71 results about "Tissue Differentiation" patented technology

An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered.

Quantified differences, such as chi<2 >error parameters, between a mono-exponential, logarithmic best fit of a series of line scan diffusion-weighted magnetic resonance signals taken over a range of b-factors between about 100 and about 5000 sec / mm<2 >are obtained. The quantified differences so generated are displayed as an image wherein the brightness of each pixel depends upon the size of its associated quantified difference. The resulting image is characterized by high signal to noise ratio and distinctness between varying tissue types.

There is provided a simplified and inexpensive method for the in-vitro identification, isolation and culture of human vasculogenic progenitor cells. The method and the progenitor cells isolated thereby can be used for in-vitro vascular engineering, treatment of congenital and acquired vascular and hematological abnormalities, for evaluation and development of drugs affecting vasculo- and angiogenic processes, and for further investigation into tissue differentiation and development.

This present invention relates to methods of manipulation, storage, modeling, visualization and quantification of datasets. One application of the present invention is related to developing point-models of datasets represented by the various points in a multi-dimensional map. The invention can be adapted to genomic analysis by Fractal Genomics Modeling (FGM) for developing single point gene models which can be used for studying cellular chronomics and causal relationships of genes. Using FGM, evidence of genes that govern fundamental clocking cycles in cell development and tissue differentiation of an organism can be produced. This clocking mechanism and the FGM methods used to produce its genetic components and function are described in this disclosure.

The invention discloses a simulation system for long bone fracture healing based on tissue differentiation, and relates to the field of biomedical engineering. The simulation system is used for predicting the complicated process of the fracture healing and searching for the optimal scheme for the fracture healing. The system comprises a fracture area geometric modeling module, a fracture area biomechanics finite element analysis module, a callus unit tissue differentiation module and a program determination judging module. The fracture area geometric modeling module is used for establishing a three-dimensional geometric model of the fracture area; the fracture area biomechanics finite element analysis module is used for conducting finite element analysis on the established three-dimensional geometric model to obtain unit mechanical stimulation; the unit tissue differentiation module is used for simulating tissue differentiation and making the content of each tissue in the unit be updated; the program determination judging module is used for judging whether the program is determined or not. According to the simulation system for the long bone fracture healing based on the tissue differentiation, the fracture area is regarded as a diphasic porous elastic model, the fracture healing process can be more accurately simulated, and the system provides beneficial help for searching for the optimal scheme for the fracture healing.

Medical illumination systems and devices for illuminating a target surgical area with a pre-selected type of multispectral light to aid tissue differentiation as viewed by the human eye, especially in open-surgery settings, and methods for practicing the same. A light source may have multiple settings selectable to provide various types of multispectral light configured to reduce reflection from corresponding tissue types relative to full-spectrum light. A pre-selected type of multispectral light may be configured to reduce reflection from blood. An illumination system or device can have one more illumination elements, including combinations of LEDs, lasers, and filtered broadband light sources. The multispectral light may be or comprise one or more of a continuous or pulsed wave.

The invention discloses the application of NFI transcription factors in esophageal squamous cell carcinoma, and particularly relates to the application of a transcription factor NFIB in the diagnosisof esophageal squamous cell carcinoma and the application of a transcription factor NFIA in evaluating the differentiation degree, TNM staging and prognosis of esophageal squamous cell carcinoma. Thelevel of the NFI transcription factors of esophageal squamous cell carcinoma is detected and analyzed by the immunohistochemical technique, it is found that patients with high expression of NFIA havea low tumor differentiation degree, a high TNM stage and poor prognosis, and high expression of NFIB corresponds to a low esophageal squamous cell carcinoma tissue differentiation degree, in this way,a new way is provided for the diagnosis and prognosis judgment of esophageal squamous cell carcinoma, and a reference is provided for clinicians to analyze the condition of patients with esophageal squamous cell carcinoma.

A method of differentiating tissues in Magnetic Resonance Imaging (MRI) comprising applying a Magnetization Transfer (MT) pre-pulse in combination with the Diffusion Weighted Imaging (DWI) pulse sequence to obtain an image of the tissue under evaluation. Analysis maps and / or measurements are generated from the obtained image, from which values representative of the macromolecular content are computed for obtaining tissue differentiation.

The invention relates to methods for isolating and purifying specific types of neurons, such as cortical or other projection neurons including corticospinal motor neurons, subcerebral projection neurons, and callosal projection neurons. The invention also relates to genes that are specific for particular neuronal subtypes, and the use of such genes in genetic / molecular control of cell development. The isolated cells and subtype-specific genes also have uses in diagnostics, therapeutics, and screening assays for pharmaceutical molecules.

The invention relates to a method for inducing adventitious buds of hybrid eucalyptus isolated organs through callus tissue differentiation. The method comprises: an axillary bud acquisition step: clipping a bud strip from hybrid eucalyptus, disinfecting the bud strip, and inoculating the disinfected bud strip into a culture medium so as to carry out germination culture to grow axillary buds; a rooting induction culture step: cutting the axillary buds, transferring the axillary buds to an MS (Murashige and Skoog) culture medium so as to carry out successive transfer culture to grow sprouts which meet requirements, cutting the sprouts and transferring the sprouts to a 1 / 2 MS culture medium so as to carry out rooting induction culture to obtain a rooted seedling; a sprout culture step: cutting off the terminal buds of the rooted seedling, reserving 1-4 axillary buds of root and base parts, inoculating the axillary buds onto the MS culture medium so as to carry out sprout culture; a callus tissue induction culture step: inoculating a cut sprout section utilized as an explant onto a callus induction culture medium so as to culture under a dark condition and then under a weak illumination condition, thus obtaining callus tissues; and an adventitious bud differentiation step: transferring the callus tissues onto a differential medium so as to carry out successive transfer culture, thus obtaining the adventitious buds. The method is based on the bud strip of clonal adult eucalyptus, thus the regeneration efficiency reaches about 60%.

A simplified and inexpensive method for the in-vitro identification, isolation and culture of human vasculogenic progenitor cells is provided. The method and the progenitor cells provided herein can be used for in-vitro vascular engineering, treatment of congenital and acquired vascular and hematological abnormalities, for evaluation and development of drugs affecting vasculo- and angiogenic processes, and for further investigation into tissue differentiation and development.