171 results about "Metabolome" patented technology

The invention comprises methods for diagnosing the risk of onset of type 1 diabetes and for preventing the onset of type 1 diabetes. The genetic background, metabolomes, antibodies and diversity of gut microbiota of an individual can be used for diagnosis.

The invention describes novel nitrosated and / or nitrosylated nebivolol, novel nitrosated and / or nitrosylated metabolites of nebivolol and novel compositions comprising at least one nitrosated and / or nitrosylated nebivolol and / or at least one nitrosated and / or nitrosylated metabolite of nebivolol, and, optionally, at least one nitric oxide donor and / or at least one antioxidant or a pharmaceutically acceptable salt thereof, and / or at least one compound used to treat cardiovascular diseases or a pharmaceutically acceptable salt thereof, and / or at least one nitrosated compound used to treat cardiovascular diseases. The invention also provides novel compositions comprising nebivolol and / or at least one metabolite of nebivolol and at least one nitric oxide donor, and, optionally, at least one antioxidant or a pharmaceutically acceptable salt thereof, and / or at least one compound used to treat cardiovascular diseases or a pharmaceutically acceptable salt thereof, and / or at least one nitrosated compound used to treat cardiovascular diseases. The compounds and compositions of the invention can also be bound to a matrix. The nitric oxide donor is a compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and may preferably be isosorbide dinitrate and / or isosorbide mononitrate. The antioxidant may preferably be a hydralazine compound or a pharmaceutically acceptable salt thereof. The invention also provides methods for treating and / or preventing vascular diseases characterized by nitric oxide insufficiency; and for treating and / or preventing Raynaud's syndrome; and for treating and / or preventing cardiovascular diseases or disorders.

This invention refers to a new method for optimizing the composition of cell culture media. This new method comprises two main stages. In the first stage, a functional enviromics map is built through the joint screening of cell functions and medium factors by the execution of a specific cell culture protocol and exometabolome assays protocol. The functional enviromics map consists of a data array of intensity values of elementary cellular functions against medium factors. In the second stage, optimized cell culture medium formulations are developed that either enhance or repress target elementary cellular functions from columns of the functional enviromics map. The main advantage of this method lies in enabling metabolic engineering through the culture media composition manipulation, wherein an arbitrarily high number of cell functions are optimized through manipulation of medium factors, as opposed to previous methods, which are eminently empirical, are not cell function oriented, and require a much higher number of experiments. Furthermore, this new method is based on cost-effective exometabolome assays and does not require costly intracellular genomic or proteomic assays.

The invention belongs to the field of biological engineering and relates to a method for controlling the fermentation process of fumaric acid producing rhizopus oryzae. In the invention, through the measurement and comparative analysis of the metabolome of a high-yield rhizopus oryzae strain and the metabolome of an original strain, high-yield fumaric acid intracellular metabolism characteristic information of rhizopus oryzae is acquired completely to provide an important guide for the control and optimization of the fermentation process. Compared with other fermentation control policies, the method can perform detrended analysis on all metabolites in cells, help to get deeper understanding of the fumaric acid high yield mechanism of the, and is more specific and efficient for fermentation control; and therefore the method is a high-efficiency and systemic method for control and optimization of the fermentation process.