331 results about "Niacinamide" patented technology

The present invention concerns methods and compositions that can be used, for example, in skin whitening or hyperpigmentation applications. The composition, in non-limiting aspects, can include a vitamin C derivative, niacinamide, an extract formulation comprising cucumber and lemon extract or compounds that include the following formulas: where R1, R2, R3, R4, and R5 are independently an H, an alkyl group, a hydroxyalkyl group, or a carboxyalkyl group where R1, R2, R3, R4, and R5 are independently an H, an alkyl group, a hydroxyalkyl group, or a carboxyalkyl group and where x is an integer from 1 to 30.

Personal care composition comprising from about 0.05% to about 5% of at least one aquaporin-stimulating compound selected from the group consisting of xanthine, caffeine; 2-amino-6-methyl-mercaptopurine; 1-methyl xanthine; 2-aminopurine; theophylline; theobromine; adenine; adenosine; kinetin; p-chlorophenoxyacetic acid; 2,4-dichlorophenoxyacetic acid; indole-3-butyric acid; indole-3-acetic acid methyl ester; beta-naphthoxyacetic acid; 2,3,5-triiodobenzoic acid; adenine hemisulfate; n-benzyl-9-(2-tetrahydropyranyl)adenine; 1,3-diphenylurea; 1-phenyl-3-(1,2,3-thiadiazol-5-yl)urea; zeatin; indole-3-acetic acid; 6-benzylaminopurine; alpha-napthaleneacetic acid; 6-2-furoylaminopurine; green tea extract; white tea extract; menthol; tea tree oil; ginsenoside-RB1; ginsenoside-RB3; ginsenoside-RC; ginsenoside-RD; ginsenoside-RE; ginsenoside-RG1; ginseng root extract; ginseng flower extract; pomegranate extract, extracts from Ajuga turkestanica; extracts from viola tricolor and combinations thereof; an additional ingredient selected from the group consisting of niacinamide, glycerin and mixtures thereof, and a dermatologically-acceptable carrier.

Disclosed is a multi-beneficial topical skin care composition, and methods for its use, that can hydrate skin, increase the firmness of skin, reduce the appearance of fine lines or wrinkles on skin, and reduce the appearance of age spots on skin. The composition can include a combination of skin active ingredients comprising euterpe oleracea fruit extract, punica granatum sterols, caprooyl tetrapeptide-3, tocopherol or tocopherol acetate, and niacinamide, a combination of skin moisturizing agents comprising glycerin and butyrospermum parkii, a photo stable combination of sunscreen agents providing the composition with a sun protection factor (SPF) of at least about 15, and a dermatologically acceptable vehicle which imparts a non-greasy feel when applied to skin.

The invention belongs to the field of chemical synthesis, and particularly relates to a method for preparing beta-niacinamide single nucleotide or beta-niacinamide ribose, which aims at solving the technical problem of providing a method for preparing beta-niacinamide single nucleotide or beta-niacinamide ribose. The method comprises the following steps of performing condensation, deacetylation, phosphorylation and ammonolysis on ethyl niacinate and tetraacetyl ribose, so as to obtain the beta-niacinamide single nucleotide; performing condensation, deacetylation, and ammonolysis on ethyl niacinate and tetraacetyl ribose, so as to obtain the beta-niacinamide ribose. Compared with the conventional methods, the method has the advantages that the operation is simple, the amplification is easy,the purification is easy, the yield rate is high, and the like.

This invention is directed to a multi-vitamin and mineral supplement tailored to men and post-menopausal women, pre-menopausal women, and athletes which supplies the right amount of the right micronutrients at the right time to assure adequate intake of micronutrients needed for disease prevention and protection against nutritional losses and deficiencies due to lifestyle factors and common inadequate dietary patterns. The multi-vitamin and mineral supplement is comprised of vitamin A, vitamin C, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, niacinamide, vitamin B6, vitamin B12, biotin, pantothenic acid, iron, iodine, magnesium, zinc, selenium, copper, chromium, potassium, choline, lycopene, and co-enzyme Q-10.

The invention discloses whitening and skin care essence with synergistic whitening effects and a preparation method thereof. The whitening and skin care essence comprises niacinamide, a whitening complex 1, a whitening complex 2, citrus peel extract and arbutin. The whitening and skin care essence utilizes synergistic raw materials, can inhibit tyrosinase activity and melanin transfer, can brighten skin color, can cooperate in various nodes in the whitening path and can realize safe, effective and stable whitening effects.

Use of the combination of the tyrosine-arginine dipeptide or derivatives thereof and of niacinamide as a substance P antagonist for treating red blotches on the skin, skin oedema and sensitive skin. Use of this combination for the preparation of a composition for use in treating disorders associated with an excess synthesis and / or release of substance P.

The invention discloses a culture solution for inducing mesenchymal stem cells to differentiate into islet-like cells, and an inducing method and application of the culture solution. The culture solution comprises the following materials: niacinamide, Conophylline, cell growth factor, betacellulin and a base medium. The base medium contains 97% of high glucose DMEM (Dulbecco Modified Eagle Medium), 2% of B-27 and 1% of N-2. The inducing method comprises the following steps of: preparing an inducing culture solution; preparing the human mesenchymal stem cells; taking the human mesenchymal stem cells, inoculating the human mesenchymal stem cells into a six-hole ultralow absorption culture plate by 1.5-2*105cells / hole, adding 3ml inducing culture medium into each hole and carrying out suspended induction; and changing liquid at every 3 days, collecting cell supernatant at the ninth day, and storing the cell supernatant at the temperature of -20 DEG C. The culture solution disclosed by the invention has the advantages that the human mesenchymal stem cells are induced to differentiate into the islet-like cells by utilizing the combination of the niacinamide and the Conophylline, so that the inducing cycle is shortened, the suspension cells are beneficial to being clustered to form cell clusters similar to natural islets, further the induced differentiation efficiency is obviously increased and the clinical application risk is reduced; and the function of inducing the secretion of the cell insulin is obviously improved.

The invention discloses a phellinus igniarius mycelium culture medium and a process for fermenting phellinus igniarius using the same. The phellinus igniarius culture medium comprises the following components per liter: 25-35 g of maltose, 18-25 g of yeast powder, 2.4-4.2 g of mineral elements, 5-10 mg of vitamin B1, 3-5 mg of vitamin B2, 0.5-1 mg of vitamin B6, 20-30 mg of niacinamide, 2-3 mg of calcium pantothenate, 3-10 g of aqueous extract of ramulus mori and the balance of water. The phellinus igniarius is cultured in a culture solution for 4-6 days, wherein the inoculation amount is 10-20%, the culture temperature is 22-29 DEG C, the liquid amount in a shake flask is 50-70%, the rotation speed of a reciprocating shaker is 100-150 rpm and the fermentation time is 5-10 days. The invention has the advantages that: the components are clear, the quality is stable, a special nutrition source for phellinus igniarius is provided, and the invention can be used for the large-scale culture of phellinus igniarius mycelium with medicinal activity.

The invention discloses recombinant saccharomyces cerevisiae for producing dammarenediol and protopanoxadiol using xylose and a construction method. The construction method comprises the steps of replacing a promoter of a saccharomyces cerevisiae xylulokinase gene XKS1 with a promoter PFBA1 by virtue of a homologous recombination method, introducing xylose reductase XYL1 and a xylitol dehydrogenase XYL2 expression cassette, increasing the activities of transketolase TKL1 and transaldolase TAL1 so as to obtain recombinant bacteria 1, introducing a farnesyl-diphosphate farnesyltransferase gene ERG9, a squalene monooxygenase gene ERG1 and a dammarenediol synthase gene DS into the recombinant bacteria 1 so as to obtain recombinant bacteria 2, and introducing a nicotinamide adenine dinucleotide-hydroxymethylglutaryl coenzyme A reductase gene NADH-HMGr, farnesyl diphosphatesynthase ERG20 and a protopanoxadiol synthase-cytochrome P450 reductase fusion protein gene PPDS-ATR1 into the recombinant bacteria 2, so as to obtain recombinant bacteria 3. According to the recombinant saccharomyces cerevisiae, dammarenediol and protopanoxadiol can be artificially synthesized by virtue of xylose.

The invention provides a spray water with long-term moisturizing ability and a preparation method thereof. The dosage of each component of the composition is calculated by mass percentage: moisturizing agent, 5%-10%; bio-rich film, 0.1%- 5%; carnosine (β-alanyl-L-histidine), 0.5%-1.0%; asiaticoside, 0.01%-1.0%; yeast extract, 0.05%-10%; nicotinamide (vitamin B3 ), 0.1%-2.0%; rose flower oil, 0.01%-1.0%; plant extract, 1%-10.0%; antibacterial polyol, 0.1-1.0%; purified water, up to 100%; Get; long-lasting moisturizing effect.

The invention relates to a Chinese herbal composite feed additive used for transportation stress recovery of beef cattle, and effectively solves the poor digestive function and immunity problems resulted from poor body conditions brought about during transportation of beef cattle. The additive is prepared by the following components by weight percent: 22-28% of medicated leaven, 15-20% of haws, 0.5-1.5% of astragalus polysaccharides, 1-2% of active yeast, 1.5-2% of niacinamide, 0.7-1.2% of vitamin C, 0.25-0.4% of vitamin E, 0.25-0.5% of zinc sulfate, 20-25% of potassium chloride, 10-15% of ammonium chloride, and 10-15% of magnesium oxide. Specifically, each component is first crushed to a particle size below 0.5mm respectively, the niacinamide, the vitamin C, the vitamin E, the astragaluspolysaccharides and the active yeast are mixed uniformly, then the mixture is mixed with the potassium chloride, the ammonium chloride and the magnesium oxide uniformly, and finally the haws and the medicated leaven are added and stirred uniformly, thus obtaining the feed additive. The composite feed additive of the invention has the advantages of scientific prescription, abundant raw materials, and easy production. Application of the feed additive in the feed of beef cattle after transportation stress can promote the beef cattle to supplement electrolytes, trace elements and vitamins as quickly as possible after transportation stress. Thus, the composite feed additive provided in the invention has the effects of improving body conditions, enhancing digestion function and immunity.

Disclosed is a topical skin care composition, and method for its use, that includes 55 to 65% by weight of water, 15 to 20% by weight of a combination of 3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate (homosalate), 1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)propane-1,3 -dione (avobenzone), 2-ethylhexyl 2-hydroxybenzoate (octisalate), and 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate (octocrylene), 3 to 4% by weight of distearlydimonium chloride, and 1 to 3% by weight of a combination of euterpe oleracea fruit extract, punica granatum sterols, caprooyl tetrapeptide-3, tocopherol or tocopherol acetate, and niacinamide, wherein the composition has a sun protection factor of at least 15 or about 15 to 20.

The present invention relates to an inhibitor for melanin which contains tranexamic acid and niacinamide as active ingredients for inhibiting the formation of melanin cells in the skin, and a cosmetic composition containing the inhibitor for melanin as an active ingredient for relieving liver spots, blemishes, freckles and inflammatory hyperpigmentation, improving skin tone and texture, and skin whitening.

A product and method for moisturizing skin is herein described. The product is a package with associated instructions for applying a niacinamide containing cosmetic composition to skin dispensed from a heating device. The heated cosmetic composition imparts a more rapid moisturization than expected from an identical composition applied at room temperature.

The invention discloses a method for preparing pro-xylane from a biological enzyme by a one-pot method. The method is characterized by comprising the following steps of taking xylose and isopropanol as substrates, generating the pro-xylane under the catalytic action of isopropanol dehydrogenase, pro-xylane synzyme, carbonyl reductase and coenzyme nicotinamide adenine dinucleotide. The method is simple in process, free of chemical reagents, low in cost, high in yield and suitable for industrial production.

A cosmetic composition is provided which includes niacinamide, a carboxylic acid bearing structurant, and particles of a condensation polymerized polyamide, the polyamide having an amine value no lower than 0.3 and an HLB value of at least 16. The polyamide particles prevent interaction between niacinamide and the carboxylic acid / salt structurant thereby inhibiting skinfeel complexation and / or phase separation that would be adverse to skinfeel.

The invention discloses whitening and freckle-removing essence. On the basis of reasonably utilizing whitening and freckle-removing components including phenylethyl resorcinol, niacinamide, magnesiumascorbyl phosphate and the like, rosa moschata seed oil, prunus amygdalus dulcis oil and glycyrrhiza glabra root extract are added into the whitening and freckle-removing essence; the three componentsare compounded so that the whitening and freckle-removing effect of a whitening component in the whitening and freckle-removing essence is remarkably improved; when the content of each component in the whitening and freckle-removing essence is optimal, the basic healing rate of freckles reaches 90 percent and the whitening and freckle-removing essence is mild and has no irritation.

The invention provides a whitening composition, whitening skin-brightening cream comprising the same and a preparation method thereof. The whitening skin-brightening cream is prepared from the following components in percent by mass: 0.1-20% of the whitening composition, 1-25% of a wetting agent, 1-5% of an emulsifier, 1-20% of skin-moistening grease, 0.1-5% of a skin conditioner, 0.05-3% of a permeation aid, 0.01-1% of a chelating agent, 0.1-1% of a thickener, 0-1% of essence, 0.05-2% of a preservative and the balance deionized water. The whitening composition is prepared from eight traditional Chinese medicinal material extraction solutions: ginseng, cortex mori radicis, angelica sinensis, glycyrrhiza, tea leaves, ganoderma atrum, rhodiola rosea and folium ginkgo as well as conventionalwhitening agents nicotinamide and tranexamic acid, and has the functions of whitening synergically and reducing irritation. The whitening skin-brightening cream moistens the skin and is not greasy, iseasy to absorb, and is obvious in whitening and skin-brightening effect.

The invention relates to a method for preparing niacinamide nucleoside salt. The method comprises the following steps: replacing ions by niacinamide nucleoside trifluoromethane sulfonate prepared by deacetylation of triacetyl niacinamide nucleoside trifluoromethane in an organic solvent with acids, crystallizing to separate out a crude product, and pulping, thereby obtaining the corresponding niacinamide nucleoside salt. The ion replacement process in the invention overcomes the defects of chemical methods and extraction methods, and is suitable for industrial production.

The invention discloses a beverage for sub-health conditioning and its preparation method. The beverage mainly includes: a Maca extract, a guarana extract, white granulated sugar, malic acid, citric acid, sodium chloride, vitamin B6, niacinamide, inositol, and taurine. Combined use of the components of the beverage disclosed in the invention can achieve a mutually synergistic effect in the aspects of refreshing, consciousness restoring, and fatigue resistance, etc. The beverage has good pressure relieving, vitality boosting, and immune system strengthening effects, improves the sub-health status wholly, balances hormones, improves depression symptoms, enhances human body sexual functions and fertility, and has a good taste, which is sweet and sour and can promote the secretion of saliva or body fluid, thus being suitable for adults to sub-health populations to drink.

The invention relates to a method for transforming umbilical cord mesenchymal stem cells into islet cells. The method comprises the steps that after the umbilical cord mesenchymal stem cells are separated under the aseptic condition and subcultured, the induction is conducted, wherein 1 beta-nerve growth factors, activin A, niacinamide and epidermal growth factors are added into a DMEM / F12 culture medium containing fetal calf serum for conducting the induction culture; 2 a DMEM / F12 culture medium containing niacinamide, alkaline fibroblast growth factors and insulin-transferrin-selenium is added in for continuous culture till the cell transformation is ended, and islet cell sap is obtained. By means of the method, the number of the obtained islet cells is large, the quality of the islet cells is good, more insulin can be secreted, and the method is of great importance in clinic transformation of the umbilical cord mesenchymal stem cells for treating the 1 type diabetes.

The invention discloses formula milk powder to promote children's growth, which comprises various formula components of whole milk powder, skim milk powder, whey protein powder, soybean oil, white granulated sugar, maltodextrin, fructo-oligosaccharide, mineral complex, vitamin complex, and an edible essence, as well as galactooligosaccharide, docosahexaenoic acid, arachidonic acid, milk calcium, choline chloride, niacinamide, Chinese yam extract, Job's tears extract, Chinese date extract, Ampelopsis grossedentata extract, spina date seed extract, and demineralized whey powder. The invention applies to the preparation of children growth formula milk powder; the prepared milk powder is suitable for children 3-15 years hold to eat; a preparation method of the formula milk powder to promote children's growth has mutually cooperated and integral steps, and has the advantages of good process simplicity, good control convenience, low loss of nutrients of the components and the like.

Commonly used female rabbit fodder comprises the following raw materials in part by weight: 15 to 20 parts of corn, 15 to 25 parts of bean pulp, 10 to 15 parts of wheat bran, 10 to 20 parts of mango kernel powder, 25 to 40 parts of grass powder, 0.3 to 0.8 parts of methionine, 0.1 to 0.5 parts of table salt, 0.5 to 1 part of calcium hydrophosphate, and a proper amount of gunk; the gunk is formed by vitamin A, vitamin D3, vitamin E, vitamin K3, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacinamide, calcium pantothenate, D - biotin, folic acid, choline chloride and microelement additive for the fodder. The commonly used female rabbit fodder obtained according to the technical scheme is complete in nutritional ingredient, can meet the requirements of growth and development of female rabbits and is used for feeding the female rabbits in different stages; the female rabbits are high in growth rate, strong in disease resistance and higher in reproduction rate; female rabbits for breeding are good in maternity, can give birth for 6 to 7 times yearly, and about 10 baby rabbits are born each time and are healthy.

Provided is a nicotinamide adenine dinucleotide (NADPH)-cytochrome P450 reductase and a use thereof. Also provided is a polynucleotide encoding the NADPH-cytochrome P450 reductase, an expression vector and a host cell which express the NADPH-cytochrome P450 reductase, and a method for producing the protopanoxadiol.

The invention discloses a technique for synthesizing niacinamide and co-producing niacin by hydrolyzing 3-cyanopyridine, comprising the steps of producing niacinamide, producing niacin and the like. The invention has simple technological operation process and little equipment investment and is a niacin and niacinamide co-producing technique, the conversion ratio of 3-cyanopyridine is 100%, the recovery of niacinamide is 90%, and the total recovery of niacin is 99.8%.