The invention relates to a phosphogypsum reverse flotation, desilication and impurity removal process; and targeting at the characteristic that the content of SiO2, phosphorus, F, acid insoluble substances and other impurities in phosphogypsum solid waste is high, a process of carrying out single or double reverse flotation by adding in regulator and collector is adopted; the regulator used in the reverse flotation is NaOH, Na2CO3, water glass, CaO, hydrochloric acid, sulfuric acid and other conventional regulator, and the used amount of the regulator is 1kg / t to 15kg / t. The collector used in the reverse flotation is fatty acid collector, negative ion collector, amine collector and other conventional desilicated collector, and the used amount of the collector is 1kg / t to 10kg / t. The process reduces the SiO2, phosphorus, F, acid insoluble substances and other impurities in the phosphogypsum, can prepare low-silicon and high-grade gypsum products, improve the grade and quality of gypsum, improve the mineral characteristics of the gypsum, and lay technical foundation for the industrialization of the phosphogypsum.