70365results about How to "High activity" patented technology

A cell in which genome is modified so as to have a more decreased or deleted activity of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through alpha-bond in a complex N-glycoside-linked sugar chain than its parent cell, and a process for producing an antibody composition using the cell.

The present invention provides for a modified antibody of class IgG, in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250, 314, and 428 is substituted with another amino acid which is different from that present in the unmodified antibody, thereby altering the binding affinity for FcRn and / or the serum half-life in comparison to the unmodified antibody.

The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.

The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and / or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and / or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and / or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention also has important implications in the eradication of drug-resistant pathogens and drug-resistant diseased cells (such as cancer cells).

The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for producing an antibody composition using the cell, the antibody composition and use thereof.

There is described a process and a catalyst for the hydroalkylation of an aromatic hydrocarbon, particularly benzene, wherein the catalyst comprises a first metal having hydrogenation activity and a crystalline inorganic oxide material having a X-ray diffraction pattern including the following d-spacing maxima 12.4+ / -0.25, 6.9+ / -0.15, 3.57+ / -0.07 and 3.42+ / -0.07.

Methods for using a doorbell that is configurable to wirelessly communicate with a remotely located computing device can include obtaining the doorbell that comprises a speaker, a microphone, and a camera. Methods can include entering a sleep mode in which the doorbell's wireless communication, the camera, and the microphone are disabled. Methods can include exiting the sleep mode and entering a standby mode in response to the doorbell detecting a first indication of a visitor. The standby mode can increase electrical activities of the doorbell's camera and microphone relative to the sleep mode. Methods can include entering an alert mode in response to detecting a second indication of the visitor. The doorbell can record an image using the camera during the alert mode. Wireless communication can be enabled during the alert mode to send an alert to the remotely located computing device.

This invention relates to catalyst compositions, methods, and polymers encompassing at least one first Group 4 metallocene compound comprising bridging η5-cyclopentadienyl-type ligands, in combination with at least one second Group 4 metallocene with non-bridging η5-cyclopentadienyl-type ligands, typically in combination with at least one cocatalyst, and at least one activator. The compositions and methods disclosed herein provide ethylene polymers with a bimodal molecular weight distribution.

Disclosed are methods and apparatus, which enable the reconfigurable control of vehicles, homes, computers and other applications. Physical controls and virtual displayed controls on single and multipoint touch screens are used, separately or in combination to enable higher visibility and understanding of control information and easier operation of controls, particularly useful in stressful situations. Some embodiments use optical sensors and rear projection of displayed embodiments, and are advantageous where curved screens are desired such as in a car.

Methods can include using a doorbell to wirelessly communicate with a remotely located computing device. Doorbells can include a speaker, a microphone, a camera, and a button to sound a chime. A doorbell shipping mode can detect whether the doorbell is electrically coupled to an external power source. Methods can include entering a setup mode or a standby mode in response to detecting electricity from the external power source.

The invention includes various prototypical amperometric biosensors for the quantification of biological substrates such as fructose, creatinine, creatine, and sarcosine, and the methods for producing these biosensors. Also included in the invention is a minaturized version of the biosensing devices. The components of these prototypical biosensors are immobilized on a self-assembled monolayer (SAM) comprising chemisorbed alkanethiols. The deposition of an amphiphilic lipid layer to these systems increases the stability and activity of the resultant biosensor and enhances the rejection of many interferents. An additional feature of the invention is the co-deposition of the components of the sensor via a novel detergent dialysis protocol. The invention features two particular biosensor systems. One embodiment involves fructose dehydrogenase as the redox / sensor enzyme and fructose as the substrate / analyte. Another embodiment involves the measurement of the substrates / analytes, creatinine, creatine and sarcosine, using sacrosine dehydrogenase as the redox / sensor enzyme, with the involvement of creatinine amidohydrolase and / or creatine amidinohydrolase in the reaction pathway.

A photosensitizer together with complementary light energy are used to prevent the development of infection associated with an indwelling medical catheter or device. Light of a selected wavelength or wavelength band is coupled to the catheter or device and transmitted by a wall or walls thereof to one or both of the external and internal surfaces thereof. The catheter or device also incorporates at least one photosensitizer which releases a toxic substance when activated by the light energy which destroys bacteria on or around the catheter or device. A method of preventing infection using photosensitizers and complementary light energy is also disclosed.

The present invention is directed to variant polypeptides having enhanced ketoreductase activity and / or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.

The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step is under microfluidic control. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.

This invention relates to compounds, compositions, and methods useful for modulating BCL2 gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of BCL2 gene expression and / or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of BCL2 genes (e.g., BCL2, BCL-XL, BCL2-L1, MCL-1 CED-9, BAG-1, E1B-194 and / or BCL-A1). The small nucleic acid molecules are useful in the treatment of cancer, malignant blood disease, polycytemia vera, idiopathic myelofibrosis, essential thrombocythemia, myelodysplastic syndromes, autoimmune disease, viral infection, and proliferative diseases and conditions

Disclosed are what I call “Reconfigurable Tactile Control Displays” particularly suited for applications such as automobile instrument panels where large displays and controls are desirable to provide a wide range of information, with minimal driver distraction and the safe input of data to vehicle subsystems or for communication based activities. Preferred embodiments utilize rear projection displays with electro-optically sensed controls and offer, at low cost, a maximum of reconfigurability to different car lines, drivers, and tasks. Also disclosed are novel implementations for military vehicles, and other applications such as control of appliances, heating and other household functions which may share common control and display presentation with those used in the vehicle.

The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anri-ErbB receptor antibody-maytansinoid conjugates.

The present invention provides an anti-human TIM-3 antibody having high ADCC activity or antibody fragment thereof by screening a monoclonal antibody or antibody fragment thereof which binds to the amino acid sequence of the extracellular region of TIM-3 or its three-dimensional structure and exhibits ADCC activity; a hybridoma which produces the antibody; a DNA encoding the antibody; a vector comprising the DNA; a transformant which is obtainable by introducing the vector; a method for producing the antibody or the antibody fragment thereof which comprises using the hybridoma or the transformant; a therapeutic agent and a diagnostic agent comprising the antibody or the antibody fragment thereof as an active ingredient.

This invention relates to a process for transforming methanol to aromatic hydrocarbons, comprising: use methanol as raw material, with modified ZSM-5 molecular sieve as catalyst, under conditions of operation pressure 0.1-5.0Mpa, operation temperature 300-460Deg C, raw material liquid air speed 0.1-6.0h-1, transformed to products with aromatic hydrocarbons as main components; separate the gas-phase products lower carbon hydrocarbons from the liquid-phase C5+ hydrocarbons by cooling separation; the liquid-phase C5+ hydrocarbons then can be separated to be aromatic hydrocarbons and non-aromatic hydrocarbons by extracting separation. This invention is characterized of high total selectivity of aromatic hydrocarbons and flexible process operation.

This invention relates to rigid porous carbon structures and to methods of making same. The rigid porous structures have a high surface area which are substantially free of micropores. Methods for improving the rigidity of the carbon structures include causing the nanofibers to form bonds or become glued with other nanofibers at the fiber intersections. The bonding can be induced by chemical modification of the surface of the nanofibers to promote bonding, by adding "gluing" agents and / or by pyrolyzing the nanofibers to cause fusion or bonding at the interconnect points.

Athletic performance monitoring and tracking may provide multiple ways in which to track athletic movement and activity. Workouts may also be tagged with various parameters including mood, weather, terrain, athletic equipment, friends used and the like. Workout information may be shared to social messaging and networking outlets. Workout information shared may include map information including images of maps, interactive maps, links to maps, route information and the like and / or combinations thereof. Additionally or alternatively, an application may be configured to execute within a context of a social networking system to facilitate athletic activity data transfer and generation of workout entries in the social networking site.

The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and / or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and / or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.

The present invention provides an improved alkali metal catalyzed steam gasification process that utilizes a CO2 trap material and / or a mineral binder material within the gasifier. The process optimally achieves over 90% carbon conversion with over 80% yield of methane. The raw gas product can be used directly as fuel. The catalyst can be recovered from the solid purge and recycled to the gasifier and / or the CO2 trap can be regenerated and recycled to the gasifier.

Methods can include using a doorbell to wirelessly communicate with a remotely located computing device. Doorbells can include a speaker, a microphone, a camera, and a button to sound a chime. Some embodiments include using a doorbell to close an electrical circuit that has a sound output device in a way that precludes the sound output device from inappropriately emitting a notification sound.