1710 results about "Senile dementia" patented technology

The present invention relates to extraction process of total tanshin phenolic acid, the preparation process and application of its preparation. The total tanshin phenolic acid and its preparation mayuse in preparing medicine for preventing and treating cardiac and cerebral vascular diseases, senile dementia and hypomnesia caused by cerebral ischemia. The total tanshin phonelic acid prepared based on the process of the present invention has rich active components of tanshin and obvious pharmacological effect, stable performance and les stoxicity and is safety and reliable.

This invention is directed to compounds of the following formula:wherein when a is 0, b is 1 or 2; when a is 1, b is 1, m is from 0-3, X is 0 or S, Y is halogeno, R1 is hydrogen C1-4 alkyl, R2 is hydrogen, C1-4 alkyl, or optionally substituted propargyl and R1 and R4 are each independently hydrogen, C1-6 alkyl, C6-12 aryl, C6-12 aralkyl each optionally substituted.This invention is also directed to the use of these compounds for treating depression, Attention Deficit Disorder (ADD), Attention Deficit and Hyperactivity Disorder (ADHD), Tourette's Syndrome. Alzheimer's Disease and other dementia's such as senile dementia, dementia of the Parkinson's type, vascular dementia and Lewy body dementia.This invention is further directed to a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

A method of treating a neurological disorder comprises administering to a person affected from such a disorder a microbial oil comprising DHA, a microbial oil comprising ARA or a combination of DHA and ARA oils in an amount sufficient to elevate the levels of circulating DHA and / or ARA in the person's blood to at least normal levels.

A dispersing oxiracetam tablet for preventing senile dementia and treating hypomnesia is prepared from oxiracetam, disintegrant,lubricant, flowing aid and adhesive through proportionally and sequentially mixing, granulating, baking and tabletting. Its advantage is high curative effect.

Methods and compositions for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a preferred embodiment the administration of triglycerides or fatty acids with chain lengths between 5 and 12, to said patient at a level to produce an improvement in cognitive ability.

The tubiflorous desert cistanche preparation containing phenethyl alcohol glycoside contains echinacoside in 10-70 wt% and acteoside in 1-40 wt%. The preparation of the present invention may be applied as active component for preparing medicine treating and preventing senile dementia and for preparing medicine inhibiting platelet aggregation.

The present invention belongs to the technological field of food production. DHA and EPA, named cerebral gold, are long-chain unsaturated fatty acids essential for human body and has the health functions of nourishing brain, promoting intelligence growth, preventing arteriosclerosis, preventing senile dementia, lowering blood fat, regulating immunity, etc. The technological process of preparing the fish oil DHA powder includes dispersing fined fish oil in water solution of capsule material to complete the first embedding, the second embedding with natural polymer material, such as easy-to-dissolve Arabic gum and corn dextrin, as ideal carrier material. The product has DHA content over 15%, and high stability in hot water, and may be used in milk product, food heatlh article, medicine, feed, additive, etc.

The invention discloses an image-based early diagnosis system for senile dementia. The early diagnosis system comprises a brain image collector (1) and a memorizer (2) and is characterized by comprising image preprocessing equipment (3), an image asymmetry characteristic extraction device (4), a consolidator (5), a characteristic vector selector (6), an optimization classifier (7) and an output device. The early diagnosis system has the remarkable effect of being capable of obviously improving the accuracy of early diagnosis of the senile dementia when being applied to the early diagnosis of the senile dementia. The early diagnosis system not only can be used for realizing the clinical application of sequential asymmetry characteristics of anatomical structures in the brain MR (Magnetic Resonance) images in the early diagnosis of the senile dementia, but also is high in diagnosis accuracy and real-time performance.

Compounds shown by the above formula or salt thereof show a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases and heart diseases (e.g. hypercardia, heart failure, cardiac infarction), strokes, cerebral apoplexy, nephritis, atherosclerosis, Alzheimer's disease, senile dementia, etc.

The invention relates to a prescription and a preparation method of rejoicing powder having a new dosage form and used for preventing or treating the senile dementia, and belongs to the biological medicine field. The rejoicing powder having a new dosage form is based on rejoicing powder having an ancient classic prescription and treats Radix Polygalae, Acorus gramineus and the like as primary medicines, the primary medicines are pretreated, partial or all medicines are extracted with water or an organic solvent in necessity to obtain effective components, the primary medicines or the effective components are mixed with proper medicinal auxiliary materials, and the rejoicing powder having the new dosage form is prepared through a certain preparation technology. The traditional prescription and the traditional technology for preparing the powder through simply crushing all medicines are changed in the invention, a new method and a new technology are applied against modern clinic medicine use characteristics to prepare the novel powder, and technological products have the characteristics of safety, effectiveness, controllable quality, convenient taking and the like of modern medicines, have the advantages of high biological utilization degrees of the effective components, fast effectiveness, substantial improvement of the product quality, and effective guarantee of the basic efficacies comprising qi benefiting, heart nourishing, nerve calming and tranquilizing, and have unique clinic application values in the prevention and the treatment of the senile dementia.

Methods and composition for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a preferred embodiment the administration of novel esterified saccharide compounds to said patient at a level to produce an improvement in cognitive ability.

The invention relates to a pyrro-quinoline quinine (PQQ) sodium salt derivative and a preparation method thereof, belonging to the field of pharmacy. In the preparation method, PQQ is used as a raw material, and an acid-base neutralization reaction with PQQ is carried out in a basic solvent of sodium hydroxide to prepare the PQQ sodium salt derivative represented in the structural formula (I), wherein R1, R2 and R3 can be identical or different and respectively represents H, ammonium ion (NH3), potassium ion, sodium ion, magnesium ion, calcium ion or zinc ion, and at least one of R1, R2 and R3 is sodium ion. The invention has mild reaction conditions, easy product refining and purification, simple preparation steps and high yield more than 80%. The PQQ sodium salt derivative has the functions of inhibiting GSK-3 activity, reducing senile pigment formation in a transgenic mouse brain, reducing tau protein phosphorylation and the like. Thus, the PQQ sodium salt derivative can be medically used for treating senile dementia and other diseases.

The invention belongs to the technical field of bioscience and medical science health-care foods and relates to a formula and preparation method of a ginseng health-care cake containing eight delicacies. The ginseng health-care cake containing eight delicacies is obtained by formulating and processing Chinese medicines including ginseng, coix seeds, hindu lotus lumule, gordon euryale seeds, Chinese yam, tuckahoe, atractylis ovata, semen lablab album and the like together with food rice powder (or glutinous rice flour or flour), white sugar (or gooey or xylitan), osmanthus and the like by using a biotechnology, medical science theory and a health-care food formula preparing technology, is rich in nutrition, has the effects of resolving phlegm, detoxicating, destroying intestinal worms, clearing liver, improving vision, reinforcing the spleen, arresting diarrhea, enriching skin, polishing, effectively improving blood circulation of blood vessels of the brain and peripheral vessels, treating arteriosclerosis, hypertension, diabetes and senile dementia, lowering serum and cholesterin, resisting ageing, nodule and fungi, preventing the growth and the diffusion of cancer cells, invigorating the brain, strengthening the body, keeping fit, beatifying and preventing and treating diseases, and is a safe, nutritional and healthy food for people to eat.

The invention provides an Oxiracetam compound and a new method thereof. The method comprises the following steps: firstly dissolving Oxiracetam in water, carrying out adsorption and purification with activated carbon, precipitating with an organic solvent, separating and purifying with a chromatographic column, and finally carrying out crystallization with an organic solvent, thus the high purity Oxiracetam compound is obtained. The purity of the final product is greatly improved compared with the existing product, the quality of preparation is improved, the toxic and side effects are reduced, and the safety in the application of preparing a drug used for treating senile dementia is ensured; and meanwhile, compared with the prior art, the process in the invention is simple and feasible, the reaction conditions are mild, the cost is low, the yield is high, and the product purity is high, thus being applicable to industrialized production.

The invention relates to tanshinone derivatives represented by a general formula (I), wherein the tanshinone derivatives are substituted by different groups on A ring, B ring, C ring, and D ring. The invention also relates to medicine compositions with the derivatives as active components, preparation methods of the medicines, and applications thereof in preparing a 1-type 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) inhibiting agent. The invention also provides applications of the compounds represented by the general formula (I) in preparations of medicines used for treating diabetes and related metabolic diseases (such as hypertension, obesity, senile dementia, and the like).

The invention discloses a senile dementia monitoring system based on a mobile internet. The senile dementia monitoring system based on the mobile internet comprises an intelligent terminal, a cloud server and a brain electrical monitoring device, wherein the electrical brain monitoring device is used for acquiring brain electrical information of senile dementia patients or healthy people in real time, and sending the brain electrical information to the intelligent terminal; the intelligent terminal is used for receiving the brain electrical information, completing cognitive-psychological assessment, inputting clinic information, and uploading the brain electrical information, the cognitive-psychological assessment and the clinic information to the cloud server through the mobile internet; the cloud server is used for receiving MRI (Magnetic Resonance Imaging) image information uploaded by hospitals and information uploaded by the intelligent terminal so as to complete auxiliary diagnosis and generate corresponding nursing instruction suggestions, and then feeding auxiliary diagnosis results and the nursing instruction suggestions back to the intelligent terminal. According to the senile dementia monitoring system based on the mobile internet, the mobile internet technology is utilized, the automatic auxiliary diagnosis of senile dementia can be realized, the accuracy of the diagnosis is improved, and the prevention and the early detection of the senile dementia can be realized favorably.

The body of a herbaceous plant, Cistanche tubulosa (Schenk.) Wight, is used to make a medicinal preparation containing phenylethanoid glycosides and comprising 10–70% of echinacoside by weight of the preparation and 1–40% of acteoside by weight of the preparation. The medicinal preparation is used as an active ingredient of medicinal composition for use in prevention of senile dementia, and inhibition of aggregation of blood platelets.

The invention discloses a medicine combination for treating senile dementia; the invention are prepared with ten traditional Chinese medicines of manyprickle acanto-panax root, epimedium herb, white peony root, angelica, RhizomaChuanxiong, largehead atractylodes rhizome, oriental waterplantain rhizome, roasted thinleaf milkwort root-bark, poria cocos and grassleaf sweelflag rhizome. The medicine combination of the invention has functions of reinforcing the kidney to strengthen the spleen, nourishing blood to soothe the liver and being benefit for brain, and is used for treating senile dementia. The invention has the advantages of good healing effect, no toxic and side effect, suitable for long-term use, convenient to obtain raw materials, low cost, simple production art and wide application value.

Methods and compositions for treating or preventing, the occurrence of senile dementia of the Alzheimer's type, or other conditions arising from reduced neuronal metabolism and leading to lessened cognitive function are described. In a preferred embodiment the administration of triglycerides or fatty acids with chain lengths between 5 and 12, to said patient at a level to produce an improvement in cognitive ability.

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described.

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and / or premature ejaculation are described.

The invention discloses a traditional Chinese medicinal composition preparation for preventing and treating senile dementia and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The preparation is prepared from ginseng, Chinese angelica, polygala tenuifolia, rhizoma acori graminei, radix curcumae, poria, ligusticum wallichii and other traditional Chinese herbal medicines in a certain ratio, can be mixed with pharmaceutically suitable vectors to prepare various preparations according to a specific process. The invention also provides a preparation of the industrially applicable preparation. The preparation has functions of nourishing yin and tonifying kidney, strengthening spleen and qi, activating blood circulation to remove stasis, and can be used in treatment of senile dementia and syndrome of yin deficiency of spleen and kidney.

The invention relates to a 7 and 20 dehydro-silybin dialky ether and preparation method and medicine use thereof. The compounds are capable of obviously preventing the lipid superoxide induced by the free radical from being generated; effectively protecting the injury rat adrenal pheochromocytoma cells PC12 due to hydrogen dioxide, namely with oxidation resistance injury protection function on thePC12 cells which simulate the cranial nerves; preventing the brain cells and the cranial nerves from being oxidized and controlling the neurodegenerative diseases such as senile dementia. In addition, the compounds have strong chelation on the ferrous ion. The pharmacodynamics result shows that: the compounds are anticipated to prepare the medicine for controlling the neurodegenerative diseases.

The disclosed antibody special for beta-amyloid polypeptide has amino acid sequence and the coded nucleotide sequence shown as SEQ ID No.2 and SEQ ID No.1 respectively, and can be used to prepare drug to cure or prevent senile dementia.

The present invention relates to American goldenrod herb total flavone extract and its preparation process and use. The American goldenrod herb total flavone extract contains quercetin, quercetin-3-O-beta-D-heteroside, kaempferol-3-O-alpha-L-rhamnoside, chlorogenic acid, etc. capable of preventing and treating senile dementia, various inflammatory respiratory diseases, esophagus cancer, etc. The preparation process is simple, high extracting rate, and the extract has high pharmacological effect, stable property, low toxicity and controllable quality.

The present invention relates to Tau protein relative polypeptide antigen and antibody. The specific polypeptide antigen of the present invention has the amino acid sequence of SEQ ID No. 1, and corresponding polyclonal or monoclonal antibody may be obtained in available method. The antibody of the present invention may be prepared into kit for detecting and diagnosing senile dementia.

The invention relates to edible nutrition oil with an intelligence developing effect. The edible oil adopts plant grease as main raw materials, and is added with DHA algal oil, arachidonic acid grease and natural antioxidant, wherein the content of DHA is 0.01-0.5 percent of the weight of the edible nutrition oil, the content of arachidonic acid is 0.015-0.75 percent of the weight of the edible nutrition oil, and the content of the natural antioxidant is 0.01-0.3 percent of the weight of the edible nutrition oil. The fatty acid proportion of the nutrition oil is reasonable, the added DHA and the added arachidonic acid have the effects of brain building and intelligence developing, promoting the growth of the retina of a baby, and the like. The natural antioxidant is soybean vitamin E with the physiological activity being higher than that of synthetic vitamin E, and the oil can be ate more safely. The edible oil is balanced in nutrition, is high-end nutrition food healthy for all people, is particularly suitable for daily eating by pregnant woman, infants, children and middle-aged and elderly people, promotes the intelligence development of fetus and infants, eliminates the brain fatigue of young and middle-aged people, and prevents senile dementia of aged and elderly people.

The invention discloses a method for monitoring beta amyloid protein aggregation process by aggregation-induced emission, belonging to the technical field of biomedical research and clinical detection. With the method, the high affinity between sulfydryl on cysteine and maleimide is utilized to specially combine the beta amyloid protein on an aggregation-induced emission probe. The beta amyloid protein aggregation process is monitored on the basis of aggregation-induced emission enhancement phenomenon. The method has the advantages of high sensitivity, high selectivity, good stability, low manufacture cost and the like and is easy to control. The A beta42 and A beta40 contents can be monitored in a micromole, even a nano-mole level, the detection speed of the method is improved by 15 times if being compared with that of the detection method which utilizes probes, such as ANS (8-aniline-1-naphthalene sulfonic acid) and the like. The beta amyloid protein aggregation process can be qualitatively and quantitatively monitored, the method has a good application prospect if being applied to the pathologic diagnosis of latent patients suffering from senile dementia.

The invention relates to Isopentenyl-oxyl substituted dehydrogenized silybin ether and the preparation method and the application thereof. The compound has the activity of eliminating extracorporeal extracorporeal 1-diphenyl-2-picrylhydrazyl radical, the activity of obviously inhibiting the generation of lipid peroxide induced by radical and the function of powerfully preventing the damage of therat adrenal pheochromocytoma PC12 cells due to the hydrogen peroxide, i.e. the function of preventing the oxidative damage of the PC12 cells simulating the brain nerve cells, thereby playing a positive role in preventing the brain cell tissue oxidation and brain never oxidation and preventing and treating the senile dementia and other neurodegenerative diseases. The pharmacodynamic result shows that 7-site substituted dehydrogenized silybin ether can be expectantly used for preparing the medicament for preventing and treating the neurodegenerative diseases.