The invention discloses a long-acting
skin marking pen based on a
genipin coloring principle. The long-acting
skin marking pen comprises raw materials as follows: 1%-6% of
genipin, 1%-3% of gentian violet, 20%-30% of ethyl
alcohol, 10%-20% of
propylene glycol, 0.3%-0.5% of
xanthan gum, 2%-3% of
polyvinylpyrrolidone and 60%-70% of water. The
genipin is added, is an
iridoid compound and can react with silk
fibroin to form a final color product, the color product can permanently dye hard membrane outer
layers of
human skin to form black blue temporary tattoo unit
skin is regenerated after 2-3 weeks, so that the duration is up to 2-3 weeks after coloring by the skin marking pen, a traditional invasive
laser dotting making manner can be replaced,
pain experience of patients during marking can be avoided; secondly, the long-acting skin marking pen can avoid the condition that colors fade after marking by common skin marking pens to affect treatment accuracy.