412 results about "Anaphylactic reaction" patented technology

Methods and devices for treating bronchial constriction related to asthma and anaphylaxis wherein the treatment includes providing an electrical impulse to a selected region of the vagus nerve and / or the lungs of a patient suffering from bronchial constriction.

A method for treating an allergic reaction other than asthma in a mammal need thereof comprising administering to said mammal a tetracycline compound in an amount that is effective to treat said allergic reaction.

The method of the present application is directed towards a method for suppressing an allergic response in response to an allergic trigger. This method comprises the following steps; applying, topically, to an affected area an effective amount of a minocycline composition so that the minocycline composition contacts the affected area for an effective amount of time and removing the minocycline composition from the affected area.

The invention relates to a flexible and extendable electronic device based on biocompatible films and a manufacturing method, and belongs to the technical field of flexible and extendable electronic devices. The flexible and extendable electronic device is technically characterized in that the biocompatible films are used as an encapsulation layer and a substrate layer of the flexible and extendable electronic device, a bonding layer used for enhancing the boundary strength between the encapsulation layer and a functional layer can be further arranged between the encapsulation layer and the functional layer, and an adhesive layer used for enhancing the adhesive force of the device with the surface of an object to be tested is arranged underneath the substrate layer; the functional layer is of a flexible and extendable structure. In the manufacturing process of the flexible and extendable electronic device, a transfer printing technology based on a solution is mainly adopted to achieve integration of the functional layer and a flexible substrate. The flexible and extendable electronic device structurally keeps and even improves flexibility and extensibility. Meanwhile, compatibility features such as waterproofness, breathability and low allergenicity of the flexible and extendable electronic device allow the flexible and extendable electronic device to normally work on the surface of a human body for more than 24 hours without causing a foreign body feeling and discomfort, and skin soaking or rubefaction or other anaphylactic reactions caused by poor biocompatibility can be avoided.

The invention relates to an immunoassay detection kit, and provides an allergenic specific IgE antibody immunoassay detection kit and a preparation method thereof. The detection kit comprises magnetic microspheres coupled with allergenic protein, magnetic microspheres coupled with anti-human IgE antibody, a human IgE antibody standard substance, alkali phosphatase labeled anti-human IgE antibody and an alkali phosphatase chemical luminous substrate AMPPD. The preparation method for the detection kit comprises the following steps: coupling the allergenic protein to the magnetic microspheres, coupling the anti-human IgE antibody to the magnetic microspheres, preparing the human IgE antibody standard substance, preparing the alkali phosphatase labeled anti-human IgE antibody, preparing the alkali phosphatase chemical luminous substrate AMPPD and packing the combination. The detection kit has the advantages of high sensitivity, high accuracy, quick response, convenient usage, low dosage and low cost, can assist in precisely and quantitatively measuring sensitive allergene, and guides clinical anaphylactic reaction treatment.

The invention concerns bifunctional fusion molecules for the treatment of IgE-mediated allergic conditions and FcepsiRI-mediated autoimmune conditions. The invention provides a new therapeutic approach for the treatment of both acute and late-phase allergic responses due to ingestion, inhalation, cutaneous and parenteral exposure to allergens, responses including asthma, allergic rhinitis, atopic dermatitis, severe food allergies, chronic urticaria and angioedema, as well as anaphylactic reactions due to exposures such as bee stings or penicillin allergy. In addition, the invention provides for a novel, safer and more efficacious form of allergy vaccination.

Submandibular peptides have been isolated and characterised and provide pharmaceutical compositions for the treatment or prevention of anaphylactic reactions, endotoxic reactions and SIRS-induced shock.

Compositions suitable for reducing symptoms of an allergic response to environmental allergens comprising molecules that specifically inhibit the ability of the allergen to bind to mast cells in an animal predisposed to having an allergic response to the allergen and methods for reducing such symptoms comprising contacting a source of the environmental allergen with such compositions. Kits, packages, medicaments, and means of communicating about the compositions and methods are also provided.

The invention provides a traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic and a preparation method thereof, and the traditional Chinese medicine comprises the following raw medicinal materials: cumin, galangal, rhizome cyperi, three-nerved spicebush roots, cuttlebone, green tangerine peels, medicated leaven, malts, immature bitter orange, rheum officinale, mirabilite, cortex magnoliae officinalis, radix aucklandiae, amomum, agastache rugosa, finger citron, hawthorns, radish seeds, calcined concha arcae, evodia, pinellia ternate, semen arecae, atractylodes macrocephala koidz, rhizoma nardostachyos and fritillary bulb. The traditional Chinese medicine gastrointestinal auxiliary for type-B ultrasonic has the beneficial effects of being safe to use, painless, noninvasive, non-toxic, free from anaphylactic reaction, short in examination time, high in development rate, convenient to use and low in cost, providing a new technology and a new method for corrective early-stage diagnosis of diseases, and powerful basis for clinical diagnosis, and being a desirable novel auxiliary. Furthermore, the preparation process is simple and practical.

The invention discloses a Prinsepia utilis Royle oil-containing functional skin care product and a preparation method thereof. The Prinsepia utilis Royle oil-containing functional skin care product is prepared from the following raw materials in part by weight: 1 to 2 parts of Prinsepia utilis Royle oil, 10 to 25 parts of purslane extracting solution, 5 parts of glycerol, 2 to 3 parts of 1,2-pentanediol, 5 to 7 parts of caprylic / caprictriglycerides, 2 parts of synthetic squalane, 1 to 5 parts of tocopheryl acetate, 1 to 3 parts of cetearyl alcohol, 0.1 to 0.2 part of allantoin, 0.6 to 0.9 part of coconut oil-base glucoside, 0.5 to 1 part of coconut oil alcohol, 0.5 to 2 parts of glyceryl stearate, 0.1 to 1 part of sodium hyaluronate and the balance of water. The functional skin care product has mild property and high safety without toxic or side reaction and anaphylactic reaction, can repair the destructed skin barrier, resists inflammation and skin ageing, and has a good effect and high safety of assisting in treating skin diseases related with skin barrier destruction, such as facial dermatitis (hormone dependence dermatitis, allergic dermatitis and acne), atopic dermatitis and the like.

The invention concerns bifunctional fusion molecules for the treatment of IgE-mediated allergic conditions and FcεRI-mediated autoimmune conditions. The invention provides a new therapeutic approach for the treatment of both acute and late-phase allergic responses due to ingestion, inhalation, cutaneous and parenteral exposure to allergens, responses including asthma, allergic rhinitis, atopic dermatitis, severe food allergies, chronic urticaria and angioedema, as well as anaphylactic reactions due to exposures such as bee stings or penicillin allergy. In addition, the invention provides for a novel, safer and more efficacious form of allergy vaccination.

The invention relates to the technical field of fibers, in particular to a mite and mosquito-bite preventing underwear, sleepwear and home wear which is characterized by comprising the following processing steps of: preparing medical liquid; carrying out dyeing and printing and other pre-treatments on cottons or cotton blended fabrics; preparing bleaching and dyeing liquid; dyeing cloth; carrying out high temperature tentering; and processing so as to prepare the underwear, the sleepwear and the home wear. According to the invention, the fabrics provided by the invention have the obvious effects of mite preventing, mosquito preventing, anti-bacterium, deodorization, rot resistance, itching relieving, blood circulation invigoration and meridians activation and the like; the repellent rate of dust mite is as high as 99 percent; the repellent rate of mosquito is 95 percent; the repellent rate of termite is 95 percent; fabric-touching pathogens such as staphylococcus aureus, staphylococcus epidermidis, gonococcus and esherichia coli and the like can be completely killed; all efficacies of the fabrics still reach to over 97 percent after the fabrics are washed for 50 times; and the fabrics have the advantages of no irritation to skin, no anaphylactic reaction, no toxicity to the human body, comfort for wearing and can effectively prevent the infection of asthma and other diseases.

The invention discloses a method for detecting an allergen almond component in foods by a fluorescent PCR technology, belonging to allergen detecting technologies, in particular a method for detectingan allergen almond component in foods by an exonuclease probe fluorescent PCR technology (TaqMan). Aiming at an allergen almond component Pru du 1.06B DNA sequence a primer and a TaqMan probe are designed, the fluorescent PCR detecting method is established. The method includes the designed primer and a probe of the almond component specificity, and the fluorescent PCR reaction condition matchedwith the primer and the probe. The method has no cross reaction with peanuts, hazelnuts, chestnuts, walnuts, pine nuts, macadamia nuts, and the like and has specificity; and the detecting sensitivitycan reach 5mg / kg. The method can be used for detecting the allergen in the foods and preventing anaphylactic reaction caused by the foods and has practical meanings.

The invention discloses a water-soluble drug composition of taxol for injection. The drug composition comprises taxol as an active component, polyethyleneglycol 15- hydroxy stearic acid ester as a solubilizer, alcohol as a latent solvent and injection water as a solvent. Polysorbate, cyclodextrin derivatives, poloxamer, polyethylene glycol (PEG) and reducing sugar are also added and are favorable for improving the solubility and stability of the taxol in the composition. The composition is prepared to freeze-dried powder injection for injection, can not produce serious anaphylactic reaction, has small simulation, remarkably improves the clinical compliance of patients and has good water solubility and high convenience for medication by clinicians. The powder injection has good stability, can be stored at room temperature and is favorable for storage and transportation. The powder injection is simple in preparation process, easy to control quality, low in production cost and convenient for industrialized production and also greatly reduces the economic burden of the patients for medication. The invention also discloses a method for preparing the drug composition and clinical application thereof.

Methods and compositions for treating allergic reactions, including cutaneous, ocular, nasal and bronchial allergic disease, are disclosed. Interleukin-1 and Tumor Necrosis Factor receptors, and analogues thereof, are employed which bind the respective effector competitively and thereby suppress allergic reactions.

The present invention is related to a method for modulating the immune system of a mammal patient towards an allergen, which comprises the step of inducing a pre-sensitisation of the immune system of said patient towards an immunogen carrying at least one T cell epitope homologous and functionally similar to an epitope present on said allergen and deriving from a naturally-occurring antigen in order to modify the response of said patient to a further sensitisation to said allergen, allowing that the immune response towards the allergen is modulated and that no allergy towards said allergen towards said allergen will be developed in said patient.

The invention discloses a large-scale preparation method for foot-and-mouth disease totivirus marked vaccine with high yield, high purity and high safety and a product thereof. The method comprises the following steps: a)collecting a virus solution; b)performing deep filtration on a membrane, performing ultrafiltration and performing enzymolysis on nuclease; c)purifying through a strong anion exchange adsorption bed or an adsorption film; d)depositing by PEG, extracting by chloroform-isoamyl aleohl; e)inactivating; F)performing density gradient centrifugation on an inactivation liquid through cane sugar and purifying; g)performing ultrafiltration dialysis and aseptic filtration; and h)reserving a stock solution or emulsifying. The provided foot-and-mouth disease totivirus marked vaccine antigen is uniform and complete foot-and-mouth virus particle, The vaccine is injected into body, so animal infection and immunization can be completely distinguished, does not contain foot-and-mouth disease virus non-structural protein and other virus particle, and does not contain animal-based foreign protein, polypeptide and oligopeptides, animal latent anaphylactic reaction, carcinogenesis and latent risk such as mad cow disease for causing animal infectious diseases due to vaccine injection can be effectively reduced, and the vaccine has no influence on animal food safety and trade.

The invention discloses a duplex dentin hypersensitivity resistant composition and an application of the composition. The active ingredients of the duplex dentin hypersensitivity resistant composition include a potassium salt and titanium containing bioactive glass, wherein the weight percentage of the potassium salt in the composition is 0.3-12%, and the weight percentage of the titanium containing bioactive glass in the composition is 0.5-15%. The duplex dentin hypersensitivity resistant composition disclosed by the invention can be used for preventing and treating (eliminating or relieving) dentin hypersensitivity; on one side, the potassium salt releases potassium ions to rapidly relieve pain (by reducing the excitability of a dental pulp nerve), on the other side, the bioactive glass can be used for supplementing minerals for a tooth structure to form stable carbonated hydroxyapatite so as to deeply close a dentinal tubule (by improving the permeability of the dentinal tubule); treatment effect is greatly improved, and aching feeling and anaphylaxis can be radically eliminated to achieve the purposes of treating both symptoms and root causes; in addition, as the bioactive glass comprises titanium, the phosphorite layer formed on the surface of a tooth is firmer and more wear-resistant, and the tooth can better resist daily stimulation.

The invention belongs to health care products and particularly relates to compound essential oil capable of protecting and developing hairs and a preparation method thereof. The preparation method comprises steps of placing rosewood oil, ylang oil, rosemary oil, ginger oil, cinnamon oil and curcuma oil in a container; stirring to enable all raw materials to be fully mixed evenly; then adding jojoba oil; stirring; fully diluting and fusing; splitting charging and sealing; and achieving the compound essential oil. The compound essential oil uses various plant essential oil for matching scientifically, can well play effects of the plant essential oil due to the synergistic effect, has significant nutrition required for growth of hairs, can quickly activate hair follicles to fast resolve subcutaneous fat and dredge capillaries of scalps to enable active ingredients to quickly reach the hair follicles to achieve the purposes of protecting hairs, raising hairs, preventing alopecia and the like, and is suitable for various hairs and scalps with various characteristics, free of anaphylactic reactions and side effect after being used, quick in effect and good in effects of hair developmentand hair care.

The invention provides a fully human monoclonal antibody against tetanus toxin. The amino acid sequences of a heavy-chain variable region and a light-chain variable region of the monoclonal antibody are SEQ ID No. 3 and SEQ ID No. 4, respectively; preferably, the amino acid sequences of a heavy chain and a light chain of the monoclonal antibody are SEQ ID No. 1 and SEQ ID No. 2, respectively. The invention further provides a preparation method and application of the fully human monoclonal antibody against tetanus toxin and a derivative thereof. The fully human monoclonal antibody against tetanus toxin provided by the invention can eliminate the biological risks of anaphylactic reaction and virus contamination, has a sufficiently long half life and high titer and in-vivo activity, can be applied to large-scale industrial production.

The invention relates to a medicament for treating cerebral infarction. A preparation method comprises the following steps: using gingko leaves, hawthorn leaves, angelica, rhizoma gastrodiae, caulis milletiae, sweetgum fruit, earthworm, uncaria, clematis root, dried orange peel and licorice as raw material drugs, adding water into the raw material drugs and decocting the mixture, condensing the decoction to be thick paste, drying and crushing the thick paste into medicinal powder, filling the medicinal powder into capsules, sterilizing and disinfecting the capsules to obtain the capsule preparation. The medicament treats both symptoms and root causes during cerebral infarction treatment, has the characteristics of definite effect and quick healing, has no toxic and side effect or allergic reaction, uses little amount of medicament, has low cost, has obvious effect on acute cerebral infarction, can also control disease development of chronic cerebral infarction, and is easy to be accepted by patients. The cure rate for treating the acute cerebral infarction is 96 percent, and the cure rate for treating the chronic cerebral infarction is 93 percent.

The present invention relates to one kind of polycinnamic alcohol injection and its preparation. The polycinnamic alcohol injection is used mainly in treating esophagus varication hemorrhage and esophagus varication cirrhosis under endoscope. The polycinnamic alcohol injection contains in each 100 ml polycinnamic alcohol 1 g and alcohol 5 ml. Alcohol can dissolve polycinnamic alcohol easily and has slight narcosis, so that the polycinnamic alcohol injection has no pain caused, low viscosity for easy injecting, no side effect and less complication.

The invention provides a method for producing pseudorabies living vaccines by using a subculture cell source and a pseudorabies living vaccine product thereof. The method comprises the following steps: culturing pseudorabies virus low-virulent strains by using subculture cells; harvesting the strains to obtain cell culture venom; and then adding a stabilizing agent and an antibiotic into the cellculture venom, and freezing and vacuum-drying the mixture to obtain the pseudorabies living vaccines of the subculture cell source. The subculture cells are subculture cells ST of pig testicle or subculture cells PK15 or IBRS-2 of pig kidney. The method for producing the pseudorabies living vaccines by using the subculture cell source has the advantages of simple and stable production process, easy operation, high virus content, little batch difference and controllable quality, can remarkably improve the yield and quality of the vaccines and reduce the anaphylactic reaction and the like. The pseudorabies living vaccines obtained by using the production method of the invention have good safety and high immune efficacy, and have better immune protection effect on pseudorabies virulent attack.

The invention provides an MRGPRX2 protein serving as a protein marker for screening drug anaphylactoid reaction susceptive groups and application thereof. Researches find out that the relative expression of the MRGPRX2 protein in peripheral blood has relevance to drug anaphylactoid reaction susceptivity of testers, and the MRGPRX2 protein can serve as a protein marker for screening the drug anaphylactoid reaction susceptive groups. The relative expression of the MRGPRX2 protein is used for evaluating risk of anaphylactoid reaction of patients occurring in the medication process, and has significance on clinical guiding of pharmacy safety. The method for screening drug anaphylactoid reaction susceptive groups provided by the invention is used for screening occurrence risk of anaphylactoid reaction of the patients and has extremely high susceptivity and specificity. Moreover, since the clinically available peripheral blood is adopted for detection, the method is convenient to use and issuitable for screening of large scale population of patients before medication, advanced discovery of the anaphylactoid reaction susceptive groups is facilitated, and the medication safety is improved.

An allergy emergency kit (AEK) for use in treating urgent allergic reactions in common areas for allergens to exist. Generally speaking, the kit comprises a container for securing allergy medicines, a customizable panel for fastening allergy medicine in an orderly fashion, at least anaphylaxis device fastened to the panel and positioned within the container, and an instruction sheet positioned within the container and listing urgent care details for victims of allergens. Preferably, the anaphylaxis device includes at least one of either an adult-dosed and a child-dosed anaphylaxis device such as an EpiPen or similar epinephrine injection device. The allergy emergency kit may also contain auxiliary allergy medicine, such as diphenhydramine hydrochloride, antihistamine, anti-inflammatory, anti-itch, pain relief, mild sedative, asthma inhaler, ipecac, anti-nausea medicines and other such medicines, herbs or remedies which might be useful in treating the symptoms of an allergic reaction.

The invention discloses a bioactive facial mask and a preparation method therefore. The facial mask is of a composite structure, and comprises a bracket layer and a porous nano active layer which is adhered on the bracket layer; and silk fibroin which is mixed with a bioactive factor, a medicament factor or the mixture of the two is adsorbed on the active layer. The preparation method comprises the following steps of: preparing the silk fibroin into the bracket layer by dissolving-film making procedures; coasting or spraying aqueous solution of silk fibroin on the surface of the bracket layer, quickly freezing the bracket layer at low temperature and performing freeze drying on the bracket layer under vacuum to obtain the porous nano active layer; and then soaking the porous nano active layer in the solution of silk fibroin mixed with the bioactive factor, the medicament factor or the mixture of the two, demoulding and packaging the porous nano active layer in the wet state to obtain the bioactive facial mask. The bioactive facial mask has the advantages of wide range of application people, natural source, green and safety, no chemical additives, no anaphylactic reaction, high biological safety and biological activity, simple preparation method, mature process and easy control.

The invention relates to a Chinese medicinal herb fragrant bath formula for nursing and caring skin and resisting aging, wherein cinnamon, radix angelicae, Sichuan lovage rhizome, angelica sinensis, ginger and folium artemisiae argyi are cut into pieces or sections which are about 1-2 cm long; grinding folium syringae, rosemary and radix paeoniae alba into coarse powder; and then proportionally mixing the coarse powder with rose flowers dried in the shade, and then packaging the mixture in a small gauge bag. The Chinese medicinal herb fragrant bath formula provided by the invention employs Chinese medicinal herbs and realizes scientific compatibility thereof, and thus has good effects on improving the human body immunity and delaying skin aging and are suitable for the symptoms of skin aging of various features; after the Chinese medicinal herb fragrant bath formula is used, no any anaphylactic reaction and no any toxic and side effect are caused; if the Chinese medicinal herb fragrant bath formula is taken for a long time, the active substances of the medicinal herbs penetrate into the skin and thus are absorbed by the skin, so that the purposes of nursing the skin, softening cutin, resisting aging and the like are achieved; and the Chinese medicinal herb fragrant bath formula is quick in effect taking and good in effect.

The invention relates to a preparation method for a diploid cell rabies vaccine and a purified rabies vaccine, and the method uses a serum-free medium to culture human diploid cell rabies purified vaccine, thus greatly reducing anaphylactic reaction and being beneficial to purification.

An endotoxic adsorpting method for treating endotoxemia and anaphylactic reaction caused by endotoxemia is prepared through activating the hydroxy group of agarose gel or DVA as carrier by cyanogen bromide or epoxy chloropropane or sulfuryl chloride, and adding polymyxin solution.

Pharmacological test shows that the externally-used preparation of Cetirizine has ideal allergy resistant and anti-inflammatory action to the rat passive cutaneous anaphylaxis (Rat PCA) model and dimethylbenzene caused mouse otitis model, and also prevents the adverse effect to the central system caused by whole body administration. It is also found in the test, that the externally used preparation of Cetirizine also has very fine inhibitory action to dinitrofluorobenzene caused mouse porphyria hypersensitivity (PTH), the novel pharmacological action of the Cetirizine shows that the Cetirizine external preparation has good therapeutic action to skin inflammations which mainly include porphyria hypersensitivity.