to distinguish a subtype that is unlikely to metastasize
InactiveUS20130225420A1Significant likelihoodMicrobiological testing/measurementLibrary screeningSquamous CarcinomasDentistry
Owner:RGT UNIV OF CALIFORNIA
Biomarkers in Peripheral Blood Mononuclear Cells for Diagnosing or Detecting Lung Cancers
ActiveUS20110251098A1Sugar derivativesNucleotide librariesReference samplePeripheral blood mononuclear cell
Methods and compositions are provided for diagnosing or detecting a condition, e.g., lung disease in a mammalian subject by use of a micro-RNA expression level or an expression level profile of multiple miRNA in the peripheral blood mononuclear cells (PBMC) of the subject which is characteristic of COPD or NSCLC. Detection of changes in expression in specific miRNA biomarkers from that of a reference sample or miRNA expression profile are correlated with non-small cell lung cancer (NSCLC) and / or COPD and permit differentiation among healthy subjects, subjects with COPD and subjects with adenocarcinoma or squamous cell carcinoma.
Owner:THE WISTAR INST OF ANATOMY & BIOLOGY
Bifunctional nucleoside hydrogel and preparation method and application thereof
InactiveCN110151776AEnhanced inhibitory effectOrganic active ingredientsSugar derivativesDihydrogen oxideSquamous Carcinomas
Owner:SICHUAN UNIV
Treatment of cancers using anti-NKG2A agents
ActiveUS10329348B2Effectively eliminate head and neck cancer cellsHigh expressionImmunoglobulins against cell receptors/antigens/surface-determinantsAntibody ingredientsSquamous CarcinomasTumor Escape
Owner:INNATE PHARMA SA
Yew branch and leaf extract, extraction method and applications thereof
InactiveCN102949385AEasy to operateOrganic active ingredientsDermatological disorderTonsilSquamous Carcinomas
The present invention relates to a yew branch and leaf extract, an extraction method and applications thereof. The yew branch and leaf extract is extracted by adopting branches and leaves of Taxus chinensis var. mairei as raw materials, and comprises cephalomannine and 7-epitaxol, wherein the active ingredients provide an inhabitation effect for squamous cells in skin cancers, and especially provide significant treatment effects for anal squamous cell carcinoma, esophagus squamous carcinoma and tonsil squamous cell carcinoma. According to the present invention, resource advantages of the yew are utilized to deep develop, utilize and research the Taxus chinensis var. mairei; and a yew anti-skin cancer component extraction method with a characteristic of simple operation is provided, and an effect of the component in anti-skin cancer application is determined.
Owner:JIANGSU HONGDOUSHAN BIOLOGICAL TECH
7-azaindole or 4,7-diazaindole derivatives as ikk epsilon and tbk1 inhibitor and pharmaceutical composition comprising same
Provided are 7-azaindole or 4,7-diazaindole derivatives as an IKKε (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor. The 7-azaindole or 4,7-diazaindole derivative effectively inhibits IKKε and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.
Owner:THE GREEN CROSS CORP
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