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3244 results about "Glutathione" patented technology

Glutathione (GSH) is an antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals. It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side chain and cysteine. The carboxyl group of the cysteine residue is attached by normal peptide linkage to glycine.

Methods of treating chronic inflammatory diseases using carbonyl trapping agents

InactiveUS6444221B1Improved therapeutic propertyImprove propertiesBiocidePeptide/protein ingredientsEtiologyBenzoic acid
These and other objects of this invention are achieved by providing a novel method and compositions for the clinical treatment of chronic inflammatory diseases. This invention involves use of systemically administered compositions which include primary amine derivatives of benzoic acid as carbonyl trapping agents. These primary therapeutic agents act by chemically binding to and sequestering the aldehyde and/or ketone products of lipid peroxidation. Increased levels of lipid peroxidation have been repeatedly demonstrated as a part of the non-enzymatic "inflammatory cascade" process which underlies the secondary etiology of chronic inflammatory diseases. p-Aminobenzoic acid (or PABA) is an example of the primary therapeutic agent of the present invention. PABA has a small molecular weight, is water soluble, has a primary amine group that reacts with carbonyl-containing metabolites under physiological conditions and is tolerated by the body in relatively high dosages and for extended periods. The carbonyl sequestering agents are used in combination with at least one co-agent so as to produce an additional beneficial physiological effect of an anti-inflammatory nature. Such compositions are administered systemically entirely via the oral route. Co-agents of the present invention include anti-oxidants and free radical trapping compounds (e.g., alpha-tocopherol), compounds having indirect anti-oxidant activity (e.g., selenium), vitamins (e.g., pyridoxine HCl), compounds which facilitate kidney drug elimination (e.g., glycine), metabolites at risk of depletion (e.g., pantothenic acid), sulfhydryl containing chemicals (e.g., methionine), compounds which facilitate glutathione activity (e.g., N-acetylcysteine), and non-absorbable polyamine co-agents (e.g., chitosan).
Owner:SECANT PHARMA

Method and composition to reduce cancer incidence

The five component composition consisting essentially of: (1) Water soluble antioxidant vitamin C or ascorbic acid, or any of its forms or derivatives, or mixtures thereof. (2) Oil soluble antioxidant vitamin E or Alpha-tocophorol, or any of its forms or derivatives, or mixtures thereof. (3) The element selenium, or a chemical (or composition) containing it, or mixtures thereof. The most preferred chemical containing selenium is dimethyl selenide and mixtures thereof. The words "dimethyl selenide" here and hereinafter mean dimethyl selenide and / or it's oxidation products, including dimethyl selenoxide. (4) A sulfur amino acid, in any form, or a sulfur peptide, or a sulfur protein, or any of their derivatives, or mixtures thereof. The mixture of methionine and cysteine, which contains as impurities some seleno-methionine and some selenocysteine, is preferred,-the tripeptide glutathione containing cysteine is also preferred. (5) Another antioxidant, other than vitamin C and other than vitamin E, which is synthetic or natural and water soluble or oil soluble, or a mixture of such antioxidants, or a combination of such forms thereof. The mixtures of butylated hydroxyanisole and ethoxyquin is preferred.
Owner:LIFE SCI LAB

Compositions and methods useful for treating and preventing chronic liver disease, chronic HCV infection and non-alcoholic steatohepatitis

The invention relates generally to compositions comprising antioxidants useful for reducing oxidative stress and lipid peroxidation, and treating chronic liver disease, chronic hepatitis C virus infection and non-alcoholic steatohepatitis. In particular, the invention relates to the preparation and oral administration of compositions comprising glycyrrhizin, schisandra, ascorbic acid, L-glutathione, silymarin, lipoic acid, and d-alpha-tocopherol. The invention also relates to the preparation and parenteral administration of compositions comprising glycyrrhizin, ascorbic acid, L-glutathione, and vitamin B-complex, preferably by infusion or intravenous injection. The invention further relates to methods of using the antioxidants, oral compositions and parenteral compositions.
Owner:ZABRECKY GEORGE

Compositions and methods for modulating S-nitrosoglutathione reductase

Disclosed herein are methods and compositions for modulating the levels and / or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions.
Owner:DUKE UNIV

Immune enhancing compositions and methods of use thereof

A method of administering parenterally, particularly intramuscularly, glutamine and cystine and glycine plus selenium; or lactalbumin plus selenium; or lactalbumin and glutamine and cystine and glycine plus selenium, through a long-acting pharmaceutically acceptable carrier to a patient. The method comprises injecting a mixture of glutamine, cystine, glycine, lactalbumin and selenium in order to maintain the mixture systemically or locally for a sufficient time period so as to maintain blood levels of glutathione within an improved therapeutic range.
Owner:CRUM ALBERT

Topical management of ocular and periocular conditions

Chronic glaucoma, cataract, ocular and periocular aging are treated and prevented by the administration of agents that affect metabolic subsystems such as (i) mitochondrial bioenergetics, (ii) free radical moderation and glutathione maintenance, (iii) constitutive nitric oxide / endothelin-1 balance, and (iv) calcium wave signaling and associated neuronal excito-toxicity. Included among the agents are tetrahydrobiopterin, R-alpha-lipoic acid, coenzyme Q10, 17 alpha-estradiol, and glutathione.
Owner:CHRONORX

Pharmaceutical preparations of glutathione and methods of administration thereof

InactiveUS6896899B2Increase in intracellular glutathione levelBiocidePowder deliveryPharmaceutical formulationMammalian cell
A method of increasing glutathione levels in mammalian cells comprising administering an oral bolus of encapsulated pharmaceutically stabilized glutathione in a rapidly dissolving formulation to a mammal on an empty stomach. Pharmaceutical formulations including glutathione are also disclosed.
Owner:MOLECULAR DEFENSES HLDG LLC

Health-care food with effects of neutralizing effect of alcoholic drinks and protecting liver

ActiveCN101731630AAnti-alcoholicAnti-lipid peroxidationFood preparationAlcoholCorn flour
The invention discloses a health-care food with the effects of neutralizing the effect of alcoholic drinks and protecting the liver. The health-care food comprises the following components by weight percent: 1.0-100.0% of corn flour oligopeptide, 0.0-40.0% of taurine, 0.0-30.0% of alanine, 0.0-50.0% of cysteine, 0.0-30.0% of leucine, 0.0-30.0% of glutathione, 0.0-30.0% of hoveniae semoveniae semen extract, 0.0-30.0% of brown rice germ, 0.0-30.0% of radix puerariae extract and 0.0-95.0% of auxiliary materials. In the invention, various raw materials with definite effects are reasonably matched by a scientific prescription, the alcohol metabolism of a human body can be effectively promoted, and the toxicity of alcohol to the liver is lowered, thereby exerting the functions of neutralizing the effect of alcoholic drinks and protecting the liver.
Owner:PERFECT CHINA +1

Skin Dressings

A skin dressing is adapted, on activation, to release one or more S-nitrosothiols, preferably S-nitroso-L-glutathione. S-nitrosothiols decompose spontaneously to produce nitric oxide, which has beneficial effects on tissues, particularly in wound healing.
Owner:INSENSE LIMITED

Compositions for potentiating glutatthione

A composition for potentiating glutathione, which contains at least one member selected from the group consisting of 2-(3,4-dihydroxyphenyl)ethanol or a glycoside thereof, a plant containing 2-(3,4-dihydroxyphenyl)ethanol or a glycoside thereof, an extract of said plant, a hydrolysate of said plant, and a hydrolysate of the extract of said plant (excluding Olea europaea and an extract thereof), and which further contains at least one member selected from among an S-containing compound that is a supply source of cysteine, a protein that contains cysteine and / or cystine, a yeast that contains cysteine and / or cystine, and a vitamin.
Owner:FUAN KERU

C-nitroso compounds and use thereof

A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. When the compound is obtained from a carbon acid with a pKa less than about 10, it provides vascular relaxing effect when used at micromolar concentrations and this activity is potentiated by glutathione to be obtained at nanomolar concentrations. When the compound is obtained from a carbon acid with a pKa ranging from about 15 to about 20, vascular relaxing effect is obtained at nanomolar concentrations without glutathione. In another embodiment, a biocompatible polymer incorporates a C-nitroso moiety.
Owner:DUKE UNIV

In-situ composite system based on carbon quantum dot/manganese dioxide nanometer sheet layer and using method for detecting content of glutathione

The invention discloses an in-situ composite system based on a carbon quantum dot / manganese dioxide nanometer sheet layer and a using method of the in-situ composite system. The using method comprises the following steps: firstly, completely quenching fluorescence by using a manner that carbon quantum dots are adsorbed on a manganese dioxide nanometer sheet layer prepared by reducing potassium permanganate in situ, and then quantitatively analyzing and determining the content of the GSH in a GSH to-be-tested sample based on a principle of causing digestion of the manganese dioxide nanometer sheet layer, releasing the carbon quantum dots and recovering the fluorescence thereof by virtue of a redox reaction between glutathione (GSH) and manganese dioxide. According to the in-situ composite system, the detection method is high in precision, the repeatability is good, a used carbon material is low in price, easily available, and free from polluting the environment, and has relatively good biological safety; meanwhile, the in-situ composite system is simple and convenient to operate, relatively strong in practicability, high in sensitivity, and excellent in selectivity of the GSH.
Owner:ZHENGZHOU UNIV

Serum-free medium for culturing placenta mesenchymal stem cells

The invention discloses a serum-free medium for culturing placenta mesenchymal stem cells. The serum-free medium takes a DMEM (Dulbecco Modified Eagle Medium) culture solution as a basis and also contains a fibroblast growth factor receptor 2, growth hormone, insulin, transferrin, glutathione, BMP-4, L-glutamine, sodium pyruvate, non-essential amino acids and beta-mercaptoethanol. According to various serum-free media provided by the invention, growth and proliferation of the placenta mesenchymal stem cells in a serum-free medium system can be effectively promoted, the placenta mesenchymal stem cells have higher growth and proliferation rate in the serum-free medium system compared with a serum cell culture medium, the characteristics of the stem cells are preserved, the serum-free medium has multiple differential potentials, and the stem cells can be directionally induced into fat cells and osteoblasts.
Owner:章毅 +10

Topical glutathione treatments

Topical treatment of psoriasis and other inflammatory skin diseases by application to affected skin areas of a composition containing glutathione. In the preferred embodiments of the invention, the glutathione is provided in a carrier at very high concentration levels, in the range of 16-70 percent by weight, more preferably 40-60 percent by weight. Alpha lipoic acid may be included as an adjunct component in the composition.
Owner:N V PERRICONE

Anti-stress fermentation protein feed and producing method thereof

The invention provides an anti-stress fermentation protein feed which is produced by composite bacterium inoculation and high-temperature and moderate-temperature fermentation of a plant derived protein raw material, a terrestrial animal derived protein raw material and a marine animal derived protein raw material. Macromolecular substances in the protein feed are digested and decomposed into micromolecular substances, stressors in nutritional ingredients are decreased, anti-stress active factors such as genistein, glutathione and glucosamine are increased, the immunity of fed animals is improved, and the protein feed shows a good anti-stress capability. The invention further provides a producing method of the anti-stress fermentation protein feed. The feed product with high functionality, good anti-stress effect and high economical efficiency is obtained with the adoption of the multiple derived protein raw materials, a specific formula and an appropriate matching ratio and by mixed fermentation through a special secondary fermentation process.
Owner:BEIJING GOLDENWAY BIO TECH

Trace Metals synergized copper nucleotides and copper glycosides for anti-aging and antiviral compositions

I have discovered that trace metals such as copper, zinc, iron, and manganese that are necessary for the proper functioning of superoxide dismutase (SOD) and other deactivators of active-oxygen molecules (which cause aging of skin and other skin disorders), can be delivered from the topical compositions. This is achieved by the preparation of copper and other trace metal complexes with phosphorylated nucleosides, such as nucleotides, and phosphorylated monosaccharides, such as phosphorylated glycosides which act as small molecular weight (SMW) transporter molecules. These trace metal complexes of nucleotides and glycosides can be prepared by an in-situ method in water, water-miscible organic solvent, or a mixture of water and water-miscible organic solvent from commonly available ingredients in concentrations that are desirable and can be accurately controlled. I have additionally discovered compositions to achieve the transport of copper from the surface layers of skin into the deeper layers of skin utilizing SMW transporter molecules; and the intra-cellular storage of copper ions in the cell, for example in a bound form with glutathione; and the intra-cellular transport of copper from glutathione to SOD apoprotein by metallochaperones; and the supply of energetic molecules, such as ATP, ADP, or phosphorylated saccharides for SOD metallochaperones to perform their intra-cellular metal transfer function. These cosmetic or pharmaceutical compositions are useful for antiaging and antiviral benefits.
Owner:GUPTA SHYAM K

Lead ion colorimetric detection probes and application method thereof

The invention belongs to the technical field of detection and particularly relates to lead ion colorimetric detection probes and an application method thereof. In the method, glutathione modified gold nanoparticles are used as colorimetric probes, glutathione combines with gold nanoparticles by utilizing sulfydryl groups of the glutathione for coordination to form a stable structure of which the surface contains two free carboxyl radicals. In the process of detection, the carboxyl radicals can coordinate with heavy metal ions; and by utilizing the property of surface plasma resonance of the gold nanoparticles, the existence of the heavy metal ion Pb2+ in aqueous solution can be indicated by the color change of the solution. The lead ion colorimetric detection probes have the advantages that: the sensitivity and selectivity are high; in-situ quick detection can be realized without large-size instruments; the detection results are visual and can be observed by naked eyes; the operation is simple and the cost is low; and the used solvents and the operation processes have no toxic or side effects.
Owner:NORTHEAST NORMAL UNIVERSITY

Systemic administration of NAC as an adjunct in the treatment of bioterror exposures such as anthrax, smallpox or radiation and for vaccination prophylaxis, and use in combination with DHEA for the treatment of smallpox and other viruses

InactiveUS20040022873A1No toxicityWithout fear of compromisingBiocideTripeptide ingredientsWhole bodyPoisonous effects
The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and / or antiviral therapy to ameliorate the toxic effects of infection with materials used in Bioterror incidents such as Bacillus anthracis and smallpox virus, and alternatively, upon exposure to radiation, during testing, and vaccination, as treatment prior to treatment with antibiotic or antiviral therapy to ameliorate the toxic effects of infection and exposure with these organisms.
Owner:YOUR ENERGY SYST

Method for preparing nitrogen and sulfur-doped fluorescent carbon quantum dots

The invention discloses a method for preparing nitrogen and sulfur-doped fluorescent carbon quantum dots. According to the method, citric acid is taken as a carbon source, L-glutathione is taken as a nitrogen-sulfur dopant, a microwave oven is taken as a reaction platform, the carbon quantum dots with fluorescence properties are prepared in a heating manner, the residues and moisture are removed through dialysis and freeze drying, and quantum dot powder is obtained. The nitrogen and sulfur-doped carbon quantum dots are prepared by adopting the method disclosed by the invention; the method is simple in operation, low in cost, high in yield, simple in preparation process and equipment, free of a solvent, and easy to popularize and produce on a large scale, and can be rapidly finished within a short period of time; and the prepared carbon quantum dots have the advantages of good water solubility, high fluorescence properties, photobleaching resistance, adjustable emission spectrum, good biocompatibility, low cytotoxicity and the like, and have a good application prospect in the fields of bioimaging, biosensors and photo-electric devices.
Owner:NANCHANG UNIV

Stabilized bioactive peptides and methods of identification, synthesis, and use

InactiveUS20060099571A1Slow down rate of intracellular degradationBacteriaPeptide/protein ingredientsLac operonΑ helical
An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues.
Owner:PEPTIDE BIOSCI

Production process of germ and corn composite nutritional powder and product of production process

The invention relates to a production process of germ and corn composite nutritional powder and the product of the production process, and belongs to the technical field of food processing. The production process is characterized in that mixing corn which sprouts in stress with wheat germ which is subjected to microwave enzyme inactivation; performing extrusion and superfine grinding to prepare germ and corn meal; adding carrot meal, spirulina meal, white granulated sugar, maltodextrin and vegetable fat powder into the germ and corn meal; and sterilizing and packaging to prepare the germ and corn composite nutritional powder. The production process is simple and high in industrial degree, so that the germ resource can be further utilized, corn can be completely utilized, and the additional value of agricultural products can be increased. The germ and corn composite nutritional powder produced by the production process is good in dissolubility, fine in taste and high in nutritional value, is rich in gamma-aminobutyric acid, glutathione, octacosanol, dietary fiber and other components, has the functions of improving brain functions, calming nerves, improving sleeping, resisting oxidation, delaying senescence, improving body immunity and the like, and is an ideal health-care nutritional food, wherein the content of gamma-aminobutyric acid in the product is between 20 and 60mg / 100g.
Owner:JIANGSU HENGHUI FOOD CO LTD

Application of glutathione-based stable gold nano cluster particles to detection of sulfhydryl compound

The invention discloses application of glutathione-based stable gold nano cluster particles to detection of a sulfhydryl compound, wherein the glutathione-based stable gold nano cluster particles are prepared from a chloroauric acid solution and a glutathione solution, wherein a molar ratio of chloroauric acid to glutathione is between 1:0.5 and 1:1. By using an fluorescence enhancement characteristic of the glutathione-based stable gold nano cluster particles after the addition of the sulfhydryl compound, through detecting the change of fluorescence intensity before and after the sulfhydryl compound with an unknown concentration reacts with the glutathione-based stable gold nano cluster particles, a linear standard curve chart is drawn, and a calibration relation is obtained by adopting linear fitting, so that the sulfhydryl compound with the unknown concentration is detected.
Owner:SOUTHEAST UNIV

Cold storage solution for organ and biological tissue preservation

Cold storage solutions for the preservation of organs and biological tissues prior to implantation, including a prostaglandin having vasodilatory, membrane stabilizing, platelet aggregation prevention upon reperfusion, and complement activation inhibitory properties, a nitric oxide donor, and a glutathione-forming agent.
Owner:ORGAN RECOVERY SYST

Plant Growth Regulator and use Thereof

ActiveUS20100016166A1Effectively controlling buddingGuaranteed efficient growthBiocideTripeptide ingredientsGrowth plantAnthesis
A plant growth regulator containing glutathione allows increasing harvest index. This provides a technique for specifying a control factor for a plant, thereby effectively controlling germination, growth, anthesis etc. of the plant.
Owner:JAPAN SCI & TECH CORP +1

N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress

Methods and compositions comprising N-acetylcysteine amide (NAC amide) and derivatives thereof are used in treatments and therapies for human and non-human mammalian diseases, disorders, conditions and pathologies. Pharmaceutically or physiologically acceptable compositions of NAC amide or derivatives thereof are administered alone, or in combination with other suitable agents, to reduce, prevent, or counteract oxidative stress and free radical oxidant formation and overproduction in cells and tissues, as well as to provide a new source of glutathione.
Owner:SAEGIS PHARMA

Method for simulating peroxidase by manganese dioxide nanosheet for detection of reductive biological molecules

ActiveCN106093272AStrong characteristic absorption peakTo achieve the purpose of quantitative analysisChemical analysis using catalysisMaterial analysis by observing effect on chemical indicatorPeroxidaseCatalytic oxidation
The invention relates to a method for simulating peroxidase by manganese dioxide nanosheet for detection of reductive biological molecules. The peroxidase simulated by manganese dioxide nanosheet can perform catalytic oxidation on substrates of 3,3',5,5'-tetramethyl benzidine TMB, 2,2-azino-di(3-ethyl-benzothiazoles-6-sulfonic acid) diammonium salt ABTS and o-phenylenediamine OPD, and changes the color from colorless to blue, green and orange respectively, at the same time, the manganese dioxide nanosheet can sensitively and selectively perform an oxidation reduction reaction with reductive biological molecules such as glutathione and ascorbic acid, oxidation product concentration of the substrates such as TMB, ABTS and OPD is changed, and then, the reductive biological molecules such as glutathione and ascorbic acid are subjected to quantitative determination through a colorimetric analysis method. The method has the characteristics of simple operation, high sensitivity, good reappearance and high selectivity; a detection linear scope of glutathione is 1-15 [mu]M, the detection limit is 0.3 [mu]M; the detection linear scope of ascorbic acid is 3-100 [mu]M, the detection limit is 0.8 [mu]M; and the method can be used for detecting various phenolic compounds.
Owner:XI AN JIAOTONG UNIV
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