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Application of serine in preparing medication for treating cerebral ischemia

A technology of serine and cerebral ischemia, applied in the direction of drug combination, cardiovascular system diseases, etc., can solve the problems of no application of cerebral ischemia, and achieve the best effect

Inactive Publication Date: 2007-10-10
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report on its application in cerebral ischemia

Method used

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  • Application of serine in preparing medication for treating cerebral ischemia
  • Application of serine in preparing medication for treating cerebral ischemia
  • Application of serine in preparing medication for treating cerebral ischemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0033] An application of L-serine in the preparation of medicine for treating cerebral ischemia.

[0034] Specific positive test:

[0035] 1. Experimental materials and methods

[0036] 1 material

[0037] 1.1 Experimental animals: healthy adult male Sprague-Dawley (SD) rats, clean grade, weighing 240-260g, provided by the Experimental Animal Center of Nantong University.

[0038] 1.2 Main reagents and solutions: Taurine (Taurine) powder was purchased from Sigma-Aldrich; Glycine: Sinopharm Chemical Reagent Co., Ltd.; L-serine: Sinopharm (Group) Shanghai Chemical Reagent Company; β-Alanine: Sigma Company (U.S.); L-alpha-alanine: China Pharmaceutical (Group) Shanghai Chemical Reagent Company; red tetrazolium (2,3,5-triphenyltetrazolium, TTC) powder was purchased from Shanghai Lingjin Fine Chemical Co., Ltd.; anti-β -actin monoclonal antibody was purchased from Sigma; Cleaved Caspase-3 (Asp175) rabbit anti-mouse monoclonal antibody was purchased from CellSignaling; the seconda...

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Abstract

An application of L-serine in preparing the slow-release or release controllable medicines in the form of solid, liquid, or spray for treating cerebral ischemia is disclosed.

Description

Technical field: [0001] The present invention relates to a new medical application of L-serine. Background technique: [0002] Cerebrovascular disease is a brain dysfunction caused by various vascular brain lesions, and stroke (also known as apoplexy) is a clinical event in which acute cerebral circulation disorders rapidly lead to localized or diffuse brain function defects. Stroke includes ischemic stroke and hemorrhagic stroke, with the former accounting for 70%. Its main feature is focal neurological deficit in the area dominated by the diseased blood vessels, such as disturbance of consciousness, hemiplegia, hemianopia, hemisensory disturbance, and aphasia. According to statistics, the incidence rate of stroke in my country is 120-180 / 100,000 people, and the annual new stroke is more than 1.5 million people, and the stroke mortality rate is the second in the world (mortality rate is 80-120 / 100,000 people). Therefore, About 1.2 million people die from stroke every year....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61P9/10
Inventor 姜正林王国华
Owner NANTONG UNIVERSITY
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