Provided are compositions and methods for treating
lung or respiratory disorders or conditions characterized by
airflow obstruction or limitation, or a symptom thereof (e.g.,
asthma, rhinitis, allergic rhinitis, and chronic obstructive
pulmonary disease (
COPD) and
COPD-associated conditions (e.g.,
bronchitis, emphysema,
asthma), emphysema, pneumonia,
bronchitis, influenza, SARS,
tuberculosis, and
whooping cough (pertussis), and the like) in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically altered fluid (gas-enriched (e.g.,
oxygen-enriched) electrokinetic fluids) comprising an ionic
aqueous solution of charge-stabilized
oxygen-containing nanostructures as disclosed herein. In certain aspects, the methods comprise regulating
intracellular signal transduction by modulation of at least one of cellular membranes,
membrane potential, membrane proteins (e.g., membrane receptors, (e.g., to
G protein coupled receptors, and intercellular junctions)). Additional aspects include therapeutic compositions, and combination treatment methods comprising administration of electrokinetically generated fluid in combination with at least one additional therapeutic agent.