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Method for extracting squalene from vegetable oil deodorized distillate

A technology for deodorizing distillate and vegetable oil, applied in the field of recovering vitamin E and phytosterol, can solve the problems of high price, waste of solvent and high production cost, and achieve the effects of reducing separation cost, reducing load and low price

Inactive Publication Date: 2010-09-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are relevant studies on extracting squalene from vegetable oils, but there are many disadvantages in the process method, (1) vegetable oils are mostly used, such as olive oil, palm oil, and these oils are expensive, and there is no oil in the process of extracting squalene. It involves the recovery of other useful components in it, so the production cost is too high; (2) column chromatography technology is mostly used, although high-purity products can be obtained, but in the case of not combining other separation processes, the yield is extremely low and wasteful A large amount of solvent; (3) Some processes undergo multi-stage molecular distillation after esterification or esterification / transesterification. The extraction steps are complicated and cumbersome. Not only the load of molecular distillation is not reduced, but the separation cost is also increased.

Method used

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  • Method for extracting squalene from vegetable oil deodorized distillate
  • Method for extracting squalene from vegetable oil deodorized distillate
  • Method for extracting squalene from vegetable oil deodorized distillate

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Extraction of squalene from soybean oil deodorization distillate (SODD) and recovery of vitamin E, phytosterols

[0025] 1) Preparation of unsaponifiable matter: get 300gSODD (see attached figure 1 , the squalene retention time is 21min), the squalene content is 1.91%, vitamin E 4.82%), the KOH-ethanol solution of 1200ml 0.5mol / L is in the flask, reacts 1h under the situation of 90 ℃ of stirring refluxes, After stopping the reaction, add 500ml of distilled water at the top of the reflux tube, and rotate the shaking flask. After cooling, use 300ml of normal hexane to extract five times, combine the extraction phases, and then use 10% aqueous ethanol (V 乙醇 :V 水 =1:9) wash the extract phase, remove alkali and soap, then put the washed extract phase in the refrigerator, the soap is precipitated and removed, and the solvent is evaporated with a rotary evaporator at 100°C to obtain about 60g of unsaponifiable matter, liquid According to the phase determination, the content...

Embodiment 2

[0030] Basic technology is as embodiment 1, and concrete operation parameter is as follows:

[0031]1) Preparation of unsaponifiable matter: get 300gSODD (squalene content is 1.91%, vitamin E is 4.82%), in the KOH-ethanol solution of 600ml1.5mol / L and in the flask, react under the situation of stirring and reflux at 60 ℃ 4h, after stopping the reaction, add 500ml of distilled water at the top of the reflux tube, and rotate and shake the three-necked flask. After cooling, use 300ml of n-hexane to extract five times, combine the extraction phases, and then use 10% aqueous ethanol (V 乙醇 :V 水 =1:9) wash the extract phase, remove alkali and soap, then put the washed extract phase in the refrigerator, the soap is precipitated and removed, and the solvent is evaporated with a rotary evaporator at 100°C to obtain about 60g of unsaponifiable matter, liquid According to the phase determination, the content of squalene is 10.2%, and the fatty acid can be recovered after acidification of...

Embodiment 3

[0036] Basic technology is as embodiment 1, and concrete operation parameter is as follows:

[0037] 1) Preparation of unsaponifiable matter: get 300g rapeseed oil deodorization distillate (squalene content is 2.05%, vitamin E is 4.84%), the KOH-ethanol solution of 900ml 1.5mol / L is in the flask, at 75 ℃ React for 2.5 hours with stirring and reflux. After stopping the reaction, add 500ml of distilled water to the top of the reflux tube, and rotate and shake the three-necked flask. Aqueous solution (V 乙醇 :V 水 =1:9) wash the extract phase, remove alkali and soap, then put the washed extract phase in the refrigerator, the soap is precipitated and removed, and the solvent is evaporated with a rotary evaporator at 100°C to obtain about 55g of unsaponifiable matter, liquid The content of squalene is 13.8% according to phase determination, and fatty acid can be recovered after acidification of the obtained saponification.

[0038] 2) Two-stage molecular distillation to obtain squa...

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Abstract

The invention relates to a method for extracting squalene from vegetable oil deodorized distillate. A process method of combining molecular distillation with extraction and crystallization is used to extract high-concentration squalene and recover natural vitamin E and phytosterol with a certain purity from vegetable oil deodorized distillate. The method comprises the following steps of: carryingout a saponification reaction of the raw material; twice molecularly distilling unsaponifiable matter obtained by extraction; using the distillate obtained during the second distilling as a raw material for cold crystallization to obtain phytosterol; recovering squalene and mixed tocopherol from the filtrate; and extracting with multi-stage solvents to respectively enrich squalene and vitamin E in two phases. The process has simple flows, low-prices raw material and higher separation efficiency and recovery rate and comprehensively utilizes useful contents in the deodorized distillate.

Description

technical field [0001] The invention relates to a new method for extracting squalene from vegetable oil deodorization distillate and simultaneously recovering vitamin E and phytosterol. Background technique [0002] The chemical name of squalene is 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene, as a lipid unsaponifiable, Widely distributed in most animals and plants, squalene has good biological activity and can be used as an effective drug for anti-tumor, anti-cancer, anti-infection and treatment of cardiovascular and cerebrovascular diseases. It is also widely used in beauty drugs and cosmetics. In addition, it can also be used as an antibacterial agent, lubricating oil, etc. At present, the main source of squalene is shark liver oil. The low reproductive rate and scarcity of sharks limit its production. Studies have shown that squalene is widely distributed as a lipid unsaturated substance. In plants, it is higher in olive oil and palm oil, especially the c...

Claims

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Application Information

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IPC IPC(8): C07C11/21C07C7/04C07C7/10C07D311/72C07J75/00C07J9/00
Inventor 丁辉齐德珍徐世民张艳华
Owner TIANJIN UNIV
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