The invention relates to the field of compound fertilizers, and particularly relates to a natural disease-resistant high-yield slow-release compound fertilizer which is prepared from the following raw materials in parts by weight: 10-15 parts of 1250-2000-mesh kieselguhr, 18-23 parts of monoammonium phosphate, 10-12 parts of potassium chloride, 15-18 parts of ammonium chloride, 3-5 parts of walnut green seedcase, 6-8 parts of boron-magnesium fertilizer, 2-5 parts of raw gypsum powder, 3-5 parts of ferrocene, 6-8 parts of Alexandria laurel leaf, 10-12 parts of horse manure, 3-5 parts of safflower Lycoris radiata aqueous extract, 6-8 parts of wood dust, 3-6 parts of poplar peel, 7-9 parts of calcium phosphate, 2-4 parts of tonka powder, 1-3 parts of sweet orange peel ultramicropowder, 1-3 parts of water-soluble lanolin, 5-7 parts of polyvinylpyrrolidone, 10-12 parts of gelatin, 2-3 parts of thiocarbamide and 4-5 parts of assistant. The compound fertilizer fully utilizes common cheap organic matters in daily production and life, lowers the production cost, improves the soil environment, and utilizes the kieselguhr and modified gelatin slow-release coating agent to form dual coatings on the nutrients, so that the fertilizer efficiency is more endurable, thereby reducing the inefficient loss of nutrients, effectively enhancing the yield and quality of the crops and enhancing the disease-resistant and antimicrobial capacities of the crops.