609 results about "Superoxide" patented technology

A multifunctional membrane is provided. The multifunctional membrane is suitable for use in an analyte sensor. In a particular application, the multifunctional membrane may be used in connection with an amperometric biosensor, such as a transcutaneous amperometric biosensor. Some functions of the membrane are associated with properties of membrane itself, which is comprised of crosslinked polymers containing heterocyclic nitrogen groups. For example, the membrane, by virtue of its polymeric composition, may regulate the flux of an analyte to a sensor. Such regulation generally improves the kinetic performance of the sensor over a broad range of analyte concentration. Other functions of the membrane are associated with functional components, such as a superoxide-dismutating / catalase catalyst, either in the form of an enzyme or an enzyme mimic, that can be bound to the scaffold provided by the membrane. The effect of any such enzyme or enzyme mimic is to lower the concentration of a metabolite, such as superoxide and / or hydrogen peroxide, in the immediate vicinity of the sensing layer of the biosensor. Lowering the concentrations of such metabolites, which are generally deleterious to the function of the sensor, generally protects or enhances biosensor integrity and performance. The membrane is thus an important tool for use in connection with analyte sensors, amperometric sensors, biosensors, and particularly, transcutaneous biosensors. A membrane-covered sensor and a method for making same are also provided.

A guidewire with a sensor which can detect NO and / or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.

Systems and methods for generating reactive oxygen species formulations useful in various oxidation applications. Exemplary formulations include singlet oxygen or superoxide and can also contain hydroxyl radicals or hydroperoxy radicals, among others. Formulations can contain other reactive species, including other radicals. Exemplary formulations containing peracids are activated to generate singlet oxygen. Exemplary formulations include those containing a mixture of superoxide and hydrogen peroxide. Exemplary formulations include those in which one or more components of the formulation are generated electrochemically. Formulations of the invention containing reactive oxygen species can be further activated to generate reactive oxygen species using activation chosen from a Fenton or Fenton-like catalyst, ultrasound, ultraviolet radiation or thermal activation. Exemplary applications of the formulations of the invention among others include: cleaning in place applications, water treatment, soil decontamination and flushing of well casings and water distribution pipes.

This invention is a modular, adjustable, easy to maintain, portable or fixed food sanitation tunnel, comprising an enclosing means for subjecting food to sanitizers including UV light, ozone, hydroperoxides, superoxides and hydroxyl radicals, and a method for using the system. The enclosing means includes one or more UV radiation sources and one or more target rods located within a tunnel, such as a c-shaped shell. The UV radiation sources are preferably UV light sources that emit UV light of approximately 185 to 254 nm. The target rods are approximately up to 0–30% titanium dioxide, up to 0–30% silver and up to 0–30% copper, by weight. The system may include a mister for the efficient production of hydroxyl radicals by the UV light sources. Parts of the system are easily removable for cleaning and for maintenance. Also, in an alternative embodiment, the tunnel is located on a frame, and the frame is on wheels.

The invention relates to a high-efficient combined inhabitor for pyrite in complex sulfide ores and the application method of the inhabitor. The inhabitor comprises calcium superoxide and HA-Na. The inhabitor of the invention can inhibit complex vulcanized iron-bearing minerals selectively, has better inhibition properties for magnetic pyrite, pyrite and arsonopyrite, and is an inhabitor of high selectivity. Compared with the prior inhibitors such as lime, cyanide, bichrome, potassium permanganate, sodium sulfide, sulphite, zinc sulphate and trisodium phosphate, the invention has the advantages of lower use level, good effects, no pollution, and other advantages.

The present invention provides for a method to increase the triplet yield of a photosensitizer by the coupling to metal surface plasmons which leads to increased singlet oxygen generation by electric field enhancement or enhanced energy absorption of the photosensitizer. The extent of singlet oxygen enhancement can be tuned for applications in singlet oxygen based clinical therapy by modifying plasmon coupling parameters, such as metallic nanoparticle size and shape, photosensitizer / metallic nanoparticle distance, and the excitation wavelength of the coupling photosensitizer.

The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.

Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2−) scavengers, β-adrenergic agonists, cAMP-dependent protein kinase activators, α1-adrenergic antagonists, L-type Ca2+ channel blockers, estrogens, ATP-sensitive K+ channel activators and smooth muscle relaxants are used.

The present invention is process of treating refractory organic effluent with free radical and the electrically catalyzed reactor therewith. The present invention features that in an electrochemically hydrating proton reaction kettle and in the presence of initiator, free hydroxyl radical, superoxide anion free radical, free nitrogen radical, active free oxygen radical, etc are generated circularly and reacted in an electrically catalyzing high pressure reaction kettle with various kinds of refractory organic compounds for efficient decomposition. The present invention has high organic waste water degrading rate and low cost, and is suitable for high concentration organic waste water treatment in papermaking, petrochemical and other industry.

A process for preparing the oligose of fucosan sulfate includes such steps as preparing the aqueous solution of fucosan sulfate, adding oxidant chosen from hydrogen peroxide, hypochlorous acid, nitrous acid, or their salts, heating, membrane ultrafilter, vacuum concentrating and freeze drying. Its advantages are high medical effect to protect liver and take care of health, and low cost.

The invention provides environment-friendly water-based paint and a preparation method thereof. The environment-friendly water-based paint comprises water-based resin dispersion, water, compound anion powder, an anion additive, a coalescing agent, a deforming agent, a thickening agent, a dispersing agent and a pH regulator. Crystal salt can undergo water loss after absorbing water molecules from air and the process is carried out alternately to continuously generate anions, so that the redundant cations in the air can be effectively neutralized, the floating dust and particles in the air are adsorbed and the air is purified. Nano silicon dioxide, nano phosphate titanium dioxide and nano zinc dioxide are used as photocatalyst materials which can be used for effectively degrading the harmful gases such as formaldehyde in the air under illumination so as to generate superoxide anion free radicals and accompany negative oxygen ions. Under the combined action of the crystal salt and the photocatalyst, the prepared environment-friendly water-based paint has the advantages of forming high-concentration negative oxygen ion environment which can be kept and sufficiently absorbing the harmful gases and particles such as dust so as to effectively improve the indoor air quality.

The present invention provides compounds, compositions and methods for inhibiting or reducing reactive oxygen species (ROS) production in cells, such as in cells of the vascular system and in particular the smooth muscle-containing vasculature and / or endothelial cell-containing vasculature and / or adventitial fibroblast-containing vasculature. ROS production may also be inhibited in non-vascular cells of animals including mammals such as humans. Non-vascular cells contemplated herein include nerve cells, stem cells, progenitor cells and some cancer and rumor cells. More particularly, the present invention provides agents and even more particularly, cell-impermeable agents, capable of modulating NADPH oxidase activity, function or levels, thereby controlling superoxide production and production of downstream ROS. The present invention particularly enables agents which are selective against a form of Nox4-containing NADPH oxidase which has a portion of the enzyme such as all or part of the Nox4 component extracellularly exposed.

The invention relates to a mussel meat protein antioxidative peptide and a preparation method thereof. The invention is characterized in that the antioxidative peptide is a pentapeptide compound with an amino acid sequence of YPPAK (Tyr-Pro-Pro-Ala-Lys), and according to ESI-MS detection, a molecular ion peak of m / z [M+H]<+> 575.26 is given out. The preparation method comprises the steps consisting of slurry homogenizing, degreasing, mixing, enzymatic hydrolysis, desalination, ultrafiltration, chromatography and the like. The prepared high-activity antioxidative peptide YPPAK (Tyr-Pro-Pro-Ala-Lys) has a good removal effect on DPPH free radicals, hydroxyl free radicals and superoxide anion free radicals; meanwhile, the YPPAK (Tyr-Pro-Pro-Ala-Lys) shows a good inhibitory effect on lipid peroxidation. The YPPAK (Tyr-Pro-Pro-Ala-Lys) has the advantages of safety, no toxic and side effects, good antioxidant activity, easy digestion and absorption, etc., and can be used as a medicine, a health food or foodstuff additive and the like.

The invention relates to a 7 and 20 dehydro-silybin dialky ether and preparation method and medicine use thereof. The compounds are capable of obviously preventing the lipid superoxide induced by the free radical from being generated; effectively protecting the injury rat adrenal pheochromocytoma cells PC12 due to hydrogen dioxide, namely with oxidation resistance injury protection function on thePC12 cells which simulate the cranial nerves; preventing the brain cells and the cranial nerves from being oxidized and controlling the neurodegenerative diseases such as senile dementia. In addition, the compounds have strong chelation on the ferrous ion. The pharmacodynamics result shows that: the compounds are anticipated to prepare the medicine for controlling the neurodegenerative diseases.

The invention provides an antioxidation feedstuff for improving the immunity of sturgeons, which relates to an antioxidation feedstuff. The antioxidation feedstuff solves the problems that the sturgeons bred manually with the prior feedstuff have low immunity, are easy to be infected, are hard to cure with common drugs after catching a disease, and are sensitive to the common drugs. The antioxidation feedstuff for improving the immunity of the sturgeons is prepared by mixing fish meal, bean pulp, wheat middling, fish oil, soybean lecithin, aloe powder, cellulose, zeolite and a premix. The antioxidation feedstuff for improving the immunity of the sturgeons does not have obvious influence on the production performance of the sturgeons, obviously improves the blood plasma superoxide dismutase activity (P is less than 0.05), obviously reduces the blood plasma malonaldehyde activity (P is less than 0.05), improves the immunity of the sturgeons, and preventing the sturgeons from being infected and catching diseases.

The present invention provides a high density fermentation and a purification process of a recombination high temperature resistance superoxide dismutase, the construction method of the invention includes: using gene coded for SOD in a thermophilic bacteria as a template, designing specific primer amplification target gene having restriction enzyme sites, after double digestion, connecting to plasmid vector pET28a after the same double digestion, constructing a recombinant plasmid, named for pSOD, transforming plasmid pSOD to competence escherichia coli BL21(DE3) by chemical transformation method, obtaining strain having high SOD yield after screening, completing the construction of SOD engineering bacteria; the fermentation process includes four steps of first order seed culture, secondary order feed culture, batch fermentation and induced expression, fermentation product SOD is finally obtained; the fermentation process realizes high level expression of SOD, the expression of the target protein is more than 60% of the bacterial protein total; SOD has excellent thermal stability and heat resistance, the expression product accounts for more than 60% of the whole proteins, and fully soluble protein, avoiding any trouble in the course of inclusion body renaturation; the purification process is simple, having high yield, lower cost, the final product SOD has high purification, high activity and strength stability.

The invention relates to a precious-metal recovery method, specifically relates to a method of recovering platinum / rhodium from insoluble residue of dualistic royal water for solving problems of the existing platinum / rhodium recovering method that the process flow is lengthy and complicated, operational process is dangerous, the isolation effect is bad, and the like. The method comprises steps of preprocessing the insoluble residue of royal water by using barium superoxide, oxidizing the platinum and rhodium thereof, dissolving the oxidized platinum and rhodium in hydrochloric acid; using ammonium chloride to deposit platinum after being converted to a sodium type, adding hydrazine hydrate for recovering the spongy platinum, complexing by adding sodium nitrite into the filter liquor after platinum deposition, depositing rhodium by using ammonium chloride, adding hydrochloric acid for dissolving and sodium type conversion, eliminating base metal in the liquid by using ion exchange resin, finally using hydrazine hydrate and hydrogen gas flame for recovering rhodium powder. The method is a precious-metal-resource secondary recovery utilization and purification method, and has advantages of simple technique, short purification period, convenient operations, high coefficient of recovery, little discharging of waste gas and waste matter, and environment protection, and the like.

The present invention provides a composition for preventing or treating periodontal diseases comprising an extract of Achyranthis radix, Ulmus cortex or a mixture thereof which inhibits the productions of superoxide, prostaglandin, and interleukin (IL-1.beta.) which are inducers for periodontal diseases and inhibits the enzyme activity of collagenase which decomposes collagen protein which is a substrate for the periodontal tissues, and at the same time promotes collagen protein synthesis, thereby treating periodontal diseases efficiently.

The invention discloses unsaturated carboxylic acid metal salt modified ethylene-propylene-diene monomer (EPDM) and a preparation method thereof. Carbon black, metallic compound, stearic acid, accelerant, inert filler, sulphur, superoxide and unsaturated carboxylic acid are added in the EPDM, then mixing treatment and sulfidizing are conducted, and therefore the unsaturated carboxylic acid metal salt modified EPDM is obtained. According to the unsaturated carboxylic acid metal salt modified EPDM and the preparation method thereof, unsaturated carboxylic acid metal salt in in-situ reaction is used for modifying the EPDM, preparation process is simple, modification effect is good, the prepared modified rubber has good physical mechanical performance and especially has good bonding strength with metal, and the application range is wide.

The present invention is a high volume, wall-mountable air sanitation apparatus for disinfecting and removing VOC's with high energy UV light and ozone. The apparatus has a powerful fan and an elongated UV light source and target for use with the movement of a large volume of air. The target includes a mesh and a secondary target both comprising a target compound which creates hydro-peroxides, super oxide ions and hydroxyl radicals in the presence of water also for removing pollutants in the air.

The invention relates to a method for preparing gold thread jujube enzyme from jujube paste of gold thread jujube, comprising the following steps of: making the jujube paste, carrying out primary enzymolysis and secondary enzymolysis, blending, sterilizing, fermenting, freezing, drying and finally obtaining the enzyme of the jujube paste of the gold thread jujube with the water content of being less than 5%. The gold thread jujube enzyme prepared by the method contains rich protease, lipase, superoxide dismutase, amylase, vitamins, minerals and secondary metabolites such as phenols, flavonoids and the like, and as a novel food and cosmetic additive in the market, the gold thread jujube enzyme has a very wide application prospect.

The invention provides a method of stimulating hair growth, comprising administering a therapeutic amount of a hydrogel matrix to an intradermal or subdermal site where hair growth is desired, the matrix composition comprising gelatin, such as denatured collagen, and a long chain carbohydrate, such as dextran. The matrix may further include polar amino acids, nitric oxide inhibitors and super oxide inhibitors. Injection is a preferred method of administration.

The invention discloses an antioxidant peptide of hairtail fish protein as well as a preparation method and uses of the antioxidant peptide. In particular, hairtail fish is used as raw materials; an enzymatic hydrolysis solution is obtained through degreasing and enzymolysis of protamex and neutral protease; the enzymatic hydrolysis solution is separated and purified through ultra-filtration, purification of macroporous resins, cation exchange resin chromatography, gel column chromatography, and reversed-phase high-performance liquid chromatography so as to obtain the antioxidant peptide Asn-Trp-Asp-Met-Glu-Lys-Ile-Trp, and the ESI-MS determining molecular weight is 1121.25da. The high-activity antioxidant peptide disclosed by the invention has a good scavenging effect on DPPH free radicals, hydroxyl radicals and superoxide anion free radicals; besides, the antioxidant peptide shows a good effect of lipid peroxidation inhibition. The antioxidant peptide has the advantages of safe use, zero toxic or side effects, high oxidative activity and the like, is liable to digest and absorb, and can be used as medicines, health food or food additives, and the like.

The invention relates to Chinese traditional medicine biology crimple dispelling and skin delicating cosmetic and manufacturing method. It extracts natural amino acid, plant female incretion in angelica, notoginseng, kudzu root and raspberry and so on ten kinds of Chinese herbal medicines with current supercritical and supersonic extraction technology, adds in super oxide dismutase, collagen, transparent acid, natural vitamin E, transmits the effective component such as plant essence into corium with fat skin penetrating absorption technology, it can eliminates dissociated oxygen free radical, at the same time, it can supplement the collagen, plant female incretion and other nutriment for skin, reaches the balance between discharge and supplementation.

The invention discloses an extraction and an application of exopolysaccharide metabolite of a bacillus amyloliquefaciens C-1 strain. A 16s rRNA amplified fragment of the bacillus amyloliquefaciens C-1 strain is sequenced and compared with a 16s rRNA sequence of bacteria in a NCBI (national center of biotechnology information) database; a comparison result proves that the bacillus amyloliquefaciens C-1 strain belongs to B.amyloliquefaciens; and an NCBI register number of the 16s rRNA sequence of the bacillus amyloliquefaciens C-1 strain is JN974457. The bacillus amyloliquefaciens C-1 strain is collected in china center for type culture collection (CCTCC), has the effects of reducing exopolysaccharide, removing DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radical, scavenging hydroxyl free radical (.OH), scavenging superoxide anion (O<2->), inhibiting lipid peroxidation and inhibiting human tumor cell proliferation, and opens up a new way and a new research field for exploring anti-tumor drugs.

The invention discloses a sustained oxygen release fertilizer which adopts a mixture comprising calcium superoxide, sodium bentonite and polyvinyl formal. The mass ratio of sodium bentonite to calcium superoxide is 12 to 5, and the mass of the polyvinyl formal is 15 percent of the gross mass of the sustained oxygen release. The sustained oxygen release fertilizer discusses the oxygen release feature and the pH value variation in the condition of aqueous medium. Experimental results show that compared with applying calcium superoxide powder only, the sustained oxygen release fertilizer has the characteristics that the fertilizer effect period is long, the applying method is simple, the production technology is simple, the source of material selected is wide, the material is environmentally friendly, and the sustained oxygen release fertilizer can be widely applied.

Charged fine particulate water is provided, which has a nanometer particle size, for example, a particle size of 3 to 100 nm, and contains radicals such as hydroxyl radicals and superoxides. This charged fine particulate water can be generated by applying an electric-field intensity of 700 to 1200 V / mm between a pair of electrodes, while supplying water between the electrodes. By allowing the thus obtained charged fine particulate water to diffuse into an indoor space, it is possible to effectively remove bad odor components / bacteria from the indoor space.

This invention provides modified biopolymers comprising biopolymers attached to at least one non-proteinaceous catalyst capable of dismutating superoxide in the biological system or precursor ligand thereof. The invention further provides pharmaceutical compositions comprising the modified biopolymer and therapeutic methods comprising administering the modified biopolymer to a subject in need thereof.