78 results about "In vivo analysis" patented technology

This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.

A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.

A system for in vivo analysis which includes agglutinative particles capable of interacting with at least one analyte so as to cause an optical change; and at least one in vivo imaging system (220, 230, 240) configured for detecting the optical change in vivo. The system may be incorporated within an ingestible capsule (100).

The invention is related to the instrument for measuring a Raman signal of tissue, the instrument comprising a laser, a signal detection unit for measuring the Raman signal, and a fiber optic probe, wherein the fiber optic probe comprises one or more optical fibers for directing laser light onto the tissue and for collecting light that is scattered by the tissue and guiding the collected light away from the tissue towards the signal detection unit, wherein the fiber or fibers for collecting light have substantially no Raman signal in one or more parts of the 2500-3700 cm⁻¹ spectral region, and wherein the detection unit records the Raman signal scattered by the tissue in said spectral region. The invention enables ex vivo, in vitro and in vivo analysis and diagnosis of atherosclerotic plaque and detection of tumor tissue with great advantages over current state-of-the-art technology.

The invention discloses a laser-induce self-assembly method for preparing a high-sensitivity optical fiber SERS probe. The method comprises the steps of conducting fusion welding on one end of an optical fiber and an output tail fiber of a laser device, and inserting the other end of the optical fiber into precious metal nano-particle sol; slowly lifting the optical fiber from the sol to be higher than the liquid level by a certain height by means of a one-dimensional precise displacement platform, so that a specific meniscus structure is formed; switching on a laser light source to enable precious metal nano-particles at the position of the meniscus to be self-assembled at the end face of the optical fiber under laser radiation, so that the optical fiber SERS probe is formed. The laser-induce self-assembly method has the advantages of being low in cost, easy to operate, short in preparation cycle, high in preparation repeatability and the like. The prepared optical fiber SERS probe has high detection sensitivity and high spectrum repeatability and has important application prospects in remote/field detection of environment pollutants, in-vivo analysis in biomedicine, real-time detection of chemical reaction process and other fields.

Devices, systems and method for in vivo analysis. For example, an in vivo device includes: a reaction chamber to store a detecting reagent able to react with a sample collected in vivo; and optionally a labeled-substance chamber to store a labeled substance able to bind to at least a portion of a compound resulting from a reaction of the detecting reagent and the sample.

A method for detecting the presence of a substance such as an antigen, the method including the steps of: maintaining a signaling material at a first pH within a liposome; contacting the liposome with a sample having a second pH such that if the substance is present in the sample the liposome will rupture thereby exposing the signaling material to the second pH; and detecting a change in an optical property, such as color, of the signaling material, the change caused by the exposure to the second pH.

The present invention generally relates to processes, computer programs and systems, methods of making such and methods of using such for improving the determination of one or more digestive effects upon an ingestable substance. The underlying data used in this determination may originate from either an in vitro or in vivo analysis. The processes may be either partially or fully manual or automated, and combinations thereof.