277 results about "Intracranial pressure" patented technology

Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

In one embodiment, the invention provides a device for decreasing intracranial or intraocular pressures. The device comprises a housing having an inlet opening and an outlet opening that is adapted to be interfaced with a person's airway. The device further includes a valve system that is operable to regulate respiratory gas flows through the housing and into the person's lungs during spontaneous or artificial inspiration. The valve system assists in lowering intrathoracic pressures during each inspiration to repetitively lower pressures in the venous blood vessels that transport blood out of the head to thereby reduce intracranial or intraocular pressures.

A system for measuring and converting to an observer intelligible form an internal physiological parameter of a medical patient. The invention allows transcutaneous telemetry of the measured information intracranial pressure via a system which includes a patient implanted sensor module and a processing and display module which is external of the patient and optically coupled to the sensor module via an external coupling module. A sensor within the implanted module transduces the measured information and a near infrared (NIR) emitter transmits this telemetry information when interrogated by the complementary external coupling module. Power for the sensor module is derived inductively through rectification of a transcutaneously-applied high-frequency alternating electromagnetic field which is generated by a power source within the external coupling module, in concept much like a conventional electrical transformer. A computer within the processing and display module calculates the parameter value from the NIR telemetry signal and represents this data either in numerical, graphical, or analog format.

Disclosed are formulations of gamma-hydroxybutyrate in an aqueous medium that are resistant to microbial growth. Also disclosed are formulations of gamma-hydroxybutyrate that are also resistant to the conversion into GBL. Disclosed are methods to treat sleep disorders, including narcolepsy, with these stable formulations of GHB. The present invention also provides methods to treat alcohol and opiate withdrawal, reduced levels of growth hormone, increased intracranial pressure, and physical pain in a patient.

The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual's overall vascular health. The invention can track the onset, progression and treatment efficacy in an individual experiencing increased intracranial pressure, or can help identify underlying vulnerabilities of the vascular system to normal pressures, associated with and manifested as hydrocphalus or dementia.

A method of treating a disorder of a patient, such as a neurological disorder, is provided. The method comprises intravascularly delivering at least one of a stimulation lead and a sensing lead within the head of the patient. For example, one or both of the leads can be delivered into the patient's head via the circulatory system (e.g., vein or artery) or the ventricular system (e.g., through the intrathecal space of the spine). The method further comprises sensing a physiological event associated with the disorder (e.g., physiological electrical activity, a blood parameter, or intracranial pressure) using the sensing lead, and stimulating neural tissue with the stimulation lead in response to the sensed physiological event.

A method of estimating at least one intracranial hemodynamic parameter in a subject, the method comprising: a) obtaining data of changes in electrical impedance across the subject's head as a function of time; b) analyzing the data; and c) estimating one or more of intracranial pressure, cerebral blood volume, and a factor related to at least one of cerebral perfusion pressure and a mean transit time through cerebral capillaries.

A method and system to determine brain stiffness is disclosed. A probe to measure tissue water content is inserted through an aperture (burr hole) in the cranium into brain tissue. The probe has two electrically separated plate conductors with a dielectric which forms a capacitor plane. One conductor has a surface mount resistor to allow exact impedance matching to the core of a coaxial cable. The other conductor attaches electrically to the shield of the coaxial cable. The probe is stabilized in the brain tissue through a plastic ventriculostomy bolt which has been secured by screw tapping into the cranium. The coaxial cable connects to a spectrum analyzer. Brain water content and blood congestion alter the resonant frequency of the probe, allowing a realtime readout of apparent tissue water content. By monitoring the momentary shift in center resonant frequency or, alternatively, the standing wave ratio slightly off resonant frequency, a beat-to-beat pulsatile waveform is derived relating to the perfusion of the brain. A strain gauge intracranial pressure sensor (ICP) is separately affixed through the bolt and adjacent to the water content probe. By comparing the phase angle or lag time difference between the pressure tracing and the perfusion tracing, a realtime measurement of organ stiffness or compliance is derived.

A method for increasing circulation and providing oxygen to a patient in cardiac arrest includes the step of coupling an interface to the patient's airway, the interface providing access to the patient's respiratory system. A valve system is operably attached to the interface. Oxygen is delivered through the interface a rate of between about 1.0 to about 10.0 L / min to provide a continuous supply of oxygen to the patient. While supplying the oxygen, a body structure of the patient is manipulated to increase the magnitude and duration of the patient's negative intrathoracic pressure. During the manipulation, the valve system prevents additional respiratory gases from entering the lungs until a negative intrathoracic pressure level in the range from about −1 cm H2O to about −15 cm H2O, the valve system assisting in increasing the magnitude and duration of negative intrathoracic pressure thereby enhancing the amount of blood flow in the heart and lungs and lowering intracranial pressure, therein further increasing blood flow to the brain.

A system and method for non-invasively detecting intracranial pressure (ICP) of a living being by detecting impedance mismatches between carotid arteries and cerebral vessels via a reflection of the carotid pressure waveform using a pressure sensor positioned against the palpable carotid artery, as well as analyzing the reflection and comparing the analysis with known cerebral vasculature data, to calculate ICP non-invasively. A remote blood pressure waveform can also be used to compensate for blood system impedance.

Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided. Systems for acquiring acoustic data from a desired target site in a subject's body using various types of acoustic source and detector elements are also provided, including single use acoustic source / detector combinations are also provided. Acoustic arrays for use with these systems may include multiple capacitive micro-machined ultrasound transducer (cMUT) elements, and may include a combination of different types of acoustic arrays. Methods of targeting localized sites within a broad target area based on acoustic data having various properties are also disclosed.

A central nervous system (CNS) catheter assembly adapted for use as a ventriculostomy catheter and a spinal catheter includes a catheter body defining at least one lumen therethrough having a drug delivery branch and a monitoring / sensing branch. The drug delivery branch and the monitoring / sensing second branch are in fluid communication with the lumen. Openings are disposed in fluid communication with the lumen and being located at proximal ends of the drug delivery branch and the monitoring / sensing branch. Another opening is disposed at a distal end of the main body. The assembly further includes a component such as an intracranial pressure / osmotic pressure monitoring system, a fluid drainage system, an attachable introduction aid, a patient surface attachment aid, a micromanipulator and a comprehensive intracranial pressure evaluation and relief system. The assembly optionally includes a filter assembly containing a proton exchange membrane.