8836 results about "Control manner" patented technology

A surgical instrument is adapted for stapling tissue in a highly controlled manner. The surgical instrument includes a frame having a proximal end and a distal end, with a handle positioned at the proximal end and an end effector positioned at the distal end. The end effector is shaped and dimensioned for selectively receiving a cartridge module containing a plurality of surgical fasteners. A firing mechanism is associated with the end effector and the cartridge module for selective actuation of the surgical fasteners. The cartridge module includes a cartridge housing in which the surgical fasteners are housed and an anvil shaped and dimensioned for engagement with the surgical fasteners to facilitate stapling. The cartridge housing and anvil are relatively movable between a first spaced apart position and a second position in close approximation with one another. A retainer is removeably positioned between the anvil and the cartridge housing to prevent undesired movement of the cartridge housing toward the anvil.

Electroporation is performed in a controlled manner in either individual or multiple biological cells or biological tissue by monitoring the electrical impedance, defined herein as the ratio of current to voltage in the electroporation cell. The impedance detects the onset of electroporation in the biological cell(s), and this information is used to control the intensity and duration of the voltage to assure that electroporation has occurred without destroying the cell(s). This is applicable to electroporation in general. In addition, a particular method and apparatus are disclosed in which electroporation and / or mass transfer across a cell membrane are accomplished by securing a cell across an opening in a barrier between two chambers such that the cell closes the opening. The barrier is either electrically insulating, impermeable to the solute, or both, depending on whether pore formation, diffusive transport of the solute across the membrane, or both are sought. Electroporation is achieved by applying a voltage between the two chambers, and diffusive transport is achieved either by a difference in solute concentration between the liquids surrounding the cell and the cell interior or by a differential in concentration between the two chambers themselves. Electric current and diffusive transport are restricted to a flow path that passes through the opening.

Cigarettes manufactured using modified automated cigarette making apparatus can possess smokable rods having additive materials applied to paper wrapping materials as patterns. The additive materials can be applied to a continuous paper web using rollers.) One of those rollers can have a series of pockets in its roll face to receive additive formulation from a reservoir and to define the pattern of the formulation on the paper. The additive material in the recessed pockets of a first roller can be transferred in a controlled manner to a second roller and from the second roller to desired locations on the paper web. The additive material can also be applied to a transfer roller, transferred from the transfer roller to pick-up roller, transferred from the pick-up roller to an application roller, and transferred to the paper web that passes between the application roller and a back-up roller.

Methods for treating total and partial occlusions employ a perfusion conduit which is penetrated through the occlusive material. Oxygenated blood or other medium is then perfused through the conduit in a controlled manner, preferably at a controlled pressure below the arterial pressure, to maintain oxygenation and relieve ischemia in tissue distal to the occlusion. In another aspect, interventional devices, such as stents or balloon catheters, are passed through the perfusion catheter to remove obstructions. Optionally, the occlusion may be treated while perfusion is maintained, typically by introducing a thrombolytic or other agent into the occlusive material using the perfusion conduit or by employing mechanical means to remove the obstruction. Such methods are particularly suitable for treating acute stroke to prevent damage to the cerebral tissue.

A device with a functional tip containing at least one active electrode capable of creating a controlled perforation in body tissue through the application of energy (e.g. Radio Frequency (RF)) is described. The position of the tip of the device can be determined in response to ECG measured at the tip and determined by a monitor coupled to the device. The device is useful to remove or perforate unwanted tissue in a controlled manner in any location in the body, particularly in the atrial septum for controlled transseptal puncture. In this application, the device is introduced into the right atrium, and the functional tip is then positioned against the atrial septum. ECG is used to locate the region of the fossa ovalis on the atrial septum. Energy is applied to create the perforation and ECG is monitored to determine if the perforation was created in a desired location.