The present invention relates to a
system for automatically evaluating
oxygen saturation of the
optic nerve and
retina, said
system comprising: image capturing
system further comprising: a
fundus camera (26), a four wavelengths
beam splitter (27), a
digital image capturing device (28), a computer system,
image processing software performing in real-time the steps of: registering set of multi-spectral images (1) by, binarizing the multi-
spectral image (7), find the all the border regions of each image by finding the region including the straight line that passes the most number of points in the region (8), use the orientation of the borders to evaluate the orientation of each
spectral image (9), equalize the orientation of each
spectral image by rotating the spectral image (10), edge detect each spectral image (11), estimate the translation between the spectral images based on the edges of adjacent images (12), transform the images to a stack of registered images (13), locating blood vessels (2) in each of the multi-spectral images by, retrieving registered spectral images (14), for each spectral image, remove defective pixels (15), enhance
image contrast (16), perform top-hat transform using
structuring element larger than the largest
vessel diameter (17), binarize each image (18), apply filter for
smoothing the image (19), combine all the spectral images using binary AND operator (20), skeletonize the resulting image (21), prune the skeleton image (22), re-grow the pruned image (23), locate junction points (24), evaluating the width of the blood vessels (3) by calculating the normal vector to the vessel direction to, estimate the direction and position of the vessel profile, evaluate positions of vessel walls based on the vessel profile obtained, evaluate vessel width based on the position of the vessel walls, selecting samples for calculating
optical density, calculating the
optical density ratio (4), evaluating
oxygen saturation level (5), and presenting the results (6), wherein presenting the results may include presenting numerical and visual representation of the
oxygen saturation.