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Method for extracting squalene by using camellia oleosa seeds as raw materials and tea oil and squalene soft capsules

A technology of camellia seed and squalene, applied in the field of biomedicine, can solve the problems of ecological imbalance of deep-sea sharks, and achieve the effects of improving human immune function, enhancing brain power, improving immunity and regeneration.

Inactive Publication Date: 2011-08-10
李文东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high content of squalene in the liver of deep-sea sharks, such as 40%-74% in armored shark liver oil, and 49%-89% in small spiny sharks, most of them currently use deep-sea shark liver oil to extract squalene; but The production of squalene in such a large amount will lead to the ecological imbalance of deep-sea sharks

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] a. Take 300 kilograms of fresh camellia oleifera seeds, wash them with clear water, dry them in air, chop them up and put them into an extraction tank;

[0032] b. Add 1.5-2.4 tons of 85% ethanol (weight content) to the tank, heat (at a temperature of 60-70° C.) for reflux extraction for 2-3 hours, filter out the extract, and add 1.5-2.4 tons of 85% ethanol Ethanol (weight content), boil and leach for 2-3 hours again, discard the residue after filtering out the leachate; merge two leachate for subsequent use;

[0033] c. Concentrate the above-mentioned standby extract by heating (at a temperature of 60-70° C.), reclaim ethanol, and collect 200 liters of concentrated solution for subsequent use;

[0034] d, add 0.4-1.0mol / L sodium hydroxide-methanol solution (the consumption of sodium hydroxide is 0.3-0.8 kilogram, the consumption of methyl alcohol is 20 liters) in the above-mentioned standby concentrate solution, and then, its Place in a water bath at 70°C, reflux unde...

Embodiment 2

[0047] ① Take gelatin, glycerin, and water to prepare capsule shells according to the ratio (weight ratio) of 1.0:0.4:0.6, and set aside;

[0048] ②According to the percentage by weight:

[0049] 90 parts of squalene essential oil with squalene content ≥ 80%, 5 parts of polyethylene glycol 400, 3 parts of beeswax, and 2 parts of phospholipids, the total is 100 parts, mixed evenly, filled in the capsule shell, and the tea is made Finished oil squalene soft capsules.

Embodiment 3

[0051] ① Take gelatin, glycerin, and water to prepare capsule shells according to the ratio (weight ratio) of 1.0:0.4:0.6, and set aside;

[0052] ②According to the percentage by weight:

[0053] 90 parts of squalene essential oil with squalene content ≥ 80%, 3 parts of polyethylene glycol 400, 2 parts of beeswax, and 5 parts of phospholipids, the total is 100 parts, mixed evenly, filled in the capsule shell, and the tea is made Finished oil squalene soft capsules.

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Abstract

The invention discloses a method for extracting squalene by using camellia oleosa seeds as raw materials and tea oil and squalene soft capsules and relates to the technical field of biomedicine. The extraction method comprises the following process flows of material preparation, grinding, leaching, concentration, methyl esterification, complexant-borax reaction, macroporous resin chromatographic separation and purification, concentration, extraction, washing, concentration, preparation of squalene crude oil and supercritical carbon dioxide extraction, so that squalene essential oil with the squalene content of more than or equal to 80 percent is obtained. The tea oil and squalene soft capsules are prepared from the following raw materials in percentage by weight: 87 to 90 percent of squalene essential oil with the squalene content of more than or equal to 80 percent, 3 to 5 percent of polyethylene glycol 400, 2 to 3 percent of beewax and 2 to 5 percent of phospholipid. The raw material resources are wide. The prepared tea oil and squalene soft capsules not only can be used for medicine, but also can be used for food therapy, are particularly suitable for administration of treatment and food therapy of patients suffering from hepatitis, fatty liver, acute and chronic inflammation, tumor, chemotherapy, diabetes mellitus and cardio-cerebrovascular disease and have no toxic or side effects.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a method for extracting squalene from camellia oleifera seeds and tea oil squalene soft capsules made from the squalene extracted by the method as the main raw material. Background technique [0002] Squalene is a lipid unsaponifiable substance, originally discovered from shark liver oil, named Squalene in 1914, and its chemical name is 2,6,10,15,19,23-hexamethyl-2 , 6, 10, 14, 18, 22-Tetracosahexaene, an open-chain triterpene, also known as cod liver oil terpene, can improve the activity of superoxide dismutase (SOD) in the body, enhance the body's immunity, and improve sexual function , anti-aging, anti-fatigue, anti-tumor and other physiological functions, it is a non-toxic marine bioactive substance with the effect of preventing and curing diseases. Squalene is widely distributed in plants, but the content is not high, mostly lower than 5% of the unsaponifiable matter in...

Claims

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Application Information

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IPC IPC(8): C07C11/21C07C7/10A61K31/01A61P1/16A61P37/02A61P35/00A61P39/02A61P39/06A61P29/00A61P3/10A61P9/00A23L1/29A23L33/00
CPCY02P20/54
Inventor 李文东管天球邹先明郑晓宏桂平李昕
Owner 李文东
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