102 results about "Blood volume" patented technology

A method and system measure the instantaneous volume of blood contained within a chamber of a heart, irrespective of its shape, whereby stroke volume and cardiac output volume can be continuously monitored and feedback to a non-blood contacting cardiac assist device. In a preferred form the device uses the distances between the sensors which are implanted in a biomaterial that integrates with a heart surface to determine changes in heart volume. Sonomicrometry crystal measurements are disclosed as a preferred mode of obtaining distance readings. A computer readable medium carries instructions to convert data from dimension sensors into sensor positions within a predetermined coordinate system. Ventricular volume is based on the sensor positions.

Blood separation methods and systems are provided for mid-processing calculation of blood composition. Blood is conveyed into a device having an outlet line and the device is spun to separate a blood component from the blood. A flow of blood component is conveyed from the device by the outlet line and the blood component in the outlet line is optically measured. With said optical measurement, a current blood component yield, a blood component pre-count, the volume of blood to process to collect a target amount of said blood component, and / or the processing time required to collect a target amount of said blood component is calculated. The optical measurement can also be used to calculate an amount of storage fluid to convey into a collection container with the blood component.

The present invention provides a method of measuring a component in blood, by which the amounts of blood cells and an interfering substance can be measured with high accuracy and high reliability and the amount of the component can be corrected accurately based on the amounts of the blood cells and the interfering substance. In a sensor for measuring a blood component, a first working electrode 13 measures a current that flows during a redox reaction of a blood component, a second working electrode 17 measures the amount of blood cells, and a third working electrode 12 measures the amount of an interfering substance. Next, based on the measurement results, the amount of the blood component to be measured is corrected. Thus, more accurate and precise measurement of the amount of the blood component can be realized.

In patients with carcinomas tumor cells are shed into the blood, enumeration and characterization of these cells offers the opportunity to obtain a “real time” biopsy of the tumor and may improve the management of the disease. The frequency of circulating tumor cells is rare (<1 cell / ml) and technology is needed that has sufficient sensitivity and specificity to enumerate and characterize these cells. The present system was developed to provide an immunophenotype, fluorescence wave forms as well as images of immunomagnetically enriched cells. Blood volumes ranging from 7.5-30 ml are immunomagnetically enriched for epithelial cells. The sample volume is reduced to 320 μl and inserted into an analysis chamber. Upon introduction of the chamber in a magnetic field, the immunomagnetically tagged cells rise out of the sample and align between nickel lines (period 30 μm, space 15 μm) that are present on the viewing surface of the chamber. A multi laser system is used to detect the fluorescence emitted by DAPI, Phycoerythrin and Allophycocyan labeled and magnetically aligned cells. Compact disk optics are used to maintain alignment and focus of the laser beams onto nickel lines while moving the chamber. The chamber is scanned with a speed of 10 mm / sec and the entire chamber is analyzed in approximately 5 minutes. The fluorescent signals obtained from the events provide an immunophenotype similar to that of a flow cytometer. The fluorescence waveforms improve the characterization of the events and add to the classification as background, cellular debris and cells. Since the cell locations are preserved, objects that immunophenotypically classify as epithelial cells can be revisited for further analysis. Bright field and fluorescent images of the selected objects are captured to confirm that the identified objects are tumor cells.

Methods, systems, computer-readable media, and apparatuses for obtaining at least one bodily function measurement are presented. A mobile device includes an outer body sized to be portable for user, a processor contained within the outer body, and a plurality of sensors physically coupled to the outer body. The sensors are configured to obtain a first measurement indicative of blood volume and a second measurement indicative of heart electrical activity in response to a user action. A blood pressure measurement is determined based on the first measurement and the second measurement. The sensors also include electrodes where a portion of a user's body positioned between the electrodes completes a circuit and a measurement to provide at least one measure of impedance associated with the user's body. A hydration level measurement is determined based on the measure of impedance.

An apparatus and method is provided that provide, in real-time, an accurate detection and warning of dangerous blood or fluid loss to warn of impending hypovolemia, by non-invasive monitoring and processing of photoplethysmography data.

A device used to treat heart disease by decreasing the size of a diseased heart, or to prevent further enlargement of a diseased heart. The device works by limiting the volume of blood entering the heart during each cardiac cycle. The device partitions blood within the heart, and protects the heart from excessive volume and pressure of blood. The device is placed within the interior of the heart, particularly within a ventricular cavity. The device is a hollow sac, with two openings, which simulates the shape and size of the interior lining of a ventricle of a normal heart. It allows the ventricle to fill through one opening juxtaposed to the annulus of the inflow valve to a predetermined, normal volume, and limits filling of the heart beyond that volume. It then allows blood to be easily ejected through the second opening through the outflow valve. By limiting the amount of blood entering the ventricle, the ventricle is not subjected to the harmful effect of excessive volume and pressure of blood during diastole, the period of the cardiac cycle when the heart is at rest. This allows the heart to decrease in size, or to reverse remodel, and to recover lost function. In some applications, a second device may be simultaneously placed inside the heart to take up excessive space between the heart and the primary device.

A device used to treat heart disease by decreasing the size of a diseased heart, or to prevent further enlargement of a diseased heart. The device works by limiting the volume of blood entering the heart during each cardiac cycle. The device partitions blood within the heart, and protects the heart from excessive volume and pressure of blood. The device is placed within the interior of the heart, particularly within a ventricular cavity. The device is a hollow sac, with two openings, which simulates the shape and size of the interior lining of a ventricle of a normal heart. It allows the ventricle to fill through one opening juxtaposed to the annulus of the inflow valve to a predetermined, normal volume, and limits filling of the heart beyond that volume. It then allows blood to be easily ejected through the second opening through the outflow valve. By limiting the amount of blood entering the ventricle, the ventricle is not subjected to the harmful effect of excessive volume and pressure of blood during diastole, the period of the cardiac cycle when the heart is at rest. This allows the heart to decrease in size, or to reverse remodel, and to recover lost function. In some applications, a second device may be simultaneously placed inside the heart to take up excessive space between the heart and the primary device.

In order to offer a new and useful device in being able to objectively assess the psychological state when a subject performs an assignment, a psychological state assessment device is configured to irradiate a specified measurement site in the brain of a subject with near infrared light of a specified wavelength, to obtain time change data indicating time change data for the amount of blood and / or amount of blood components respectively while performing a task and while at rest, and to assess the psychological state of the subject while performing the assignment based on time change data during the rest period in comparison with time change data while performing the task.

Aspects of the invention relates to systems and methods for hypovolemia and / or hypervolemia detection of a living subject using peripheral intravenous waveform analysis. In one embodiment, the method includes: acquiring, from a vein of the living subject, peripheral venous signals; performing a spectral analysis on the acquired peripheral venous signals to obtain a peripheral venous pressure frequency spectrum; and performing a statistical analysis on amplitudes of peaks of the peripheral venous pressure frequency spectrum to determine the blood volume status of the living subject in real time. Specifically, at least two peaks, respectively corresponding to a first frequency and a second frequency, are obtained on the peripheral venous pressure frequency spectrum. Amplitude change of the second peak is used to determine the blood volume status of the living subject. Hemorrhage may be detected when a significant amplitude decrease is detected from the second baseline peak to the second peak.

Venous reservoirs are interposed between the patient and the arterial pump and serve to remove air bubbles and provide compliance that accommodates variations in the volume of blood circulating in the extracorporeal circuit during cardiopulmonary bypass (CPB). The invention is a reservoir that incorporates automated means to remove air bubbles from the venous line prior to the blood entering the arterial blood pump. In another form, the reservoir includes means that handles foam prior to the blood entering the blood pump. In yet another form, the invention is means that improve air removal in a soft shell venous reservoir. These features are applicable to CPB circuits using gravity drainage or vacuum assisted venous drainage.

An apparatus and method for non-invasive monitoring and detection of sudden changes in cardiovascular hemodynamics, in which a PPG signal is obtained from a patient, a time-frequency spectrum (TFS) is computed from the PPG signal, instantaneous modulations at a plurality of time points defining a curve of a prominent frequency of oscillation are extracted from the TFS, a peak power spectral density sequence is computed using the instantaneous modulations, and instantaneous peak values for following prominent frequency oscillations are monitored.

Novel devices which can be used to both collect blood samples from and administer medical fluids to a patient on a repeated and continual basis using one rather than multiple needle insertions. The devices are capable of removing blood from one of the patient's veins using the intrinsic venous pressure of the blood and capillary action of the device, thereby preventing vacuum-induced collapse of the vein. The device typically includes a main tubing segment confluently connected to a cannula for insertion in the patient's vein. A syringe port and a volumeter for collecting blood branch separately from the main tubing segment. The device is used to collect blood by attaching an empty blood collection syringe to the syringe port, inserting the cannula in the patient's vein, allowing passive flow of blood from the main tubing segment into the volumeter under intrinsic venous blood pressure and capillary action, and then facilitating active flow of blood from the volumeter into the blood collection syringe by extending the syringe plunger. The blood-filled syringe may be replaced by additional empty blood collection syringes and the procedure repeated, as needed, depending on the quantity of blood to be obtained. The device may be used to administer medical fluids to the patient by first removing the residual blood from the main tubing segment and volumeter, flushing the main tubing segment with sterile normal saline and administering the fluids to the patient through the main tubing segment from a medical fluid syringe or catheter attached to the syringe port.

The endoscope system includes: an image signal acquisition unit acquiring first image signal in first wavelength range where the amount of light absorption changes according to the concentration of yellow dye, second image signal in second wavelength range where the amount of light absorption changes according to the blood volume of an observation target, and third image signal in third wavelength range where a change in the amount of light absorption according to the concentration of the yellow dye is smaller than the first wavelength range and a change in the amount of light absorption according to the blood volume is smaller than the second wavelength range; a signal ratio calculation unit calculating first signal ratio based on the first and second image signals and calculating second signal ratio based on the second and third image signals; and a warning notification unit calculating a threshold value and generates warning signal.

Disclosed are a method and apparatus for accurately measuring nuclear magnetic resonance (NMR) longitudinal axis relaxation time by minimizing the influence of the amount of blood. The method includes applying a first magnetic field MO to a living body portion into which the blood flows magnetizing the blood in a first direction; applying a second magnetic field MZ to at least a portion of the living body portion, to which the first magnetic field MO is applied, magnetizing at least a portion of the blood in a second direction vertical to the first direction;; blocking MZ detecting a signal that is induced as magnetization is returned from the second direction to the first direction; detecting the amount of blood to which the second magnetic field MZ is applied; and calculating the longitudinal axis relaxation time T1 of the blood based on the induced signal and based on the amount of blood.

The invention relates to a kit of extracting a whole genome DNA (Deoxyribonucleic Acid) from blood and a using method thereof. The kit is characterized by comprising a red blood cell lysate, a white blood cell scrubbing solution, digestive juice, proteinase K, a purifying liquid, gDNA salting out liquid, a gDNA scrubbing solution, a gDNA eluant and the like. The using method of the whole genome DNA extraction kit for blood is characterized by comprising the following steps: washing the red blood cell split to obtain the white blood cell; splitting the white blood cell by the digestive juice containing the proteinase K; and further purifying by an improved lithium chloride purifying liquid, salting out the liquid layer, and carrying out chromatography to obtain the high purity whole genome DNA. When the kit provided by the invention is used to extract the whole genome DNA in blood, plasma and serum in blood are not separated in advance but fresh or frozen anti-freezing whole blood is taken, wherein the lowest blood volume required reaches 20 microliters or blood cakes are required. According t the kit provided by the invention, the whole genome DNA with high purity can be fully unlinked and the PCR (Polymerase Chain Reaction) amplification is efficiently carried out, so that the kit is used for scientific research or clinical diagnostic analysis such as PCR amplification, gene expression, gene sequencing, whole genome sequencing, exome sequencing, gene mutation and single nucleotide polymorphism.

The invention discloses an electric-shock-prevention safe socket. Through detecting the frequency of changes of the blood volume of finer blood capillaries along with the cardiac impulse, whether a finger is inserted into the socket or not is judged. The safe socket concretely comprises a socket shell, a touch switch, a detection circuit, a socket internal insertion spring, an LED infrared light emitting tube and a photosensitive receiving tube. In need of using the socket, the touch switch is turned on to supply power to the detection circuit, the LED infrared light emitting tube and the photosensitive receiving tube, the LED infrared light emitting tube emits light, when the finger is inserted into a hole of the socket, the photosensitive receiving tube receives beat frequency, the detection circuit detects the beat frequency of the impulse of the human body, and the socket is powered off; when a non-light-transmitting metal object or other objects is / are inserted into the socket, the detection circuit obtains a low-level waveform, and the socket is powered on; when no object is inserted into the socket, the detection circuit obtains a high-level waveform, the socket is powered off, and accordingly the detection circuit enters into dormancy. The safe socket has the advantages of being safe to use and reasonable in structure, reducing energy consumption and the like.

The invention discloses a blood plasma separation adsorber, comprising a shell. An inlet cushion chamber, an outlet cushion chamber and a blood purifying chamber are arranged in the shell. A blood inlet is arranged on the wall of the inlet cushion chamber; a blood outlet is arranged on the wall of the outlet cushion chamber; a blood plasma outlet is arranged on the wall of the blood purifying chamber; at least a hollow fibrous membrane is arranged in the blood purifying chamber and two ends of each hollow fibrous membrane are communicated with the inlet cushion chamber and the outlet cushion chamber respectively; and at least a fiber-shaped adsorbent is arranged in the blood purifying chamber. The adsorber has the advantages of simultaneous blood plasma separation and adsorption, shortened process of blood plasma adsorption and reduced blood amount of extracorporeal circulation, thereby reducing burden of patients and risks of incompatibility of blood.

The abdominal circulatory pump uses expulsive manoeuvres performed by contraction of the diaphragm while stabilizing, contracting or compressing the abdominal wall to increase abdominal pressure and pump blood. At the same time, it can be used to lower pleural pressure around the surface of the lung to provide ventilation. In humans the blood in the splanchnic circulation; i.e., the blood in the abdominal contents, is a reservoir of about 20% to 25% of the whole body blood volume. The increase in abdominal pressure forces this blood to flow out of the abdomen and through the body.

A method and system for accurately measuring a very small volume of blood is used for accurate evaluation of an amount (volume) of blood collected by a lancing device, evaluation of a scientific very small amount of blood, and so on. The method includes the steps of collecting the very small volume of blood, absorbing the very small volume of collected blood into an absorption medium, drying the absorption medium, scanning the dried absorption medium using an image scanner connected to a computer to obtain a digital image, and calculating the very small volume of blood from the digital image using an analysis program.

An apparatus for detecting and notifying occurrence of post-partum haemorrhage in female patients is envisaged. Continued tracking of the blood discharged from a female patient's body during labor as well as postnatal operation procedures is provided for, and as soon as the amount of blood discharged from the body of the female patient exceeds a predetermined threshold value, a light-based alarm and sound-based alarm are triggered. The apparatus includes a first connector connected to the female patient when she is on a Labor Recovery Delivery bed, and a second connector woven onto an undergarment to be worn by the female patient. The first connector and second connector are connected to single use, disposable blood collection bags, whose weights are measured using weight sensors for an accurate calculation of the total amount of the blood lost by the female patient during labor operation procedures and postnatal operation procedures.

Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.

The invention provides an Angus beef finished cattle feeding and management method. The method comprises the following steps that 1, finished cattle are divided into bred cattle and young dairy cattle, the bred cattle refer to 6-18-months-old cattle, and the young dairy cattle refer to 18-months-old cattle to prenatal cattle; 2, the following buffering agent is added into daily ration to serve as an additive; 3, a good feeding and management environment is set up, a pasture is kept clean and sanitary, disinfection is carried out in time, infectious diseases are prevented, treatment needs to be carried out in time during attack, and according to the treatment rules, acidosis is eliminated, electrolyte is supplemented, and the blood volume is expanded. The formula of feed and the feeding and management method are optimized, and finally the morbidity of rumen acidosis is reduced and reduced to be smaller than 15%. The method is applied to feeding, the cattle grow fast, and the weight is increased by 1.2 kg or above.

This document discusses, among other things, quantification of hemoglobin content, and therefore blood volume, of muscle. An analysis of the optical spectra can determine the ratio of hemoglobin (Hb) to myoglobin (Mb) content in intact muscle. The peak position of the in vivo optical spectra from intact tissue is used to determine the ratio of Hb to Mb contributing to the optical signal. The wavelength of the peak is a linear function of the percent contribution of Hb to the optical spectra. Such analysis in combination with known Mb concentrations yields a non-invasive measure of the Hb content for in vivo muscle.

Ruptured Abdominal Aortic Aneurysms (AAA) cause a large number of deaths annually. Ruptures occur even in people who are already diagnosed with AAA and are being monitored. The reason is that the interval between tests is too long because of the need to visit a pathological facility with imaging equipment. It is preferable to estimate the progress of AAA frequently, once detected, in a non-invasive manner, preferably at the subject's home, without the need for the subject to visit a pathological facility. A device is disclosed for detecting a state of a vascular pathology of a subject, comprising a sensor signal unit (103) for providing a signal representative of a blood volume in a body part of a subject, a comparator (107) for comparing the sensor signal with a reference signal, and a user interface (109) for conveying a result based on the comparison to a user of the device.

The invention discloses a double-layer gas-protection vacuum blood collection tube. The double-layer gas-protection vacuum blood collection tube comprises a tube body and a sealed rubber plug, the tube body comprises an outer tube and an inner tube, the outer tube and the inner tube are formed integrally in an injection-molding mode, the upper end of the outer tube is higher than that of the inner tube, and an interlayer cavity is formed between the outer tube and the inner tube; the side wall of the sealed rubber plug is provided with multiple rounds of elastic bulge loops, the sealed rubber plug is clamped with the inner wall of the outer tube through the bulge loops in a sealed mode, the diameter of the bottom end of the sealed rubber plug is the same as that of the inner tube, and the sealed rubber plug stretches into the inner tube and is buckled with the inner tube. According to the double-layer gas-protection vacuum blood collection tube, by arranging the outer tube and the inner tube which are formed into one in the injection-molding mode, and connecting a crimpling short tube to the lower end of the inner tube, the blood volume of a vacuum blood collection tube can be accurately controlled, the sealing property between the sealed rubber plug and a single tube can be improved, and the expiration date of the vacuum blood collection tube is prolonged.

A method determines cardiac output or stroke volume by receiving signal data representing multiple parameters of a patient concurrently acquired over a particular time period and comprising at least one of, (a) a parameter derived from an ECG waveform of the patient, (b) a parameter derived from a blood pressure signal of the patient, (c) a parameter derived from signal data representing oxygen content of blood of the patient and (d) a parameter derived from a patient cardiac impedance value. A selected parameter of the multiple concurrently acquired parameters is used in calculating a heart stroke volume of the patient comprising volume of blood transferred through the blood vessel in a heart cycle, in response to, a combination of a weighted summation of values of the selected parameter over the particular time period. Data representing the calculated heart stroke volume is provided to a destination device.

An optical vital signs sensor (100) is provided, which comprises a PPG sensor (102), a force transducer (130) configured to measure a force applied via the PPG sensor (102) to a skin (1000) of the user and a processing unit (140) configured to extract information regarding a blood volume pulse from the output of the PPG sensor (102) and to map the extracted information to the blood pressure value at a specific force applied to the PPG sensor (102).

The invention discloses a blood vessel blocker capable of controlling the blood flow volume. The blood vessel blocker comprises a supporting plate and a squeezing plate which are oppositely arranged on the two sides of a blood vessel. The supporting plate is connected with a support spanning the blood vessel, a groove with the central line perpendicular to the squeezing plate is formed in the end, located outside the squeezing plate, on the support, an air bag and a guiding block moving along the central line of the groove are arranged in the groove, the air bag is communicated with an inflating device, and the guiding block is connected with a squeezing plate through a connecting rod. The blood vessel blocker further comprises a pressure sensor used for measuring the pressure of the blood vessel, and a probe of the pressure sensor is arranged on the inner side of the supporting plate or the squeezing plate. By means of the blood vessel blocker, blood flow blocking at any degree can be obtained in operation according to experimental needs, and thus the blood flow blocking situation of blood vessels of different thicknesses and different kinds can be more accurately and more visually measured; meanwhile, the reversible operation of increasing or decreasing of the blood flow volume can be achieved, and convenience is provided for blood flow volume detection related experiments or treatment control.

The invention relates to a terlipressin acetate nasal cavity spray and a preparation method thereof. The spray is composed by terlipressin acetate, absorption enhancer, osmotic pressure regulator, preservative and pH regulator. The preparation method of the spray mainly comprises raw material preparing, dissolving, bottle washing, filling, packing and the like. The spray has the main functions of contracting smooth muscles of visceral vessels and reducing blood flow volume of the viscera, accordingly, the portal vein blood flow and portal vein pressure are reduced, and meanwhile, the spray can be used for the smooth muscles of the esophagus and the uterus. The spray is convenient to dose, has high bioavailability, and is beneficial to patients to accept.