740 results about "Squalene" patented technology

The invention discloses an oil-in-water emulsion free of surfactant. The emulsion comprises a metabolizable oil phase, a water phase and oil-water amphipathic solid particles dispersed in the water phase and having biocompatibility, wherein the oil phase comprises squalene or / and tocol; the water phase is any one or a combination of at least two of purified water, water for injection, aqueous liquid of glycerol, buffered saline liquid and clinically available infusion liquid; and the average grain diameter of the solid particles is at nanometer-to-micron grade. The emulsion can be used as a vaccine adjuvant or a medicine delivery or controlled release carrier; the properties of the emulsion can be controlled and regulated; the obtained emulsion is stable; the use of a surfactant is avoided; and harm to the human body and pollution on the environmental can be reduced.

The invention relates to a method for extracting high-purity squalene by taking olive oil as a raw material. A technological route formed by adopting a secondary molecular distillation and silica gel column chromatography is as follows: an olive oil unsaponifiable substance is taken, squalene is separated and purified by using two stages of molecular distillation, primary molecular distillation is carried out under the conditions of the evaporation surface temperature of 100 to 200 DEG C, the systemic pressure of 0.001 to 0.01mbar and the scraping film rotor speed of 150 to 300rpm, and secondary molecular distillation is carried out to the obtained distillate; the secondary molecular distillation is carried out under the conditions of the evaporation surface temperature of 150 to 300 DEG C, the systemic pressure of 0.001 to 0.01mbar and the scraping film rotor speed of 200 to 350rpm, and the obtained distillate is a squalene crude product; ethyl acetate-normal hexane with different concentrations is used as a mobile phase to carry out gradient elution, the obtained eluent is collected according to time and a solvent is evaporated, the same fractions are merged through chromatographic detection, and the high-purity squalene can be obtained, wherein the content of the raw material olive oil of the squalene is enhanced from 3.6% to about 98%; and especially, by considering the requirement of industrialized production to select an extraction condition especially, the large-scale production of the squalene taking the olive oil as the raw material can be realized.

The invention describes an overall process for the extraction of sterols, vitamin E, squalene and other plant-based hydrocarbons from deodorization distillates of plant oils. After an esterification of the free fatty acids, then a transesterification of the combined fatty acids (glycerides and sterides) by the same short alcohol, three successive distillations make it possible to successively recover a first fraction of hydrocarbons, the main fraction of alkyl esters, then the heaviest alkyl esters with squalene. The third distillate will be used for the production of squalene and a second fraction of hydrocarbons. The residue of the third distillation will be used for the production of sterols and vitamin E. By using bioethanol, plant-based glycerol and the plant-based hydrocarbons of the process, the process makes it possible to extract each of the four unsaponifiable substances without any solvent of oil-based origin and to claim the seals of approval for products obtained by natural physical and chemical processes.

The invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity. In a preferred embodiment, the adjuvant mixture comprises an acrylic acid polymer, most preferably Carbopol, and a mixture of a metabolizable oil such as one or more unsaturated terpene hydrocarbons, preferably squalene or squalane, and a polyoxyethylene-polypropylene block copolymer such as Pluronic®. The vaccine composition may optionally include a preservative, preferably thimerosol and / or EDTA. In another emodiment, the invention provides an improved Mycoplasma hyopneumoniae bacterin vaccine composition, which advantageously provides immunity from infection after a single administration, and comprises an inactivated Mycoplasma hyopneumoniae bacterin and an adjuvant or adjuvant mixture, which, in combination, provide immunity from Mycoplasma hyopneumoniae infection after a single administration, and elicit an immune response specific to Mycoplasma hyopneumoniae bacterin and including cell-mediated immunity and local (secretory IgA) immunity, in combination with other vaccine components.

The present invention provides a dry cleaning process for the in-home dry cleaning of laundry articles, comprising one or more cleaning steps followed by one or more rinse steps whereby at least one rinse step comprises contacting the laundry article with a rinse composition, said rinse composition comprising a low grade non-flammable non-chlorine containing organic dry cleaning solvent and said low grade solvent comprising at least 0.1 ppm and less than 50 000 ppm of squalene.

The present invention discloses an oil-in-water emulsion containing no surfactant, which comprises a metabolizable oil phase, an aqueous phase and oil-water amphipathic solid particles dispersed in the aqueous phase and having biocompatibility, wherein the oil phase comprises squalene or / and tocol; the aqueous phase is any one selected from the group consisting of purified water, water for injection, glycerine aqueous solution, buffering salts aqueous solution or clinically usable transfusion, or the combination of at least two selected therefrom; the solid particles have an average particle size in a scale of from nanometer to micrometer. The emulsion of the present invention can be used as vaccine adjuvant, drug delivery carrier or sustained / controlled-release carrier, and have the controllable properties. The resultant emulsion is stable, avoids the use of surfactants and can reduce the human poisoning and environmental pollution.