Mds to aml transition and prediction methods therefor

A prediction model and transcriptome technology, applied in the field of transition from MDS to AML and its prediction

Inactive Publication Date: 2019-06-18
NANTOMICS LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no known method for robust prediction of the time to progression from MDS to AML

Method used

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  • Mds to aml transition and prediction methods therefor
  • Mds to aml transition and prediction methods therefor
  • Mds to aml transition and prediction methods therefor

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Embodiment

[0031] In a first attempt to identify predictive markers for the progression of MDS to AML, the inventors compared patient data with different progression times and mutational burdens, particularly of protein-coding genetic sequences. Omics analysis was performed using whole-genome sequencing of MDS and AML cells from the same patient and incremental localization-guided simultaneous alignment using BAMBAM, such as described in US9721062. figure 1 Exemplary results of this analysis are depicted. Notably, the median mutational change was approximately +2.5 coding mutations in the patient population with progression time <38 months, whereas the median mutational change in the patient population with progression time greater than 38 months and less than 80 months is about -2.0 coding mutations. On the other hand, among patients with a time to progression of more than 80 months, the median mutational change was approximately +15.0 coding mutations. While this increase at least a...

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Abstract

Contemplated systems and methods allow for prediction of time for MDS to AML transition using a predictive model that is based on selected features with significant differential expression levels and / or pathway activity between MDS to AML cells.

Description

[0001] This application claims priority to US Provisional Applications Serial No. 62 / 413917, filed October 27, 2016, and US Provisional Application Serial No. 62 / 429036, filed December 1, 2016. technical field [0002] The field of the invention is the method of omics analysis for the prediction and analysis of the progression of MDS (myelodysplastic syndrome) to AML (acute myelogenous leukemia). Background technique [0003] The following description includes information useful for understanding the present invention. It is not an admission that any information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art. [0004] All publications and patent applications identified herein are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. If a defi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B5/00G16B25/00G16B5/20G16B25/10G16B45/00
CPCG16B5/00G16B25/00C12Q1/6886C12Q2600/158C12Q2600/118G16B25/10G16B5/20G16H50/20G16B40/00G16H50/50C12Q2600/156
Inventor 斯蒂芬·查尔斯·本茨安德鲁·纽伦A·J·塞奇威克C·司徒
Owner NANTOMICS LLC
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