The present application relates to a method for determining a risk
score that indicates a risk that a clinical event will occur within a certain period of time. The risk
score is based at least in part on a combination of inferred activities of two or more cellular signaling pathways in a tissue and / or cells and / or a
body fluid of a subject. The cellular signaling pathways comprise a Wnt pathway, an ER pathway, an HH pathway, and / or an AR pathway. The risk
score is defined such that the indicated risk that the clinical event will occur within the certain period of time decreases with an increasing PER and increases with an increasing max(PWnt, PHH), wherein PER, Pwnt, and PHH denote the inferred activity of the ER pathway, the Wnt pathway, and the HH pathway, respectively.