4990results about How to "Reduce mortality" patented technology

Surgical method and apparatus for resectioning tissue, preferably lumenal tissue, with a remaining portion of an organ being anastomized with staples or other fastening devices, preferably endolumenally. The apparatus may be inserted via a naturally occurring body orifice or a surgical incision and then advanced using either endoscopic or radiological imaging guidance to an area where surgery is to be performed. Under endoscopic or diagnostic imaging guidance the apparatus is positioned so tissue to be resected is manipulated into an inner cavity of the apparatus. The apparatus then cuts the diseased tissue after stapling and retains the diseased tissue within the apparatus. The rent resulting in a border of healthy tissue is anastomosed with surgical staples.

A system for accessing a patient's cardiac anatomy which includes an endovascular aortic partitioning device that separates the coronary arteries and the heart from the rest of the patient's arterial system. The endovascular device for partitioning a patient's ascending aorta comprises a flexible shaft having a distal end, a proximal end, and a first inner lumen therebetween with an opening at the distal end. The shaft may have a preshaped distal portion with a curvature generally corresponding to the curvature of the patient's aortic arch. An expandable means, e.g. a balloon, is disposed near the distal end of the shaft proximal to the opening in the first inner lumen for occluding the ascending aorta so as to block substantially all blood flow therethrough for a plurality of cardiac cycles, while the patient is supported by cardiopulmonary bypass. The endovascular aortic partitioning device may be coupled to an arterial bypass cannula for delivering oxygenated blood to the patient's arterial system. The heart muscle or myocardium is paralyzed by the retrograde delivery of a cardioplegic fluid to the myocardium through patient's coronary sinus and coronary veins, or by antegrade delivery of cardioplegic fluid through a lumen in the endovascular aortic partitioning device to infuse cardioplegic fluid into the coronary arteries. The pulmonary trunk may be vented by withdrawing liquid from the trunk through an inner lumen of an elongated catheter. The cardiac accessing system is particularly suitable for removing the aortic valve and replacing the removed valve with a prosthetic valve.

The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic virus for packaging and transport. The invention delivers therapeutic viral vectors via rAAV affixed to support matrixes (i.e., sutures, surgically implantable materials, grafts, and the like).

An endoscopic staple and related stapling device that can be used in conjunction with flexible or rigid endoscopy. The staple can also be used for other surgical procedures. The invention relates to performing a stapling operation on internal body tissues as part of a surgical procedure, diagnostic procedure or therapeutic procedure. This invention includes a surgical staple, an associated staple holder, and an associated staple delivery and deployment device. The staple holder and delivery system have a design iteration whereby the holder can be reloaded with additional staples to be used on the same patient. There is another design iteration whereby the staple holder and stapler are reusable after appropriate cleaning and sterilization.

A real-time body status monitoring system (RBMS) is presented in this invention. A wearable monitoring apparatus (WMA) worn by users consists of one or a few sensor nodes and a computing module. Sensor nodes communicate with the computing module via either wired or wireless protocols. RBMS incorporates a monitoring center that connects and serves many WMAs. Together with the sensors and context-aware information fusion and analysis, the system in the invention goes beyond sampling rare events that may be of profound diagnostic, prognostic, or therapeutic importance. It measures the physiological responses to therapeutic interventions during daily activities, which constitute direct and practical health indicators for the patient.

An endoscopic staple and related stapling device that can be used in conjunction with flexible or rigid endoscopy. The staple can also be used for other surgical procedures. The invention relates to performing a stapling operation on internal body tissues as part of a surgical procedure, diagnostic procedure or therapeutic procedure. This invention includes a surgical staple, an associated staple holder, and an associated staple delivery and deployment device. The staple holder and delivery system have a design iteration whereby the holder can be reloaded with additional staples to be used on the same patient. There is another design iteration whereby the staple holder and stapler are reusable after appropriate cleaning and sterilization.

A system and method for displaying a health status of hospitalized patients. Patient data associated with hospitalized patients is selected according to display rules. A display module selects selected patient data, applies display rules to the selected patient data, and displays the selected patient data. A smart alert module generates and applies patient specific rules to other selected patient data elements. If a patient-specific rule for a hospitalized patient has been contravened, an alert is issued from the remote command center. Graphical attributes may be assigned to patients for whom an alert has been issued and to selected patient data elements that fall outside of an acceptable range. The graphical attributes determine how selected patient data appear on a display screen.

A resuscitation system for use by a rescuer for resuscitating a patient, comprising at least two high-voltage defibrillation electrodes, a first electrical unit comprising circuitry for providing resuscitation prompts to the rescuer, a second electrical unit separate from the first unit and comprising circuitry for providing defibrillation pulses to the electrodes, and circuitry for providing at least one electrical connection between the first and second units. In another aspect, at least two electrical therapy electrodes adapted to be worn by the patient for extended periods of time, circuitry for monitoring the ECG of the patient, an activity sensor adapted to be worn by the patient and capable of providing an output from which the patient's current activity can be estimated, and at least one processor configured for estimating the patient's current activity by analyzing the output of the activity sensor, analyzing the ECG of the patient, and determining whether electrical therapy should be delivered to the electrodes.

A system and method for observing patients in geographically dispersed health care locations. A patient is assigned to a health care location comprising a patient visual monitoring system, a patient audio receiver, and a patient controller. The visual monitoring system is responsive tri-axially to command signals received via a patient controller connected to the network. The patient controller sends patient imaging data and patient audio data to a remote command center via the network. A computerized patient care management system comprising the remote command center monitors patient data, patient imaging data, and patient audio data determines from the patient data, the patient imaging data, and the patient audio data if intervention with the selected patient is warranted.

A method and apparatus for performing coronary artery bypass surgery establishes a channel leading directly from a chamber of a heart into a coronary artery. The coronary artery bypass procedure may be performed with or without cardiopulmonary bypass.

Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.

An implantable sensor array incorporates active electronic elements to greatly increase the number of sensors and their density that can be simultaneously recorded and activated. The sensors can be of various configurations and types, for example: optical, chemical, temperature, pressure or other sensors including effectors for applying signals to surrounding tissues. The sensors / effectors are arranged on a flexible and stretchable substrate with incorporated active components that allow the effective size, configuration, number and pattern of sensors / effectors to be dynamically changed, as needed, through a wired or wireless means of communication. Active processing allows many channels to be combined either through analog or digital means such that the number of wires exiting the array can be substantially reduced compared to the number of sensors / effectors on the array.

A patient-worn monitoring system and method for geographically dispersed health care locations. A patient-worn monitoring system comprises a network, a body-worn monitoring station, a monitoring station server, a remote command center, and a rules engine. The network comprises a first sub-network and a second sub-network. The body-worn monitoring station comprises monitoring equipment. The body worn monitoring station monitors data elements from a patient assigned to a health care location and sends monitored data elements to a monitoring station server via the first sub-network. The monitoring station server receives the monitored data elements from the body worn monitoring station and relays the monitored data elements to the remote command center via the second sub-network. The remote command center receives the monitored data elements from the monitoring station server, associates the monitored data elements with the patient assigned to the health care location, accesses patient data elements indicative of a medical condition associated with the patient, and establishes a patient-specific rule associated with the patient. The rules engine selects data elements from the monitored data elements and the patient data elements associated with the patient and applies the patient-specific rule to the selected data elements continuously and simultaneously. A determination is made whether the patient-specific rule for the patient has been contravened. An alert is issued from the remote command center in the event the patient-specific rule for the patient has been contravened.

A method and apparatus for performing coronary artery bypass surgery establishes a channel leading directly from a chamber of a heart into a coronary artery. The coronary artery bypass procedure may be performed with or without cardiopulmonary bypass.

The present invention involves a blood pump having a pump housing with an internally disposed rotor that collectively provide a dual inflow capability which prevents thrombus formation and reduces hemolysis during use.

A method and apparatus for performing coronary artery bypass surgery establishes a channel leading directly from a chamber of a heart into a coronary artery. The coronary artery bypass procedure may be performed with or without cardiopulmonary bypass.

A video visitation system and method for dispersed health care locations. A patient data server, a teleconferencing server, a patient visual monitoring system and a visitor visual monitoring system are connected to a network. A patient data server receives patient data indicative of the condition of a patient and serves the patient data continuously and in real time to the teleconferencing server. The patient visual monitoring system acquires patient imaging data from a patient location and conveys the patient imaging data to the teleconferencing server. The visitor visual monitoring system acquires visitor imaging data from a visitor location and conveys the visitor imaging data to the teleconferencing server. The patient visual monitoring system displays the visitor imaging data and the visitor visual monitoring system simultaneously displays patient imaging data and the continuous real time feed of the patient data.

A resuscitation system for use by a rescuer for resuscitating a patient, comprising at least two high-voltage defibrillation electrodes, a first electrical unit comprising circuitry for providing resuscitation prompts to the rescuer, a second electrical unit separate from the first unit and comprising circuitry for providing defibrillation pulses to the electrodes, and circuitry for providing at least one electrical connection between the first and second units. In another aspect, at least two electrical therapy electrodes adapted to be worn by the patient for extended periods of time, circuitry for monitoring the ECG of the patient, an activity sensor adapted to be worn by the patient and capable of providing an output from which the patient's current activity can be estimated, and at least one processor configured for estimating the patient's current activity by analyzing the output of the activity sensor, analyzing the ECG of the patient, and determining whether electrical therapy should be delivered to the electrodes.

A system and method for displaying a health status of hospitalized patients. Patient data associated with hospitalized patients is selected according to display rules. A display module selects selected patient data, applies display rules to the selected patient data, and displays the selected patient data. A smart alert module generates and applies patient specific rules to other selected patient data elements. If a patient-specific rule for a hospitalized patient has been contravened, an alert is issued from the remote command center. Graphical attributes may be assigned to patients for whom an alert has been issued and to selected patient data elements that fall outside of an acceptable range. The graphical attributes determine how selected patient data appear on a display screen.

An apparatus for electrocardiogram measurement including a first non-conductive pad. A first and second electrode are disposed on the first non-conductive pad. The first electrode represents any one of V4, V5, or V6 and the second electrode is either (i) positioned on the subject below the first electrode in order to represent left leg (LL) or (ii) is placed on a line on the subject defined by the V4, V5, and V6 precordial positions in order to represent any one of V4, V5, or V6 not represented by the first electrode. The apparatus includes a second non-conductive pad. A third electrode is disposed on the second non-conductive pad. The third electrode is a right arm (RA) electrode that is for positioning at a position that is on or close to the right arm of the subject. Each electrode is adapted for electrical connection with the skin in order to receive and transmit electrical impulses. The apparatus further includes an electrical connection that connects each electrode disposed on the first and second non-conductive pads to an electrocardiological measuring apparatus. The electrocardiological measuring apparatus is capable of measuring a first lead and a different second lead without user intervention.

A system and method for observing patients in geographically dispersed health care locations. A portable monitoring station is associated with a patient assigned to a health care location. The portable monitoring station comprises monitoring equipment that monitors physiological measures of the patient. A remote command center receives the monitored data elements, accesses patient data elements indicative of a medical condition associated with the patient, and applies a patient-specific rule to selected data elements to determine whether the patient-specific rule has been contravened. The monitored equipment may further comprise video and audio equipment that captures patient video data and patient audio data and provides these data to the central command center.

The present invention provides compositions, methods, and kits for treating or preventing a viral infection (e.g., an infection caused by an influenza virus).

The invention relates to a buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce said biologically active molecules into the cells using an electric current and to a method for introducing biologically active molecules into animal or human cells using an electric current and a buffer solution. The inventive buffer solution has a buffering capacity of at least 20 mmol*I−1*pH−1 and an ionic strength of at least 200 mmol*I−1 during a change to the pH value from pH 7 to pH 8 and at a temperature of 25° C. The use of a buffer solution of this type in the corresponding method allows biologically active molecules to be introduced into animal and human cells with a high degree of transfection efficiency and at the same time a low cell mortality. Different cell types, in particular dormant and actively dividing cells of low activity, can be successfully transfected in said buffer solution.

Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (Ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose IL-2 therapy using angiopoietin-2 antagonist compounds. Methods for diagnosing and monitoring vascular leak disorders, hypotension, or a procoagulant state that include the measurement of Ang-2 polypeptide or nucleic acid levels are also disclosed. Methods for inducing a vascular leak using an Ang-2 agonist are also disclosed.

The invention discloses an ecological scale breeding method of green shell egg laying hens. The method mainly includes the following steps: (1) selecting breeding hens; (2) stocking in a rotational grazing mode in woodland and meadow; (3) selecting hatching eggs; (4) incubating the hatching eggs with an incubator; (5) managing broods of the green shell egg laying hens; (6) managing feeding of the green shell egg laying hens; and (7) preventing epidemic diseases of the green shell egg laying hens. The method is strong in systematicness, changes traditional breeding technology of the green shell egg laying hens, combines with effective breeding measures, improves quality of the breeding hens and the hatching eggs and production capacity of the green shell egg laying hens, increases egg weight and egg yield, and lowers morbidity and mortality rates of the green shell egg laying hens.

A method for treating or preventing spontaneous preterm birth in pregnant women and improving neonatal morbidity and mortality. The method includes administering to a pregnant woman in need thereof an effective amount of progesterone sufficient to prolong gestation by minimizing the shortening or effacing of her cervix. Treatment and prophylaxis with progesterone in pregnant women having symptoms of short cervix has been clinically shown to increase neonatal health.

An apparatus for vascular access devices such as syringes and guidewires placement devices capable of differentiating type of blood vessel penetrated by a cannula, including a chamber in flow communication with the cannula, the chamber being adapted to house a vacuum pressure to accelerate backflow of blood from a blood vessel penetrated by the cannula and a slideable, displaceable member within the chamber, such as a piston, displaceable against a calibrated pressure sensitive resilient member such as a spring. The displaceable member is displaced against the pressure sensitive spring rearwardly by the blood pressure indicating to the operator the type of blood vessel penetrated by the cannula by the amount of rearward displacement of the piston in respect to a point reference tab located on the side wall of the chamber.