32276results about How to "Reduce impact" patented technology

Abstract of the DisclosureThe preferred embodiments provide a membrane system, particularly for use on an electrochemical sensor, wherein the membrane system includes an affinity domain that dampens the effects of target interferant(s) on the sensor. The affinity domain can be layer, surface, region, and / or portion of the membrane system formed using sorbents that have an affinity for the target interferant. The sorbents can be adapted to adsorb the interferants, for example using adsorbents such as chromatography packing materials. The sorbents can also be adapted to absorb the interferants by imprinting a molecular structure on the material that forms the affinity domain such that target interferants bind to the imprinted surfaces at the molecular level.

Disclosed is a surgical instrument comprising an instrument handle, an instrument shaft shaft having a distal end and a proximal end at which the instrument handle is linked, an instrument head, pivotally linked to the distal end of the instrument shaft via a hinge shaft or pins and comprising an effector rotatably supported in said instrument head around its longitudinal axis as well as a surgical tool held by said effector, and a mechanical transmission system at least partially arranged within said instrument shaft transmitting mechanical operation signals from said instrument handle to said instrument head at least for pivoting and / or rotating motions. A bending flexible as well as rotating rigid, hollow spindle is arranged bypassing said hinge shaft or pins and directly connecting said effector with the mechanical transmission system for transmitting at least rotating signals via said spindle to said effector.

This invention provides an apparatus and method for analyzing a polynucleotide sequence; either an unknown sequence or a known sequence. A support, e.g. a glass plate, carries an array of the whole or a chosen part of a complete set of oligonucleotides which are capable of taking part in hybridization reactions. The array may comprise one or more pair of oligonucleotides of chosen lengths. The polynucleotide sequence, or fragments thereof, are labelled and applied to the array under hybridizing conditions. Applications include analyses of known point mutations, genomic fingerprinting, linkage analysis, characterization of mRNAs, mRNA populations, and sequence determination.

In an encoder, multiple channels of audio information representing multidimensional sound fields are split into subband signals and the subband signals in one or more subbands are combined to form composite signals. The composite signals, the subband signals not combined into a composite signal and information describing the spectral levels of subband signals combined into composite signals are assembled into an encoded output signal. The spectral level information conveys either the amplitude or power of the combined subband signals or the apparent direction of the sound field represented by the combined subband signals. In digital implementations, adaptive bit allocation may be used to reduce the informational requirements of the encoded signal.

A communication component modifies production of an audio waveform at determined modification segments to thereby mitigate the effects of a delay in processing and / or receiving a subsequent audio waveform. The audio waveform and / or data associated with the audio waveform are analyzed to identify the modification segments based on characteristics of the audio waveform and / or data associated therewith. The modification segments show where the production of the audio waveform may be modified without substantially affecting the clarity of the sound or audio. In one embodiment, the invention modifies the sound production at the identified modification segments to extend production time and thereby mitigate the effects of delay in receiving and / or processing a subsequent audio waveform for production.

A method and apparatus for communicating with and monitoring the operation of a device implanted within a patient. A transceiver capable of being implanted within a patient provides a communication interface between an implanted medical device and a monitor external to the patient's body. The external monitor can communicate with a remote monitoring center over a communication network. The external monitor also provides control signals to the implanted device via the transceiver unit. The transceiver apparatus is capable of two-way communication between the implanted device and the external monitor. The transceiver apparatus is also capable of detecting actions performed by the implanted device and physiological signals directly from the patient's body. Thus, the transceiver apparatus provides circuitry for determining whether an implanted medical device is operating properly. The transceiver apparatus provides a way to remotely reprogram one or more implanted medical devices.

Abstract of Disclosure The present invention provides methods and compositions for attenuating expression of a target gene in vivo. In general, the method includes administering RNAi constructs (such as small-interfering RNAs (i.e., siRNAs) that are targeted to particular mRNA sequences, or nucleic acid material that can produce siRNAs in a cell), in an amount sufficient to attenuate expression of a target gene by an RNA interference mechanism, e.g., in a sequence-dependent, PKR-independent manner. In particular, the subject method can be used to alter the growth, survival or differentiation of cells for therapeutic and cosmetic purposes.

Performing data management operations on replicated data in a computer network. Log entries are generated for data management operations of an application executing on a source system. Consistency point entries are used to indicate a time of a known good, or recoverable, state of the application. A destination system is configured to process a copy of the log and consistency point entries to replicate data in a replication volume, the replicated data being a copy of the application data on the source system. When the replicated data represents a known good state of the application, as determined by the consistency point entries, the destination system(s) may perform a storage operation (e.g., snapshot, backup) to copy the replicated data and to logically associate the copied data with a time information (e.g., time stamp) indicative of the source system time when the application was in the known good state.

A multifunctional membrane is provided. The multifunctional membrane is suitable for use in an analyte sensor. In a particular application, the multifunctional membrane may be used in connection with an amperometric biosensor, such as a transcutaneous amperometric biosensor. Some functions of the membrane are associated with properties of membrane itself, which is comprised of crosslinked polymers containing heterocyclic nitrogen groups. For example, the membrane, by virtue of its polymeric composition, may regulate the flux of an analyte to a sensor. Such regulation generally improves the kinetic performance of the sensor over a broad range of analyte concentration. Other functions of the membrane are associated with functional components, such as a superoxide-dismutating / catalase catalyst, either in the form of an enzyme or an enzyme mimic, that can be bound to the scaffold provided by the membrane. The effect of any such enzyme or enzyme mimic is to lower the concentration of a metabolite, such as superoxide and / or hydrogen peroxide, in the immediate vicinity of the sensing layer of the biosensor. Lowering the concentrations of such metabolites, which are generally deleterious to the function of the sensor, generally protects or enhances biosensor integrity and performance. The membrane is thus an important tool for use in connection with analyte sensors, amperometric sensors, biosensors, and particularly, transcutaneous biosensors. A membrane-covered sensor and a method for making same are also provided.

Volume dimensioning employs techniques to reduce multipath reflection or return of illumination, and hence distortion. Volume dimensioning for any given target object includes a sequence of one or more illuminations and respective detections of returned illumination. A sequence typically includes illumination with at least one initial spatial illumination pattern and with one or more refined spatial illumination patterns. Refined spatial illumination patterns are generated based on previous illumination in order to reduce distortion. The number of refined spatial illumination patterns in a sequence may be fixed, or may vary based on results of prior illumination(s) in the sequence. Refined spatial illumination patterns may avoid illuminating background areas that contribute to distortion. Sometimes, illumination with the initial spatial illumination pattern may produce sufficiently acceptable results, and refined spatial illumination patterns in the sequence omitted.

A thin-film formation apparatus possesses a reaction chamber to be evacuated, a placing portion on which a substrate is placed inside the reaction chamber, a gas-dispersion guide installed over the placing portion for supplying a gas onto a substrate surface, a gas-supply port for introducing the gas into the gas-dispersion guide, a gas-dispersion plate disposed on the side of the substrate of the gas-dispersion guide and having multiple gas-discharge pores, a first exhaust port for exhausting, downstream of the gas-dispersion plate, the gas supplied onto the substrate surface from the gas-dispersion plate, and a second exhaust port for exhausting, upstream of the gas-dispersion plate, a gas inside the gas-dispersion guide via a space between the gas-dispersion guide and the gas-dispersion plate.

A system and method of scheduling RFID tag interrogations by a plurality of RFID readers so as to mitigate the effects of interference within an RFID environment in which the readers are deployed, and to enhance the efficiency and reliability of the overall RFID system. The system includes a plurality of RFID receivers for receiving RFID tag data, a plurality of RFID tag interrogators for transmitting RF interrogation signals for interrogating RFID tags, and a controller for providing to at least one interrogator, at least one receiver, and at least one tag, a parameter associated with operational characteristics of the interrogator, the receiver, and the tag, respectively. The interrogator, the receiver, and the tag are operative, in response to receipt of the respective parameter, to modify its operational characteristics in accordance with the respective parameter, thereby avoiding interference at the receivers and the tags.

A transistor device (10), the transistor device (10) comprising a substrate (11, 14), a fin (3, 3A) aligned along a horizontal direction on the substrate (11, 14), a first source / drain region (4) of a first type of conductivity in the fin (3, 3A), a second source / drain region (5) of a second type of conductivity in the fin (3, 3A), wherein the first type of conductivity differs from the second type of conductivity, a channel region (33) in the fin (3, 3A) between the first source / drain region (4) and the second source / drain region (5), a gate insulator (6) on the channel region (33), and a gate structure (7, 8) on the gate insulator (6), wherein the sequence of the first source / drain region (4), the channel region (33) and the second source / drain region (5) is aligned along the horizontal direction.

An immersion lithographic apparatus includes a voltage generator or power source that applies a potential difference to an object in contact with the immersion liquid such that bubbles and / or particles in the immersion liquid are either attracted or repelled from that object due to the electrokinetic potential of the surface of the bubble in the immersion liquid.

Methods are disclosed for measuring target structures formed by a lithographic process on a substrate. A grating or other structure within the target is smaller than an illumination spot and field of view of a measurement optical system. The position of an image of the component structure varies between measurements, and a first type of correction is applied to reduce the influence on the measured intensities, caused by differences in the optical path to and from different positions. A plurality of structures may be imaged simultaneously within the field of view of the optical system, and each corrected for its respective position. The measurements may comprise first and second images of the same target under different modes of illumination and / or imaging, for example in a dark field metrology application. A second type of correction may be applied to reduce the influence of asymmetry between the first and second modes of illumination or imaging, for example to permit a more accurate overly measurement in a semiconductor device manufacturing process.

There is provided a system for the delivery of medicament comprising a medicament container; a dispensing mechanism for dispensing medicament from the medicament container; an electronic data management system; and a communicator for wireless communication with a network computer system to enable communication of data between the network computer system and the electronic data management system. The electronic data management system comprises a memory for storage of data; a microprocessor for performing operations on the data; and a transmitter for transmitting a signal relating to the data or the outcome of an operation on the data.

A Catheter Based Heart Valve (CBHV) is described herein which replaces a non functional, natural heart valve. The CBHV significantly reduces the invasiveness of the implantation procedure by being inserted with a catheter as opposed to open heart surgery. Additionally, the CBHV is coated with a biocompatible material to reduce the thrombogenic effects and to increase durability of the CBHV. The CBHV includes a stent and two or more polymer leaflets sewn to the stent. The stent is a wire assembly coated with Polystyrene-Polyisobutylene-Polystyrene (SIBS). The leaflets are made from a polyester weave as a core material and are coated with SIBS before being sewn to the stent. Other biocompatible materials may be used, such as stainless steel, Titanium, Nickel-Titanium alloys, etc.

A multilayered material is provided which includes a substrate and a silicon-containing film formed on the substrate, wherein the silicon-containing film has a nitrogen-rich area including silicon atoms and nitrogen atoms, or silicon atoms, nitrogen atoms, and an oxygen atoms and the nitrogen-rich area is formed by irradiating a polysilazane film formed on the substrate with an energy beam in an atmosphere not substantially including oxygen or water vapor and denaturing at least a part of the polysilazane film. A method of producing the multilayered material is also provided.

This relates to methods and devices for treating reversible chronic obstructive pulmonary disease, and more particularly, relates to a device for exchanging energy with airway tissue such as that found in the airway of human lungs. The exchange of energy with this airway tissue in the airways reduces the ability of the air ways to constrict and / or reduces the resistance within the airway to the flow of air through the airway. This also relates to a method for decreasing responsiveness or decreasing resistance to airflow of airways involves the transfer of energy to or from the airway walls to prevent or reduce airway constriction and other symptoms of lung diseases. The treatment reduces the ability of the airway to contract during an acute narrowing of the airways, reduces mucus plugging of the airways, and / or increases the airway diameter. The methods according to the present invention provide a longer duration and / or more effective treatment for lung diseases than currently used drug treatments, and obviate patient compliance issues. This also includes additional steps that reduce the ability of the lung to produce at least one of the symptoms of reversible obstructive pulmonary disease and to reduce the resistance to the flow of air through a lung.

A traffic monitor provides statistics of traffic using an activity input for receiving data related to activity on a server system. Events being monitored are binned by topic or term, where the terms are associated with categories. The categories can be a hierarchy of categories and subcategories, with terms being in one or more categories. The categorized events include page views and search requests and the results might be normalized over a field of events and a result output for outputting results of the normalizer as the statistical analyses of traffic.

An inductive power supply system in which the receiving unit includes a secondary coil and a plurality of resonating circuits with different characteristics. Each of the resonating circuits may include a resonating coil and a resonating capacitor. The resonating coils may be inductively coupled to the secondary coil so that energy may be transferred from one or more of the resonating coils to said receiving unit. The plurality of resonating circuits are configured to provide improved power transfer efficiency or performance at different distances between the primary coil and secondary coil. The present invention may also provide a method for tuning the wireless power system including the general steps of measuring an operating characteristic in the primary unit, measuring an operating characteristic in the receiver unit and tuning one or more of the components in the primary unit and the secondary unit based on a comparison of the two measurements.

Devices and methods for non-invasively measuring at least one parameter of a sample, such as the presence of a disease condition, progression of a disease state, presence of an analyte, or concentration of an analyte, in a biological sample, such as, for example, a body part. In these devices and methods, temperature is controlled and is varied between preset boundaries. The methods and devices measure light that is reflected, scattered, absorbed, or emitted by the sample from an average sampling depth, dav, that is confined within a region in the sample wherein temperature is controlled. According to the method of this invention, the sampling depth dav, in human tissue is modified by changing the temperature of the tissue. The sampling depth increases as the temperature is lowered below the body core temperature and decreases when the temperature is raised within or above the body core temperature. Changing the temperature at the measurement site changes the light penetration depth in tissue and hence dav. Change in light penetration in tissue as a function of temperature can be used to estimate the presence of a disease condition, progression of a disease state, presence of an analyte, or concentration of an analyte in a biological sample. According to the method of this invention, an optical measurement is performed on a biological sample at a first temperature. Then, when the optical measurement is repeated at a second temperature, light will penetrate into the biological sample to a depth that is different from the depth to which light penetrates at the first temperature by from about 5% to about 20%.

An electrophoretic display comprises a pair of facing substrates, at least one of which is transparent, a plurality of particles and a gas between the substrates, and means for applying an electric field to cause the particles to move and thus change the electro-optic state of the display. The electric field means is arranged to increase the impulse applied to the display with increasing time since a reference time, or with increasing number of images written on the display. In another embodiment, an alternating current pulse is applied to the display, and the duration and / or amplitude of the alternating current pulse is increased with increasing time since a reference time.

A content addressable memory (CAM) device and process for searching a CAM. The CAM device includes a plurality of CAM cells, match-lines (MLs), search lines, and ML sense amplifiers. The ML sense amplifiers are capable of self-calibration to their respective thresholds to reduce effects of random device variation between adjacent sense amplifiers.