The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one
active agent selected from the group consisting of a channel agent, a
cholinergic agent, and a
nitric oxide donor; and (b) a foamable carrier comprising:i. about 50% to about 98% of a
solvent selected from the group consisting of water; a hydrophilic
solvent; a hydrophobic
solvent; a potent solvent; a polar solvent, a
silicone, an emollient, and mixtures thereof;ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a
silicone, an emollient, a co-solvent, a
penetration enhancer and mixtures thereof;iii. a surface-
active agent;iv. about 0% to about 5% by weight of at least one polymeric agent; andv. a liquefied or compressed gas
propellant at a concentration of about 3% to about 25% by weight of the total composition;wherein the composition is housed in a container and is substantially flowable, andwhich upon release expands to form a breakable foam; andwherein the foamable carrier is selected to generate a foam of good to excellent quality.The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted
target site.