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Tubiflorous desert cistanche prepn containing phenethyl alcohol glycoside and its prepn process and use

A technology of Cistanche pipiensis and phenylethanoid glycosides is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., and can solve the problems of complex pathogenic mechanism and no drugs yet found.

Inactive Publication Date: 2004-09-08
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the increasing aging of the world's population, many diseases related to aging, such as Alzheimer's disease, have become factors that seriously threaten the health of the elderly in today's society. Due to the complex pathogenic mechanism, no significant curative effect has been found for this disease. medicine

Method used

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  • Tubiflorous desert cistanche prepn containing phenethyl alcohol glycoside and its prepn process and use
  • Tubiflorous desert cistanche prepn containing phenethyl alcohol glycoside and its prepn process and use
  • Tubiflorous desert cistanche prepn containing phenethyl alcohol glycoside and its prepn process and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Cistanche tuberosum 10kg, cut into decoction pieces, add 8 times the amount of water to soak for 1 hour, decoct and extract for 2 hours, filter, and use the filtrate for later use. The dregs are added with 6 times the amount of water, decocted and extracted twice, each time for 1 hour, and filtered. Combine the three filtrates, concentrate under reduced pressure to a specific gravity of 1.10 (50°C), add ethanol until the alcohol content reaches 60%, refrigerate for 12 hours, pour out the supernatant, filter the remaining suspension, combine the supernatant and filtrate, The ethanol was recovered and concentrated under reduced pressure to a specific gravity of 1.10 (50° C.) to obtain 5.6 kg of extract.

Embodiment 2

[0064] Cistanche tuberosum 10kg, crushed into powder, soaked in 15 times the amount of water for 2 hours, decocted and extracted for 3 hours, filtered, and the filtrate was used for later use. Add 12 times the amount of water to the dregs, decoct and extract 4 times, 2 hours each time, and filter. Combine the filtrates, concentrate under reduced pressure to a specific gravity of 1.25 (50°C), add ethanol until the alcohol content reaches 80%, refrigerate for 24 hours, pour out the supernatant, filter the remaining suspension, combine the supernatant and filtrate, and recover Ethanol was concentrated under reduced pressure to a specific gravity of 1.25 (50°C) to obtain 7.2 kg of extract.

Embodiment 3

[0066] Cistanche tuberosum 10kg, cut into decoction pieces, add 7 times the amount of water to soak for 3 hours, decoct and extract for 4 hours, filter, and use the filtrate for later use. Add 5 times the amount of water to the dregs, decoct and extract 4 times, 4 hours each time, and filter. Combine the filtrates, concentrate under reduced pressure to a specific gravity of 1.05 (50°C), add 100% ethanol until the alcohol content reaches 50%, refrigerate for 10 hours, pour out the supernatant, filter the remaining suspension, and combine the supernatant and filtrate , recovered ethanol and concentrated under reduced pressure to a specific gravity of 1.10 (50°C), to obtain 6.5kg of extract.

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Abstract

The tubiflorous desert cistanche preparation containing phenethyl alcohol glycoside contains echinacoside in 10-70 wt% and acteoside in 1-40 wt%. The preparation of the present invention may be applied as active component for preparing medicine treating and preventing senile dementia and for preparing medicine inhibiting platelet aggregation.

Description

Technical field: [0001] The invention relates to a preparation containing phenylethanol glycoside derived from plants of the genus Cistanche and its preparation method, and its application in anti-senile dementia and inhibition of platelet aggregation. Background technique [0002] With the increasing aging of the world's population, many diseases related to aging, such as Alzheimer's disease, have become factors that seriously threaten the health of the elderly in today's society. Due to the complex pathogenic mechanism, no significant curative effect has been found for this disease. medicine. Cistanche has long been used clinically as a traditional kidney-tonifying, yang-strengthening, and essence-strengthening medicine, so it has become the subject of in-depth research. The traditional Chinese medicine Cistanche Herba Cistanche is a perennial parasitic herb belonging to the family Cistanche. It is mainly produced in the northwestern provinces of Chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61P7/02A61P25/28
Inventor 屠鹏飞宋志宏雷丽
Owner JIANGSU KANION PHARMA CO LTD
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