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Duplex dentin hypersensitivity resistant composition and application thereof

A dentin hypersensitivity and composition technology, which is applied in the field of dual anti-dentin hypersensitivity compositions, can solve problems such as dependence, palliative treatment, and human harm, so as to resist daily stimulation, eliminate pain, and improve curative effect Effect

Active Publication Date: 2013-10-09
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this composition belongs to fluoride toothpaste, which is harmful to the human body, and this composition cannot essentially repair the open dentinal tubules at the allergic site
[0011] Although the prior art discloses a variety of compositions for the prevention and treatment of dentin hypersensitivity, these compositions have the disadvantages of treating the symptoms but not the root cause, causing dependence, and high prices. Composition for preventing and treating dentin hypersensitivity

Method used

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  • Duplex dentin hypersensitivity resistant composition and application thereof
  • Duplex dentin hypersensitivity resistant composition and application thereof
  • Duplex dentin hypersensitivity resistant composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0067] In the preparation method of the above dual anti-dentine hypersensitivity composition, the rapid stirring time in step 2) is 0.5h-1h. The standing time in step 3) is 10min-2h, preferably 0.5h.

[0068] The application of the dual anti-dentin hypersensitivity composition in the preparation of a pharmaceutical composition for anti-dentin hypersensitivity also belongs to the protection scope of the present invention.

[0069] The application of the dual anti-dentin hypersensitivity composition in the preparation of pharmaceutical compositions for preventing or treating tooth erosion and bleeding gums also belongs to the protection scope of the present invention.

[0070] The application of the dual anti-dentine hypersensitivity composition in the preparation of products for tooth cleaning, dental care or oral hygiene also belongs to the protection scope of the present invention.

Embodiment 1-5

[0073] The formula of embodiment 1-5 dual anti-dentine hypersensitivity composition and comparative example is as shown in table 1:

[0074] Table 1 Embodiment 1-5 double anti-dentine hypersensitivity composition and the formula of comparative example

[0075]

[0076] The bioactive glass can be prepared by the aforementioned sol-gel method, high-temperature melting and sintering method or hydrothermal method, and will not be described again.

[0077] Embodiment 1-5 paste double anti-dentine hypersensitivity composition can be prepared according to the following steps:

[0078] 1) Weigh the raw materials according to the weight percentage in Table 1. Under the condition of rapid stirring, mix friction agent, bioactive glass powder, potassium salt, sweetener, thickener, binder, preservative, surfactant Separately pre-dispersed in humectants;

[0079] 2) Under the conditions of vacuum and rapid stirring, the friction agent, bioactive glass powder, potassium salt, sweetener,...

Embodiment 5

[0100] Teeth anti-allergic test was carried out on four groups of samples of Example 5, Comparative Example 1 (single bioactive glass group), Comparative Example 2 (single potassium salt group) and Comparative Example 3 (blank control), and 80 people suffered from dentin hypersensitivity The people in the study were randomly divided into four groups, 20 people in each group, and all the subjects used the same model toothbrush produced by the same manufacturer. All subjects used the samples at least twice a day, either to smear sensitive areas or brush their teeth with the samples, for six consecutive weeks.

[0101] Test methods: ①Clinical examination, probe the sensitive part of the affected tooth, and record the sensitivity; isolate the affected tooth from the adjacent teeth with a cotton roll, blow air-conditioning vertically at a distance of 5 mm from the buccal surface for 1 second, and record the sensitivity (ie, pain level). Repeat 2 times, if the degree of the two stim...

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Abstract

The invention discloses a duplex dentin hypersensitivity resistant composition and an application of the composition. The active ingredients of the duplex dentin hypersensitivity resistant composition include a potassium salt and titanium containing bioactive glass, wherein the weight percentage of the potassium salt in the composition is 0.3-12%, and the weight percentage of the titanium containing bioactive glass in the composition is 0.5-15%. The duplex dentin hypersensitivity resistant composition disclosed by the invention can be used for preventing and treating (eliminating or relieving) dentin hypersensitivity; on one side, the potassium salt releases potassium ions to rapidly relieve pain (by reducing the excitability of a dental pulp nerve), on the other side, the bioactive glass can be used for supplementing minerals for a tooth structure to form stable carbonated hydroxyapatite so as to deeply close a dentinal tubule (by improving the permeability of the dentinal tubule); treatment effect is greatly improved, and aching feeling and anaphylaxis can be radically eliminated to achieve the purposes of treating both symptoms and root causes; in addition, as the bioactive glass comprises titanium, the phosphorite layer formed on the surface of a tooth is firmer and more wear-resistant, and the tooth can better resist daily stimulation.

Description

technical field [0001] The invention relates to a double anti-dentine hypersensitivity composition, which comprises titanium-containing bioactive glass and potassium salt, and can be used for preventing and treating (eliminating or alleviating) dentin hypersensitivity. Background technique [0002] Dentin hypersensitivity is a common symptom of dental diseases, which refers to a special sore symptom caused by external stimuli (mechanical, chemical, temperature and osmotic pressure, etc.) on exposed dentin. The incidence rate of dentin hypersensitivity is 8%-30%, and it is a high-incidence crowd around 40 years old. It is a common and frequently-occurring disease in oral clinical practice. Dentin hypersensitivity involves a wide range of symptoms and causes, such as: wedge-shaped defect, periodontal atrophy, root exposure, dental trauma, dentin exposure, severe wear, tooth preparation, cavity preparation, scaling, scaling, Teeth discoloration, jaw adjustment, etc. The main ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K8/29A61K8/19A61P1/02A61P37/08A61P7/04A61K33/00A61K33/14
Inventor 姜丽娟王月月任芳白云峰董芳芳徐艳丽
Owner SAIKE SAISI BIOTECH CO LTD
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