100 results about "Mechanical irritation" patented technology

A neuro-stimulation system employs a includes a stimulator which may include electrode devices and / or vibration elements. A controller may be employed to drive the stimulating elements with an electrical signal. In response to the electrical signal, the stimulating elements deliver electrical and / or mechanical stimulation to the body part. The stimulation may be an aperiodic stimulation and / or may be a subthreshold stimulation. In one embodiment, the stimulator is disposable and the processor determines usage of the stimulator and ensures that the stimulator is limited to a certain amount of use. Neuro-stimulation systems may be applied to sensory cells of body parts during movement of the body parts to induce neuroplastic changes. Such movement may involve a variety of therapeutic applications, e.g. in stroke patient therapy.

A prosthetic hearing system is described that provides multi-path stimulation of the patient auditory system. A mechanical stimulation component applies mechanical stimulation signals to cerebral tissue such as the dura mater, cerebrospinal fluid, vestibular structures, etc. using multiple separate mechanical stimulation channels. And an electrical stimulation component provides electrical stimulation of auditory neural tissue of the patient user.

Described herein are methods for treating a subject suffering from or at risk for a condition mediated by an inflammatory cytokine cascade, by electrically or mechanically stimulating vagus nerve activity in an amount sufficient to inhibit the inflammatory cytokine cascade.

A method of determining a user's training load, includes determining protein combustion information and determining the user's training load based on the protein combustion information. The protein combustion information may be determined using heart rate information, activity information, carbohydrate reserve information determined using a carbohydrate combustion model and carbohydrate reserve information representing the user's carbohydrate reserves at a beginning of at least one exercise session, fitness information, intensity information, nutritional intake information representing nutritional intake during at least one exercise session, and / or a fat combustion model. The user's training load may be determined based on a mechanical stimulus and / or a modality. Recovery time information may be determined based on the training load. A corresponding apparatus and computer-readable medium correspond to the above method.

The present invention relates generally to the field of treatments for nasal congestion, and in particular, to a method and apparatus for alleviating nasal congestion in a patient by mechanically stimulating the sneezing reflex in the patient to urge drainage of the nasal passageways. The method includes inserting an instrument having a work tip portion provided with at least one filament into the nostril of the patient. The nasal mucosa of the patient is then probed with the at least one filament to stimulate in the patient the sneeze reflex. This probing action causes the patient to sneeze. With the patient's mouth closed, the sneeze urges at least one of mucus, fluid and debris in the nasal passages of the patient to be forcibly expelled through the nostrils of the patient thereby draining the nasal cavity of the patient. The instrument used in the performance of this method includes a handle portion upon which the work tip portion is carried. The handle portion may be integrally formed with the work tip portion or releasably attachable thereto. The instrument is further provided with a physical stop associated with one of the work tip portion and the handle portion to prevent injury resulting from the working tip portion being inserted too deeply into the nasal passages of the patient.

A sexual stimulation apparatus which may comprise a plurality of light sources for photostimulation and microbe reduction of the vagina, clitoris, or both; a plurality of vibrators for mechanical stimulation of the vagina, clitoris, or both; a plurality of modes of operation for achieving improved sexual stimulation in a user; a handle for ease of operation; a controller and programmable memory for containing modes of operation and driving the light sources and vibrators of the invention; a vaginal finger; a clitoral finger; a handle for ease of use; a keypad for user entry of commands; a charging and programming port; and a power source which may be a rechargeable battery which may be rechargeable by direct, inductive or other means; and a handle for ease of operation. The invention also comprises a flexible covering that provides smooth sliding engagement with the vagina and clitoris of a user.

In an implantable electrode for an electrode lead for a stimulation device for stimulating tissue, the electrode is formed as a biocompatible piezoelectric electrode which is adapted to be in direct electrical contact with tissue for electrically and mechanically stimulating the tissue and for detecting electrical and mechanical evoked response of the stimulated tissue. The stimulation device can include circuitry for making a diagnosis of a heart condition using signals received from the implantable electrode.

The present disclosure provides systems and methods for treating apnea by controlled delivery of a swallow stimulus to a subject in which apnea is detected. In the systems and method, burst electrical or mechanical stimulation to one or more swallow-related nerves and / or muscles can be timed for delivery between the expiratory phase of the respiration cycle, following detection of an apneic event in the subject.

The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device (2). Preferably the therapeutic substance is contained within a pellet form (14) that is deliverable into the interior of the device (2) after it has been implanted. In a preferred embodiment the implant device (2) comprises a flexible coiled spring body, the coils (4) of which have the proper diameter and spacing to contain the pellet (14) within the interior of the device (2) to contact the therapeutic agent. In treatment of ischemic tissue such as that of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device (2) can help to provide an angiogenic effect. Additionally, the cavity (18) provided by the interior of the device (2) permits blood to pool around the pellet (14) and mix with the therapeutic agent. Several delivery systems have provided for delivering the implant and pellet (14) sequentially or simultaneously.

Devices and methods for tissue treatment produce a mechanical stimulation therapy and electromagnetic field therapy. The mechanical stimulation therapy provides stimulation of blood circulation and stimulates treated cells. The electromagnetic field enables thermal treatment of tissue. Combination of both therapies improves soft tissue treatment, mainly connective tissue in the skin area and fat reduction.

Apparatus and methods for delivering electromagnetic energy to a patient's tissue with a reduction in the pain experienced by the patient. The tissue treatment apparatus includes a delivery device configured to transfer electromagnetic energy through the skin surface to a region of tissue and a vibration device mechanically coupled with the delivery device. The vibration device is configured to transfer mechanical vibrations through the skin surface to the region of tissue.

Devices and methods for tissue treatment produce a mechanical stimulation therapy and electromagnetic field therapy. The mechanical stimulation therapy provides stimulation of blood circulation and stimulates treated cells. The electromagnetic field enables thermal treatment of tissue. Combination of both therapies improves soft tissue treatment, mainly connective tissue in the skin area and fat reduction.

A method is provided for stimulating nerve growth, especially for nerve regeneration after damage to the nerve. The method comprises: applying thermal energy to one or more nerve segments adjacent a damaged region of the nerve, such that nerve fibers from the treated adjacent segment are stimulated to grow and extend toward the damaged region. The method may be used to enhance mechanical stimulative effect at a terminus of a severed nerve or a region of nerve injured by crush or other physical forces. The method may also be used to treat nerve segments retrograde up the nerve fiber and to increase the response of the injured nerve to regrowth and extension rapidly. An apparatus for delivery of thermal energy to the distal terminus of the severed nerve or region is disclosed. Thermal conductive or electromagnetic energy is delivered through a probe having a handle and a shaft. An energy delivery portion of the probe is configured to apply thermal energy to the distal segments of the severed nerve to promote rapid and more extensive growth of the nerve cells.

A sexual stimulation apparatus and method which may comprise a plurality of light sources for photostimulation of the vagina, clitoris, or both; a plurality of vibrators for mechanical stimulation of the vagina, clitoris, or both; a handle for ease of operation; a controller and programmable memory for containing modes of operation and driving the light sources and vibrators of the invention; a vaginal finger; a clitoral finger; a handle for ease of use; a keypad for user entry of commands; and a charging and programming port. The invention comprises sensors that sense physiologic parameters of a user and adjust sexual stimulation parameters to achieve a desired sexual stimulation effect. Blood oxygen level, temperature, pulse rate and muscle electrical activity may be sensed by the invention. The invention also comprises a flexible covering that provides smooth sliding engagement with the vagina and clitoris of a user.

A method for collapsing a target vein in a patient. The method comprises providing an intravascular irritation element having a plurality of mechanical irritating objects, inserting the intravascular irritation element into a venous lumen of a target vein, and irritating the target vein by moving the plurality of mechanical irritating objects in contact with the inner surface thereof, thereby triggering a collapse of said target vein.

The present invention relates generally to the field of treatments for nasal congestion, and in particular, to a method and apparatus for alleviating nasal congestion in a patient by mechanically stimulating the sneezing reflex in the patient to urge drainage of the nasal passageways. The method includes inserting an instrument having a work tip portion provided with at least one filament into the nostril of the patient. The nasal mucosa of the patient is then probed with the at least one filament to stimulate in the patient the sneeze reflex. This probing action causes the patient to sneeze. With the patient's mouth closed, the sneeze urges at least one of mucus, fluid and debris in the nasal passages of the patient to be forcibly expelled through the nostrils of the patient thereby draining the nasal cavity of the patient. The instrument used in the performance of this method includes a handle portion upon which the work tip portion is carried. The handle portion may be integrally formed with the work tip portion or releasably attachable thereto. The instrument is further provided with a physical stop associated with one of the work tip portion and the handle portion to prevent injury resulting from the working tip portion being inserted too deeply into the nasal passages of the patient.

Devices and methods for tissue treatment produce a mechanical stimulation therapy and electromagnetic field therapy. The mechanical stimulation therapy provides stimulation of blood circulation and stimulates treated cells. The electromagnetic field enables thermal treatment of tissue. Combination of both therapies improves soft tissue treatment, mainly connective tissue in the skin area and fat reduction.

Tissue implants prepared for the repair of tissues, especially avascular tissues such as cartilage. One embodiment presents an electric potential capable of receiving and accumulating desirable factors or molecules from surrounding fluid when exposed to dynamic loading. In another embodiment the implant promotes tissue conduction by retarding, restricting and controlling cellular invasion through use of gradients until competent tissue forms. Further embodiments of the tissue implants may be formed into a multi-phasic device that provides deep tissue mechanical stimulus by conduction of mechanical and fluid forces experienced at the surface of the implant.

A neuro-stimulation system employs a includes a stimulator which may include electrode devices and / or vibration elements. A controller may be employed to drive the stimulating elements with an electrical signal. In response to the electrical signal, the stimulating elements deliver electrical and / or mechanical stimulation to the body part. The stimulation may be an aperiodic stimulation and / or may be a subthreshold stimulation. In one embodiment, the stimulator is disposable and the processor determines usage of the stimulator and ensures that the stimulator is limited to a certain amount of use. Neuro-stimulation systems may be applied to sensory cells of body parts during movement of the body parts to induce neuroplastic changes. Such movement may involve a variety of therapeutic applications, e.g. in stroke patient therapy.

Devices, systems and methods for stimulating (e.g., noninvasively) a subject's inflammatory reflex are provided to reduce bleed time. The method may include the step of non-invasively stimulating the inflammatory reflex (e.g., the vagus nerve, the splenic nerve, the hepatic nerve, the facial nerve, and the trigeminal nerve) of a subject, such as by mechanical stimulation, in a manner which significantly reduces bleed time in the subject. Devices for non-invasively stimulating the inflammatory reflex may include a movable tip or actuator that is controlled to mechanically stimulate the ear. The devices may be hand-held or wearable, and may stimulate the cymba conchae region of the subject's ear.

A method, system and device for enhancing muscle training and performance by accelerating blood flow to the muscles and enhancing flow in the lymphatic system, incorporating mechanical stimulation and in some cases electrical stimulation of the muscle. A muscle recovery apparatus includes: an active compression device and an electrical stimulation device, where the active compression device is configured to be disposed about a user's muscle and to mechanically compress the user's muscle to facilitate muscle recovery, and where the electrical stimulation device is coupled to an inner surface of the active compression device, such that the electrical stimulation device can be placed in contact with the user to electrically stimulate the user's muscle.

The invention relates to a method and an apparatus for stimulating and / or measuring visceral pain in a bodily hollow system of a human being or an animal. The method and apparatus is especially well suited for multi-modal stimulation and measuring, where different stimulus modalities are integrated into one stimulus device. The stimuli may be any one or more of the stimuli: mechanical stimulus, thermal stimulus, chemical stimulus and electric stimulus. The stimuli may activate superficial and deeper layers of the hollow system. Distinct responses to the individual stimuli and robust stimulus-response relations are obtained and result in the possibility of comparative studies of different visceral sensations.

A sleeve that provides mechanical stimulation to the arm to prevent bone density loss. A primary goal of this product is to prevent bone density loss that occurs during extended space travel. For one embodiment, only the predefined frequency specifications had to be met (between 40 Hz and 60 Hz). By meeting these frequencies for a duration of 30 minutes the product will theoretically prevent the loss of bone density. Additionally, clinical trials will need to be conducted before this product can be marketed. The product includes of several mechanical vibrators attached to a sleeve. The vibrators are small unbalanced-mass motors which are similar to those found in cell phones. The motors are encased in dome shaped housings designed to reduce lateral vibrations along the arm. The product is controlled using an Arduino board attached to the sleeve that actuates the motors. The motors, in turn, provide the specified frequency to the arm for 30 minutes. The spacing of the motor housings was determined from PEA simulations. This resulted in the motors being spaced 2 in apart along the arm at 90° increments around the axis of the arm. The controller has a display that allows for user interaction and includes a session timer. In addition, this product is contemplated for use in reducing muscle atrophy, eliminating bed sores, and treating other ailments that can result from sedentary behavior.

The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for regenerating cartilage that improves cartilage regenerative action and ease of application to a cartilage injury lesion, and a composition for treating a cartilage disease, which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing a cartilage injury lesion, and inhibiting inflammation and pain of joint tissue.

A sexual stimulation apparatus and method which may comprise a plurality of light sources for photostimulation of the vagina, clitoris, or both; one or more vibrators for mechanical stimulation of an area of the vagina; a handle; a controller and programmable memory for containing non-transitory instructions for modes of operation and driving the light sources and vibrators of the invention; a vaginal finger; a handle for ease of use; a keypad for user entry of commands; and a charging or programming port. The invention may also comprise sensors that sense physiologic parameters of a user and adjust sexual stimulation parameters to achieve a desired sexual stimulation effect. Blood oxygen level, temperature, pulse rate and muscle electrical activity may be sensed. The invention also may comprise a flexible covering that provides smooth sliding engagement with an area of the vagina of a user.

A system and method for instant and permanent pain relief on pain-spasm-pain neurological reflex cycles that cause pain and functional disability in muscles suffering from acute and chronic soft tissue disorders is disclosed. The invention comprises a device for diagnosing PSP (pain-spasm-pain) cycles by creating a calibrated mechanical stimulation on the Golgi Tendon (GT) receptors of related muscle fibres, over which pain relief is later on provided by simultaneously applying calibrated pressure on said GT receptors. The system involves diagnosis and treatment steps performed instantly, in consequence of which the muscles permanently retain their normal physiological and mechanical values. The system proposed by the invention is characterized by a stimulator tip which is used to apply mechanical pressure the golgi tendon receptors beneath the skin, and which is attached to said tensiometric instrument (8) used for measuring the GT pain pressure thresholds and GT inhibition pressure thresholds.

The present invention provides an ex vivo vascular remodeling methods and system by which an excised, small diameter blood vessel can be harvested and expanded to provide viable vascular grafts, as demonstrated at the physical and molecular levels, and as optimized in vivo. The tissue-engineered vessels generated by the present invention closely resemble native vessels in terms of structure, histologically, including endothelial coverage and intricate structural components such as the internal elastic lamina, viability (as measured with the MTT assay and TUNEL analysis), and function (vasoactivity, mechanical and biomechanical properties). Thus, the resulting vascular grafts behave in a manner similar to native arteries in terms of mechanical integrity, and provide clinically relevant patency rates when implanted in vivo. Moreover, the ex vivo methods and system permit the precise control of the mechanical environment involving the excised vessel, while at the same time permitting careful monitoring of the resulting growth / remodeling, thereby opening new avenues of research regarding the mechanical stimuli responsible for specific aspects of remodeling in vivo.

A sexual stimulation apparatus which may comprise a plurality of light sources for photostimulation and microbe reduction of the vagina, clitoris, or both; a plurality of vibrators for mechanical stimulation of the vagina, clitoris, or both; a plurality of modes of operation for achieving improved sexual stimulation in a user; a handle for ease of operation; a controller and programmable memory for containing modes of operation and driving the light sources and vibrators of the invention; a vaginal finger; a clitoral finger; a handle for ease of use; a keypad for user entry of commands; a charging and programming port; and a power source which may be a rechargeable battery which may be rechargeable by direct, inductive or other means; and a handle for ease of operation. The invention also comprises a flexible covering that provides smooth sliding engagement with the vagina and clitoris of a user.

Apparatus and methods for delivering electromagnetic energy to a patient's tissue with a reduction in the pain experienced by the patient. The tissue treatment apparatus includes a delivery device configured to transfer electromagnetic energy through the skin surface to a region of tissue and a vibration device mechanically coupled with the delivery device. The vibration device is configured to transfer mechanical vibrations through the skin surface to the region of tissue.