54 results about "Intact tissue" patented technology

Devices and methods for transplanting tissue for the purpose of regeneration, for treating a patient having injured myocardial tissue, and / or for improving cardiac function through cell regrowth. More specifically, the devices and methods obviate the need for cellular alteration. The devices comprise a hollow tube with a sharp distal end, a stylet that is disposed and movable within the hollow tube, and a stopping device that constrains movement of the stylet. The methods comprise removing intact tissue from a first region of a mammalian organ and implanting the tissue in a second region of the same organ.

Provided herein are devices, methods, and systems for in situ gene sequencing of a target nucleic acid in a cell in an intact tissue. Methods of screening a candidate agent to determine whether the candidate agent modulates gene expression of a nucleic acid in a cell in an intact tissue are also provided herein.

The invention relates to an embedding method for a metallographic specimen. The required device comprises a low-temperature chamber electric furnace and a mould; a mould crucible is prepared by taking the following components by weight percent: more than or equal to 99% of Al2O3, less than or equal to 0.2% of SiO2, less than or equal to 0.1% of Fe2O3 and the balance of alkali; the mould can be in various specifications, such as 15mm*15mm*20mm and phi 15mm*20mm; and tin and lead scraps containing 60-80wt% of tin are taken as embedding materials. The method comprises the following steps: putting a to-be-embedded specimen into the mould; adding a right amount of the tin and lead scraps according to the size of the mould; putting into an electric furnace at a preset temperature and then heating for 0.5-5h; taking out and solidifying for 0.5-2h at room temperature, thereby being capable of taking out the specimen; polishing the specimen step by step by using 120#, 320#, 800#, 1000# and 1500# abrasive paper, and then observing by the polished etched specimen. The specimen prepared according to the method provided by the invention can be applied to the observation for a metallographic microscope or a scanning electron microscope and EBSD (Electron Back-Scattered Diffraction) and EDS (Electronic Differential System) detection, and the data, such as a true and complete organization structure of the specimen, can be acquired.

Methods and devices for conducting high-speed, high-resolution imaging of large intact tissue samples are provided. Aspects of the methods include placing a sample in an optically homogenous sample manipulation component, performing a calibration procedure to align a light sheet and a detection focal plane at a plurality of locations within the sample, and performing an imaging procedure on the sample to collect an image from each location. The collected images are reconstructed to form a three-dimensional image of the sample. Devices for carrying out the steps of the methods are also provided.

The invention provides a method for displaying an ultralow carbon IF (Interstitial-Free) sheet metallographic structure, belonging to the technical field of metallographic examination. The method comprises the testing steps of inserting a test sample, roughly grinding, elaborately polishing and etching, and collecting pictures. The method has the advantages that clear and complete structure pictures of ferrite crystal grains can be obtained through the technology, the operation is simple, the problems that ultralow carbon sheet ferrite crystal grains are incompletely displayed and grain boundaries are embossed seriously can be solved, and the method is especially applicable to structure display of ultralow carbon IF sheet steel with the carbon content of 0.002% below.

Shape memory tissue engagement elements (15) are created using shape memory alloys or shape memory (SM) composite sheets (33, 36) with one or more SM material sheets (20, 32). Arrays of the tissue engagement elements may then be inserted or molded into flexible base materials forming pads for tissue engagement. In certain embodiments, the composite sheets incorporate two SM material layers (20, 32) having differing transition temperatures to allow activation of one layer for tissue engagement and activation of the second layer for tissue release. In exemplary embodiments, insertion of interconnected tissue engagement elements (46) into a base layer (19) with slots (48) provides a completed pad array. In alternative exemplary embodiments, vacuum forming of composite sheets (51) with cutting of corrugated sides (53) to form tissue engagement elements allow production of complete arrays of tissue engagement elements. Overmolding the arrays with a flexible base material (19) provides a completed pad.

A low coherence enhanced backscattering tomography (LEBT) method is disclosed for depth-selective sensing of the superficial layer of tissue. 3D images of the microarchitecture and molecular conformation of the superficial layer of tissue are obtained. The method combines the high resolution advantage of low coherence light and the high sensitivity advantage of light scattering to tissue structure and composition. Intact tissue can be examined without the need of excision or processing. The method can be applied in in situ measurements. According to the method, 3D images of the nuclear morphology and cellular structure for the superficial layer of the tissue are generated; this is particularly useful in detecting cancer and precancer at the earliest stage of carcinogenesis.

This document discusses, among other things, quantification of hemoglobin content, and therefore blood volume, of muscle. An analysis of the optical spectra can determine the ratio of hemoglobin (Hb) to myoglobin (Mb) content in intact muscle. The peak position of the in vivo optical spectra from intact tissue is used to determine the ratio of Hb to Mb contributing to the optical signal. The wavelength of the peak is a linear function of the percent contribution of Hb to the optical spectra. Such analysis in combination with known Mb concentrations yields a non-invasive measure of the Hb content for in vivo muscle.

Methods and system provide a focused spot having a cross-sectional size within a range from about 50 [mu]m to about 200 [mu]m full width half maximum (FWHM); the corresponding cavitation can be similarly sized within similar ranges. The ultrasound beam can be focused and pulsed at each of a plurality of locations to provide a plurality of cavitation zones at each of the target regions. Each pulsemay comprise a peak power within a range generating focal negative peak pressures within a range from about 10 MPa to about 80 MPa. While the treatment pulses can be arranged in many ways within a region, in many instances the pulses can be spaced apart within a region to provide intact tissue such as intact sclera between pulses.

Devices and methods for transplanting tissue for the purpose of regeneration, for treating a patient having injured myocardial tissue, and / or for improving cardiac function through cell regrowth. More specifically, the devices and methods obviate the need for cellular alteration. The devices comprise a hollow tube with a sharp distal end, a stylet that is disposed and movable within the hollow tube, and a stopping device that constrains movement of the stylet. The methods comprise removing intact tissue from a first region of a mammalian organ and implanting the tissue in a second region of the same organ.

The invention belongs to the technical field of medical instruments, and discloses a cardiovascular intubation image auxiliary detection device and a detection method. The cardiovascular intubation image auxiliary detection device comprises an image acquisition module, a heart rate detection module, a respiratory frequency detection module, a central control module, a classification module, a datamanagement module, a data storage module and a display module. The invention establishes a new optimized CNN model through a classification module, and then superimposes the boundary map and the segmentation map to form a complete organization structure map, which makes up for the loss of image information caused by the reduction of the output image resolution, has high restoration degree of theorganization structure and better image display effect. At the same time, the data management module establishes different data quality evaluation models according to the data characteristics and datause purposes of different stages, so as to ensure the accurate and effective evaluation of the data quality, and overcome the shortcomings of lacking effective data quality evaluation models in the prior art.

A low coherence enhanced backscattering tomography (LEBT) method is disclosed for depth-selective sensing of the superficial layer of tissue. 3D images of the microarchitecture and molecular conformation of the superficial layer of tissue are obtained. The method combines the high resolution advantage of low coherence light and the high sensitivity advantage of light scattering to tissue structure and composition. Intact tissue can be examined without the need of excision or processing. The method can be applied in in situ measurements. According to the method, 3D images of the nuclear morphology and cellular structure for the superficial layer of the tissue are generated; this is particularly useful in detecting cancer and precancer at the earliest stage of carcinogenesis.

The invention provides a friction cloth for manufacturing liquid crystal panels of velvet fabric, the velvet fabric has: a base fabric structure formed by warp yarns (11)-(22) and weft yarns (1)-(6) and warp yarns along the base fabric structure Pile yarns (A) to (D) woven in the direction, the friction cloth for liquid crystal panel manufacturing is characterized in that: in a complete weave of the velvet fabric, the warp yarn has: a part (11) forming a plain weave and (12) and floating yarns (21) and (22) which are woven in a state of floating on the upper side of the weft yarn at the surface on the side where the end of the pile yarn protrudes enter.

Devices and methods for transplanting tissue for the purpose of regeneration, for treating a patient having injured myocardial tissue, and / or for improving cardiac function through cell regrowth. More specifically, the devices and methods obviate the need for cellular alteration. The devices comprise a hollow tube with a sharp distal end, a stylet that is disposed and movable within the hollow tube, and a stopping device that constrains movement of the stylet. The methods comprise removing intact tissue from a first region of a mammalian organ and implanting the tissue in a second region of the same organ.

The present invention relates to a method of dehydrating pieces of intact plant or animal tissue, said pieces containing at least 30 wt. % of water, the method comprising (i) contacting the pieces of intact tissue with a pressurized gas to reduce the water content of the pieces by at least 50%, said pressurized gas having a pressure of at least 0.5×Pc and a temperature of at least Tc−60° C., Pc representing the critical pressure of the gas and Tc representing the critical temperature of the gas, and (ii) separating the pressurized gas from the dehydrated pieces, wherein at least 80 wt. %, preferably at least 90 wt. % of the matter removed by the gas from the pieces of intact plant or animal tissue is water. The invention also provides a method of dehydrating a material containing at least 30 wt. % of water, using a method as described before, followed by drying the separated pressurized gas by contacting said pressurized gas with a water absorbent water adsorbent; and recirculating the dried pressurized gas to the partially dehydrated material.