658 results about "Caffeic acid" patented technology

The present invention relates to color stable personal care compositions that provide anti-oxidiation, moisturization, and / or prevent biodegradation in personal care formulations. These compositions contain erythorbic acid or a salt thereof, caffeic acid or a salt thereof, δ-gluconolactone, or a mixture thereof. The present invention further relates to methods of moisturizing skin with erythorbic acid or a salt thereof, or δ-gluconolactone. The present invention also relates to concentrates of active ingredients preloaded with a sufficient amount of an anti-oxidation, moisturizing and / or biodegradation prevention agent so that when it is diluted for use, the final formulation includes an anti-oxidation, moisturizing and / or biodegradation prevention effective amount of the anti-oxidation, moisturizing, and / or biodegradation prevention agent.

The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2 / STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.

A cosmetic composition containing a caffeic acid ester for treating human skin.

The objetive of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-alpha-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivative, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.

The present invention relates to a compound of the formula: R-AR—O—Y—R′Wherein R represents one or more members selected from H, alkoxy, benzyloxy, aldehyde, halogen, carboxylic acid, —NO2, —NH2, —NHCOCH3, and —NH—Y—R′, which is attached directly to AR or attached through an aliphatic chain. The carboxylic acid moiety in R includes but is not limited to the following carboxylic acids: benzoic acids, cinnamic acids, ferulic acid, caffeic acid, syringic acid, salicylic acid, vanillic acid, phenylacetic acids, phenylpropionic acids, and sinapinic acid. -AR—O— is a biologically active phenolic moiety comprising 1 to 6 substituted or unsubstituted aryl rings that are directly bonded to each other, fused together, or joined through a linking group. Y represents a member selected from: —COCH2O— (glycolic ester moiety) —COCH(CH3)O— (lactic ester moiety) —COCH2OCH2CH2O— (dioxanone ester moiety) —COCH2CH2CH2CH2CH2O— (caprolactone ester moiety) —CO(CH2)mO— where m is an integer between 2-4 and 6-24 inclusive —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; and R′ is either hydrogen or a benzyl or an alkyl group, the alkyl group being either straight-chained or branched. The resultant functionalized phenolic compounds, used singly or in combinations, and their polymers have controllable degradation profiles, releasing the active component over a desired time range. The polymers are useful for biomaterials and biomedical devices, wherein said biologically active phenolic moiety is a residue of a phenolic compound.

Embodiments of the invention generally relate to pharmaceutical compositions containing at least one caffeic acid compound and methods for the topical treatment of proliferative and inflammatory skin disorders such as plaque psoriasis, atopic dermatitis, and other disorders. In some embodiments, the topical treatment includes applications of the pharmaceutical composition containing at least one caffeic acid compound or a mixture of caffeic acid compounds such as caffeic acid ester compounds, caffeic acid amide compounds, analogues thereof, derivatives thereof, salts thereof, or mixtures thereof. The pharmaceutical composition or topical dosage may contain the caffeic acid compound at a concentration by weight within a range from about 0.01% to about 20%, preferably, from about 0.1% to about 15%, preferably, from about 1% to about 10%, more preferably, from about 3% to about 7%, and more preferably, from about 4% to about 6%.

The present invention relates to ascorbic acid single-phase solution compositions that provide enhanced stability, enhanced solubility and an enhanced photoprotective effect as compared to prior compositions. The compositions comprise L-ascorbic acid; a cinnamic acid derivative such as p-coumaric acid, ferulic acid, caffeic acid, sinapinic acid, a derivative thereof, and a combination thereof; a solvent comprising a glycol ether and an alkanediol; and water; the composition having a pH of no more than about 3.5. The compositions may also comprise a form of Vitamin E and are useful for treatment of radical-induced damage to a subject, particularly the skin of a subject.

A cosmetic skin-care composition containing as the active principle a depigmentationally active combination of (a) an acidic mixture including (i) at least one alpha-hydroxylated acid or a derivative thereof, with the exception of ascorbic acid, and (ii) at least one compound selected from the group which consists of kojic acid, caffeic acid, azelaic acid, aminobutyric acid, fusaric acid, 5-hydroxy 2-hydroxymethyl-gamma-pyridone, and derivatives thereof, and (b) at least one active component of a plant extract from at least one plant selected from white mulberry, liquorice, skull cap, grapefruit, birch, heather, strawberry tree, bearberry, lemon, lettuce, oarweed, cucumber, ginseng, hop, sweet corn, feverfew, sage, soya, elder, spirulina, lime, ferocious aloe, yukinoshita, bloodwort, hoelen, wood rose, alpha-orizanol, burnet, ginkgo biloba, tanlex VB and Eclipsa alba, with the proviso that when the composition contains kojic acid and a liquorice extract, it contains at least one other plant extract component. The use of said composition for preparing a drug or in a cosmetic method is also disclosed.

The invention discloses an environment-friendly rust remover, comprising the following raw materials in parts by weight: 15-30 parts of organic acid, 5-15% of glycerin, 0.1-2 parts of dextrin, 0.5-10 parts of sodium molybdate, 0.5-2 parts of phosphoric acid, 45-70 parts of water and 0.05-0.1 part of SI-1 additive. The organic acid used in the invention is any one of citric acid, tartaric acid, malic acid, chlorogenic acid, oxalic acid, benzoic acid, salicylic acid and caffeic acid. The invention improves the traditional formula, the manufacturing process is advanced and the manufacturing method is simple, rapid and efficient. The invention overcomes the shortcoming that the existing rust removers pollute the environment, and the rust remover not only has good rust removing function, but also has excellent rust prevention function.

The invention relates to an agent for preventing, improving or treating hypertension, which exhibits a hypotensive effect, inhibits the rise of blood pressure and improves hypertension, and food for preventing or improving hypertension, which does not become a burden in daily intake, has a higher antihypertensive effect and is useful as a diet during treatment for patients of hypertension. The agent for preventing, improving or treating hypertension contains the following components (A) and (B): (A) a compound selected from the group consisting of caffeic acid, chlorogenic acid and ferulic acid, and esters and pharmaceutically acceptable salts thereof; and (B) a component selected from the group consisting of central nervous system stimulating components, food fibers, extracts of perennial evergreen leaves of the genus Camellia, Theaceae, or Eucommia ulmoides Oliver, Eucommiae, organic acids having a molecular weight of 60 to 300 (excluding citric acid) and pharmaceutically acceptable salts thereof, and sugar alcohols.

A composite spot-removing liquid for removing senile plaque, chloasma, ephelides, etc and beautifying and whitening skin is prepared from 24 Chinese-medicinal materials including liquorice root, ginseng, mulberry bark, aloe, etc and 9 other raw materials including konjic acid, VA, caffeic acid, VB3, etc. Its preparing process is also disclosed.

Microorganisms are genetically engineered to synthesize caffeic acid from simple carbon sources via a tyrosine intermediate by means of a dual pathway that utilizes both endogenous and engineered enzymatic activities.

Processes for isolating bitter quinides for use in food and beverage products entailing contacting a bitter quinide solution with an adsorbent to adsorb bitter quinides from the bitter quinide solution, desorbing the bitter quinides from the adsorbent to obtain a bitter quinide isolate, and adding the bitter quinide isolate to a food or beverage product to enhance the flavor thereof. A bitter quinide isolate made up of at least one of 3-O-caffeoyl-γ-quinide, 4-O-caffeoyl-γ-quinide, 5-O-caffeoyl-epi-δ-quinide, 5-O-caffeoyl-muco-γ-quinide, 3-O-feruloyl-γ-quinide, 4-O-feruloyl-γ-quinide, 3,4-O-dicaffeoyl-γ-quinide, 4-O-caffeoyl-muco-γ-quinide, 3,5-O-dicaffeoyl-epi-δ-quinide, 4,5-O-dicaffeoyl-muco-γ-quinide, 5-O-feruloyl-muco-γ-quinide, 4-O-feruloyl-muco-γ-quinide, 5-O-feruloyl-epi-δ-quinide, quinide esterified with one or more of caffeic acid, ferulic acid, p-courmaric acid, 2,4-dimethoxycinnamic acid and mixtures thereof.

The invention discloses a preparation method of graphene, belonging to the technical field of nanomaterials. The method comprises the steps of adding graphite oxide powder into deionized water, and carrying out ultrasonic oscillation to obtain a graphene oxide dispersion liquid of the graphene oxide in the deionized water; adding green and nontoxic caffeic acid powder into the graphene oxide dispersion liquid to carry out reduction reaction to obtain a graphene solution; finally, filtering through a microporous filter membrane, collecting and carrying out vacuum drying to obtain graphene. By using the method, caffeic acid as a reducing agent widely exists in various plants so as to be green and nontoxic; in addition, the preparation method is simple in process, mild in reaction condition and free of causing environment pollution and generating hazards to human health; moreover, caffeic acid has strong reducing capacity, so that impurity elements or functional groups can not be introduced to a reduzate, the prepared graphene is high in purity and quality, and caffeic acid is suitable for the large-scale industrial production of the graphene and beneficial to the wide application of relevant materials of the graphene.

The invention relates to a method for ultrasonically extracting and preparing flavonoids pigment from chrysanthemum, belonging to the field of food processing and especially used for deep processing chrysanthemum. The process comprises the following steps of: blanching, drying and hermetically storing chrysanthemum at a low temperature, filtering by using a 100-mesh sieve, soaking in 60% ethanol as an extraction solvent in a liquid-material ratio of 40 / 1 (v / w) for 2 h, ultrasonically extracting a dry base in a water bath at 70 DEG C for 10 min to acquire the yield of 13.34 percent; and evaporating in the water bath at 70 DEG C by using the 60% of ethanol extraction liquid in a rotating way to release an ethanol taste; and freezing and drying in vacuum, wherein analytical compositions reach 52.01% of the dry base and comprise flavonoids, linarin, flavonoids (luteolin, acacetin and apigenin), flavonols (quercetin), phenolic acid (chlorogenic acid and caffeic acid), metal elements, and the like. The invention provides a new method for deep processing the chrysanthemum and has strong maneuverability, good safety and good repetitiveness.

The invention provides a method for simultaneously detecting main components of paeoniflorin, beta ecdysterone, laetrile, mulberroside A, caffeic acid, ferulic acid, salvianolic acid B, astragaloside, formononetin, cryptotanshinone and tanshinone IIA of a Naoxintong capsule in a plasma sample by a liquid chromatography-tandem mass spectrometry (HPLC-MS / MS). In a liquid chromatogram, a mobile phase consists of acetonitrile and a formic acid aqueous solution of which the volume fraction is 0.1%, and gradient elution is used. A mass spectrum uses a quick positive and negative ions switching and analyzing mode and an MRM (Multiple Reaction Monitoring) scanning manner. After the Naoxintong capsule is taken, the situations of the changes of the blood-medicine concentration of several kinds of main components in the plasma of a rat are detected at the same time. The methodological survey results indicate that the established method conforms to determination requirements on biological samples in a body; the method is good in sensitivity, high in specificity, stable, reliable, and suitable for detecting substances with lower contents.

The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.

The invention discloses a metabonomics-based diagnosis marker for chronic obstructive pulmonary disease and application thereof. The diagnosis marker comprises the following 28 blood plasma metabolismmarkers: phosphatidylcholine PC 16:1-36:3, phosphatidylcholine PC 26:0-22:4, phosphatidylcholine PC 26:0-22:3, phosphatidylcholine PC 47:5e, phosphatidylcholine PC 44:11e, phosphatidylcholine PC 16:0-24:5, phosphatidylcholine PC 20:2-20:3, phosphatidylcholine PC 40:10, phosphatidylcholine PC 38:9e, phosphatidylcholine PC 18:1-20:4, phosphatidylcholine PC 16:0-20:3, phenylacetaldehyde, dihydrouracil, nicotinamide, 4-methoxycinnamic acid, ketovaline, threonine, DL-3-aminoisobutyric acid, pyruvic acid, stachyose, caffeic acid, N, N-dimethylaniline, maltotriose, D(-)-gulonate-gamma-lactone, and L-asparaginase. The marker provided by the invention has good classification on metabolome data of patients suffering chronic obstructive pulmonary disease and healthy people, and can accurately distinguish the patients suffering chronic obstructive pulmonary disease from the healthy people.

The invention relates to a method for simultaneously measuring the content of chlorogenic acid and caffeic acid in a dandelion preparation by utilizing the HPLC method. The measurement method can effectively solve the problem that the chlorogenic acid and the caffeic acid are taken as the index components to simultaneously carry out the content measurement in order to lay the foundation for the quality standard of the dandelion preparation. The specific technical proposal comprises the following steps: respectively preparing a sample solution to be measured and a reference product solution, gradient-eluting with the RP-HPLC method by taking the methanol-phosphoric acid water as the mobile phase and measuring the content of the chlorogenic acid and the caffeic acid. The method has the advantages of convenience, reliability, rapidness, high sensitivity, good repeatability and high recovery rate, takes the chlorogenic acid and the caffeic acid as the index components, lays the foundation for the quality standard establishment of dandelion and the preparation thereof and provides more scientific basis.

The invention discloses total phenyl propanoid extract and total phenol extract extracted from grassleaved sweetflag rhizome and its preparation method. Total phenyl propanoid extract mainly comprises beta -asaricin, alpha -asaricin, eudesmin, galgravin, veraguensin and other derivant with veraguensin as mother nuclide. Total phenol extract mainly comprises caffeic acid, protocatechuic acid, ferulic acid, vanillic acid and glucosides with vanillic acid as mother nuclide and other derivants. Total phenyl propanoid extract and total phenol extract of grassleaved sweetflag rhizome can be extracted through one or more of methods of solvent-extraction, solvent extraction, precipitation method, macroporous adsorbent resin, extraction by supercritical fluid, column chromatography, and liquid-liquid countercurrent distribution chromatography. Total percentage content of phenyl propanoids in the obtained total phenyl propanoid extract of Grassleaved sweetflag rhizome is 5-100% (w / w), wherein content of beta -asaricin and alpha -asaricin occupy 5-100% (w / w).Total percentage content of phenols in total phenol extract of grassleaved sweetflag rhizome is 5-100% (w / w), wherein content of caffeic acid and protocatechuic acid occupy 5-100% (w / w).

Compositions are provided containing molecules having at least one moiety from beta-(3,4-dihydroxyphenyl)lactic acid and / or caffeic acid, which are found in extracts from the plant genus Salvia, said moieties being of formula(I), the active agents having a molecular weight of at least 190 daltons. A class of preferred agents are those which are conjugated to form dimers, trimers, tetramers and larger polymers containing said moieties, with the most preferred being salvianolic acid dimers, trimers, tetramers and larger polymers. The compounds and compositions may be administered in pharmaceutically acceptable carriers and excipients systematically or locally to treat viral infections.

The invention provides a method for extracting compound from kidney tea stalks and leaves, crushing the stalks and leaves, successively adopting water extraction, alcohol extraction, and ethyl acetate to extract water soluble, alcohol soluble and fat soluble compounds, which are rosemary acid, caffeic acid, bear fruit acid, Yuan er tea acid, isoflavone, rosemary acid acetate and other phenolic compounds and flavone compounds. The invention is a kidney tea compound extracting method, effective and applied to industrial production.

The invention relates to a high performance liquid chromatography-mass spectrometry (HPLC-MS) quantitative method for measuring 10 components of a fructus evodiae formula granule. The method is characterized in that a HPLC-MS technology is used; acetonitrile is taken as the A phase; acetic acid (0.12%)-ammonium acetate (1 mmol / L) is taken as the B phase; gradient elution with four scale transformations is performed; the flowing speed is 0.8 mL / min; the column temperature is 40 DEG C; in a multiple reaction monitoring (MRM) mode, positive ions and negative ions are monitored at the same time, the ion source is an ESI source, the atomized gas (GS1) is N2, the auxiliary gas (GS2) is N2; nitrogen gas is used during the whole process; the collision gas pressure is medium; the resolutions of Q1 and Q3 are both UNIT; the method can detect 10 components in the fructus evodiae formula granule, namely chlorogenic acid, caffeic acid, rutin, hyperin, hesperidin, dehydroevodiamine, limonin, evodiamine, rutaecarpin, and evocarpine; 10 components can be all detected in 22 minutes, and the method is rapid and accurate and is not disturbed.

The invention discloses a method for preparing a benzolene propionic acid benzene alkyl ester compound, particularly a method for preparing a caffeic acid 3,4-dihydroxyl phenethyl ester. The preparation method has the advantages of single reaction product obtained in each step, less byproducts, easy separation and purification, high yield of target products and suitability for the industrialized production.

The invention discloses a preparation method of a chitosan derivative and application of the chitosan derivative to food preservation. According to the preparation method of the chitosan derivative, the chitosan derivative is obtained by performing reaction on chitosan powder in reaction liquid containing phenolic acid compounds and recombinant bacterial laccase at the temperature of 60 to 85 DEGC for 0.5 to 4 hours; and the phenolic acid compounds are selected from any one of ferulic acid, caffeic acid, chlorogenic acid, trihydroxybenzoic acid, gallic acid, catechinic acid, tannic acid and tea polyphenol. Compared with the chemical method, the preparation method of the chitosan derivative under catalyzed synthesis of bacterial laccase has the advantage of environmental friendliness and is a green production mode. The recombinant bacterial laccase has high heat stability, and catalytic reaction liquid can be reused repeatedly. The chitosan derivative has a good preservation effect invarious foods of fruit and vegetables, meat products, dairy products, grease products and the like.

The invention discloses a method for simultaneously determining twenty-two flavones and phenolic acids in citrus fruits by adopting high performance liquid chromatography-diode array detector-fluorescence detector (HPLC-DAD-FLD). The method is capable of simultaneously determining twenty-two phenolic compounds in citrus fruits such as gallic acid, synephrine, chlorogenic acid, protocatechuic acid,caffeic acid, p-coumaric acid, rhamnosylvitexin, eriocitrin, ferulic acid, rutin, benzoic acid, narirutin, naringin, hesperidin, diosmin, neohesperidin, quercetin, naringenin, kaempferol, nobiletin,hesperetin, acacetin and the like, derivatization is not needed, and the method is high in accuracy, high in sensitivity and excellent in repeatability.

The invention relates to a rapid separation liquid chromatography detection method for naoxintong capsules. The method comprises the chromatographic conditions that octadecyl bonded silica gel columns serve as filling agents, 0.1% formic acid water serves as an A mobile phase, acetonitrile serves as a B mobile phase, the volume ratio of the A mobile phase to the B mobile phase is 10-85:15-90, and linear gradient elution is performed, the flow velocity is set at 0.20 mL.min<-1>, the column temperature is set at 25 DEG C, and the sample introduction volume is 5 microliters. The content of gallic acid, tanshinol, hydroxysafflor yellow A, chlorogenic acid, amygdalin, protocatechualdehyde, epicatechin, caffeic acid, albiflorin std, ononin, paeoniflorin, rutin, salvianolic acid A, cinnamic acid, fermlononetin, dihydrotanshinone I in the naoxintong capsules is detected. The detection method has the advantages of being rapid, stable and accurate.

The invention discloses a fluorescent probe and a preparation method thereof, and application in detecting superoxide anions. The structural formula of the fluorescent probe is disclosed in the specification. The preparation method comprises the following steps: in an inert gas protective atmosphere, dissolving melamine and caffeic acid in a DMF (N,N-dimethylformamide) and CH2Cl2 mixed solution, adding HOBT (N-hydroxybenzotriazole) and EDC.HCL (1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), and stirring to react at room temperature for 8-16 hours; after the reaction, concentrating to remove the solvent, thereby obtaining the fluorescent probe crude product; and separating and purifying the fluorescent probe crude product with a silica gel thin-layer chromatographic sheet to obtain the fluorescent probe pure product. The fluorescent probe has the advantages of novel structure, high sensitivity, high selectivity and high light stability.