234 results about "Blood level" patented technology

Sustained release oral solid dosage forms of opioid analgesics are provided as multiparticulate systems which are bioavailable and which provide effective blood levels of the opioid analgesic for at least about 24 hours. A unit dose of the opioid analgesic contains a plurality of substrates including the opioid analgesic in sustained release form. The substrates have a diameter from about 0.1 mm to about 3 mm.

The present invention provides methods and compositions for increasing the growth rates, alleviating the symptoms, or improving the metabolism of human patients having insulin-like growth factor-1 deficiency (IGFD). The invention relates to methods comprising administering insulin-like growth factor-I to a patient having a height which, at the time of treatment or prior to initial treatment with IGF-1, is at least about 2 standard deviations below normal for a subject of the same age and gender, a blood level of insulin-like growth factor-I that, and at the time of treatment or prior to initial treatment with IGF-1, is below normal mean levels, usually at least about 1 standard deviations below normal mean levels, for age and gender.

An apparatus is described for extracorporeal blood treatment (1), comprising a treatment unit (2), an extracorporeal blood circuit (8) and a fluid evacuation line (10). The apparatus comprises a control unit (21) connected with a pressure sensor (13, 14) and with a blood pump (9) and configured to move the blood pump (9), generating a variable flow (Q(t)) with a constant component (Qb) and a variable component (Qvar(t)) having a nil average value; the variable flow generates, in the expansion chamber (11, 12), a progression of the pressure that is variable over time (P(t)) with a pressure component (Pvar(t)) oscillating about an average value (Pavg). The control unit receives, from the sensor, a plurality of values (Pj) and calculates the average value of the pressure (Pavg), acquires an estimated value of volume variation (AP) in the expansion chamber (11, 12) connected to the variable flow component (Qvar(t)), calculates, as a function of the pressure values (Pj), an estimated value of pressure variation (AP) in the expansion chamber (11; 12) that is representative of the oscillating pressure component (Pvar(t)) and determines a representative magnitude of a blood level (L) in the expansion chamber (11, 12) as a function of the average value (Pavg) of the pressure (P(t)), of the estimated value of volume variation (AV) and of the estimated pressure variation (AP) in the expansion chamber.

An apparatus is described for extracorporeal blood treatment (1), comprising a treatment unit (2), an extracorporeal blood circuit (8) and a fluid evacuation line (10). The apparatus comprises a control unit (21) connected with a pressure sensor (13, 14) and with a blood pump (9) and configured to move the blood pump (9), generating a variable flow with a constant component equal to a desired blood flow value and a variable component having a nil mean value; the variable flow generates, in the expansion chamber (11, 12), a progression of the pressure that is variable over time (P(t)) with a pressure component (ΔP) oscillating about a mean value (Pavg). The control unit receives, from the sensor, a plurality of values (Pj) over a period of time (T) comprising a plurality of oscillations of the pressure about the mean value and calculates, according to the pressure values (Pj), a control value that is representative of the oscillating pressure component (ΔP) and then compares the control value with a reference threshold to determine the verification or not of a condition of variation of the blood level in the expansion chamber (11; 12).