A Cardiovascular imaging and functional analysis system and method employing a dedicated fast, sensitive, compact and economical imaging gamma camera system that is especially suited for heart imaging and functional analysis. The system uses a dedicated nuclear cardiology small field of view imaging camera, allowing image physiology, while offering inexpensive and portable hardware. In some variations, a basic modular design suitable for cardiac imaging with one of several radionucleide tracers is used. The detector is positioned in close proximity to the chest and heart from several different projections, allowing rapid accumulation of data for first-pass analysis, positron imaging, quantitative stress perfusion, and multi-gated equilibrium pooled blood tests. In one variation, a Cardiovascular Non-Invasive Screening Probe system provides rapid, inexpensive preliminary indication of coronary occlusive disease by measuring the activity of emitted particles from an injected bolus of radioactive tracer.