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4135 results about "Nitric oxide" patented technology
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Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO. It is one of the principal oxides of nitrogen. Nitric oxide is a free radical, i.e., it has an unpaired electron, which is sometimes denoted by a dot in its chemical formula, i.e., ·NO. Nitric oxide is also a heteronuclear diatomic molecule, a historic class that drew researches which spawned early modern theories of chemical bonding.
Sensors for detecting substances indicative of stroke, ischemia, infection or inflammation
ActiveUS20080176271A1Thickness minimizationTransport of glucose to the sensor is not altered over timeStentsMicrobiological testing/measurementMetaboliteNitric oxide
A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.
Owner:SILVER JAMES H
Measuring nitrogen oxides and other gases by ozone formation
InactiveUS20090137055A1Improve signal-to-noise ratioRecalibration requirement is also reducedMaterial analysis by electric/magnetic meansMaterial analysis by optical meansNitrogen dioxideNitric oxide
A photochemical sensing system enables the measurement of nitrogen oxides (nitrogen dioxide and nitric oxide) by photolyzing nitrogen dioxide to form oxygen atoms which combine with oxygen molecules to form ozone. Ozone reacts with nitric oxide to for nitrogen dioxide-decreasing ozone. Changes in ozone concentration are measured as a surrogate for the nitrogen dioxide and nitric oxide. Any species which photolyzes to yield oxygen atoms may be measured by this technique. Additional specificity for nitrogen oxides is conferred by allowing the nitric oxide to react with the ozone to recreate the nitrogen dioxide. By periodically photolyzing the nitrogen dioxide (to form ozone), and then allowing the resulting nitric oxide to react with the ozone (thereby reducing ozone), a pulsed signal is obtained whose amplitude is proportional to the total amount of nitrogen dioxide and nitric oxide present. Medical applications include measuring nitric oxide concentrations in expired air samples.
Owner:BOGNAR JOHN A
Low-temperature dielectric film formation by chemical vapor deposition
InactiveUS7994070B1Semiconductor/solid-state device manufacturingSemiconductor devicesDielectricWater vapor
A method for depositing a dielectric film on a substrate includes positioning a plurality of substrates in a process chamber, heating the process chamber to a deposition temperature between 400° C. and less than 650° C., flowing a first process gas comprising water vapor into the process chamber, flowing a second process gas comprising dichlorosilane (DCS) into the process chamber, establishing a gas pressure of less than 2 Torr, and reacting the first and second process gases to thermally deposit a silicon oxide film on the plurality of substrates. One embodiment further includes flowing a third process gas comprising nitric oxide (NO) gas into the process chamber while flowing the first process gas and the second process gas; and reacting the oxide film with the third process gas to form a silicon oxynitride film on the substrate.
Owner:TOKYO ELECTRON LTD
Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof
A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nano-fibers of linear poly(ethylenimine) diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.
Owner:AKRON THE UNIV OF
Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses
InactiveUS20080317679A1Efficient deliveryMinimizing systemic penetrationOrganic active ingredientsBiocideActive agentNitric oxide
The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising:i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof;ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof;iii. a surface-active agent;iv. about 0% to about 5% by weight of at least one polymeric agent; andv. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition;wherein the composition is housed in a container and is substantially flowable, andwhich upon release expands to form a breakable foam; andwherein the foamable carrier is selected to generate a foam of good to excellent quality.The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.
Owner:FOAMIX PHARMACEUTICALS LIMITED
Targeted release of nitric oxide in the CNS circulation for modulating the BBB and treating disorders
A method for delivering molecules to a central nervous system (CNS) of a subject includes supplying the molecules to a blood circulation of the CNS; supplying, to a body of the subject, a carrier system that encapsulates a nitric oxide (NO) facilitator; and applying energy to the carrier system at an energy level sufficient to cause the carrier system to release the NO facilitator in a blood circulation of the subject in a vicinity of a blood-brain barrier (BBB) of the subject and thereby increase passage of the molecules from the blood circulation of the CNS, through the BBB, and into the CNS of the subject.
Owner:BRAINSGATE LTD
Method for combined removal of mercury and nitrogen oxides from off-gas streams
InactiveUS7118720B1Promote oxidationProcess economyGas treatmentNitrogen compoundsNitrogen dioxideNitrogen oxide
A method for removing elemental Hg and nitric oxide simultaneously from a gas stream is provided whereby the gas stream is reacted with gaseous chlorinated compound to convert the elemental mercury to soluble mercury compounds and the nitric oxide to nitrogen dioxide. The method works to remove either mercury or nitrogen oxide in the absence or presence of each other.
Owner:THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF ENERGY
Inhibitors and methods of use thereof
New triterpenoid derivatives with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) were synthesized. Among them, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile (CNDDO), 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole, 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)-2-methylimidazole, 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl)-4-methylimidazole show extremely high inhibitory activity (IC50=0.01-1 pM level) against production of nitric oxide induced by interferon-γ in mouse macrophages. These compounds can be used in the prevention or treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, rheumatoid arthritis, and other inflammatory diseases. All the new triterpenoid derivatives are more potent than previously known CDDO.
Owner:TRUSTEES OF DARTMOUTH COLLEGE THE
Method for reducing NOX in combustion flue gas using metal-containing additives
InactiveUS6206685B1Improved control deviceSure easyDispersed particle separationSolid fuel combustionAtmospheric airNitric oxide
Various methods for decreasing the amount of nitrogen oxides released to the atmosphere as a component of combustion gas mixtures are provided. The methods specifically provide for the removal of nitric oxide and nitrogen dioxide (NOx) from gas mixtures emitted from stationary combustion systems. In particular, methods for improving efficiency of nitrogen oxide reduction from combustion systems include injecting metal-containing compounds into the main combustion zone and / or the reburning zone of a combustion system. The metal containing compounds react with active combustion species, and these reactions change radical concentrations and significantly improve NOx conversion to molecular nitrogen. The metal-containing additives can be injected with the main fuel, in the main combustion zone, with secondary or reburning fuel addition, or at several locations in the main combustion zone and reburning zone. Optionally, nitrogenous reducing agents and / or overfire air can be injected downstream to further increase NOx reduction.
Owner:GE ENERGY & ENVIRONMENTAL RES
Multi-component removal in flue gas by aqua ammonia
InactiveUS7255842B1Regeneration process is less-costlyIncrease load capacityGas treatmentNitrogen compoundsNitric oxideSlurry
A new method for the removal of environmental compounds from gaseous streams, in particular, flue gas streams. The new method involves first oxidizing some or all of the acid anhydrides contained in the gas stream such as sulfur dioxide (SO2) and nitric oxide (NO) and nitrous oxide (N2O) to sulfur trioxide (SO3) and nitrogen dioxide (NO2). The gas stream is subsequently treated with aqua ammonia or ammonium hydroxide which captures the compounds via chemical absorption through acid-base or neutralization reactions. The products of the reactions can be collected as slurries, dewatered, and dried for use as fertilizers, or once the slurries have been dewatered, used directly as fertilizers. The ammonium hydroxide can be regenerated and recycled for use via thermal decomposition of ammonium bicarbonate, one of the products formed. There are alternative embodiments which entail stoichiometric scrubbing of nitrogen oxides and sulfur oxides with subsequent separate scrubbing of carbon dioxide.
Owner:THE UNITED STATES AS REPRESENTED BY THE DEPARTMENT OF ENERGY
Nitric oxide-releasing metallic medical devices
InactiveUS6887485B2Promote wound healingPromote vasodilationBiocideInorganic active ingredientsNitric oxideSilanization
Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.
Owner:METRONIC VASCULAR
Electrical Stimulation of Blood Vessels
ActiveUS20080215117A1Increase heightReducing platelet aggregationStentsTransvascular endocardial electrodesNitric oxideSecretion
Apparatus (20) is provided, including a bifurcation stent (50) comprising one or more electrodes (32), the stent (50) configured to be placed in a primary passage (52) and a secondary passage (54) of a blood vessel (30), and a control unit (34), configured to drive the electrodes (32) to apply a signal to a wall (36) of the blood vessel (30), and to configure the signal to increase nitric oxide (NO) secretion by the wall (36). Other embodiments are also described.
Owner:ENOPACE BIOMEDICAL
Systems and methods for topical treatment with nitric oxide
InactiveUS7048951B1Reduce skin irritationBiocideInorganic active ingredientsSandwich likeTransdermal patch
A simple, biocompatible system and procedure for generating nitric oxide (NO) is described. A mixture of powdered sodium nitrite, ascorbic acid, and maleic acid (or another organic acid of adequate strength) immediately generates nitric oxide (NO) on treatment with water. To slow down the NO generation, one may prepare an ointment from a nonaqueous medium (petrolatum, Vaseline™) and the three powdered ingredients, which on being applied topically on the skin will release NO as water permeates through this medium; alternatively, one may convert the aqueous sodium nitrite solution into a gel with hydroxyethylcellulose (or other gel-forming compound) and combine this gel with another gel obtained from aqueous ascorbic and maleic acids with hydroxyethylcellulose for topical application (on intact skin, burns intra-cavity, burns, intra-cavity, etc.). The two gels may be admixed immediately before use (possibly from a single container with separate chambers and dual nozzle, via pushing or squeezing the two gels through the nozzle), or may be applied in sandwich-like fashion (possibly as a transdermal patch) for further slowing down the delivery of NO.
Owner:NITRIC SOLUTIONS
Topical nitric oxide donor devices and methods for their therapeutic use
The present invention is related to topical nitric oxide delivery systems, and to using the same for mitigating or remediating various disease states The present invention is also related to using topical nitric oxide delivery systems for enhancing blood flow.
Owner:AKRON UNIV OF
Method of biochemical treatment of persistent pain
InactiveUS20050152905A1Reduce releaseAvoid exposureBiocidePeptide/protein ingredientsInterleukin 6Interleukin-1beta
This invention relates to a method for the biochemical treatment of persistent pain disorders by inhibiting the biochemical mediators of inflammation in a subject comprising administering to said subject any one of several combinations of components that are inhibitors of biochemical mediators of inflammation. Said process for biochemical treatment of persistent pain disorders is based on Sota Omoigui's Law, which states: ‘The origin of all pain is inflammation and the inflammatory response’. Sota Omoigui's Law of Pain unifies all pain syndromes as sharing a common origin of inflammation and the inflammatory response. The various biochemical mediators of inflammation are present in differing amounts in all pain syndromes and are responsible for the pain experience. Classification and treatment of pain syndromes should depend on the complex inflammatory profile. A variety of mediators are generated by tissue injury and inflammation. These include substances produced by damaged tissue, substances of vascular origin as well as substances released by nerve fibers themselves, sympathetic fibers and various immune cells. Biochemical mediators of inflammation that are targeted for inhibition include but are not limited to: prostaglandin, nitric oxide, tumor necrosis factor alpha, interleukin 1-alpha, interleukin 1-beta, interleukin-4, Interleukin-6 and interleukin-8, histamine and serotonin, substance P, Matrix Metallo-Proteinase, calcitonin gene-related peptide, vasoactive intestinal peptide as well as the potent inflammatory mediator peptide proteins neurokinin A, bradykinin, kallidin and T-kinin.
Owner:OMOIGUI OSEMWOTA SOTA
Method of treating a patient with a neurodegenerative disease using ultrasound
InactiveUS7211054B1Promote wound healingPromote healingUltrasound therapyChiropractic devicesDiseaseNitric oxide
The present invention provides methods for treating patients with ultrasound to promote healing. In particular, the present invention provides a method for improving blood flow to ischemic tissue by applying ultrasound to ischemic tissue. The invention also provides a method for increasing nitric oxide production in tissue by applying ultrasound to tissue.
Owner:UNIVERSITY OF ROCHESTER
Nitric oxide donor composition and method for treatment of anal disorders
A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and / or topical anesthetic. The composition is useful in a method for treating anal disorders such as anal fissure, anal ulcer, hemorrhoidal disease, levator spasm, and so forth, by topical application to or proximate the affected area.
Owner:STRAKAN INT S A R L
Nitric oxide-releasing polymers derived from modified polymers
InactiveUS20070053952A1Treat and inhibit restenosisSurgerySynthetic polymeric active ingredientsPolymer modifiedVulnerable plaque
Modified polyimines and derivatives thereof suitable as implantable medical devices and coatings therefore are provided. Specifically, implantable medical devices and / or coatings comprise amphiphilic polymers derived from modified polyimines. The medical devices and coatings of the present invention can also be used for in situ nitric oxide release / controlled release drug delivery and are useful for treating or preventing medical conditions such as restenosis, aneurysms and vulnerable plaque.
Owner:MEDTRONIC VASCULAR INC
Ozone oxidation and denitration method of boiler flue gas
The invention provides a method for processing de-nitration on the boiler smoke, belonging to the environmental protective technique. The method comprises: ejecting ozone O3 into the low-temperature section of smoke channel of boiler whose temperature ranges from 110-150Deg. C; oxygenizing the nitric oxide NO into high-state nitrogen oxide as NO2, NO3 or N2O5; washing the smoke with alkali liquor to remove the nitrogen oxide in the smoke. Compared to other de-nitration method, said invention has higher efficiency, lower cost, and non-secondary pollution, while the absorption effect combined with alkali liquor can reach more than 80%. In addition, the invention can apply variable boiler devices, which is not relative to the burning condition of boiler.
Owner:ZHEJIANG UNIV
Electrical smoking system and method
InactiveCN1633247AReduce gaseous componentsIncandescent ignitionCigar manufactureIntegratorAcrylonitrile
An electric smoking system includes a cigarette including a cylindrical tobacco web partially filled with tobacco material to define a filled tobacco rod portion and an unfilled tobacco rod portion, and an electric lighter. The wrapper includes a filler of ammonium-containing compounds effective to reduce the gaseous constituents of the smoke produced during smoking. The system includes a pilot burner including at least one heating vane and a controller adapted to control heating of the heating vane. The lighter is configured to at least partially contain the cigarette such that the heater blade heats the heating region of the cigarette. Manipulating the controller to limit the heating of the heater blades to a predetermined temperature range which allows the delivery of the smoke generated when the portion of the tobacco rod is heated while at least reducing the amount of smoke present in the smoke as compared to smoking a cigarette having only calcium carbonate as filler. A gaseous component. The gaseous components that can be reduced include carbon monoxide, 1,3 butadiene, isoprene, acrolein, acrylonitrile, hydrogen cyanide, 0-toluidine, 2-naphthylamine, nitrogen oxide, benzene, NNN, Phenol, catechol, benzanthracene and benzopyrene.
Owner:PHILIP MORRIS PROD SA
Beneficial Effects of Increasing Local Blood Flow
InactiveUS20090105336A1Increase oxygenationImprove tissue nutritionBiocideOrganic active ingredientsTopical creamArginine
The present invention provides a treatment for enhancing the ability of the body to heal wounds. A topical cream is described which improves blood flow by the transdermal delivery of the nitric oxide precursor L-Arginine either alone or with an adjunct, theophylline. The delivery of the active agents is accomplished by use of a vehicle which contains a hostile biophysical environment which is also hostile to hydrogen bond formation.
Owner:STRATEGIC SCI & TECH
Ventilator device
InactiveUS6019100AIncrease ciliary beat frequencyRestore natural nasal breathing patternTracheal tubesOperating means/releasing devices for valvesActive agentNitric oxide
The present invention restores the normal low-dose flushing of the lower airways with air from the upper airways, containing nitric oxide (NO) and possible other biologically active agents by aspiration of air from the upper airways and introducing said air in the inspiratory airflow of a ventilator. The inventive apparatus and method is free from the risks associated with traditional administration of exogenous NO.
Owner:ALVING KJELL +3
Topical treatments for pain
InactiveUS20130029989A1Increase blood flowGood analgesic effectBiocideNervous disorderPhosphodiesteraseNitric oxide
Owner:MCGILL UNIV
Aerosolized nitrite and nitric oxide -donating compounds and uses thereof
Disclosed herein are formulations of nitrite, nitrite salt, or nitrite- or nitric oxide-producing compounds suitable for aerosolization and use of such formulations for aerosol administration of nitrite, nitrite salt, or nitrite- or nitric oxide-donating compounds for the treatment of pulmonary arterial hypertension, intra-nasal or pulmonary bacterial infections, or to treat or prevent ischemic reperfusion injury of the heart, brain and organs involved in transplantation. In particular, inhaled nitrite, nitrite salt, or nitrite- or nitric oxide-donating compound specifically formulated and delivered to the respiratory tract for the indications is described. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures and manufacturing processes for production and use of the compositions described.
Owner:AIRES PHARMA
Multi-stage system for selective catalytic reduction
A first aspect of the present disclosure includes a method of controlling nitric oxides emissions. The method may include producing an exhaust gas stream containing NOx and supplying the exhaust gas stream to an exhaust passage. The method may further comprise supplying ammonia to the exhaust passage at a location upstream of a first selective catalytic reduction catalyst, wherein the amount of ammonia supplied at the first location is less than about 90% of the effective amount of ammonia needed for reduction of all NOx at the first location. Further, ammonia may be supplied to the exhaust passage at a second location downstream of the first selective catalytic reduction catalyst and upstream of a second selective catalytic reduction catalyst.
Owner:CATERPILLAR INC
Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing
InactiveUS7516742B2RespiratorsOperating means/releasing devices for valvesAutonomous breathingNitric oxide
A device and method is disclosed for delivering NO to a patient. The device utilizes a single controller that controls two separate flow controllers to deliver an oxygen-containing gas and a NO-containing gas to the patient to provide NO-containing gas at a flow profile that is proportional or quasi-proportional to a flow profile of the oxygen-containing gas throughout patient inspiration. The controller further comprises logic for setting a nitric oxide delivery profile comprising at least two different concentrations of nitric oxide containing gas and for automatically switching between the at least two different concentrations of nitric oxide containing gas on a timed basis.
Owner:VYAIRE MEDICAL 207 INC +1
Topical Gels and Methods of Using the Same
Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments. The topical gels comprise diazeniutndiolate-functionalized polysiloxane macromolecules.
Owner:NAVAN INC
Methods for reducing NOx in combustion flue gas using metal-containing additives
InactiveUS6471506B1Simple and inexpensive methodReduce penetrationDispersed particle separationIncinerator apparatusAtmospheric airMolecular nitrogen
Owner:GE ENERGY & ENVIRONMENTAL RES
Nitric-oxide detection using Raman spectroscopy
InactiveUS20060074282A1Accurate conditionHigh precisionRadiation pyrometryDiagnostics using spectroscopyDiseaseResonance Raman spectroscopy
In an emergency medicine patient, accurate measurement of change or lack thereof from non-shock, non-ischemimc, non-inflammation, non-tissue injury, non-immune dysfunction conditions is important and is provided, as practical, real-time approaches for accurately characterizing a patient's condition, using Raman spectroscopy with a high degree of accuracy, Resonance Raman spectroscopy is used to monitor tissue nitric oxide activity either in vivo or in vitro, especially as a function of its interaction with hemoglobin or other metalloproteins. Measurement times are on the order of seconds. High-accuracy measurement is achieved with Raman spectroscopy interrogation of tissue. Measurements may be non-invasive to minimally invasive. The invention may be used to monitor the effect of instituting therapies using nitric oxide or disease processes that produce nitric oxide.
Owner:VIRGINIA COMMONWEALTH UNIV
Beneficial effects of increasing local blood flow
InactiveUS20110028548A1Increase oxygenationImprove tissue nutritionBiocidePeptide/protein ingredientsArginineNitric oxide
Owner:STRATEGIC SCI & TECH
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