852 results about "Hemodialysis" patented technology

Methods and apparatus for patient care detect a current medical condition of a patient receiving medical treatment, e.g., by sensing blood pressure, heart rate, weight, glucose level, hemoglobin level, and / or blood potassium level (all by way of example) and transmit information regarding that medical condition to a digital data processing system disposed remotely from the medical treatment apparatus. The medical treatment apparatus can be, for example, one for peritoneal dialysis and hemodialysis, and the medical condition can be sensed by sensors coupled to or otherwise utilized in connection with such apparatus.

Splitable-tip catheters are disclosed with bioresorbable adhesive to provide spatial separation of distal tip elements during use. The invention can be particularly useful in hemodialysis applications where it is desirable to separate blood extraction and return lumens. The adhesive facilitates insertion of the distal end of the catheter as an assembly, e.g., into a blood vessel using a single guidewire, while the bioresorbable nature of the adhesive allows the tip elements to separate in vivo.

Methods and devices for performing percutaneous and surgical interventions. The devices comprising a tubular portion and retractable mechanism at the distal end of the tubular portion. The retractable mechanism prevents the device from pulling out of an anatomical structure during complex interventions, for example, when switching from an antegrade to a retrograde approach within a blood vessel, enables the use of a single sheath when declotting AV hemodialysis fistulas and can provide occlusion of blood flow during interventions and means of removal of debris or clot from the blood vessel.

A hemodialysis apparatus includes a dialyzing device, a measuring device and a calculation device. The dialyzing device dialyzes and ultrafiltrates blood of a patient circulating extracorporeally to perform hemodialysis treatment. The measuring device measures a variation rate of a body weight of the patient and a variation rate of a predetermined blood benchmark during the hemodialysis treatment using the dialyzing device. The calculation device calculates, during the hemodialysis treatment, a parameter relating the variation rate of the body weight and the variation rate of the predetermined blood benchmark to each other, and correlating to a dry weight of the patient.

The invention provides a catheter for placement within a vessel of a patient. The catheter comprises an elongated catheter body, a septum extending longitudinally through the interior of the catheter body from the dividing the interior of the catheter body into a first lumen and a second lumen. Each lumen has curved or angled internal walls at the distal end of the catheter that terminate at ports located on opposing sides of the catheter body. The invention also provides a method for exchanging fluids in a patient comprising the step of positioning the catheter of the present invention in communication with a fluid-containing vessel of a patient. The method is particularly well-suited for hemodialysis, plasmapheresis, and other therapies which require removal and return of blood from a patient.

An apparatus for establishing a re-usable, recurring, mechanical connection to an organ within a patient is provided. A subcutaneous needle connection system for providing bidirectional, straight and turbulent-free fluid flow access to a vascular system of a patient includes a housing defining a needle access opening for receiving a needle, a cannula opening in communication with the vascular system and a passageway connecting the needle access opening to the cannula opening. The housing can additionally have a second needle access opening connected to a second cannula opening via a second passageway. The subcutaneous needle connection system allows for blood to be removed from the vascular system via one cannula opening, passed to a hemodialysis system via a needle inserted in an associated needle access opening, treated using the hemodialysis system, and returned to the vascular system via the other needle access opening and associated cannula opening. The implantable needle connection system provides enhanced mechanical stability under the skin, improved fluid flow dynamics, improved needle hole healing potential of the skin, and improved needle edge interfacing to minimize flow turbulence and blood cell trauma during use.

The invention provides a system for continuously monitoring a patient during hemodialysis. The system includes a hemodialysis machine for performing the hemodialysis process that features a controller, a pump, a dialyzer filter, a lumen, and an interface to a body-worn monitor. A patient attaches to the dialysis machine through the lumen, and wears a body-worn monitor for continuously measuring blood pressure. The monitor includes an optical system for measuring an optical waveform, an electrical system for measuring an electrical waveform, and a processing component for determining a transit time between the optical and electrical waveforms and then calculating a blood pressure value from the transit time. The body-worn monitor features an interface (e.g. a wired serial interface, or a wireless interface) to transmit the blood pressure value to the controller within the hemodialysis machine. The controller is configured to receive the blood pressure value, analyze it, and in response adjust the dialysis process.

A catheter (100) having a first lumen (110) having a first distal tip (112) and a second lumen (130) having a second distal tip (132). The first and second distal tips (112,132) include openable portions that are normally closed when undeflected by lumen fluid pressure imbalance relative to the blood pressure of the patient. The first lumen (110) has an openable portion, flap (114) that opens proximally into the first lumen when the first lumen is under negative pressure to withdraw blood from the vessel through the first lumen to be dialysed (but that can open distally into the vessel under positive lumen pressure to permit blood flow into the vessel). The second lumen (130) extends distally beyond the first distal tip (112) to its second distal tip (132), and its openable portion is several lip sections (135) that are normally closed against each other when undeflected but that open outwardly when the second lumen is positively pressurized during hemodialysis, permitting blood to return to the patient's vessel.

A hemodialysis treatment apparatus includes a circulating blood volume variation rate detecting device, a vital sign detecting device and a display. The circulating blood volume variation rate detecting device detects a circulating blood volume variation rate of a patient in a time-course of a hemodialysis treatment. The vital sign detecting device detects a vital sign value of the patient in the time-course of the hemodialysis treatment. The display has a screen and displays both the circulating blood volume variation rate and the vital sign value on the screen along a time scale. The hemodialysis treatment apparatus dialyzes and ultrafiltrates extracorporeally circulating blood of the patient to perform the hemodialysis treatment.

A membrane module for hemodiafiltration having a cylinder-shaped housing and a bundle of hollow-fiber membranes capable of supporting fluid flow and arranged in the direction of the longitudinal extent of the housing. The ends of the hollow-fiber membranes are embedded in a fluid-tight manner in first and second sealing compounds joined to the housing inner wall in a fluid-tight manner. The exterior space formed around the hollow-fiber membranes and delimited by the first and second sealing compounds and the housing inner wall is divided along the longitudinal extent of the housing into a dialyzate space and a substituate space by a dividing wall that is made from a substantially dimensionally stable material. The dividing wall encloses each hollow-fiber membrane and is arranged substantially transversely to the hollow-fiber membranes. The dialyzate space and substituate space each have at least one opening for introducing or draining a fluid. In the exterior space, at least one throttle is arranged by which the dialyzate space and substituate space are in fluid communication with each other.

A hemodiafiltration system for treating blood which has module having a housing in which hollow-fiber membranes are arranged in the direction of the longitudinal extent and are embedded at their ends in first and second sealing compounds joined to the inner wall of the housing in a fluid-tight manner. The membrane module also has a dialyzate space and a substituate space separated from the dialyzate space in a fluid-tight manner by a continuous dividing wall. The membrane module further includes means for delivering and withdrawing a dialyzate to and from the dialyzate space, and means for delivering a substituate to the substituate space. The hollow-fiber membranes are used for blood treatment, filtration of the substituate, and delivery of the substituate to the blood. An exterior space is formed around the hollow-fiber membranes that is delimited by the inner wall of the housing and sealing compounds and is divided along the longitudinal extent of the housing by a dividing wall into the substituate space and the dialyzate space, the dividing wall encloses each individual hollow-fiber membrane.

The invention provides a catheter for placement within a vessel of a patient. The catheter comprises an elongated catheter body, a septum extending longitudinally through the interior of the catheter body from the dividing the interior of the catheter body into a first lumen and a second lumen. Each lumen has curved or angled internal walls at the distal end of the catheter that terminate at ports located on opposing sides of the catheter body. The invention also provides a method for exchanging fluids in a patient comprising the step of positioning the catheter of the present invention in communication with a fluid-containing vessel of a patient. The method is particularly well-suited for hemodialysis, plasmapheresis, and other therapies which require removal and return of blood from a patient.

A safety catheter device for hemodialysis and donor collection (see FIG. 9) comprises a catheter unit (101), a needle (105) guided by a needle port (114) into the catheter unit to introduce it into patient's vein, an indication channel for blood supply into an indication cavity (109) during catheter emplacement, a blood stream channel for blood supply to hemodialysis or collection set through a blood stream port (112). The minimal cross-sectional area of the blood stream channel is substantially more than one of the indication channel. Forming the blood stream channel is accomplished by retracting the needle and, in version embodiment, by rotating a port unit (111) including the needle and blood stream ports relative to the catheter unit. There are means preventing blood leakage and personnel infecting.

Methods and apparatus for applying focused pressure to a target vessel to dilate the target vessel for hemodialysis.

In a hemodiafiltration apparatus, a control and command unit (11) halts a replacement fluid supply pump (8) and contemporaneously modifies the control mode of a blood pump (1) passing from a control based on the pump velocity to a control based on the blood pressure measured by a sensor (12) arranged downstream of a hemodiafilter (3). The aim is to prevent risks due to excessive hemo-concentration in the blood circuit between the ultrafiltration zone and the infusion zone.

Methods and devices for performing percutaneous and surgical interventions. The devices comprising a tubular portion and retractable mechanism at the distal end of the tubular portion. The retractable mechanism prevents the device from pulling out of an anatomical structure during complex interventions, for example, when switching from an antegrade to a retrograde approach within a blood vessel, enables the use of a single sheath when declotting AV hemodialysis fistulas and can provide occlusion of blood flow during interventions and means of removal of debris or clot from the blood vessel.

A medical filtering machine for the hemodialysis is composed of main body with console panel, blood loop consisting artery loop and vein loop, liquid-supplementing loop, water channel system and operation-control system. Said water channel system consists of reverse osmosis jointer, heat exchanger, heater, gear pump, deaerating unit, two concentrated liquid pumps, mixer, ion concentration monitor, volume balance and ultrafiltration unit, and endotoxin filter.

A hemodialysis apparatus includes a dialysis device, a detecting device, an evaluation device and a memory device. The dialysis device dialyzes and ultrafiltrates blood of a patient according to an ultrafiltration volume based on an estimated dry weight while performing hemodialysis treatment on the blood circulating extracorporeally. The detecting device obtains time series data by measuring a parameter related to concentration of the blood circulating extracorporeally at a plurality of points in time series in a process of the hemodialysis treatment by the dialysis device. The evaluation device evaluates appropriateness of the hemodialysis treatment by evaluating whether the estimated dry weight approximates to a dry weight after the hemodialysis treatment by the dialysis device. The memory device stores a plurality of time series data when the hemodialysis treatment is evaluated to be appropriate by the evaluation device.

Splitable-tip catheters are disclosed with bioresorbable adhesive to provide spatial separation of distal tip elements during use. The invention can be particularly useful in hemodialysis applications where it is desirable to separate blood extraction and return lumens. The adhesive facilitates insertion of the distal end of the catheter as an assembly, e.g., into a blood vessel using a single guidewire, while the bioresorbable nature of the adhesive allows the tip elements to separate in vivo.

A hemodialysis treatment apparatus includes a circulating blood volume variation rate detecting device, a vital sign detecting device and a display. The circulating blood volume variation rate detecting device detects a circulating blood volume variation rate of a patient in a time-course of a hemodialysis treatment. The vital sign detecting device detects a vital sign value of the patient in the time-course of the hemodialysis treatment. The display has a screen and displays both the circulating blood volume variation rate and the vital sign value on the screen along a time scale. The hemodialysis treatment apparatus dialyzes and ultrafiltrates extracorporeally circulating blood of the patient to perform the hemodialysis treatment.

Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and / or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and / or predict a patient's hemodynamic reserve index in the future. Tools and techniques for estimating and / or predicting a patient's dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient's estimated and / or predicted hemodynamic reserve index.

A conductivity detector detects the electrical conductivity of a fluid under analysis for determining chemical or physical properties of the fluid that are related its electrical properties. Such conductivity detectors may find use in, for example, hemodialysis systems for analyzing the effectiveness of the hemodialysis treatment. In an aspect, to improve accuracy of the conductivity measurements, the detector utilizes four-wire resistance measurement methods. In another aspect, to avoid fouling or contamination of the electrodes, the detector utilizes capacitively-coupled contactless conductivity detection (C4D) methods so that the electrodes are physically unconnected to the fluid contained in a fluid chamber. In a possible further aspect, the fluid chamber may be a disposable component removable from the electrodes. The conductivity detector can include other features such as calibration circuits and features for electrically isolating the fluid under detection from the fluid in the rest of the system.

The present invention relates to a method for using lectins that bind to pathogens having high mannose surface glycoproteins or fragments thereof which contain high mannose glycoproteins, to remove them from infected blood or plasma in an extracorporeal setting. Accordingly, the present invention provides a method for reducing viral load in an individual comprising the steps of obtaining blood or plasma from the individual, passing the blood or plasma through a porous hollow fiber membrane wherein lectin molecules are immobilized within the porous exterior portion of the membrane, collecting pass-through blood or plasma and reinfusing the pass-through blood or plasma into the individual.

Hemodialysis systems and methods with streamlined blood flow paths are provided. Such streamlined blood flow paths facilitate flow without undue damage to circulating cells.

Described herein are cryolipolysis devices, systems, and methods for facilitating percutaneous access to a target blood vessel by performing cryolipolysis on subcutaneous adipose tissue obscuring the target blood vessel (e.g., a vessel used for hemodialysis treatment). Generally, the devices include a cooling member carrying a coolant that cools a selected portion of adipose tissue overlying the target blood vessel to reduce the selected portion of adipose tissue, thereby forming a depression in the adipose tissue and allowing the target blood vessel closer to the surface of the skin. In some variations, the cooling member is placed subcutaneously to directly cool the selected portion of adipose tissue. In other variations, the cooling member is placed external to the patient to indirectly cool the selected portion of adipose tissue through the skin.

A system and method of non-invasive or minimally invasive evaluating the cardiovascular system parameters to estimate the cardiac output and circulating blood volume of a patient undergoing hemodialysis. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health before and during hemodialysis.

A blood purification device allows controlling a false alarm and allows detecting accurately an abnormality in a patient who is undergoing a blood purification treatment or in the device which is running. The hemodialysis equipment includes blood circuit made of an arterial blood circuit having an arterial needle at its end and a venous blood circuit having a venous needle at its end; a blood pump; a dialyzer purifying the blood flowing in blood circuit; a venous blood pressure sensor which can detect pressure of a patient's blood flowing in the venous blood circuit; a venous blood pressure monitoring means for comparing a base value of the pressure measured by the venous blood pressure sensor or pressure predicted to be measured with a predetermined alarm-threshold. The device also has a venous blood pressure monitoring means allows updating the predetermined alarm threshold at a predetermined period of time.

A method and device that identify impairments of the blood flow in an extra-corporeal blood circuit during extracorporeal treatment of the blood using an extracorporeal haemodialysis device, where the phase angle of at least one harmonic oscillation of an oscillating pressure signal that propagates in the extracorporeal blood circuit is determined. Impairments of the blood flow are detected in the extracorporeal blood circuit based on a characteristic modification of the phase angle of at least one harmonic oscillation of the pressure signal. A temporal modification of the phase angle may be compared with a predefined threshold value and an impairment is detected if the value of the modification of the phase angle is greater than the predefined threshold value. The method and device permit an early identification of a coagulation of the blood that flows through the haemodialysis unit, so that countermeasures can be initiated promptly.