65 results about "Subcutaneous adipose tissue" patented technology

A method of lipolysis. The method comprises deforming a region of skin so that the region of skin protrudes from surrounding skin. One or more radio frequency (RF) electrodes are positioned on the protruding region of skin so as to generate an electrical current through adipose tissue in the protruding region of skin when a voltage is applied to the electrode or electrodes. A voltage is then applied to the electrode or electrodes so as to deliver sufficient RF energy to the protruding region of skin to damage subcutaneous adipose tissue. The method of the invention may be used, for example, to achieve a reduction in body weight, cellulite reduction, loose skin reduction, wrinkle treatment, body surface tightening, skin tightening, and collagen remodeling.

The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.

The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.

Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and / or causing an ischemia-reperfusion injury to, the cooled tissue.

Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and / or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve / muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

Devices, systems, and methods treat cosmetic defects, and often apply cooling with at least one tissue-penetrating probe inserted through of the skin of a patient. The cooling may remodel one or more target tissue so as to effect a desired change in a composition of the target tissue and / or a change in its behavior. Exemplary embodiments of the cooling treatments will interfere with the nerve / muscle contractile function chain so as to mitigate wrinkles of the skin. Related treatments may be used therapeutically for treatment of back and other muscle spasms, chronic pain, and the like. Some embodiments may remodel subcutaneous adipose tissue so as to alter a shape or appearance of the skin surface.

The invention provides methods and apparatuses (4) for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy (42a, 42b) configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.

Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and / or causing an ischemia-reperfusion injury to, the cooled tissue.

Apparatus for treating cellulite under the surface of the skin comprising a surgical ultrasonic energy source is disclosed. An ultrasonic energy transmitting surface is driven by a surgical ultrasonic energy source. The ultrasonic energy transmitting surface is configured to concentrate ultrasonic energy in the layer of connective tissue lying at the interface between the dermis and the subcutaneous adipose tissue. The surgical ultrasonic energy source is of sufficient power to cause disruption of the layer of connective tissue lying at the interface between the dermis and the subcutaneous adipose tissue during a dosage period. An imaging ultrasonic energy transmitting surface is driven by the imaging ultrasonic energy source. An imaging ultrasonic energy detector is coupled to receive the reflected output of the imaging ultrasonic energy transmitting surface. A computing device is coupled to the output of the imaging ultrasonic energy detector. A program resident in the computing device configures the computing device to generate an image of tissues under the surface of the skin of a patient. A display for displaying the image of tissues under the surface of the skin of the patient provides the person implementing the treatment with first and second images. The first image is a before ultrasound treatment three dimensional or other image and the second image is an after ultrasound treatment image of the tissue is treated. An applicator housing is configured to be held by the hand of an individual, the imaging ultrasonic energy detector is mounted on the applicator housing.

One aspect of the invention provides a cooling device including a cooling unit and a control unit. The control unit is programmed to control operation of the cooling unit in order to cool one or more sebaceous glands within a local region for a period of time and to a temperature sufficient to disrupt function of the one or more sebaceous glands without permanently injuring epidermal tissue or cooling subcutaneous adipose tissue to 25° C. or below 25° C.

Described herein are cryolipolysis devices, systems, and methods for facilitating percutaneous access to a target blood vessel by performing cryolipolysis on subcutaneous adipose tissue obscuring the target blood vessel (e.g., a vessel used for hemodialysis treatment). Generally, the devices include a cooling member carrying a coolant that cools a selected portion of adipose tissue overlying the target blood vessel to reduce the selected portion of adipose tissue, thereby forming a depression in the adipose tissue and allowing the target blood vessel closer to the surface of the skin. In some variations, the cooling member is placed subcutaneously to directly cool the selected portion of adipose tissue. In other variations, the cooling member is placed external to the patient to indirectly cool the selected portion of adipose tissue through the skin.

Dual-energy absorptiometry is used to estimate intramuscular adipose tissue metrics and display results, preferably as related to normative data. The process involves deriving x-ray measurements for respective pixel positions related to a two-dimensional projection image of a body slice containing intramuscular adipose tissue as well as subcutaneous adipose tissue, at least some of the measurements being dual-energy x-ray measurements, processing the measurements to derive estimates of metrics related to the intramuscular adipose tissue in the slice, and using the resulting estimates. Processing the measurements includes an algorithm which places boundaries of regions, e.g., a large region and a smaller region. The regions are combined in an equation that is highly correlated with intramuscular adipose tissue measured by quantitative computed tomography in order to estimate intramuscular adipose tissue.

Method and compositions are provided for treating or preventing a skin pathology or disorder associated with diabetes and / or aging, by topical administration of at least one agent capable of restoring an impaired physiological condition of the skin associated with said skin pathology or disorder. Examples of such agents include PKC modulating agents, various adipokines and insulin signaling related molecules. In particular, restoration of the subcutaneous adipose tissue can overcome many of the diabetic skin pathologies and aging skin disorders and conditions.

Method and compositions are provided for treating or preventing a skin pathology or disorder associated with diabetes and / or aging, by topical administration of at least one agent capable of restoring an impaired physiological condition of the skin associated with said skin pathology or disorder. Examples of such agents include PKC modulating agents, various adipokines and insulin signaling related molecules. In particular, restoration of the subcutaneous adipose tissue can overcome many of the diabetic skin pathologies and aging skin disorders and conditions.

The invention discloses a preparation method for beautifying and anti-aging autologous adipose-derived stromal cells. The method comprises the following steps: acquiring normal belly subcutaneous adipose tissue; washing with PBS; cutting adipose tissues; digesting with I-type collagenase for a period of time; after digesting, adding PBS, uniformly mixing and filtering; adding a DMEM culture solution containing human autoserum; putting into an incubator for culturing; exchanging liquid with fresh culture solution at a certain time interval; causing the cells grow from the tissue blocks to original autologous adipose-derived stromal cells; washing with PBS when the original autologous adipose-derived stromal cells reach a certain fusion degree, and then adding pancreatin and EDTA digestive juice; adding human autoserum and ending digestion after the cells suspend, and then adding normal saline; moving the cell suspension to a centrifugal tube for centrifuging; collecting adipose-derived stromal cells and adjusting cell density. According to the method provided by the invention, the beautifying and anti-aging autologous adipose-derived stromal cells are prepared in agarose through the acquired autologous adipose-derived stromal cells and autologous thrombocyte-rich plasma.

The invention discloses a method for separating and extracting human subcutaneous adipose-derived mesenchymal stem cells and a special culture medium for extraction. The method comprises the following steps of: cutting up the human subcutaneous adipose tissue, centrifuging at 4 DEG C to remove big adipose tissue, and adding mixed I type and II type collagenase for water-bath digestion; suspending with the special culture medium for extraction, and performing water bath at 37 DEG C; filtering the collected cells, adding the special culture medium for extraction, and culturing primary cells for 5-7 days; culturing the cells after primary culture with a common culture medium, and optionally performing continuous culture; and adding certain concentration of fetal bovine serum, recombinant fibroblast growth factor, epidermal growth factor, insulin, acetylcysteine and thyronine, wherein the special culture medium for extraction includes a low-sugar dulbecco's modified eagle's medium. Through the invention, a great quantity of adipose-derived mesenchymal stem cells can be extracted from subcutaneous adipose, and the intracellular stem cells subjected to primary culture have higher purity and stronger activity.

The present invention is a tissue engineering skin containing the fat layer and the preparation method. The present invention is characterized in that the present invention is manufactured by the fat cell, the skin fibroblast cell, the epidermal cell and the biological frame. The fat cell and the skin fibroblast cell are mixed inside the biological frame. The active tissue engineering skin containing the fat layer is built by planting the epidermal cell on the surface. The prepared issue engineering skin containing the fat layer not only has a certain degree of elastic and toughness properties, but also has short incubation time and no significant immunological rejection. The tissue has similar structure as the natural skin and the subcutaneous adipose tissue. The present invention has multiple effects in aspects of anti infection, homeostasis and inhabiting the scar formation.

A device that reduces subcutaneous adipose tissue using a matrix of LEDs to heat and destroy fat cells. The surface facing the patient's skin may be a plate of thermally conductive material such as copper or aluminum, with apertures for the LEDs. Fat reduction may be optimized using infrared LEDs with peak spectral power in the range of 920 nm to 950 nm. The device may include multiple light emitting sections connected with flexible couplings so that the device can conform to curved body shapes; treatment surfaces of individual sections may also be curved. Sections may include cooling mechanisms to cool both the LEDs and the plate facing the patient's skin, such as thermoelectric cooling elements and air or water circulation. A user interface may provide monitoring and control of treatment parameters. The device may incorporate ultraviolet LEDs to facilitate removal of an adhesive attaching the device to the patient.

Dual-energy absorptiometry is used to estimate intramuscular adipose tissue metrics and display results, preferably as related to normative data. The process involves deriving x-ray measurements for respective pixel positions related to a two-dimensional projection image of a body slice containing intramuscular adipose tissue as well as subcutaneous adipose tissue, at least some of the measurements being dual-energy x-ray measurements, processing the measurements to derive estimates of metrics related to the intramuscular adipose tissue in the slice, and using the resulting estimates. Processing the measurements includes an algorithm which places boundaries of regions, e.g., a large region and a smaller region. The regions are combined in an equation that is highly correlated with intramuscular adipose tissue measured by quantitative computed tomography in order to estimate intramuscular adipose tissue.

Dual-energy absorptiometry is used to estimate intramuscular adipose tissue metrics and display results, preferably as related to normative data. The process involves deriving x-ray measurements for respective pixel positions related to a two-dimensional projection image of a body slice containing intramuscular adipose tissue as well as subcutaneous adipose tissue, at least some of the measurements being dual-energy x-ray measurements, processing the measurements to derive estimates of metrics related to the intramuscular adipose tissue in the slice, and using the resulting estimates. Processing the measurements includes an algorithm which places boundaries of regions, e.g., a large region and a smaller region. The regions are combined in an equation that is highly correlated with intramuscular adipose tissue measured by quantitative computed tomography in order to estimate intramuscular adipose tissue.

The invention relates to a biomechanics modeling method for subcutaneous adipose tissues based on linear elasticity and superelasticity models. According to the biomechanics modeling method, the problems that an existing subcutaneous adipose tissue model is low in simulation accuracy and speed are solved. The biomechanics modeling method comprises the following steps: (1) establishing a geometric model, and dividing grids; (2) establishing a linear elasticity biomechanics model; (3) establishing a superelasticity biomechanics model; (4) carrying out finite element simulation on the superelasticity biomechanics model according to the step (1) and the step (2); (5) carrying out finite element calculation on the linear elasticity model; and (6) carrying out finite element simulation on a mixed linear elasticity and superelasticity model. By virtue of comparison on a simulation result and an experimental result, the accuracy of the biomechanics modeling method is verified. By virtue of comparison on simulation time of the single linear model and superelasticity model, high efficiency of a simulation algorithm of the mixed linear elasticity and superelasticity model is verified. The biomechanics modeling method is applied to the field of biomedical engineering.

The invention provides an automatic intra-abdominal muscle and fat image segmentation method, which is used for simultaneously segmenting abdominal muscle tissues, visceral fat tissues and subcutaneous fat tissues. The method mainly comprises the following steps of: classifying pixels of an abdominal image to obtain a preliminary pixel value change range of fat tissues, muscle tissues and a background part; Secondly, performing further segmentation on the basis of the pixel value change range of the muscle tissue to obtain an outer contour part and an inner contour part of the muscle respectively, and finishing the segmentation of the muscle tissue based on the parts. Finally, the adipose tissue segmented in the first step is divided into two parts by the muscle tissue, and the visceral adipose tissue is located in the muscle tissue. The subcutaneous adipose tissue is located outside the muscle tissue. Compared with the prior art, the method has the advantages that all sliced musculartissues and adipose tissues are segmented at a time, the correct rate is high, and full-automatic segmentation is achieved.

The invention discloses a method for preparing adipose-derived stem cells by means of extraction. The method comprises the following steps: acquiring normal abdominal subcutaneous adipose tissue, washing the obtained adipose tissue with a phosphate buffer solution (PBS), and then shearing the adipose tissue into pieces; then, carrying out digestion on the adipose tissue for a period of time by using type I collagenase; after digestion, adding the PBS into the product, evenly mixing and filtering; adding a DMEM culture solution containing human autologous serum, putting into a culture box for culturing, and replacing the culture solution with a fresh culture solution at regular intervals, wherein the cells growing from the tissue are primary cells; when the primary cells reach a certain degree of fusion, washing the cells with the PBS again, and then adding pancreatin and ethylene diamine tetraacetic acid (EDTA) digestive juice; after the cells suspend, adjusting the density of the cells, and adding the DMEM culture solution containing the human autologous serum into the cells again to obtain second-generation cells; and when the second-generation cells reach a certain degree of fusion, adding normal saline into the cells, transferring the cells into a centrifuge tube for carrying out centrifugal filtration, taking supernatant, concentrating and extracting to obtain the adipose-derived stem cells. The adipose-derived stem cells extracted by the method contain multiple life active substances, so that the stem cell properties of the adipose-derived stem cells are further improved.

The invention discloses a human sebum thickness measuring instrument capable of controlling ultrasonic waves through pressure, and belongs to the field of human physiological signal measurement. The pressure sensor and the ultrasonic probe simultaneously act on the human skin surface; the pressure sensor measures the pressure applied by the ultrasonic probe to the measured part of the human body;the signals are sent to an analog-to-digital converter of a single-chip microcomputer through an operational amplifier circuit; the single-chip microcomputer judges that pressure reaches threshold value, a high-voltage excitation circuit excites the ultrasonic probe to emit ultrasonic waves; the ultrasonic waves pass through human body subcutaneous adipose tissue and then return echo signals; echosignals are amplified by an amplifying circuit and then enter the single-chip microcomputer; the single-chip microcomputer calculates the average walking time of the ultrasonic waves in the human body fat tissue; and the thickness of the human body subcutaneous fat is obtained by multiplying the propagation speed of the ultrasonic waves in the human body fat tissue, and the measured thickness ofthe human body subcutaneous fat is displayed on the display module.

Disclosed is a transdermal composition, which uses high-purity phosphatidylcholine that is most susceptible to oxidation and the like, and which exhibits high stability and high migration into the skin. Specifically, a transdermal composition having good stability and migration into the skin is able to be obtained by preparing a transdermal composition (a colloidal dispersion liquid of phosphatidylcholine) that contains high-purity phosphatidylcholine, carnitine, a polyhydric alcohol and water. Since the transdermal composition does not contain an oleaginous base (an oil component), the transdermal composition has skin compatibility and is thus useful as a therapeutic agent or a cosmetic preparation. In addition, phosphatidylcholine and carnitine have an effect of achieving good migration into the skin and are capable of promoting systemic or local lipid metabolism in subcutaneous adipose tissues. Consequently, the transdermal composition is able to provide a transdermal preparation that is capable of promoting lipolysis in subcutaneous adipose tissues.