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4727 results about "T cell" patented technology
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A T cell is a type of lymphocyte which develops in the thymus gland and plays a central role in the immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell receptor on the cell surface. These immune cells originate as precursor cells, derived from bone marrow, and develop into several distinct types of T cells once they have migrated to the thymus gland - for which these cells are named. T cell differentiation continues even after they have left the thymus.
Anti-PD-L1 antibodies, compositions and articles of manufacture
The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.
Owner:F HOFFMANN LA ROCHE & CO AG
Simultaneous stimulation and concentration of cells
InactiveUS6905874B2Maximizes stimulationBiocideImmunoglobulins against cell receptors/antigens/surface-determinantsT cellCells signal
The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and stimulate cells that maximizes stimulation and / or proliferation of such cells. In the various embodiments, cells are stimulated and concentrated with a surface yielding enhanced proliferation, cell signal transduction, and / or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by simultaneous concentration and cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety and applying a force that predominantly drives cell concentration and cell surface moiety ligation, thereby inducing cell stimulation, cell surface moiety aggregation, and / or receptor signaling enhancement. Also provided are methods for producing phenotypically tailored cells, including T-cells for the use in diagnostics, drug discovery, and the treatment of a variety of indications, including cancer, viral infection, and immune related disorders. Compositions of cells having specific phenotypic properties produced by these processes are further provided.
Owner:LIFE TECH CORP
Compositions of pd-1 antagonists and methods of use
InactiveUS20120114649A1Improve responseInhibitory signal transductionAntibacterial agentsOrganic active ingredientsT cellInfective disorder
Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.
Owner:MEDIMMUNE LLC
Novel artificial antigen presenting cells and uses therefor
The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each specifically bind with a cognate molecule on a T cell of interest, thereby mediating expansion of the T cell. The aAPC of the invention can further comprise additional molecules useful for expanding a T cell of interest. The aAPC of the invention can be used as an “off the shelf” APC that can be readily designed to expand a T cell of interest. Also, the aAPC of the invention can be used identify the stimulatory, co-stimulatory, and any other factors that mediate growth and expansion of a T cell of interest. Thus, the present invention provides powerful tools for development of novel therapeutics where activation and expansion of a T cell can provide a benefit.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Mammalian cell surface antigens; related reagents
InactiveUS7025962B1Abnormal immune responseFacilitated DiffusionPeptide/protein ingredientsAntibody mimetics/scaffoldsMammalT cell
Owner:MERCK SHARP & DOHME CORP
Method and compositions using a chimeric antigen receptor for enhanced anti-tumor effector functioning of T cells
Integration of costimulatory signaling domains within a tumor targeting chimeric antigen receptor (CAR), such as the IL13Rα2 specific IL13-zetakine (IL13ζ), enhances T cell-mediated responses against tumors even in the absence of expressed ligands for costimulatory receptors.
Owner:CITY OF HOPE
Anti-pd-l1 antibodies and uses thereof
ActiveUS20140341917A1Function increaseUpregulate cell-mediated immune responsesOrganic active ingredientsPeptide/protein ingredientsAntigen Binding FragmentAntigen binding
The present application relates to anti-PD-L1 antibodies or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, for the treatment of and cancer.
Owner:MERCK PATENT GMBH
Apparatus and method for computer modeling type 1 diabetes
The invention encompasses novel methods for developing a computer model of type 1 diabetes in a mammal. In particular, the models can include representations of biological processes associated with a pancreatic lymph node and one or more pancreatic islets. Alternatively, the models can include representations of biological processes associated with at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming, insulitis and hyperglycemia. The invention also provides methods for developing a computer model of a non-insulin replacement treatment of type 1 diabetes. The invention also encompasses computer models of type 1 diabetes, methods of simulating type 1 diabetes and computer systems for simulating type 1 diabetes and the uses thereof.
Owner:ENTELOS INC
Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
ActiveUS8252592B2Increase self-toleranceIncrease and reduces immune responseFused cellsFermentationRegulatory T cellLymphocyte
Owner:MEMORIAL SLOAN KETTERING CANCER CENT
Antibody for 4-1BB
The present invention includes the receptor protein 4-1BB and the cDNA gene encoding for receptor protein 4-1BB. The nucleotide sequence of the isolated cDNA is disclosed herein along with the deduced amino acid sequence. The 4-1BB protein and fragments and derivatives can be used: 1) as a probe to isolate ligands to receptor protein 4-1BB, 2) to stimulate proliferation of B-cell's expressing 4-1BB, or 3) to block 4-1BB ligand binding. A monoclonal antibody against 4-1BB was developed which specifically recognizes an epitope on the extracellular domain of receptor protein 4-1BB. The monoclonal antibody can be used enhance T-cell proliferation and activation by treating T-cells that have expressed receptor protein 4-1BB with the monoclonal antibody. The effectiveness of the treatment was enhanced when conducted in the presence of protein tyrosinase kinase. A fusion protein for detecting cell membrane ligands to receptor protein 4-1BB was developed. It comprises the extracellular portion of the receptor protein 4-1BB and a detection protein bound to the portion of the receptor protein 4-1BB.
Owner:INDIANA UNIV RES & TECH CORP
Anti-cd3 antibodies, bispecific antigen-binding molecules that bind cd3 and cd20, and uses thereof
ActiveUS20140088295A1Useful in treatmentFacilitates directed killing (cell lysis) of the targetedImmunoglobulins against cell receptors/antigens/surface-determinantsAntibody ingredientsCD20Disease
The present invention provides antibodies that bind to CD3 and methods of using the same. According to certain embodiments, the antibodies of the invention bind human CD3 with high affinity and induce human T cell proliferation. The invention includes antibodies that bind CD3 and induce T cell-mediated killing of tumor cells. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD3, and a second antigen-binding molecule that specifically binds human CD20. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of B-cell tumors expressing CD20. The antibodies and bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced targeted immune response is desired and / or therapeutically beneficial. For example, the antibodies of the invention are useful for the treatment of various cancers as well as other CD20-related diseases and disorders.
Owner:REGENERON PHARM INC
Vaccine Nanotechnology
ActiveUS20100233251A1Modulating immune systemEnhance and suppress and direct and immune responseNervous disorderAntipyreticDiseaseNanocarriers
Owner:MASSACHUSETTS INST OF TECH +4
Compositions of PD-1 antagonists and methods of use
InactiveUS8114845B2Improve responseInhibitory signal transductionAntibacterial agentsOrganic active ingredientsCompound (substance)T cell
Owner:MEDIMMUNE LLC
Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
ActiveUS20130315884A1Precise positioningPeptide/protein ingredientsAntibody mimetics/scaffoldsImmunosuppressive drugPrimary cell
Methods for developing engineered T-cells for immunotherapy that are both non-alloreactive and resistant to immunosuppressive drugs. The present invention relates to methods for modifying T-cells by inactivating both genes encoding target for an immunosuppressive agent and T-cell receptor, in particular genes encoding CD52 and TCR. This method involves the use of specific rare cutting endonucleases, in particular TALE-nucleases (TAL effector endonuclease) and polynucleotides encoding such polypeptides, to precisely target a selection of key genes in T-cells, which are available from donors or from culture of primary cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer and viral infections.
Owner:CELLECTIS SA
Chimeric receptors with 4-1bb stimulatory signaling domain
InactiveUS20130266551A1Provide immunitySpecific and vigorous preferential expansionBiocideAntibody mimetics/scaffoldsChimeric antigen receptorBiological activation
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.
Owner:ST JUDE CHILDRENS RES HOSPITAL INC
Chimeric receptors with 4-1BB stimulatory signaling domain
InactiveUS20050113564A1Antibody mimetics/scaffoldsImmunoglobulins against cell receptors/antigens/surface-determinantsNatural Killer Cell Inhibitory ReceptorsT cell
The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use. Also included is a method for obtaining an enriched population of NK cells from a mixed population of NK cells and T cells.
Owner:ST JUDE CHILDRENS RES HOSPITAL INC
Compositions and methods for priming monocytic dendritic cells and t cells for th-1response
InactiveUS20050059151A1Mammal material medical ingredientsBlood/immune system cellsDendritic cellMonocyte
The present invention provides compositions and methods for inducing maturation of immature dendritic cells (DC) and for priming those cells for inducing a type 1 immune response. The present invention also provides dendritic cell populations useful for activating and for preparing T cells polarized towards production of type 1 cytokines and / or a type 1 response. Similarly, activated, polarized T cell populations, and methods of making the same are provided.
Owner:NORTHWEST BIOTHERAPEUTICS INC
Methods of using Anti-pd-l1 antibodies and their use to enhance t-cell function to treat tumor immunity
InactiveUS20130045201A1Antibacterial agentsOrganic active ingredientsDiseaseAntiendomysial antibodies
The present application relates to methods of using anti-PD-L1 antibodies to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.
Owner:GENENTECH INC
Bispecific t cell activating antigen binding molecules
InactiveUS20130078249A1Increase in sizeSmall volumeAnimal cellsHybrid immunoglobulinsActivation cellsAntigen binding
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
Owner:ROCHE GLYCART AG
Methods of producing enriched populations of tumor-reactive t cells from tumor
Methods of obtaining a cell population enriched for tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of T cells from a tumor sample; (b) specifically selecting CD8+ T cells that express any one or more of TIM-3, LAG-3, 4-1BB, and PD-1 from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive T cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive T cells, and isolated or purified cell populations are also disclosed.
Owner:UNITED STATES OF AMERICA
Methods and Antibody Compositions for Tumor Treatment
ActiveUS20150266966A1Decreased killing of T-cellsReduce the burden onImmunoglobulins against cell receptors/antigens/surface-determinantsAntibody ingredientsDiseaseCD20
The present invention provides bispecific antibodies that bind to CD3 and tumor antigens and methods of using the same. According to certain embodiments, the bispecific antibodies of the invention exhibit reduced effector functions and have a unique binding profile with regard to Fcγ receptors. The bispecific antibodies are engineered to efficiently induce T cell-mediated killing of tumor cells. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human CD3, a second antigen-binding molecule that specifically binds human CD20, and an Fc domain that binds Fcγ receptors with a specific binding pattern. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of B-cell or melanoma tumors expressing CD20. The bispecific antibodies of the invention are useful for the treatment of various cancers as well as other CD20-related diseases and disorders.
Owner:REGENERON PHARM INC
DNA vaccines encoding antigen linked to a domain that binds CD40
InactiveUS7118751B1Improve abilitiesEasy to demonstrateAntibody mimetics/scaffoldsVirus peptidesPeptide antigenEukaryotic plasmids
Vaccines that target one or more antigens to a cell surface receptor improve the antigen-specific humoral and cellular immune response. Antigen(s) linked to a domain that binds to a cell surface receptor are internalized, carrying antigen(s) into an intracellular compartment where the antigen(s) are digested into peptides and loaded onto MHC molecules. T cells specific for the peptide antigens are activated, leading to an enhanced immune response. The vaccine may comprise antigen(s) linked to a domain that binds at least one receptor or a DNA plasmid encoding antigen(s) linked to a domain that binds at least one receptor. A preferred embodiment of the invention targets HIV-1 env antigen to the CD40 receptor, resulting in delivery of antigen to CD40 positive cells, and selective activation of the CD40 receptor on cells presenting HIV-1 env antigens to T cells.
Owner:HAYDEN LEDBETTER MARTHA S +1
Reversible MHC multimer staining for functional purification of antigen-specific T cells
ActiveUS7776562B2Preserving functional statusHigh affinityMammal material medical ingredientsDepsipeptidesStainingBasic research
The present invention relates to a new method for reversible staining and functional isolation or characterization of cells, e.g. antigen-specific T cells. With this technique, the original functional status of cells can be substantially maintained after their identification and purification. Thus, this new method is of broad benefit for basic research and clinical applications.
Owner:IBA LIFESCIENCES GMBH
Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
InactiveUS8637307B2Maintain their viabilityLower Level RequirementsGenetically modified cellsMammal material medical ingredientsT cellExogenous growth
Provided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research purposes. The cell based expansion system and methods permit the long-term growth of CTLs, preferably human CTLs. In addition, T cell proliferation can be induced without the need for antigen, thus providing an expanded T cell population that is polyclonal with respect to antigen reactivity. Further provided are methods for using the system and methods to screen and identify antigens related to specific diseases or conditions, tumors, autoimmune disorders, or an infectious disease or pathogen, and to identify target molecule for research purposes, or for developing a vaccine based thereon.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
Tr3-specific binding agents and methods for their use
InactiveUS6994976B1Prevent proliferationPeptide/protein ingredientsAntibody ingredientsAutoimmune responsesActive agent
Biologically active TR3-specific binding agents and methods for their use are disclosed. The biologically active TR3-specific binding agents are useful for inhibiting the proliferation of cells expressing TR3. These biologically active agents are particularly useful for treating T-cell mediated diseases such as graft-versus-host disease, organ rejection, tumor growth, autoimmunity, and inflammation.
Owner:TITTLE THOMAS V +1
IL-2 selective agonists and antagonists
InactiveUS6955807B1Great therapeutic useToxic reductionBacteriaSugar derivativesNatural Killer Cell Inhibitory ReceptorsNucleotide
The invention is directed to a polypeptide comprising a human IL-2 mutein numbered in accordance with wild-type IL-2 wherein said human IL-2 is substituted at at least one of positions 20, 88 or 126, whereby said mutein preferentially activates T cells over NK cells. D20H and I, N88G, I, and R, in particular have a relative T cell-differential activity much greater than native IL-2, with predicted associated reduced in vivo toxicity. The invention also includes polynucleotides coding for the muteins of the invention, vectors containing the polynucleotides, transformed host cells, pharmaceutical compositions comprising the muteins, and therapeutic methods of treatment.
Owner:AICURIS GMBH & CO KG
Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions
InactiveUS20070014810A1Reduce the possibilityImproving immunogenicitySugar derivativesViral antigen ingredientsEpitopeT cell
This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
Owner:GENIMMUNE NV +1
Preventive or therapeutic agent for sensitized T cell-mediated diseases comprising IL-6 antagonist as an active ingredient
InactiveUS20060134113A1Avoid delayPeptide/protein ingredientsImmunoglobulins against cytokines/lymphokines/interferonsInterleukin 6T cell
A preventive or therapeutic agent for sensitized T cell-mediated diseases comprising an interleukin-6 (IL-6) antagonist, for example an antibody directed against IL-6 receptor, an antibody directed against IL-6, an antibody directed against gp130, and the like.
Owner:CHUGAI PHARMA CO LTD
Vaccine Nanotechnology
ActiveUS20130236533A1Facilitate acquisitionModulating the immune systemNervous disorderAntipyreticDiseaseNanocarriers
Owner:THE BRIGHAM & WOMEN S HOSPITAL INC +3
Chimeric antigen receptors targeting b-cell maturation antigen
ActiveUS20150051266A1Antibody mimetics/scaffoldsGenetic material ingredientsAntigenAntigen receptors
The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
Owner:UNITED STATES OF AMERICA
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