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2906 results about "Central nervous system" patented technology

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord. The CNS is so named because it integrates the received information and coordinates and influences the activity of all parts of the bodies of bilaterally symmetric animals—that is, all multicellular animals except sponges and [[radiata|radially symmetric animals ] such as jellyfish—and it contains the majority of the nervous system. Many consider the retina and the optic nerve (cranial nerve II), as well as the olfactory nerves (cranial nerve I) and olfactory epithelium as parts of the CNS, synapsing directly on brain tissue without intermediate ganglia. As such, the olfactory epithelium is the only central nervous tissue in direct contact with the environment, which opens up for therapeutic treatments. The CNS is contained within the dorsal body cavity, with the brain housed in the cranial cavity and the spinal cord in the spinal canal. In vertebrates, the brain is protected by the skull, while the spinal cord is protected by the vertebrae. The brain and spinal cord are both enclosed in the meninges. Within the CNS, the interneuronal space is filled with a large amount of supporting non-nervous cells called neuroglial cells.

Glucocorticoid blocking agents for increasing blood-brain barrier permeability stan-261con

Glucocorticoid blockers, including glucocorticoid receptor antagonists, are effective to prevent glucocorticoid-induced decrease in permeability of the blood-brain barrier and to increase the permeability of the blood-brain barrier. Administration of glucocorticoid blockers, including glucocorticoid receptor antagonists, concomitant with administration of drugs for treating diseases of the central nervous system increases delivery of such drugs into the central nervous system.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV

Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and /or nerves and/or central nervous system tissue

Improved assemblies, systems, and methods provide an implantable pulse generator for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The implantable pulse generator is sized and configured to be implanted subcutaneous a tissue region. The implantable pulse generator includes an electrically conductive case of a laser welded titanium material. Control circuitry is located within the case, the control circuitry including a rechargeable power source, a receive coil for receiving an RF magnetic field to recharge the power source, and a microcontroller for control of the implantable pulse generator. Improved assemblies, systems, and methods also provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system provides at least one electrically conductive surface, a lead connected to the electrically conductive surface, and an implantable pulse generator electrically connected to the lead.
Owner:MEDTRONIC URINARY SOLUTIONS

Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders

A device and a method of use for treating a medical disorder by surgically implanting into a patient at least one sensor element capable of detecting and conveying cell signals: attaching a management unit such that a micro controller of the management unit is connected to at least one sensor element; and connecting the management unit via a lead bundle to at least one treatment device. The treatment device may be an electrical stimulation device, a magnetic stimulation device, a heat transfer device, or a medication delivery device. Responsive to signals from the one or more sensor elements, mathematical algorithms of the management unit use wavelet crosscorrelation analysis to prompt delivery of at least one treatment modality, such heat transfer, current pulses, magnetic stimulation or medication. The medical disorder may arise from the brain, central nervous system or organs and tissues outside of the central nervous system.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE

Neuro-informatics repository system

A neuro-informatics repository system is provided to allow efficient generation, management, and access to central nervous system, autonomic nervous system, effector data, and behavioral data obtained from subjects exposed to stimulus material. Data collected using multiple modalities such as Electroencephalography (EEG), Electrooculography (EOG), Galvanic Skin Response (GSR), Event Related Potential (ERP), surveys, etc., is stored using a variety of data models to allow efficient querying, report generation, analysis and / or visualization.
Owner:NIELSEN CONSUMER LLC

Omega 3 fatty acid formulations

The present invention provides highly purified omega-3 fatty acid formulations. Certain formulations provided herein have contain greater than 85% omega-3 fatty acids by weight. Certain other formulations provided herein contain EPA and DHA in a ratio of from about 4.01:1 to about 5:1. The invention also provides methods of using the dosage forms to treat a variety of cardiovascular, autoimmune, inflammatory, and central nervous system disorders by administering a formulation of the invention to a patient in need thereof.
Owner:CENESTRA

Methods for slowing familial ALS disease progression

Methods for slowing disease progression in an individual suffering from familial ALS are provided. Also provided are methods of increasing the survival time of an individual suffering from familial ALS. These methods employ antisense oligonucleotides targeted to SOD1, for use in inhibiting the expression of SOD1 in the central nervous system of an individual suffering from familial ALS.
Owner:IONIS PHARMA INC

Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue

Improved assemblies, systems, and methods provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system includes an implantable pulse generator and a lead sized and configured to be implanted subcutaneously in a tissue region. An external controller includes circuitry adapted for wireless telemetry and a charging coil for generating the radio frequency magnetic field to transcutaneously recharge a rechargeable battery in the pulse generator. Using wireless telemetry, the pulse generator is adapted to transmit status information back to the external controller to allow the external controller to automatically adjust up or down the magnitude of the radio frequency magnetic field and / or to instruct a user to reposition the charging coil, the status information adapted to allow optimal recharging of the pulse generator rechargeable battery.
Owner:MEDTRONIC URINARY SOLUTIONS

Parenteral delivery systems

Hypertonic sugar compositions administered by other than ingestion and swallowing or intravascular injection, such as by intranasal spray or drops, intraocular drops or ointment, oral spray, intraotic spray or drops, lozenges, chewable tablet, chewing gum, or gargle, pulmonary inhalation, vaginal or rectal suppositories, or transdermal creams, ointments, lotions, or patches, are effective to open the blood-brain barrier to permit entry into the central nervous system of a co-administered chemical compound, such as a nutrient or a therapeutic or diagnostic agent. In this way, the compositions and methods of the invention increase the therapeutic or diagnostic efficacy of such chemical compounds.
Owner:NAITO ALBERT T

Implantable system and methods for acquisition and processing of electrical signals from muscles and/or nerves and/or central nervous system tissue

Improved assemblies, systems, and methods provide an MES processor for acquisition and processing of myoelectric signals from muscles, nerves, or central nervous system tissue, or any combination. The MES processor is sized and configured to be implanted subcutaneous a tissue region. The MES processor includes an electrically conductive case of a laser welded titanium material. Control circuitry is located within the case, the control circuitry including a rechargeable power source, a receive coil for receiving an RF magnetic field to recharge the power source, and a microcontroller for control of the MES processor. Improved assemblies, systems, and methods also provide an acquisition and processing system for sensing myoelectric signals from muscles, nerves, or central nervous system tissue, or any combination. The acquisition and processing system provides at least one electrically conductive surface, a lead connected to the electrically conductive surface, and an MES processor electrically connected to the lead.
Owner:MEDTRONIC URINARY SOLUTIONS

Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors

The present invention relates to novel compounds, in particular novel thieno-pyridine and thieno-pyrimidine derivatives according to Formula (I), wherein all radicals are defined in the application. The compounds according to the invention are positive allosteric modulators of metabotropic receptors-subtype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.
Owner:ORTHO MCNEIL JANSSEN PHARMA

Stimulation leads, delivery systems and methods of use

InactiveUS20100179562A1Minimizing complicationMinimize side effectsSpinal electrodesDiagnosticsSide effectMedicine
Devices, systems and methods are provided for accessing and treating anatomies associated with a variety of conditions while minimizing possible complications and side effects. This is achieved by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, this involves stimulating portions of neural tissue of the central nervous system, wherein the central nervous system includes the spinal cord and the pairs of nerves along the spinal cord which are known as spinal nerves. In particular, some embodiments of the present invention are used to selectively stimulate portions of the spinal nerves, particularly one or more dorsal root ganglions (DRGs), to treat chronic pain while causing minimal deleterious side effects such as undesired motor responses.
Owner:ST JUDE MEDICAL LUXEMBOURG HLDG SMI S A R L SJM LUX SMI

Magnetic Stimulating Circuit For Nervous Centralis System Apparatus, Purpose, and Method Thereof

A magnetic stimulation apparatus for central nervous system and circuit thereof and use of the apparatus and method of using the apparatus are shown. Controlling circuit design and outputting wave form signal to a drive power supply circuit enables the drive power supply circuit to output current of corresponding wave form to coils, and by means of the design of the shape, number of turns, size, interval of the coils, generates within a certain region inside the coils a desired time-variant magnetic field which is then applied to the brain of an animal or a human being so that the central nervous system can receive a wide area synergy magnetic stimulation with a precise wave form, high frequency or a combination of a plurality of frequency components, thus achieving the treatment of nervous and psychiatric diseases or brain function improvement in combination with behavior guidance, thought guidance, or psychological guidance.
Owner:ZHENG YUNFENG

Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders

A method for delivering molecules to a central nervous system (CNS) of a subject includes supplying the molecules to a blood circulation of the CNS; supplying, to a body of the subject, a carrier system that encapsulates a nitric oxide (NO) facilitator; and applying energy to the carrier system at an energy level sufficient to cause the carrier system to release the NO facilitator in a blood circulation of the subject in a vicinity of a blood-brain barrier (BBB) of the subject and thereby increase passage of the molecules from the blood circulation of the CNS, through the BBB, and into the CNS of the subject.
Owner:BRAINSGATE LTD

Treatment of shoulder dysfunction using a percutaneous intramuscular stimulation system

InactiveUS6845271B2Retard and prevents muscle disuse atrophyMaintains muscle range-of-motionElectrotherapyArtificial respirationRisk strokeElectrical stimulations
A method of treating shoulder dysfunction involves the use of a percutaneous, intramuscular stimulation system. A plurality of intramuscular stimulation electrodes are implanted directly into select shoulder muscles of a patient who has suffered a disruption of the central nervous system such as a stroke, traumatic brain injury, spinal cord injury or cerebral palsy. An external microprocessor based multi-channel stimulation pulse train generator is used for generating select electrical stimulation pulse train signals. A plurality of insulated electrode leads percutaneously, electrically interconnect the plurality of intramuscular stimulation electrodes to the external stimulation pulse train generator, respectively. Stimulation pulse train parameters for each of the stimulation pulse train output channels are selected independently of the other channels. The shoulder is evaluated for subluxation in more than one dimension. More than one muscle or muscle group is simultaneously subjected to a pulse train dosage. Preferably, the at least two dosages are delivered asynchronously to two muscle groups comprising the supraspinatus in combination with the middle deltoid, and the trapezious in combination with the posterior deltoid.
Owner:SPR THERAPEUTICS

Multi-market program and commercial response monitoring system using neuro-response measurements

A system performs program and commercial response monitoring using neuro-response data such as central nervous system, autonomic nervous system, and effector data. Multiple subjects in multiple markets are exposed to programming and commercials and neuro-response data is collected using mechanisms such as Electroencephalography (EEG), Galvanic Skin Response (GSR), Electrocardiograms (EKG), Electrooculography (EOG), eye tracking, and facial emotion encoding. Data collected is provided for response integration to measure and track multi-market program and commercial response to stimulus materials.
Owner:THE NIELSEN CO (US) LLC

Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases

Methods of treating, preventing and / or managing central nervous system disorders, such as Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's Disease) and related syndromes are disclosed. Specific methods encompass the administration of an immunomodulatory compound of the invention, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active ingredient. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Owner:CELGENE CORP

Methods and apparatus for enhanced and controlled delivery of a biologically active agent into the central nervous system of a mammal

Disclosed are invasive and non-invasive central nervous system (CNS) drug delivery methods and devices for use in these methods that essentially circumvent the blood-brain barrier. More specifically, the disclosed methods and devices utilize iontophoresis as delivery technique that allows for enhanced delivery of a biologically active agent into the CNS of a mammal as well as for (pre)-programmable and controlled transport.
Owner:INTRABRAIN INT

Methods and compositions using immunomodulatory compounds for treatment and management of central nervous system injury

Methods of treating, preventing and / or managing a central nervous system injury / damage and related syndromes are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active agent. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Owner:CELGENE CORP

Entity and relationship assessment and extraction using neuro-response measurements

A system performs entity and relationship assessment and extraction using neuro-response data such as central nervous system, autonomic nervous system, and effector data. Subjects are exposed to stimulus material and neuro-response data is collected using mechanisms such as Electroencephalography (EEG), Galvanic Skin Response (GSR), Electrocardiograms (EKG), Electrooculography (EOG), eye tracking, and facial emotion encoding. Data collected is provided to assess and extract entity and relationship formation among individuals, groups, or objects in marketing, advertising, entertainment, and other stimuli.
Owner:THE NIELSEN CO (US) LLC

Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue

Improved assemblies, systems, and methods provide an implantable pulse generator for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The implantable pulse generator is sized and configured to be implanted subcutaneously in a tissue region. The implantable pulse generator includes an electrically conductive laser welded titanium case. Control circuitry is located within the case, and includes a primary cell or rechargeable power source, a receive coil for receiving an RF magnetic field to recharge the rechargeable power source, and a microcontroller for control of the implantable pulse generator. Improved assemblies, systems, and methods also provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system provides at least one electrically conductive surface, a lead connected to the electrically conductive surface, and an implantable pulse generator electrically connected to the lead.
Owner:MEDTRONIC URINARY SOLUTIONS

Intra-modality synthesis of central nervous system, autonomic nervous system, and effector data

An intra-modality response synthesizer analyzes and enhances central nervous system, autonomic nervous system, and effector data to evaluate subject response to stimuli. A data collection mechanism obtains response data from a subject exposed to stimuli, such as marketing and entertainment stimuli. The intra-modality response synthesizer analyzes and synthesizes a plurality of modality specific response measures from central nervous system, autonomic nervous system, and effector systems. For example, the intra-modality response synthesizer analyzes response data including neurophysiological data to evaluate the effectiveness of stimuli by analyzing interactions between multiple regions of the brain.
Owner:THE NIELSEN CO (US) LLC

Analysis of marketing and entertainment effectiveness using central nervous system, autonomic nervous sytem, and effector data

Central nervous system, autonomic nervous system, and effector data is measured and analyzed to determine the effectiveness of marketing and entertainment stimuli. A data collection mechanism including multiple modalities such as Electroencephalography (EEG), Electrooculography (EOG), Galvanic Skin Response (GSR), etc., collects response data from subjects exposed to marketing and entertainment stimuli. A data cleanser mechanism filters the response data. The response data is enhanced using intra-modality response synthesis and / or a cross-modality response synthesis.
Owner:NIELSEN CONSUMER LLC

Analysis of marketing and entertainment effectiveness using magnetoencephalography

Central nervous system, autonomic nervous system, and effector data is measured and analyzed to determine the effectiveness of marketing and entertainment stimuli. A data collection mechanism including multiple modalities such as Magnetoencephalography (MEG), Electrooculography (EOG), Galvanic Skin Response (GSR), etc., collects response data from subjects exposed to marketing and entertainment stimuli. A data cleanser mechanism filters the response data. The response data is enhanced using intra-modality response synthesis and / or a cross-modality response synthesis.
Owner:NIELSEN CONSUMER LLC

Brain pattern analyzer using neuro-response data

A system obtains neuro-response data such as central nervous system, autonomic nervous system, and effector system measurements from subjects exposed to stimulus material. Stimulus material is categorized and / or tagged. Survey based responses and resulting linguistic, perceptual, expressive, and / or motor responses are obtained, integrated with neuro-response data, and stored in a brain pattern analyzer repository. Neurological signatures for concepts such as yes, no, buy, purchase, acquire, like, dislike, correct, incorrect can be determined on a group, subgroup, or individual basis and stored in the brain pattern analyzer repository. The brain pattern analyzer repository may be used to predict behavior based on neurological signatures and / or similarly categorized and tagged stimulus materials that elicit corresponding neuro-response patterns for particular subject groups.
Owner:THE NIELSEN CO (US) LLC

Method and device for enhanced delivery of a biologically active agent through the spinal spaces into the central nervous system of a mammal

InactiveUS6913763B2Promotes high patient compliancePromotes acceptanceElectrotherapyMedical devicesDiseaseNervous system
A delivery method and implantable apparatus that allows for controlled, enhanced and (pre)-programmable administration of a biologically active agent into the spinal structures and / or the brain via the epidural space of a mammal, particularly of a human being and including a feedback regulated delivery method and apparatus specifically in the treatment of neurological diseases and chronic pain.
Owner:INTRABRAIN INT

Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)

InactiveUS20050054631A1BiocideSenses disorderAdenosinePolyadenosine diphosphate ribose polymerase
The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and / or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
Owner:AVENTIS PHARMA INC
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