4289 results about "Dialysis" patented technology

Multilayered particulate materials are formed by coating a particulate substrate with a metal and adsorbing an organic layer comprising a recognition moiety onto the metal film. The recognition moiety interacts with an analyte of interest allowing for its detection, purification, etc. Suitable recognition moieties can be selected from a range of species including, small molecules, polymers and biomolecules and the like. The novel particulate materials of the invention can be utilized in an array of methods including, ion-exchange, ion-selective ion-exchange, assays, affinity dialysis, size exclusion dialysis, as supports in solid phase synthesis, combinatorial synthesis and screening of compound libraries and the like.

The invention includes various prototypical amperometric biosensors for the quantification of biological substrates such as fructose, creatinine, creatine, and sarcosine, and the methods for producing these biosensors. Also included in the invention is a minaturized version of the biosensing devices. The components of these prototypical biosensors are immobilized on a self-assembled monolayer (SAM) comprising chemisorbed alkanethiols. The deposition of an amphiphilic lipid layer to these systems increases the stability and activity of the resultant biosensor and enhances the rejection of many interferents. An additional feature of the invention is the co-deposition of the components of the sensor via a novel detergent dialysis protocol. The invention features two particular biosensor systems. One embodiment involves fructose dehydrogenase as the redox/sensor enzyme and fructose as the substrate/analyte. Another embodiment involves the measurement of the substrates/analytes, creatinine, creatine and sarcosine, using sacrosine dehydrogenase as the redox/sensor enzyme, with the involvement of creatinine amidohydrolase and/or creatine amidinohydrolase in the reaction pathway.

Filter cartridge assemblies and housings are provided and include a tubular housing having an inner wall, an outer wall, a first end, and a second end. The housings include inner walls with shoulders or other radially-inwardly extending flow directors at the intersections of adjacent sections of the tubular body. The assemblies include a plurality of filter media sections within the housing, and each of the plurality of filter media sections preferably has a different filter media composition. One or more of the filter media sections traverses one or more of the shoulders or other radially-inwardly extending flow directors such that the flow directors evenly direct the flow of fluid through the assembly. The assemblies find particular applicability in dialysis systems.

The present invention is directed to novel systems for conducting the filtration of blood using manifolds. The manifolds integrate various sensors and have fluid pathways formed therein to direct fluids from various sources through the requisite blood filtration or ultrafiltration system steps.

The present invention is directed to a dialysis system with a disconnection monitor for determining if a blood line connection to a patient has been disconnected. It includes a blood circuit in fluid communication with a patient and a dialysis circuit, a pressure transducer for generating a signal indicative of a pulse signal in the blood circuit, a cardiac reference signal generator for generating a signal indicative of the patient's pulse and a disconnection monitor. The disconnection monitor includes a pressure transducer data receiver for receiving the signal indicative of the pulse signal in the blood circuit, a cardiac reference signal receiver for receiving the signal indicative of the patient's pulse, and a processor for cross-correlating the signal indicative of the pulse signal in the blood circuit and the signal indicative of the patient's pulse to generate data indicative of a disconnection of the blood line connection to the patient.

One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Extracorporeal blood treatment systems draw blood at such a high rate that a loss of integrity in the blood circuit can be catastrophic. There are a number of mechanisms for detecting and preventing leaks and/or air infiltration, but none is perfect. According to the present invention, multiple inputs are combined to provide greater security against leakage and/or air infiltration by providing sensors for external presence of liquid (plasma, replacement fluid, blood, etc.) outside a fluid circuit and infiltration of air or bubbles into the fluid circuit.

An integrated disposable cartridge for dialysis or ultrafiltration treatment of blood is disclosed that includes integral miniature pressure sensors. Sensors are embedded in the tubing of the cartridge to measure pressure of blood or other fluids. Cartridge elements form a continuous smooth bore passage for blood that reduces probability of clotting.

A system is disclosed having a server, a dialysis machine configured to connect to the server through a network and client device configured to connect to the server through the network. In one embodiment, the server is configured to maintain an access list to determine whether the client device is authorized to connect to the dialysis machine. The server is further configured to provide a connection for transfer of data between the dialysis machine and the client device. Various methods of accessing the network using the system components are further disclosed.

A device and methods for treating renal failure are disclosed. One embodiment of the device is an implantable peritoneal dialysis device. When in use, the device can have a semi-permeable reservoir implanted in the peritoneal cavity. The reservoir can receive blood waste and drain through one or more conduits, via a pump, to the biological bladder. Solids and/or a solution benefiting dialysis can be pumped to the reservoir and/or implanted in the peritoneal cavity.

One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Such systems draw blood at such a high rate that a loss of integrity in the blood circuit can be catastrophic. The most reliable leak detection method known is the detection of infiltrated air in the blood line, but this only works in blood lines under negative pressure. According to the invention, a leak detector for return lines is provided by periodically generating a negative pressure, which may be brief or at a 50% duty cycle, in the blood return line to draw air into it and thereby reveal the leaks using an air sensor. Although the return line is ordinarily under positive pressure, during the negative pressure cycle, the blood return line draws air through any leaks or disconnects. If air is detected, the system is shut down and an alarm generated.

A blood circuit (1) for a dialysis machine is made form plastic material and is provided with a metallic plate (30), which is applied to an external face of the blood circuit (1) and is connectable to a voltage generator (34) in such a way as to form a capacitor, in which the plate (30) and the blood act as the capacitor plates and the plastic material acts as the dielectric.

The invention provides a system for continuously monitoring a patient during hemodialysis. The system includes a hemodialysis machine for performing the hemodialysis process that features a controller, a pump, a dialyzer filter, a lumen, and an interface to a body-worn monitor. A patient attaches to the dialysis machine through the lumen, and wears a body-worn monitor for continuously measuring blood pressure. The monitor includes an optical system for measuring an optical waveform, an electrical system for measuring an electrical waveform, and a processing component for determining a transit time between the optical and electrical waveforms and then calculating a blood pressure value from the transit time. The body-worn monitor features an interface (e.g. a wired serial interface, or a wireless interface) to transmit the blood pressure value to the controller within the hemodialysis machine. The controller is configured to receive the blood pressure value, analyze it, and in response adjust the dialysis process.

A method of operating a dialysis machine comprising receiving patient specific data, storing the received patient specific data in a non-volatile memory device, and implementing a treatment according to one of an acute care mode or a home care mode is disclosed. In the case of the acute care mode of treatment, the patient specific data is deleted after implementing the treatment. In the case of the home care mode of treatment, the patient specific data is retained after implementing the treatment. Hardware for implementing the disclosed method is also disclosed. Because of the rules governing abstracts, this abstract should no be used to construe the claims.

An extracorporeal blood treatment system comprises an ECB station with an ECB unit, such as a dialysis machine. Via a web server and a browser, the ECB station communicates with a data net to which external browsers and external web servers are connected. Thus, settings and maintenance operations may be performed on the ECB unit from a remote location. On the other hand, patient-related, machine-related or drug-related data or statistical data or consumption-related data can be transmitted from the ECB station to a remote location. The communication between a user interface, e.g., a touch screen, and the ECB unit is done via the internal browser. Thus, the user interface has access to the data net. The ECB unit receives all data, information and instructions via the web server. Thereby, data of different sources can be processed in the same format and be given different authorizations.

A method of disinfection of a dead-ended fluid line in a medical instrument such as a dialysis machine is described. The method comprises introducing a heated fluid into the fluid line, allowing the fluid to remain in the line for an experimentally determined optimal dwell period, removing the fluid from the fluid line, and then repeating the cycle for a time period sufficient to achieve a disinfection of the fluid line. The optimum dwell period and frequency for exchanging the heated fluid is determined so that the heated fluid is left resident in the line to exert a cidal effect but not so long that the it cools to the point of being ineffective, nor changed so frequently that that the time spent with no hot water resident in the line begins to detract (e.g., unduly prolong) the disinfection process. A representative cycle is introducing water at a temperature of about 85 degrees C, allowing it to reside in the fluid line for about 10 seconds, withdrawing the water, and then reintroducing water at 85 degrees C. The process continues for 1-2 hours. Variation from the representative cycle will be expected based on parameters such as the degree to which disinfection is to be achieved, the length and diameter of the fluid line, the temperature of the fluid, the ambient temperature, the presence of elements in the fluid line that contribute to heat loss, the material used for fluid line tubing, and whether the fluid comprises water or a disinfection solution such as a dilute citric acid solution. The optimum dwell period and frequency of the cycles can be determined experimentally from the teachings described herein.

A disposable fluid circuit kit for extracorporeal blood treatment systems that supply replacement fluid to a patient is described. The circuit has a blood portion that carries blood and subjects it to some treatment, such as dialysis or hemofiltration. A portion carries filtrate or dialysate. A replacement fluid portion that carries fluid used to compensate for fluid loss is connectable to a supply of replacement fluid. a sterilizing filter in the replacement fluid portion sterilizes the replacement fluid before introduction into the patient acting as a guard against touch contamination of the connected replacement fluid container. Preferably, the filter has a pore size effective to eliminate pyrogens.

The invention discloses a medication thermal energy water circulating blanket which comprises a liquid heat radiation circulating loop structure formed by connecting a dialysis macromolecule energy pipe, a constant-temperature furnace, a minitype mute water pump and the like, the dialysis macromolecule energy pipes is evenly arranged on a cotton blanket body to cool the cotton blank body. According to the medication thermal energy water circulating blanket, needed medicinal materials only need to be placed on a filter screen in the constant-temperature furnace, nutrition ingredients of the medicinal materials are absorbed by water, agentia is pumped to the dialysis macromolecule energy pipes to circulate, the dialysis macromolecule energy pipes distribute the nutrition ingredients of the agentia to a bed blanket slowly to be absorbed by a human body through pores of the human body at this moment, and therefore people can be moisturized by the water and can obtain the nutrition effect of the medicinal materials in sleep, people can feel warm and comfortable, and can maintain beauty and keep young, and the special effect of preventing diseases can be achieved. Heating, circulating and heat preservation in the whole process are automatically controlled, the medication thermal energy water circulating blanket is simple in structure, low in cost, convenient to use and good in market prospect and has good market prospects, and social benefits and economic benefits are considerable.

The present application discloses a portable dialysis system for conducting a dialysis treatment. The portable dialysis system has a controller unit that includes a display, a scale, a bar code reader, and a memory storing a plurality of programmatic instructions. Upon execution, the instructions generate a first graphical user interface, a second graphical user interface, and a third graphical user interface for presentation on the display. The first graphical user interface displays each additive required for use in the dialysis treatment. The second graphical user interface prompts a user to submit additives to scanning using the bar code scanner. The third graphical user interface prompts a user to submit additives to measurement using the scale.