Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

1536results about How to "Prevent relapse" patented technology

Humanization of antibodies

InactiveUS20050042664A1Limited diversityFast and less labor intensive productionHybrid immunoglobulinsMicrobiological testing/measurementAntigen bindingHumanized antibody
The present invention provides methods of re-engineering or re-shaping an antibody from a first species, wherein the re-engineered or re-shaped antibody does not elicit undesired immune response in a second species, and the re-engineered or re-shaped antibody retains substantially the same antigen binding-ability of the antibody from the first species. In accordance with the present invention, a combinatorial library comprising the CDRs of the antibody from the first species fused in frame with framework regions derived from a second species can be constructed and screened for the desired modified antibody. In particular, the present invention provides methods utilizing low homology acceptor antibody frameworks for efficiently humanizing an antibody or a fragment thereof. The present invention also provides antibodies produced by the methods of the invention.
Owner:MEDIMMUNE LLC

Methods and compounds for controlled release of recombinant parvovirus vectors

The invention uses recombinant parvoviruses, and particularly recombinant adeno-associated virus (rAAV) to deliver genes and DNA sequences for gene therapy following manipulation of the therapeutic virus for packaging and transport. The invention delivers therapeutic viral vectors via rAAV affixed to support matrixes (i.e., sutures, surgically implantable materials, grafts, and the like).
Owner:NORTH CAROLINA AT CHAPEL HILL THE UNIV OF

Orthodontic retainer

The present invention relates to an orthodontic retainer to be fitted to an orthodontically treated dentition in order to fix the teeth in their orthodontic treatment state. In particular, the present invention relates to an orthodontic retainer that achieves, for example, improvement of strength of the retainer, improvement of wearing comfort and esthetics, reduction in cost, and improvement of a function as the retainer.
Owner:ASO INT +1

Method for diagnosing pancreatic cancer

Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.
Owner:ONCOTHERAPY SCI INC

Method of reducing sebum production by application of pulsed light

A method of reducing sebum production in human skin, used primarily for cosmetic purposes, including the prevention of acne vulgaris, comprising the use of pulsed light having a wavelength, if monochromatic, or a wavelength range, if produced by a filtered non-monochromatic source, which targets the lipids contained within the sebaceous gland, thus destroying the differentiated and mature sebocytes by photothermolysis without damage to the surrounding and overlying tissue or to the basement membrane of the sebaceous gland.
Owner:STEWART BOB W

Surgical fasteners and devices for surgical fastening

A surgical fastening device for pinning a surgical filament to a body tissue. The device includes a grasping handle and a slender shaft extending from the grasping handle. A compartment contains one or more surgical fasteners. An ejecting mechanism is used to eject a surgical fastener from a compartment containing one or more surgical fasteners. The device also includes a filament dispensing system that dispenses surgical filament along the shaft so that a fastener grasps the filament when being ejected from the shaft. The invention also provides surgical fasteners and surgical filaments for use in the device.
Owner:ENDOGUN MEDICAL SYST

Smoking cessation treatments using naltrexone and related compounds

Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of an opioid antagonist such as nalmefene, naloxone or naltrexone or a mixture of any one of these, and either clonidine or related compounds either while awake, or while under sedation or anesthesia, followed by continued administration of an effective amount of an opioid antagonist with or without agents that enhance nicotine dependency treatment. Persons are also treated for nicotine dependency with more gradual detoxification methods using administration of a combination of an effective amount of an opioid antagonist such as nalmefene, naloxone, naltrexone, or a mixture of any of these, and an effective amount of agents used to treat nicotine withdrawal including nicotine, such as that delivered by a nicotine patch, nicotine chewing gum, nicotine inhaler or other methods for delivering nicotine, antidepressants and antianxiety agents, and / or clonidine and related compounds. Administration of an effective amount of an opioid antagonist to prevent relapse, attenuate craving, and reduce weight gain during and after treatment for nicotine dependency is continued in some embodiments.
Owner:YALE UNIV

Automatic analysis of security related incidents in computer networks

Solutions for responding to security-related incidents in a computer network, including a security server, and a client-side arrangement. The security server includes an event collection module communicatively coupled to the computer network, an event analysis module operatively coupled to the event collection module, and a solution module operatively coupled to the event analysis module. The event collection module is configured to obtain incident-related information that includes event-level information from at least one client computer of the plurality of client computers, the incident-related information being associated with at least a first incident which was detected by that at least one client computer and provided to the event collection module in response to that detection. The event analysis module is configured to reconstruct at least one chain of events causally related to the first incident and indicative of a root cause of the first incident based on the incident-related information. The solution module is configured to formulate at least one recommendation for use by the at least one client computer, the at least one recommendation being based on the at least one chain of events, and including corrective / preventive action particularized for responding to the first incident.
Owner:AO KASPERSKY LAB

Compositions and methods for the prevention and treatment of autoimmune conditions

ActiveUS20090155292A1Suppress autoreactive T-cell responsesPrevent and ameliorate T1DPowder deliveryAntipyreticDiseaseAutoimmune disease
The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and / or ameliorate autoimmune diseases.
Owner:THE GENERAL HOSPITAL CORP

Monoterpene as a chemopreventive agent for regression of mammalian nervous system cell tumors, use of monoterpene for causing regression and inhibition of nervous system cell tumors, and method for administration of monoterpene perillyl alcohol

The present invention refers to a composition based on monoterpenes with chemopreventive and chemotherapeutic effects in malignant neoplasias of humans and animals containing from 0,03% to 30% of monoterpenes and 99,97% of solvents. Another objective of the present invention is an application of monoterpenes in inhibition of cell growth and metastasis control of primary tumors being applied in vitro and in vivo gliomas cell lines C6 and U 87 and A172. Further another objective of the present invention refers to a specific methods for applying the composition with chemopreventive and chemotherapeutic effects in humans and animals showing malignant neoplasias by inhalation and nebulization treatment, oral and intratumoral, followed or not by radiotherapy with dilutions from 0,03% to 30% of the monoterpene perillyl or its derived metabolites diluted in the solvents specified by the usual techniques.
Owner:PEREIRA DA FONSECA CLOVIS ORLANDO +3

Device and method for treatment of eyelid diseases

ActiveUS20060104914A1Prevent relapsePromotes better eyelid hygieneAerosol deliveryMedical applicatorsDiseaseMedicine
A container has an impermeable outer membrane sized to fit generally within the peri-orbital region and sufficiently flexible to mold to the structure of the closed eye. Heat which is generated by an exothermic reaction inside the container, which provides steady-state heat to the eyelids. A soft, non-abrasive, lint-free material is presoaked in a pH controlled (preferably antibacterial and hypoallergenic) detergent, with or without an ophthalmic antibiotic solution. The compress may also have a handle which makes holding and maneuvering the compress more feasible, while protecting the user's fingers from the heat, and preventing the contamination of the compress by the fingers. The compress may be packed in a watertight, sterile wrapper which will prevent drying of the detergent solution. Other embodiments are also described and claimed.
Owner:OCUGIENE

Immunoglobulin variants and uses thereof

Variant immunoglobulins with one or more amino acid modifications in the Fc region that have increased in vivo half-lives, and methods of using the same are provided.
Owner:F HOFFMANN LA ROCHE & CO AG

1,3,5-triazinane-2,4,6-trione derivatives and uses thereof

The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and / or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases.
Owner:MASSACHUSETTS INST OF TECH

BMP microsphere loaded 3D printing porous metal stent and preparation method thereof

InactiveCN104353121AEarly recovery of weight bearing functionPrevent relapseProsthesisBone tissueInsertion stent
The invention relates to the technical field of biomedical materials, and particularly relates to a BMP microsphere loaded 3D printing porous metal stent and a preparation method thereof. According to the invention, a loaded microsphere-containing three-dimensional micro-stent is built in each hole of a 3D printing titanium stent. The problem that in the prior art, because the diameter of a hole is overlarge, cells only can be subjected to climbed growth on the two-dimensional space of the wall of the hole, and difficult to be subjected to three-dimensional hierarchical growth in the whole hole is solved, and by filling the three-dimensional micro-stent with a rhBMP-2 or rhBMP-7 loaded chitosan microsphere, a better growth and differentiation environment is provided for cells, thereby further promoting the combination of bone tissues and the stent. The three-dimensional micro-stent provided by the invention makes the complete healing of numerous patients with bone tissue defect caused by illnesses and accidents and the like possible; the three-dimensional micro-stent can also be used as a novel interbody fusion instrument, and applicable to an interbody fusion surgery, therefore, the three-dimensional micro-stent has an important clinical application value.
Owner:吴志宏

Dosage form for treating gastrointestinal disorders

The present invention is directed to drug dosage forms that can be used to treat diseases characterized by abnormal gastric acid secretion. The dosage forms have a core containing a proton pump inhibitor surrounded by an enteric coating or multiple particles containing proton pump inhibitor, each particle being surrounded by an enteric coating. The enteric coating delays the release of drug until the surrounding pH has risen. The tablets also include an outer coating that contains either a proton pump inhibitor or an H2 blocker. The outer coating is designed to rapidly dissolve in a patient's stomach.
Owner:POZEN INC

Methods of modulating immune function

Presented herein are therapeutic agents that modulate one or more immune functions and uses of such therapeutic agents in the prevention, treatment and management of diseases. In one aspect, the therapeutic agents modulate one or more signal transduction pathways induced by the binding of B7-H7 to B7-H7CR, or the binding of B7-H2 to either ICOS, CD28, or CTLA-4. In another aspect, the therapeutic agents modulate the binding of B7-H7 to B7-H7CR, or the binding of B7-H2 to either ICOS, CD28, or CTLA-4. The therapeutic agents can be used in the prevention, treatment and / or management of diseases in which it might be useful to modulate one or more immune functions (e.g., cancer, infectious disease, autoimmune disease, and transplantation rejection). In another aspect, presented herein are methods for identifying receptor-ligand interactions.
Owner:THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE

Targeted biocides

The present invention relates to retroviral constructs that encode novel monoclonal antibodies, novel fusion proteins, and chimeric monoclonal antibodies and to methods of using and producing the same. In particular, the present invention relates to methods of producing a fusion protein comprising a microorganism targeting molecule (e.g., immunoglobulin or innate immune system receptor molecule) and a biocide (e.g., bactericidal enzymes) in transgenic animals (e.g., bovines) and in cell cultures. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., beef carcass processing). The present invention also relates to methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in various diagnostic applications in number of diverse fields such as agriculture, medicine, and national defense.
Owner:IOGENETICS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products