The invention relates to glycyrrhizic acid, glycyrrhetinic acid or glycyrrhetate, or derivative thermosensitive gel thereof, including 10-40 percent of
poloxamer, 0.1-10 percent of
carboxymethyl chitosan, 0.0001-10 percent of the glycyrrhizic acid, the glycyrrhetinic acid, the glycyrrhetate, the glycyrrhetinic
acid salt or the derivative of the glycyrrhetinic acid, and 40-90.9 percent of water. The preparation method is as follows: the
poloxamer is stirred evenly by adding water, the
carboxymethyl chitosan is added to be stirred evenly as well, after the defoaming, the gel is added into the mixture until scattered and dissolved by stirring, and then the thermosensitive gel can be obtained by high-pressure sterilizing, filling and sealing; the
medicine is the glycyrrhizic acid, the glycyrrhetinic acid, the glycyrrhetate and the glycyrrhetinic
acid salt or the derivative of the glycyrrhetinic acid thereof. The invention can be used as a mucosa dosage preparation and an injection dosage preparation and can treat
inflammatory bowel disease,
stomatitis, oral ulcer,
ocular inflammation and intracoelomic inflammations. The invention is convenient for clinical application, which can reduce the frequency of
drug administration, improve the
patient compliance, enhance the effectiveness of treatment and reduce
toxicity and side effects.