156 results about "Photostimulation" patented technology

A method and apparatus using photo-stimulation to treat or pretreat a sample site prior to analyte concentration determination is presented. More particularly, photo-stimulation at or near at least one sample site is used to enhance perfusion of the sample site leading to reduced errors associated with sampling. Increased perfusion of the sample site leads to increased volume percentages of the target analyte and / or allows the blood or tissue constituent concentrations to more accurately and / or precisely track corresponding sample constituents in more well perfused body compartments or sites such as arteries, veins, or fingertips. In one embodiment, analysis of the photo-stimulated site is used in conjunction with glucose analyzers to determine the analyte concentration with greater ease, accuracy, or precision and may allow determination of the analyte concentration of another non-sampled body part or compartment.

A system for energy upconversion and / or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ1 of radiation, to generate a second wavelength λ2 of radiation having a higher energy than the first wavelength λ1 and 2) a metallic structure disposed in relation to the nanoparticle. A physical characteristic of the metallic structure is set to a value where a surface plasmon resonance in the metallic structure resonates at a frequency which provides a spectral overlap with either the first wavelength λ1 or the second wavelength λ2, or with both λ1 and λ2. The system for producing a photostimulated reaction in a medium includes a receptor disposed in the medium in proximity to the nanoparticle which, upon activation by the second wavelength λ2, generates the photostimulated reaction.

An apparatus and method to apply photo-stimulation, photo-dynamic therapy and / or ablation laser treatment to biological tissue. The apparatus includes a plurality of radiation energy sources, preferably laser beams. Additionally, the apparatus allows either a single wavelength or a combination of various wavelengths, either coincidentally or adjacently, to be utilized to achieve a desired treatment effect. Laser beams are transmitted to the treatment area by one or more fiber optic cables which terminate at an assembly structured to collimate the emitted radiation prior to application to the tissue. In addition, the apparatus includes a focal length setting mechanism which assures that a constant, fixed distance exists between the point of discharge of the laser beam and the biological tissue, thus assuring a constant energy density at the point of application. A method is presented for applying photo-stimulation, photocollagen stimulation and / or ablation laser treatment utilizing the above apparatus.

A sexual stimulation apparatus which may comprise a plurality of light sources for photostimulation and microbe reduction of the vagina, clitoris, or both; a plurality of vibrators for mechanical stimulation of the vagina, clitoris, or both; a plurality of modes of operation for achieving improved sexual stimulation in a user; a handle for ease of operation; a controller and programmable memory for containing modes of operation and driving the light sources and vibrators of the invention; a vaginal finger; a clitoral finger; a handle for ease of use; a keypad for user entry of commands; a charging and programming port; and a power source which may be a rechargeable battery which may be rechargeable by direct, inductive or other means; and a handle for ease of operation. The invention also comprises a flexible covering that provides smooth sliding engagement with the vagina and clitoris of a user.

According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain slices in any arbitrary spatio-temporal pattern, using two-photon uncaging of photo-sensitive compounds such as MNI-glutamate and / or RuBi-Glutamate with beam multiplexing. Such exemplary method and device can have single-cell and three-dimensional precision. For example, by sequentially stimulating up to a thousand potential presynaptic neurons, it is possible to generate detailed functional maps of inputs to a cell. In addition, it is possible to combine this exemplary approach with two-photon calcium imaging in an all-optical method to image and manipulate circuit activity. Further exemplary embodiments of the present disclosure can include a light-weight, compact portable device providing for uses in a wide variety of applications.

A system and process for treating retinal diseases includes passing a plurality of radiant beams, i.e., laser light beams, through an optical lens or mask to optically shape the beams. The shaped beams are applied to at least a portion of the retina. Due to the selected parameters of the beams—pulse length, power and duty cycle—the beams can be applied to substantially the entire retina, including the fovea, without damaging retinal or foveal tissue, while still attaining the benefits of retinal phototherapy or photostimulation.

An ophthalmic phototherapy device and associated phototherapy treatment method for promoting healing of damaged or diseased eye tissue. The ophthalmic phototherapy device includes a light emitting mechanism for transmitting light of at least one preselected wavelength to the eye tissue. The ophthalmic phototherapy method includes directing light of at least one wavelength for a selected period of time to a portion of damaged or diseased eye tissue, whereby the light transmitted to the damaged or diseased eye tissue stimulates cellular activity in the eye tissue to promote healing.

A radiation imaging system includes a radiation head with a radiation source and an adjustable angular orientation. A radiation image detection device has a photostimulable medium that records an image according to radiation emitted from the radiation source. An measurement sensor apparatus, preferably inertial, is coupled to the photostimulable medium to provide three-dimensional data for determining the orientation of the photostimulable medium. There is at least one indicator responsive to the orientation data from the measurement sensor apparatus for indicating an orientation adjustment of the radiation source is needed in at least one direction.

A sexual stimulation apparatus and method which may comprise a plurality of light sources for photostimulation of the vagina, clitoris, or both; a plurality of vibrators for mechanical stimulation of the vagina, clitoris, or both; a handle for ease of operation; a controller and programmable memory for containing modes of operation and driving the light sources and vibrators of the invention; a vaginal finger; a clitoral finger; a handle for ease of use; a keypad for user entry of commands; and a charging and programming port. The invention comprises sensors that sense physiologic parameters of a user and adjust sexual stimulation parameters to achieve a desired sexual stimulation effect. Blood oxygen level, temperature, pulse rate and muscle electrical activity may be sensed by the invention. The invention also comprises a flexible covering that provides smooth sliding engagement with the vagina and clitoris of a user.

An apparatus and method to apply photo-stimulation, photo-dynamic therapy and / or ablation laser treatment to biological tissue. The apparatus includes a plurality of radiation energy sources, preferably laser beams. Additionally, the apparatus allows either a single wavelength or a combination of various wavelengths, either coincidentally or adjacently, to be utilized to achieve a desired treatment effect. Laser beams are transmitted to the treatment area by one or more fiber optic cables which terminate at an assembly structured to collimate the emitted radiation prior to application to the tissue. In addition, the apparatus includes a focal length setting mechanism which assures that a constant, fixed distance exists between the point of discharge of the laser beam and the biological tissue, thus assuring a constant energy density at the point of application. A method is presented for applying photo-stimulation, photocollagen stimulation and / or ablation laser treatment utilizing the above apparatus.

The invention provides a photoelectric integrated stretchable flexible neural electrode and a preparation method. The flexible neural electrode comprises a first elastic substrate, a photostimulationelectrode, a second elastic substrate and a recording electrode, and the photostimulation electrode and the recording electrode are both in snakelike curved wire arrangement structures. The lower surface of the photostimulation electrode is provided with a first silicon dioxide layer, and the photostimulation electrode is bonded to the surface of the first elastic substrate by strong chemical bonds generated in condensation reaction of the first silicon dioxide layer and the first elastic substrate. The upper surface of the photostimulation electrode is provided with the second elastic substrate, the lower surface of the recording electrode is provided with a second silicon dioxide layer, and the recording electrode is bonded to the surface of the second elastic substrate through strong chemical bonds generated in condensation reaction of the second silicon dioxide layer and the second elastic substrate, so that the recording electrode and the photostimulation electrode are integratedstructurally. The flexible neutral electrode is available for long-term implantation, high in flexibility and capable of bearing deformation influences of brain tissue expansion and shrinkage and thelike.

An ophthalmic phototherapy device (10) and associated phototherapy treatment method for promoting healing of damaged or diseased eye tissue. The ophthalmic phototherapy device (10) includes a light emitting mechanism (12) for transmitting light of at least one preselected wavelength to the eye tissue, whereby the light transmitted to the damaged or diseased eye tissue stimulates activity in the eye tissue to promote healing. The ophthalmic phototherapy method includes exposing the damaged or diseased eye tissue to light of at least one wavelength for a selected period of time.

A sexual stimulation apparatus and method which may comprise a plurality of light sources for photostimulation of the vagina, clitoris, or both; one or more vibrators for mechanical stimulation of an area of the vagina; a handle; a controller and programmable memory for containing non-transitory instructions for modes of operation and driving the light sources and vibrators of the invention; a vaginal finger; a handle for ease of use; a keypad for user entry of commands; and a charging or programming port. The invention may also comprise sensors that sense physiologic parameters of a user and adjust sexual stimulation parameters to achieve a desired sexual stimulation effect. Blood oxygen level, temperature, pulse rate and muscle electrical activity may be sensed. The invention also may comprise a flexible covering that provides smooth sliding engagement with an area of the vagina of a user.

A photostimulation device of decision behaviors comprises a central control system, a barrier maze system, a photostimulation system, an infrared detection system and a video analysis system, wherein the central control system is respectively connected with the photostimulation system, the infrared detection system and the video analysis system and is used for controlling the photostimulation system, the infrared detection system and the video analysis system, the photostimulation system is used for applying photostimulation signals to animals to be tested, the infrared detection system is used for monitoring the moving process of the animals to be tested in the barrier maze system, and the video analysis system is used for recording and analyzing the moving state of the animals to be tested in the barrier maze system. According to the device, a reward-system-based and effort-based decision behavior testing model is established, the states of the animals before and after the choice and the reaction incubation period are judged, and people can have interference in the decision behaviors of the animals by combining optogenetics method.

The invention relates to a device for treating Parkinson's disease. The device comprises an electrophysiological signal generation detecting system, a drug delivery system, a photostimulation system, and a central processing system. The central processing system controls the electrophysiological signal generation detecting system, the drug delivery system, and the photostimulation system. The electrophysiological signal generation detecting system comprises a neurotransmitter sensor, a recording electrode, and a stimulating electrode. The drug delivery system comprises a syringe pump and a micro-catheter. The central processing system controls the syringe pump to perform drug slow release through the micro-catheter. The photostimulation system comprises a waveform generator, a light source and optical fibers. The waveform generator controls frequency of laser emitted by the light source. The laser emitted by the light source is transmitted to the optical fibers and is used for photostimulation treatment on imported nervous tissue cells with photaesthesia genes. A device for treating the Parkinson's disease is provided, and the device has relatively good monitoring and treating effects and is relatively safe.

A wireless remote control photostimulation system for animals comprises an upper computer and a wearable photic stimulator which is wirelessly connected with the upper computer, wherein the photic stimulator comprises a control unit, a drive unit for driving a light emitting unit to emit light, the light emitting unit for emitting light to photically stimulate light sensation genetic cells and a power supply unit. An optical module is also arranged and connected with the light emitting unit through an optical coupling interface, and the light emitting unit, the optical coupling interface and the optical module are installed in an animal body. The photic stimulator of the wireless remote control photostimulation system for animals is in a wireless connection wear type, so that an experimental object is prevented from fracture due to winding which is easily caused by free moving in an experimental process, the experiment failure risk is reduced, and the system is reliable; and moreover, the light emitting unit is connected with the optical module and the optical coupling interface and then implanted into the animal body, accordingly, the deep nuclei of the animal can be deeply stimulated, and the photostimulation effectiveness is ensured.

The non-invasive intracranial pressure monitoring method adopts the flash eye-shield to give out standard photostimulation signal to human eye, said signal is sensed by retina and converted into electric signal, said electric signal can be picked up by detection electrode and undergone the process of amplifier treatment, then inputted into computer to display flashing visual evoked potential (FVEP) characteristic curve and define the peak latency of III wave, then the function relationship of intracranial pressure and peak latency of III wave, ICP=f(III Latency) can be used to display intracranial pressure value correspondent to wave peak (negative phase) point of III wave on the FVEP-Latency curve on the display screen.

he invention discloses a sleep-aiding method. The method comprises the following steps: a sensor acquires a human body blood oxygen signal and coverts the human body blood oxygen signal into a digitalsignal; a controller determines the real-time sleep state of a user by means of the signal through a corresponding algorithm and controls a light execution module to give photostimulation of a corresponding light mode, thereby guiding the user to gradually enter a sleep state; the user can set the time for get up, a light execution system emits illumination containing many blue light components with ever-increasing intensity when the time is about to reach, thereby inhibiting secretion of melatonin and creating a environment for the user to wake up naturally; and after a sleep cycle is finished each time, a local system uploads all kinds of feature data of the current sleep cycle to a cloud server, the server utilizes the data to analyze and make a sleep-aiding strategy more suitable forthe user through the corresponding algorithm and returns to a client-end controller, and a local controller implements sleep guidance according to the sleep-aiding strategy.

The invention discloses an intelligent bird egg living embryo incubation system. The intelligent bird egg living embryo incubation system comprises an incubator body and further comprises an acquisition and processing unit, heating units, a humidification unit, a photostimulation unit, a ventilation and oxygenation unit and an egg turning unit. The heating units are arranged on the two sides of the incubator body. The humidification unit and the egg turning unit are arranged at the bottom of the incubator body. The photostimulation unit and the ventilation and oxygenation unit are arranged on the top of the incubator body. The output ends of the acquisition and processing unit are connected with the corresponding input ends of the heating units, the corresponding input end of the humidification unit, the corresponding input end of the photostimulation unit, the corresponding input end of the ventilation and oxygenation unit and the corresponding input end of the egg turning unit respectively. The intelligent bird egg living embryo incubation system provides standard natural incubation conditions for bird egg incubation including temperature and humidity, photostimulation, ventilation and egg turning, and has the advantages of uniform temperature field, red light stimulation, interactive incubation parameter setting, high success rate, good expansibility, simple operation and the like, thereby having a wide application market in breed bird egg living embryo production, incubation and the like.

To provide a laser scanning microscope including a laser beam source for stimulation that emits a laser beam for stimulation for applying photostimulation to a sample, a scanner that performs scanning with the laser beam for stimulation, a control device that controls the scanner, and an objective lens that condenses the laser beam for stimulation used for scanning by the scanner to the sample. The scanner has at least one acoustooptic device arranged on an optical path of the laser beam for stimulation. The control device determines a plurality of frequencies on the basis of the position and the range of a photostimulation region, and simultaneously applies the high-frequency signals of the determined plurality of frequencies to a vibrator attached to the acoustooptic device.

A computed radiography system comprises a radiation detecting system wherein an image is formed by the steps of (1) exposing an object to radiation; (2) forming a first digitized image directly captured from said radiation by a detector; (3) storing said digitized image from said radiation on an intermediate medium; (4) forming a latent image originating from the same radiation, as an image stored in a photostimulable phosphor layer, and (5) retrieving said directly captured digitized image and superposing it onto a digitized image originating from said latent image in said photostimulable phosphor layer after photostimulation of said phosphor layer with radiation having a lower energy than the said exposure radiation.

A photocurable composition excellent in the effect of reducing the mold releasing force even in a small amount of light exposure, and a photosensitive gas generating agent contained in the photocurable composition are provided.The photosensitive gas generating agent is a compound having a photostimulation responsive gas generating group to generate a gas by photostimulation, a perfluoroalkyl group and a polyalkyleneoxy group to link the photostimulation responsive gas generating group and the perfluoroalkyl group. The photocurable composition contains the photosensitive gas generating agent.

The invention discloses a near-infrared laser-driven elastic nanometer composite fiber and a preparation method thereof. The composite fiber is prepared through in-situ polymerization of a carbon nanomaterial used as a filling material and silicone rubber used as a matrix, wherein a weight ratio of the carbon nanomaterial to the silicone rubber is 0.05-5: 100, and the carbon nanomaterial is a carbon nanotube, graphene or oxidized graphene. The composite fiber is rapidly prepared by using a reaction spinning method; the carbon nanomaterial is uniformly mixed with liquid silicone rubber, and then dispersion liquid is extracted and injected into a hot oil bath medium for a rapid cross-linking reaction to produce the composite fiber. According to the invention, the carbon nanomaterial is used to generate mechanical response after absorption of near infrared laser and to convert luminous energy into heat energy to trigger photoinduced deformation of polymer elastomer, and a carbon nanomaterial reinforced polymeric material improves output power of an actuator. The preparation method for the fiber is simple, has a fast fiber formation speed, enables fiber diameter to be controllable and regulates and controls optical actuating behaviors of the nanometer composite fiber by adjusting the amount of the filling material and laser power.

The invention relates to fields like biology, medical science, neural science, etc. and discloses a system for researching of neural circuits and regulation of animal behaviors. According to the invention, visualization of cells and selection of cells of interests in a great perspective are realized; different patterns of rapid photostimulation on sample cells disposed on a fast high-precision two-dimensional electronic-control translation table are dynamically carried out; based on recorded electrophysiological signals or behavioral characteristics and the used stimulus patterns, the system is used for analyzing a selected specific neuronal projection relationship and for researching the processes of operation and integration of neurons, thereby further revealing the functions of a great specific neural circuit and regulating animal behaviors and activities.

The invention discloses a monitoring system for an in-vitro cell photostimulation array device, which is used for monitoring a culture state of photosensitive cells under photostimulation, and comprises a control module, a driving module, an LED (light-emitting diode) array and a monitoring module. The control module controls the driving module to drive the LED array to irradiate the photosensitive cells in a culture dish by groups and at regular time; the monitoring module monitors the culture state of the photosensitive cells in the culture dish, and feeds back the culture state to the control module; and the control module adjusts grouping and timing irradiation of the LED array, so as to ensure that the culture state in the culture dish is a set culture state. As the LED array is adopted for irradiating the photosensitive cells, the defect that a size of a whole culture system is too big due to the fact that a size of an irradiation source is too big is avoided. Furthermore, the monitoring module is adopted for monitoring the culture state of various in-vitro cells, so that the in-vitro cells can be cultured. Therefore, the monitoring system for the in-vitro array photostimulation device is small in size, and is suitable for monitoring in-vitro cell culture.

A transparent photoelectrode of multiple recording spots based on fibers comprises: a multi-mode fiber which includes a fiber core, cladding and a protective layer; and a flexible electrode which has a small hole at the middle portion of the flexible electrode, wherein the small hole of the flexible electrode is aligned to the fiber core of the multi-mode fiber and wraps the multi-mode fiber. The structure formed by the invention solves the problem that the current photostimulation position and the recording spots are non-synchronous, and solves the problems of the restriction of the fiber electrode recording spots and the difficult implantation of the flexible electrode. The transparent photoelectrode of multiple recording spots based on fibers has the characteristics of the stimulation precision with high photostimulation and good biocompatibility of the flexible electrode which can perform long-term record.

Disclosed is an agent for inducing receptor potential, which comprises an organic dye compound capable of inducing / evoking receptor potential in response to photostimulation in the optic nerve, wherein the organic dye compound is a polymethine organic dye compound. Also disclosed is a substituent material for the retina comprising the agent.