1585 results about "Blood supply" patented technology

Tooth tissues include the pulp mesenchyme that forms the dentin and an epithelium that is responsible for enamel formation. Cells from these tissues were obtained from porcine third molars and were seeded onto a biodegradable scaffold composed of a polyglycolic acid—polylactic acid copolymer. Cell polymer constructs were then surgically implanted into the omentum of athymic nude rats so that the constructs would have a blood supply and these tissues were allowed to develop inside the rats. Infrequently, columnar epithelial cells were observed as a single layer on the outside of the dentin-like matrix similar to the actual arrangement of ameloblasts over dentin during early tooth development. Developing tooth tissues derived from such cell polymer constructs could eventually be surgically implanted into the gum of an edentulous recipient where the construct would receive a blood supply and develop to maturity, providing the recipient with a biological tooth replacement.

Nanocells allow the sequential delivery of two different therapeutic agents with different modes of action or different pharmacokinetics. A nanocell is formed by encapsulating a nanocore with a first agent inside a lipid vesicle containing a second agent. The agent in the outer lipid compartment is released first and may exert its effect before the agent in the nanocore is released. The nanocell delivery system may be formulated in pharmaceutical composition for delivery to patients suffering from diseases such as cancer, inflammatory diseases such as asthma, autoimmune diseases such as rheumatoid arthritis, infectious diseases, and neurological diseases such as epilepsy. In treating cancer, a traditional antineoplastic agent is contained in the outer lipid vesicle of the nanocell, and an antiangiogenic agent is loaded into the nanocore. This arrangement allows the antineoplastic agent to be released first and delivered to the tumor before the tumor's blood supply is cut off by the antianiogenic agent.

A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region, which is capable of capturing embolic material which may be released into a blood vessel during a therapeutic interventional procedure at the site of a lesion in the blood vessel. The system is adapted to be utilized in a collateral blood supply system adapted to enable the flow of blood to bypass the blood vessel upon blocking thereof and to enable the reverse flow of blood through the blood vessel upon unblocking thereof. The system includes a guide wire, including a distal end, adapted to be positioned in a blood vessel relative to an interventional procedure site. A guide catheter, including a distal end, is adapted to enable the interventional procedure to be performed, and to be inserted over the guide wire and through a patient's vasculature to a position in the blood vessel relative to the interventional procedure site. An occluding device for occluding and blocking a blood vessel at a location relative to the interventional procedure site is adapted to be positionable at a location relative to he interventional procedure site, to be expandable so as to prevent and block the flow of blood past the occlusion, and to enable the capture of embolic material which may be released into the blood in the blood vessel during the therapeutic interventional procedure, and to be contracted to unblock the blood vessel and enable the recovery of captured embolic material.

The present invention provides a method of measuring a component in blood, by which an amount of the component can be corrected accurately by measuring a hematocrit (Hct) value of the blood with high accuracy and high reliability and also provides a sensor used in the method. The sensor for measuring a component in blood has a first analysis portion and a second analysis portion. The first analysis portion has a first electrode system (11,12) and a reagent layer (14), and the reagent layer (14) has an oxidoreductase that acts on the component and a mediator. In the first analysis portion, the component in the blood is measured by causing a redox reaction of the component with the oxidoreductase in the presence of the mediator and detecting a redox current caused when a voltage is applied by the first electrode (11,12). The second analysis portion has a working electrode and a counter electrode, and a mediator is provided on the counter electrode but not on the working electrode. In the second analysis portion, a Hct value of the blood is measured by supplying the blood to the electrode system, applying a voltage to cause a current to flow, and detecting a value of the current. Using this Hct value, the amount of the component is corrected.

The present invention provides a blood pump capable of substantially completely preventing thrombus from attaching to the inner bottom portion of the casing without lowering the anti-hemolytic characteristic of blood. A centrifugal blood pump in accordance with the present invention comprises a pump casing, a suction inlet disposed at the central portion on the upper side of the casing, a delivery outlet disposed at the bottom peripheral portion of the casing, a main impeller (D in diameter) for forming a centrifugal flow of blood supplied from the suction inlet in the range from the central portion to the peripheral portion to feed the blood to the delivery outlet, wherein the main impeller is provided with an stirring impeller, the surface of which is provided with one or more stirring elements (L in entire length) having the shape of a fin or a groove, and the dimensions of the stirring elements are determined to satisfy inequality (1): 0.43<LD<1.30 and inequality (2) 0.03<S / A<0.21, where S is the surface area of the blood contact surfaces of the stirring elements.

An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.

A technique for detecting and localising vascular occlusions in the brain of a patient is presented. The technique uses volumetric angiographic data of the brain. A mid-sagittal plane and / or lines is / are identified within the set of angiographic data. Optionally, the asymmetry of the hemispheres is measured, thereby obtaining an initial indication of whether an occlusion might be present. The angiographic data is mapped to pre-existing atlas of blood supply territories, thereby obtaining the portion of the angiographic data corresponding to each of the blood supply territories. For each territory (including any sub-territories), the asymmetry of the corresponding portion of the angiographic data about the mid-sagittal plane / lines is measured, thereby detecting any of the blood supply territory including an occlusion. The angiographic data for any such territory is displayed by a three-dimensional imaging technique.

A portable pneumatic abdominal aortic tourniquet for occlusion of the abdominal descending aorta to restrict blood supply to a non-compressible arterial hemorrhage in the abdominal region. The tourniquet comprising an adjustable waist strap for securing around an abdomen; a directed air bladder mounted to the waist strap having a generally “V” shaped construction operable between a deflated condition wherein the directed air bladder is collapsed, and an inflated condition wherein the directed air bladder is expanded for exerting pressure against the abdomen; and, an air source connected to the directed air bladder for operating the directed air bladder between the deflated condition and the inflated condition.

A balloon catheter is formed with a plurality of depressions. The balloon is coated with a matrix incorporating a therapeutic substance, which additionally fills the depressions. When the balloon is expanded within a body lumen, the therapeutic substance may diffuse into the lumen wall, or all or a portion of the coating transfers to the lumen wall. A lattice frame may surround the balloon, applied prior to coating if the coating is to transfer, operative to maintain a more linear balloon profile during inflation, promoting more even transfer pressure. A contrast dye is incorporated into the transferred coating, enabling ready location and inspection of the treated lumen area. Projections may alternately be formed in the balloon surface, operative to urge the coating and therapeutic substance between cells, or past cell layers of the lumen, to the interior of the lumen wall. Prior to transfer, an extended inflation period, possibly including the use of perfusion ports to maintain blood supply, enables a larger initial quantity of therapeutic substance to diffuse into the body lumen, prior to transfer of the coating and withdrawal of the catheter, balloon, and frame.

The present invention comprises compositions and methods for forming an endovascular occlusion to treat conditions such as aneurysms, arterio-venous malformations, excessive blood supply to tumors, massive vascular hemorrhaging, and other conditions which require an embolization to alleviate the condition. Embodiments of the present invention comprise compositions and methods that use calcium alginate, without or without endovascular coils or similar devices, to form occlusions at a site within the mammalian body targeted for occlusion.

Brain images are processed and analyzed with the aid of a computer for stroke diagnosis or therapeutic decision making, where multiple stroke-related images are superimposed. The superimposed images include brain images that have infarct and penumbra regions, and patient-specific brain atlas images. The infarct and penumbra regions are determined and delineated on the superimposed images. Each patient-specific brain atlas image may be formed by mapping a pre-existing brain atlas to a co-ordinate system in which the brain images are co-registered. A brain atlas may depict brain structures such as anatomy structures, blood supply territories (BST), or cerebral vasculature. The superimposed images may be used to determine any overlap between a particular brain structure and the infarct and penumbra regions.

A safety catheter device for hemodialysis and donor collection (see FIG. 9) comprises a catheter unit (101), a needle (105) guided by a needle port (114) into the catheter unit to introduce it into patient's vein, an indication channel for blood supply into an indication cavity (109) during catheter emplacement, a blood stream channel for blood supply to hemodialysis or collection set through a blood stream port (112). The minimal cross-sectional area of the blood stream channel is substantially more than one of the indication channel. Forming the blood stream channel is accomplished by retracting the needle and, in version embodiment, by rotating a port unit (111) including the needle and blood stream ports relative to the catheter unit. There are means preventing blood leakage and personnel infecting.

A system and methods useful for treating morbid obesity include the installation of a stenosis into an artery of a morbidly obese patient, the artery selected to be one that supplies blood to the small intestine of the patient.

A portable light delivery device for delivering light to the blood supply of a human body through a nonocular area of skin on the body includes an attachment member, a portable light delivery unit connected to the attachment member and a portable power supply. The portable light delivery unit provides one or more wavelengths of light within a specifically determined range of intensity and a specifically determined angle of illumination. A portable control unit may be included on the light delivery device for selectively controlling the light delivery unit. A programming device associated with the control unit selectively changes the programming of the controller. The light delivery device is portably secured to a region of the body having a substantial amount of blood vessels near the surface thereof to deliver light to the blood supply of the body for treating mood disorders, seasonal affective disorder and disorders involving circadian rhythm and sleep.

To achieve, an in vivo repair of injured mammalian nerve tissue, an effective amount of a biomembrane fusion agent is administered to the injured nerve tissue. The application of the biomembrane fusion agent may be performed by directly contacting the agent with the nerve tissue at the site of the injury. Alternatively, the biomembrane fusion agent is delivered to the site of the injury through the blood supply after administration of the biomembrane fusion agent to the patient. The administration is preferably by parenteral administration including including intravascular, intramuscular, subcutaneous, or intraperitoneal injection of an effective quantity of the biomembrane fusion agent so that an effective amount is delivered to the site of the nerve tissue injury.

A technique for providing vascularized autograft to a fusion site in the posteriolateral aspect of a lumbar fusion mass by using a split-thickness laminoplasty technique, is disclosed in co-pending U.S. Provisional Application 60 / 379,371 filed on May 10, 2002 and U.S. patent application Ser. No. ______ filed concurrently with the present application. Devices used to accomplish osteotomies of the laminae, facet joints, and transverse processes are disclosed. The devices include a shaft that can guide the devices, a method of deploying a wire bone saw for dividing these structures through a coronal plane, leaving the periosteum, musculature, and hence blood supply intact. This novel and non-obvious technique will allow for the application of vascularized autograft to the fusion bed in posterior or posteriolateral fusion of the spine.

Ischemia-reperfusion injury commonly results from any surgical procedure requiring stopping of blood supply to an organ followed by reperfusion such as in heart bypass, angioplasty or organ transplant. The invention discloses a method to harness the innate power of repetitive transient ischemia in protecting organs against imminent ischemia-reperfusion, or any patho-physiological insults. This method of optimal remote ischemic preconditioning (ORIP) comprises of utilizing a pair of programmable pneumatic cuffs that inflate / deflate alternately occluding blood circulation to each of the limbs for pre-defined time intervals. The apparatus delivers maximal ORIP dose in shortest possible time either as an EMS procedure during patient transportation to hospital, as elective pre-surgery treatment, or in critical care for preventing multiple-organ-dysfunction-syndrome. ORIP can be self-administered and remotely monitored by clinician especially in chronic patients for homeostasis of malfunctioning target organs. ORIP may also be deployed as adjunct in angioplasty, gene / stem cell heart repair therapies.

Compositions containing a carrier and microbubles encapsulating one or more gases, preferably oxygen, and methods for making and using the compositions are described herein. The microbubbles contain a lipid envelope formed of at least one base lipid and at least one emulsifying agent. The compositions may be administered to a patient to quickly deliver large amounts of oxygen to the patient's blood supply or directly to a tissue in need of oxygen. The compositions may be administered via injection or as a continuous infusion. The compositions contain a concentrated microbubble suspension, where the suspension contains at least 40 mL oxygen / dL suspension. The microbubbles are preferably less than 20 microns in diameter, more preferably less than 15 microns in diameter. The microbubbles described herein may be administered to a patient in an effective amount to increase in oxygen concentration in the patient's blood, and / or one or more tissues or organs. The microbubbles may be administered alone or in combination with other treatments as an adjuctive therapy.

A novel single needle hemodiafiltration apparatus and a novel single needle hemodiafiltration method for purifying blood with excellent removal performance via extracorporeal circulation with a single needle type are provided. The single needle hemodiafiltration apparatus includes a blood supply system for supplying blood, a dialysis fluid supply system for supplying a dialysis fluid and a system for controlling a movement of a fluid between the two supply systems, and a filtration / back-filtration liquid supply unit provided in the dialysis fluid supply system is controlled in conjunction with a blood pump provided in the blood supply system so that blood is removed from the body synchronously with the filtration and returned to the body synchronously with the back-filtration, thereby enabling extracorporeal circulation with the single needle. At a time of filtration, substances are removed by diffusion and ultrafiltration. At a time of recirculation in the blood circuit, substances are removed by diffusion. A high removal efficiency that cannot be achieved by the conventional single needle blood dialysis can be achieved by appropriately selecting the stroke volume per cycle, the number and order of the filtration / back-filtration / blank phases and the blood flow rate in each phase.

A blood testing tool is provided, which separates blood cells and can collect blood plasma or blood serum with a high yield. The blood testing tool includes an asymmetric porous membrane with a pore size distribution in which an average pore size varies to be reduced continuously or discontinuously in a thickness direction. The porous membrane includes a blood supply portion, a development portion, and a blood-cell blocking portion formed between the blood supply portion and the development portion and pores in the blood cell blocking portion include only pores through which blood cells cannot pass. When blood is supplied to one side with larger pores of the blood supply portion, the blood moves in a direction parallel to a surface of the porous membrane by a capillary phenomenon, but only blood plasma or blood serum moves into the development portion to develop.

An image processing apparatus includes a storage unit which stores the data of a plurality of images in an angiography sequence, and a computation unit which generates a reference time density curve concerning a reference region set in a blood supply region to a blood supplied region and a plurality of time density curves concerning a plurality of local regions set in the blood supplied region on the basis of the data of a plurality of images, and computes a plurality of indexes respectively representing the correlations of the plurality of time density curves with respect to the reference time density curve.

The present invention provides an arm model apparatus for intravenous injection training, comprising: an arm model having an insertion grooved recess formed on a top thereof, the arm model being formed such that the arm model are twisted so as to allow the back of a hand part and a cubital fossa to be oriented upwardly; a skin pad detachably mounted into the insertion grooved recess and having a blood vessel-imitating tube formed therein; a pump drive unit connected to the a blood vessel-imitating tube by a pad connecting tube; and a liquid blood supply container connected to the pump drive unit by a container connecting tube and configured to supply blood stored therein to the blood vessel-imitating tube. The inventive arm model apparatus implements a realistic skin sensation as if a syringe needle penetrated through the blood vessel of the human body through the arm model.

The invention discloses a circumcision anastomat which is used for circumcising foreskin and suturing a cut in surgery. The circumcision anastomat comprises a shell, a turncap, a transmission rod, an anastomosis base plate and a glans penis protection cover which are fixedly connected with the transmission rod, a fixing ring, a starting handle, a nail storage annular seat which is arranged at the front end of the shell, a nail pushing annular piece which is used for pushing suturing nails, and an annular blade; the transmission rod is in threaded connection with the turncap; a plurality of nail storage grooves are formed along the circumference of the nail storage annular seat; the nail pushing annular piece is provided with corresponding nail pressing teeth; and the cutting edge of the annular blade is protruded out of the nail pressing surface of the nail pushing annular piece. Too long foreskin is bonded on the fixing ring, the anastomat is contracted and pulled and is triggered, the nail pushing annular piece hammers the suturing nails into the foreskin for suturing, simultaneously the annular blade cuts the foreskin, cutting and suturing surgery is fixed at one time, and a small amount of residual foreskin naturally dies and falls off after surgery due to the shortage of blood supply, so that the cut of circumcision is tidy, the appearance is attractive after the cut is healed, and sexual life of a patient is not influenced.

The invention discloses a new traditional Chinese medicine composition for treating cerebral thrombosis and cerebral infarction and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following Chinese medicinal herbs such as dutchmanspipe root, fruit of immature citron, dried orange peel, pangolin scales, ground beeltle, ligusticum wallichii, cassia twig, angelica sinensis, radix paeoniae alba, root of red-rooted salvia, agilawood, rhizoma cyperi, rhizoma corydalis, radix curcumae, pseudo-ginseng, common burreed rhizome, curcuma zedoary, red flower, peach kernel, rhizoma gastrodiae, uncaria rhynchophylla, white muscardine silkworm, scorpio, styrax asiatic styrax and rhizoma acori graminei. The traditional Chinese medicine composition can be prepared into any one common oral preparation according to a conventional traditional Chinese medicine preparation method. The invention can remarkably improve the symptoms of aphasia from apoplexy, facial paralysis, numb hands and feet, blindness, dizziness and faint, hypertension, blood viscosity increase, insufficiency of cerebral blood supply and the like, and has accurate clinical treatment effect, remarkable treatment effect and rapid effect. The traditional Chinese medicine composition has the advantages of low cost, basically no toxic or side effects and the like.

A device for autologous blood transfusion includes a centrifuge unit with an autotransfusion set rotatably mounted thereto. The autotransfusion set includes a separation unit for concentrating a cell fraction by centrifugation and a tubing system for providing a connection to a blood supply. The tubing system includes a blood supply line leading to the separation unit for supplying blood to be processed and a return line leading away from the separation unit. A filter is integrated into the autotransfusion set in order to eliminate leukocytes and / or tumor cells, thereby yielding greater safety in autotransfusion.

The present invention, in one aspect, relates to a method for examining a target for tumors or lesions using what is referred to as “Early Increase in microvascular Blood Supply” (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue and in tissues that precede the development of such lesions or tumors. While the abnormal tissue can be a lesion or tumor, the abnormal tissue can also be tissue that precedes formation of a lesion or tumor, such as a precancerous adenoma, aberrant crypt foci, tissues that precede the development of dysplastic lesions that themselves do not yet exhibit dysplastic phenotype, and tissues in the vicinity of these lesions or pre-dysplastic tissues.