1095 results about "Cervical cancer" patented technology

The present invention concerns a pyrvinium compound or an analog thereof for the treatment of cancers. This compound inhibits Wnt activity in the cells of cancers such as adrenocortical, hepatocellular, hepatoblastoma, malignant melanoma, ovarian, Wilm's tumor, Barrett's esophageal, glioma, bladder, breast, gastric, head & neck, lung cell, mesothelioma, and cervical cancers. The present invention also provides a method for assaying for compounds that alter Wnt pathway activity. Also provided are methods for treating Wnt-related non-cancer disease states.

A device and method to diagnose an internal abnormality in a living subject by sensing a passively occurring electromagnetic radiation signal associated with the abnormality and inside an orifice of the subject. Diagnosis includes detection, imaging or identification of the abnormality. An instrument is used either to bring a sensor into the orifice or to transmit the signal to a sensor located outside of the orifice. An example of the instrument includes a prior art endoscope.

The invention relates to a Chinese medicinal preparation for treating cancer, and the Chinese medicinal preparation is prepared from 110 raw material drugs, such as yew, barbed skullcap herb, hairyvein agrimony and laggera pterodonta. The preparation can be oral solution, granules, powder, capsules, electuary and tablets. 110 Chinese medicaments are adopted, and monarch, minister, assistant and guide drugs are reasonably compatible and are comprehensively taken to play the effect of treating both principal and secondary aspect of cancers. The raw material drugs adopted in the Chinese medicinal preparation are common Chinese medicaments, and are low in manufacture cost and small in side effect. The medicament has the advantages of capabilities of effectively strengthening the body immunity and attacking pathogen without hurting a body along with quick response, high curative rate, high heal rate, low relapse rate, treatment of both principal and secondary aspect of cancers, safety and reliability, and can be used for treating various types of cancers, especially lung cancer, gastric cancer, liver cancer, esophagus cancer, pancreatic cancer, cervical cancer and breast cancer.

Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and / or prostate cancer.

The invention discloses a traditional Chinese medicine preparation for treating cancer, which is prepared by 103 types of bulk drugs such as solidago decurrens, Chinese sage herb, hypericum japonicumand the like. A preparation method of the traditional Chinese medicine preparation comprises the following steps: preparing the bulk drugs into water extract by a conventional method; using the prepared water extract for preparing oral solution by a traditional method; drying the obtained water extraction, then conducting grinding and sieving; taking the throughs for extracting powder, and using the extracted powder for preparing tablets, granules, electuaries or capsules by a traditional method. The preparation method also can be as follows: sieving out the dust of the bulk drugs, conductinggrinding and sieving, taking the throughs, conducting disinfection and sterilization to obtain raw powder, and using the raw powder for preparing tablets, granules, electuaries or capsules by a traditional method. With drugs mixed rationally, the traditional Chinese medicine preparation addresses both the symptoms and root causes of cancer. The bulk drugs are frequently-used common Chinese drugs,have low preparation cost and small side effect, and can effectively enhance own immunity, attack pathogen while do not damage body. The traditional Chinese medicine preparation can cure various typesof cancer, particularly lung cancer, stomach cancer, liver cancer, esophageal cancer, pancreatic cancer, cervical cancer and breast cancer.

Methods, compositions and systems are provided for the imaging of cavity / tissue lesions, including without limitation cavity / tissue malignant lesions, e.g. cancers of the skin, mouth, colon, digestive system cervix, bladder, lung, etc.

The invention relates to a method for segmenting cervical cancer cells. The method includes the following steps that noise of a cervical image is eliminated; a cytoplasm template is constructed for the image of which the noise is eliminated to perform rough segmentation, so that a cytoplasm area is obtained through segmentation; super-pixels are calculated for the cytoplasm area obtained through segmentation; the cytoplasm area which the super-pixels are calculated for is classified by the adoption of a convolution neural network; according to the constructed cytoplasm template of the image of which the noise is eliminated, cell nucleuses are roughly segmented; the roughly segmented cell nucleuses are corrected, and therefore segmentation on the cervical cancer cells is finished. The invention further relates to a system for segmenting the cervical cancer cells. On one hand, processing speed is guaranteed, and on the other hand, an accurate segmentation effect is achieved.

The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting of Lung cancer, Adrenal cancer, Melanoma, Colon cancer, Colorectal cancer, Ovarian cancer, Prostate cancer, Liver cancer, Subcutaneous cancer, Squamous cell cancer, Intestinal cancer, Hepatocellular carcinoma, Retinoblastoma, Cervical cancer, Glioma, Breast cancer and Pancreatic cancer in subject using phospholipid ether analogs.

The present invention provides novel phthalazinone compounds and isomer thereof, pharmaceutically acceptable salts, solvates, chemically protected forms, and prodrugs; which can be used as PARP inhibitor and pharmaceutical compositions containing the novel phthalazinone compounds; wherein A, R1 and X are defined as shown. The medicine is used for the treatment of: vascular diseases, neurotoxicity, or diseases improved through the inhibition of PARP activity; or used as adjuvants for the treatment of cancers, or used for enhancing the therapeutic effect of radiation or chemotherapeutic agents on tumor cells, wherein the cancers includes breast cancer, ovarian cancer, colon cancer, melanoma, lung cancer, gastrointestinal stromal tumor, brain cancer, cervical cancer, pancreatic cancer, prostate cancer, gastric cancer, chronic myeloid leukocytes hypercytosis, liver canser, lymphoma, peritoneal cancer, soft tissue sarcoma, neuroendocrine tumors, advanced solid tumors, and glioblastoma.

Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as those in brain, skin, bone, lungs, breast, esophagus, stomach, liver, bile duct, pancreas, colon, kidney, cervical, ovarian, and / or prostate cancer.

Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseases caused by PDGFR-α kinase, PDGFR-β kinase, c-KIT kinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusion proteins and polymorphs of any of the foregoing kinases.

Polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in SCCC cells are provided. The polynucleotides find use in diagnosis of cancer, and classification of cancer cells according to expression profiles. The methods are useful for detecting cervical cancer cells, facilitating diagnosis of cervical cancer and the severity of the cancer (e.g., tumor grade, tumor burden, and the like) in a subject, facilitating a determination of the prognosis of a subject, and assessing the responsiveness of the subject to therapy.

The invention relates to synthesis of benzimidazole-containing naphthalimide derivatives and applications of the benzimidazole-containing naphthalimide derivatives on cancer resistance, and belongs to the field of organic synthesis and pharmaceutical chemistry technology. The benzimidazole-containing naphthalimide derivatives are obtained through a method that a benzimidazole group is introduced into a fourth position of a naphthalene ring of naphthalimide. Experiments of proliferation inhibiting effects of the benzimidazole-containing naphthalimide derivatives on cancer cells adopt a microculture tetrozolium (MTT) reduction method and aim at MCF-7 human breast cancer cells, Hela human cervical cancer cells and PC12 rat adrenal medullary pheochromocytoma differentiated cells. Results of the experiments show that the benzimidazole-containing naphthalimide derivatives have the advantages of good inhibitory activity against cancer cells and good selectivity on cancer cells.

The invention relates to a penicillium citrinum sourced citrinin compound (penicitrinol O) as well as a preparation method and an application thereof. The compound has an effect on inhibiting tumor cell proliferation and has anti-tumor activity, and the structural formula is shown in the specification. The preparation method comprises the steps: fermenting and culturing penicillium citrinum IBPT-5 to obtain a fermented product; and then separating and purifying the fermented product to obtain the compound. The experiment shows that the compound has high anti-tumor activity for human cervical cancer cell line hela and can be used for preparing cell proliferation inhibition medicines or anti-tumor medicines for the study on anti-tumor.

A diagnostic system detects abnormal physical properties of tissue in a patient based upon optical properties of the tissue. A probe includes light delivery and capture fibers, and polarizers. Optical properties detected relate to polarized and unpolarized light into, and scattering from, the tissue. The optical properties detected are processed and analyzed to produce results indicative of the physical property(s) evaluated. System operation is controlled against pressure monitored via a pressure sensor coupled to the probe-tissue interface. The analysis corrects for patient physical characteristics as user inputs, such as menopausal or menstrual condition of women patients. Physical properties diagnosed include cervical dysplasia conditions in women patients, such as HSIL, cervical cancer, LSIL, or cervicitis. Analysis and diagnosis is based upon at least one of: ratios between scattered light signals captured from the tissue, slope of intensity over wavelength for scattered light signals captured, and hemoglobin-related parameters in the tissue.

The invention discloses a primer, a probe and a kit for fluorescence PCR (Polymerase Chain Reaction) detection of 18 types of high-risk human papilloma viruses. Different typing kits are detected by adding different specificity probes; the DNAs (Deoxyribose Nucleic Acids)) of 18 types of common high-risk human papilloma viruses internationally recognized and closely related to the cervical cancer can be detected once; and typing detection is carried out on HPV (Human Papilloma Virus)16 and 18. The application provides 6 universal primers and 18 specific molecular beacon probes. The DNAs of the 18 types of common high-risk human papilloma viruses can be amplified by the 6 universal primers; and meanwhile, the 18 probes are the specific molecular beacon probes designed by aiming at the 18 high-risk types; different types of probes are added according to the detection need and combined as the kits aiming at the detection need of the different high-risk types; and at the same time, the added probes are marked by different report genes, so that the purpose of carrying out typing detection on the high-risk HPV is achieved.

The present invention relates to a six-item tumor labeling material micro array (Array)-enzyme linked immunosorbent assay (ELISA) detection kit, in particular to a six-item tumor labeling material micro array (Array)-enzyme linked immunosorbent assay (ELISA) detection kit which is used for detecting the characteristic protein which has an indicating function to the liver cancer, lung cancer, colorectal cancer, stomach cancer, pancreatic cancer, breast cancer, cervical cancer, ovarian cancer, prostate cancer and other tumor diseases.

The invention discloses a CRISPR (clustered regularly interspaced short palindromic repeat) based DNA detecting and typing method and an application thereof. The method comprises following steps: (1),target DNA is subjected to PCR (polymerase chain reaction) amplification by a pair of universal primers; (2), the amplified target DNA is cut by Cas9 / sgRNA; (3), the cut target DNA is linked with DNAligase; (4), the linked target DNA is subjected to PCR amplification. According to the method, the target DNA can be subjected to specific detection and typing simply, rapidly and sensitively according to the specific identification cutting characteristics of the CRISPR technology on DNA, the method is one novel DNA detection method with high specificity and sensitivity, and the critical bottleneck problems about nucleic acid hybridization, specific PCR primer design and the like in current nucleic acid detection and typing fields are solved successfully. With the application of the method, L1 and E6 / E7 genes of HPV16 and HPV18 in human cervical cancer cells are detected successfully.

The present compounds are intermediates for the preparation of quinoline derivatives and compositions having gonadotropin-releasing hormone antagonistic activity useful as propylactics or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, uterine or cervical cancer, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; are effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a male or female contraceptive, as an ovulation-inducing agent; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; and are useful for modulating estrous cycles in animals in the field of animal husbandry, as agents for improving the quality of edible meat or promoting the growth of animals, and as agents for promoting spawning in fish.

Methods of treating ovarian cancer, endometrium cancer, cervical cancer, pancreatic cancer, bladder cancer, eve cancer, central nervous system cancer, thyroid cancer and lung cancer are disclosed. Specifically disclosed are methods of treating ovarian adenocarcinoma that has migrated into the abdominal cavity, a transitional cell carcinoma of the bladder, an epithelioid carcinoma in a pancreatic duct, an adenocarcinoma in a pancreatic duct, an adenocarcinoma in the cervical epithelium. The methods comprise administering to a patient a therapeutically effective amount of a compound of formula (Ia)wherein R1, R2, R3, R4, and R5 are described herein, wherein at least two of the five R1, R2, R3, R4, and R5 substituents are always hydrogen, at least one of the five substituents is always nitro, and at least one substituent positioned adjacent to a nitro is always iodo, and pharmaceutically acceptable salts thereof.

The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.

The present invention discloses a method for the detection of atypical vessels in digital cervical imagery. A pre-processing stage is applied to enhance the contrast of blood vessel features compared to the surrounding tissue. Next, a segmentation stage is applied to identify regions of interest for atypical vessels using texture and gradient information. Finally, a post-processing stage (1) identifies other clinically relevant features in the cervical imager, and removes these features from the region of interest; and (2) uses color, size, and shape information to further refine the region of interest to eliminate false positives and determine a final region of interest. This automated method of atypical vessel detection is especially useful for diagnostic purposes such as cervical cancer detection.

The invention discloses a cancer pain-relieving plaster prepared by a preparation A and a preparation B, wherein the preparation A is prepared by five branches, five skins, one brick, one stone, five cores, and the like; the preparation B is prepared by poria cocos, pinellia ternate, jackinthepulpit tuber rhizome, trichosanthes kirilowii maxim, centipede, zaocys dhumnade, and the like. When the cancer pain-relieving plaster is prepared, the preparation B is added into the preparation A to be decocted for 4.5-5.5 hours, red lead is added to be mixed to pasty fluid, then cold water is added for steeping to releasing fire-toxin, water is changed once one day, and the plaster is obtained after steeping for 7 days. When the plaster is used, the plaster is coated on cotton cloth or plaster paster. The cancer pain-relieving plaster mainly aims at tumour cancers of lung cancer, gastric cancer, liver cancer, pancreatic cancer, colon caner, rectal caner, kidney cancer, bladder caner, breast cancer, cervical cancer, ovarian cancer, esophagus cancer, laryngeal cancer, and the like and is obvious in pain-relieving effect.

Systems and methods are provided for treating cervical and / or uterine cancers in brachytherapy with an intracavitary brachytherapy applicator. The system comprises a tandem adapted for insertion into a cervix of a patient. An ovoid assembly comprises first and second inflatable ovoids and an ovoid support mechanism. The first and second inflatable ovoids are adapted for insertion within fornices of a patient. First and second retractors are adapted to be coupled to the ovoid assembly. The first retractor is adapted to be positioned to retract the bladder of a patient during treatment. The second retractor is adapted to be positioned to retract the rectum of a patient during treatment. The tandem and the first and second inflatable ovoids are adapted to be coupled to a radioactive source to deliver an implant radiation dose suitable for cancer treatment at a cancerous cervical treatment site in a patient.

An anti-cytoplasm thymidine kinase-IgY antibody prepared from the C-terminal 31 peptide of human cervical cancer cell (HeLa)TK1, the application of the reagent kit prepared from said antibody in diagnosing tumor, the process for preparing said antibody and reagent kit, and its test method are disclosed.

Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as breast cancer, lung cancer, esophageal cancer, rectal cancer, biliary cancer, liver cancer, buccal cancer, gastric cancer, colon cancer, nasopharyngeal cancer, kidney cancer, prostate cancer, ovarian cancer, cervical cancer, endometrial cancer, pancreatic cancer, testicular cancer, bladder cancer, head and neck cancer, oral cancer, neuroendocrine cancer, adrenal cancer, thyroid cancer, bone cancer, skin cancer, basal cell carcinoma, squamous cell carcinoma, melanoma, and / or brain tumor.

The invention discloses a cervical smear image diagnosis system on the basis of convolutional neural networks and transfer learning. The cervical smear image diagnosis system comprises a sample database, a pre-training model, a reconstruction model and a to-be-tested sample acquisition module. The sample database is used for storing training samples; the pre-training model is a convolutional neural network model and comprises a convolutional layer, a pooling layer and a full-connection layer, and training can be carried out by the aid of the training samples in the sample databases, so that multi-classification requirements can be met by the pre-training model; network structures and parameters of the convolutional layer and the pooling layer in the pre-training model can be transferred bythe reconstruction model, the architecture of the full-connection layer can be modified, and accordingly requirements of cervical smear image classification tasks can be met by the reconstruction model; the to-be-tested sample acquisition module is used for acquiring to-be-tested cervical smear image samples, and the to-be-tested cervical smear image samples can be inputted into the reconstruction model, so that corresponding classification results can be obtained. The cervical smear image diagnosis system has the advantages that images with different sizes are allowed to be inputted into thecervical smear image diagnosis system, accordingly, high-performance classification effects can be realized by the cervical smear image diagnosis system, and excellent auxiliary effects can be realized by the cervical smear image diagnosis system for cervical cancer early screening and diagnosis.

The invention discloses a cervical cancer histopathology image analysis method and device based on depth learning. The method comprises the following steps: acquiring cervical cancer histopathology images and setting image labels for each image; training two convolution neural networks respectively based on the images used for training, and obtaining the two trained convolution neural networks; fixing parameters of the two trained convolutional neural networks, and training the all-connected layer one based on the images used for training, so that the trained all-connected layer one is obtained. The image to be tested is input into the trained classifier, and the two convolution neural networks extract feature vectors from the image respectively. The output feature vectors f1 and f2 are spliced together and input to the full connection layer 1, and the output feature vector f3. The classification result is determined by the element with the largest value in the feature vector f3 The invention can automatically classify and identify the differentiation degree of the original histopathological slice micrograph collected by the doctor and assist the doctor in diagnosis.

The invention discloses a piece of cervical cancer precancerosis diagnostic equipment, comprising a cervical cancer inherent fluorescence detecting system, a uterine cervix acetic coloring detecting system, an image acquisition system and an external image processing system; wherein, the cervical cancer inherent fluorescence detecting system comprises a light source and a switch of the light source, and the light source includes an excitation light source for providing fluorescence and a cold light source for providing white light which are both installed in a reflection bowl with a specific focal distance; the uterine cervix acetic coloring detecting system comprises an acetic acid pool, a spray pipe connected to the acetic acid pool, a shift device of the spray pipe and a spray switch; the image acquisition system comprises a dim light CCD which is installed at the center of the reflection bowl; the image acquisition system is connected with an external image processing system whichcan process the images collected by the image acquisition system; the uterine cervix is sequentially irradiated by white light and excitation light and the images of the white light and the excitation light reflected by the uterine cervix are collected; the acetic acid is sprayed on the uterine cervix which is irradiated by the white light and the excitation light after waiting for a moment and the images of the white light and the excitation light reflected by the uterine cervix which is sprayed with the acetic acid are collected.